HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer

Authors: Evans, Abigail, Ball, Adrian, Johri, Akhil, Nejim, Ali, Jones, Alison, Corder, Allan, Thorne, Amanda, Anand, Ambika, Chakrabarti, Amitabha, Robinson, Anne, Skene, Anthony, Modi, Anupam, Patel, Ashraf, Kothari, Ashutosh, McFall, Brendan, Mortimer, Caroline, Lee, Caroline, Chan, Charlie, Abson, Charlotte, Holcombe, Christopher, Hinton, Christopher, Hollywood, Ciaran, Murphy, Claire, Crowley, Clare, Harding-Mackean, Claudia, Griffith, Clive, Lewanski, Conrad, Rea, Daniel, Hwang, David, Crawford, Derek, Thekkinkattil, Dinesh, Ferguson, Douglas, Adamson, Douglas, Wheatley, Duncan, Ravichandran, Duraisamy, Babu, Ed, Hyett, Elaine, Ashkanani, Fawzia, Hoar, Fiona, Kenny, Frances, Dyke, Gary, Sparrow, Geoffrey, Gilbert, Cunnick, Giles, Algurafi, Hafiz, Sweetland, Helen, Prof, Highes-Davies, Hamed, Hisham, Smith, Ian, Laidlaw, Ian, Khattak, Ilyas, Newby, Jacqueline, Rees-Lee, Jacqueline, Kokan, Jalal, Barrett, Jane, Naik, Jay Dolatrai, Vaidya, Jayant, Forrest, Jennifer, Parmar, Jitendra, Adams, Jocelyn, Fox, John, Roberts, Jonathan, Dawson, Jonathan, Doughty, Julie, Donnelly, Jull, Dunn, Kathleen, Chin, Kian, Horgan, Kieran, Thakur, Kislaya, Barthelmes, Ludger, Wyld, Lynda, Bhattacharyya, Madhumita, Hadaki, Maher, Kishore, Makam, Ornstein, Marcus, Bramley, Maria, Bews-Hair, Maria, Parton, Marina, Sibbering, Mark, Kissin, Mark, Churn, Mark, Hogg, Martin, Quigley, Mary, Hatton, Matthew, Winter, Matthew, Adelekan, Matthew, Shere, Michael, Carr, Michael, Williams, Michael, Absar, Mohammed, Sharif, Muhammad, Kelleher, Muireann, Walji, Nawaz, Williams, Nicholas, Gallegos, Nicholas, Bundred, Nigel, Hatcher, Olivia, Crellin, Perric, Crane, Peter, Donnelly, Peter, Kneeshaw, Peter, Walker, Philip, Sinha, Prakash, Bhaskar, Pudhupalayam, Soulsby, Racheal, Todd, Radha, Vidya, Raghavan, Mehra, Rakesh, Prasad, Ramachandran, Cutress, Ramsay, Sharma, Ravi, Roylance, Rebecca, Goranova, Rebecca, Salman, Reem Ramzi, Bonom, Riccardo, Johnson, Richard, Sutton, Richard, Linforth, Rick, Coleman, Rob, Grieve, Robert, Leonard, Robert, Reichert, Robert, Kennedy, Robert, Agarwal, Roshan