Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures

Authors: Di Giovannantonio, Matteo ^{1, 11}, Hartley, Fiona ¹, Elshenawy, Badran ¹, Barberis, Alessandro ¹, Hudson, Dan ^{2, 3}, Shafique, Hana S. ⁴, Allott, Vincent E.S. ⁵, Harris, David A. ⁶, Lord, Simon R. ¹, Haider, Syed ⁷, Harris, Adrian L. ¹, Buffa, Francesca M. ^{1, 8, 9, 12, ∗}, Harris, Benjamin H.L. ^{1, 5, 10, 11, 12, 13, ∗∗}

Source: In Cell Genomics 12 February 2025 5(2)

Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma

Authors: Ahern, David, Amess, Bob, Ramirez, Kristen Aufiero, Berridge, Georgina, Carroll, Thomas M., Chadwick, Joseph A., Chang, Jaeho, Cheng, Jingfei, Dobbie, Sam T., Drozdz, Magdalena, Fischer, Roman, Frangou, Anna, Fuchs, Hannah S., Griffiths, Lucinda, Inoue, Masato, Jacobs, Brittany-Amber, James, Sabrina A., Kaplinsky, Joseph, Karydis, Ioannis, Kessler, Benedikt M., Lord, Simon R., Lou, Hantao, Lu, Xin, Macri, Mary J., McCann, Katy J., McGregor, Naomi, Middleton, Mark R., Norris-Bulpitt, Stewart, Omiyale, Ayo O., Owen, Richard P., Peneva, Iliana, Phetsouphanh, Chansavath, Rei, Margarida, Ricciardi, Toni, Roth, Andrew, Puig, Carlos Ruiz, Ryan, Aileen, Schuster-Böckler, Benjamin, Siejka-Zielińska, Paulina, Song, Chunxiao, Tomkova, Marketa, Van den Eynde, Benoit J., Velikova, Gergana, Venhaus, Ralph R., White, Michael J., Xie, Phil F.

Source: In Cancer Cell 10 July 2023 41(7):1222-1241

The Impact of Body Mass Index (BMI) on Clinical Outcomes for Patients Receiving Systemic Anti-Cancer Therapies for Advanced Clear Cell Renal Carcinoma.

Authors: Greene, John, Wang, Zhe, Harris, Benjamin H. L., Dodwell, David, Lord, Simon R.

Source: Cancer Control: Journal of the Moffitt Cancer Center; 3/17/2025, p1-7, 7p

Implications of obesity and insulin resistance for the treatment of oestrogen receptor-positive breast cancer.

Authors: Javed, Sohail Rooman, Skolariki, Aglaia, Zameer, Mohammed Zeeshan, Lord, Simon R.

Source: British Journal of Cancer; Dec2024, Vol. 131 Issue 11, p1724-1736, 13p

Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma

Authors: Carroll, Thomas M., Chadwick, Joseph A., Owen, Richard P., White, Michael J., Kaplinsky, Joseph, Peneva, Iliana, Frangou, Anna, Xie, Phil F., Chang, Jaeho, Roth, Andrew, Amess, Bob, James, Sabrina A., Rei, Margarida, Fuchs, Hannah S., McCann, Katy J., Omiyale, Ayo O., Jacobs, Brittany-Amber, Lord, Simon R., Norris-Bulpitt, Stewart, Dobbie, Sam T., Griffiths, Lucinda, Ramirez, Kristen Aufiero, Ricciardi, Toni, Macri, Mary J., Ryan, Aileen, Venhaus, Ralph R., Van den Eynde, Benoit J., Karydis, Ioannis, Schuster-Böckler, Benjamin, Middleton, Mark R., Lu, Xin

Source: Cancer cell. 41(7):1222-1241.e7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194223499.0x000001&indx=1&recIds=ETOCvdc_100194223499.0x000001

Dual Erb B Inhibition in Oesophago-gastric Cancer (DEBIOC): A phase I dose escalating safety study and randomised dose expansion of AZD8931 in combination with oxaliplatin and capecitabine chemotherapy in patients with oesophagogastric adenocarcinoma

Authors: Thomas, Anne, Virdee, Pradeep S., Eatock, Martin, Lord, Simon R., Falk, Stephen, Anthoney, D. Alan, Turkington, Richard C., Goff, Matthew, Elhussein, Leena, Collins, Linda, Love, Sharon, Moschandreas, Joanna, Middleton, Mark R.

Source: In European Journal of Cancer January 2020 124:131-141

Window of opportunity clinical trial designs to study cancer metabolism

Authors: Aroldi, Francesca, Lord, Simon R.

Source: British journal of cancer. 122(1):45-51

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194083810.0x000001&indx=1&recIds=ETOCvdc_100194083810.0x000001

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer

Authors: Lord, Simon R., Cheng, Wei-Chen, Liu, Dan, Gaude, Edoardo, Haider, Syed, Metcalf, Tom, Patel, Neel, Teoh, Eugene J., Gleeson, Fergus, Bradley, Kevin, Wigfield, Simon, Zois, Christos, McGowan, Daniel R., Ah-See, Mei-Lin, Thompson, Alastair M., Sharma, Anand, Bidaut, Luc, Pollak, Michael, Roy, Pankaj G., Karpe, Fredrik, James, Tim, English, Ruth, Adams, Rosie F., Campo, Leticia, Ayers, Lisa, Snell, Cameron, Roxanis, Ioannis, Frezza, Christian, Fenwick, John D., Buffa, Francesca M., Harris, Adrian L.

Source: In Cell Metabolism 6 November 2018 28(5):679-688

New role of fat-free mass in cancer risk linked with genetic predisposition.

Authors: Harris, Benjamin H. L., Di Giovannantonio, Matteo, Zhang, Ping, Harris, David A., Lord, Simon R., Allen, Naomi E., Maughan, Tim S., Bryant, Richard J., Harris, Adrian L., Bond, Gareth L., Buffa, Francesca M.

Source: Scientific Reports; 3/27/2024, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: DISEASE risk factors, BODY composition, FAT, NON-coding RNA, LINCRNA, BIOELECTRIC impedance, BODY mass index, ADIPOSE tissues

Geographic Terms: UNITED Kingdom

Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib.

Authors: Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O'Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen

Source: Nature Communications; 8/8/2023, Vol. 14 Issue 1, p1-10, 10p

Subject Terms: METASTATIC breast cancer, CANCER patients, TRIPLE-negative breast cancer, RNA polymerase II, ORAL drug administration, SUMATRIPTAN

Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?

Authors: Lord, Simon R.¹ (AUTHOR) simon.lord@oncology.ox.ac.uk, Harris, Adrian L.¹ (AUTHOR)

Source: British Journal of Cancer. Apr2023, Vol. 128 Issue 6, p958-966. 9p.

Obesity: a perfect storm for carcinogenesis.

Authors: Harris, Benjamin H. L., Macaulay, Valentine M., Harris, David A., Klenerman, Paul, Karpe, Fredrik, Lord, Simon R., Harris, Adrian L., Buffa, Francesca M.

Source: Cancer & Metastasis Reviews; Sep2022, Vol. 41 Issue 3, p491-515, 25p

Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer.

Authors: Telli, Melinda L., Tolaney, Sara M., Shapiro, Geoffrey I., Middleton, Mark, Lord, Simon R., Arkenau, Hendrik Tobias, Tutt, Andrew, Abramson, Vandana, Dean, Emma, Haddad, Tufia C., Wesolowski, Robert, Ferrer-Playan, Jordi, Goddemeier, Thomas, Grombacher, Thomas, Dong, Jennifer, Fleuranceau-Morel, Patricia, Diaz-Padilla, Ivan, Plummer, Ruth

Source: NPJ Breast Cancer; 4/7/2022, Vol. 8 Issue 1, p1-9, 9p

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin.

Authors: Lord, Simon R.^1,2,3 (AUTHOR) simon.lord@oncology.ox.ac.uk, Collins, Jennifer M.⁴ (AUTHOR), Cheng, Wei-Chen¹ (AUTHOR), Haider, Syed⁵ (AUTHOR), Wigfield, Simon² (AUTHOR), Gaude, Edoardo⁶ (AUTHOR), Fielding, Barbara A.^4,7 (AUTHOR), Pinnick, Katherine E.⁴ (AUTHOR), Harjes, Ulrike² (AUTHOR), Segaran, Ashvina¹ (AUTHOR), Jha, Pooja⁸ (AUTHOR), Hoefler, Gerald⁸ (AUTHOR), Pollak, Michael N.⁹ (AUTHOR), Thompson, Alastair M.¹⁰ (AUTHOR), Roy, Pankaj G.¹¹ (AUTHOR), English, Ruth.¹² (AUTHOR), Adams, Rosie F.¹² (AUTHOR), Frezza, Christian⁶ (AUTHOR), Buffa, Francesca M.¹ (AUTHOR), Karpe, Fredrik^3,4 (AUTHOR)

Source: British Journal of Cancer. Jan2020, Vol. 122 Issue 2, p258-265. 8p. 1 Diagram, 4 Graphs.

Subject Terms: *PROTEIN kinases, *RESEARCH, *XENOGRAFTS, *ANIMAL experimentation, *RESEARCH methodology, *DIABETES, *CELL physiology, *GENETIC disorders, *EVALUATION research, *MEDICAL cooperation, *MITOCHONDRIA, *COMPARATIVE studies, *GENE expression profiling, *GENES, *RESEARCH funding, *METFORMIN, *LIPID metabolism disorders, *FATTY acids, *BREAST tumors, *OXIDATION-reduction reaction, *LIPID peroxidation (Biology), *MICE, *PHARMACODYNAMICS

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Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib.

Authors: Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O'Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen

Source: Nature Communications; 8/7/2023, Vol. 14 Issue 1, p1-1, 1p

Subject Terms: METASTATIC breast cancer, CANCER patients, ERIBULIN

Neoadjuvant Window Studies of Metformin and Biomarker Development for Drugs Targeting Cancer Metabolism.

Authors: Lord, Simon R, Patel, Neel, Liu, Dan, Fenwick, John, Gleeson, Fergus, Buffa, Francesca, Harris, Adrian L

Source: JNCI Monographs; 2015 May, Vol. 2015 Issue 51, p81-86, 6p

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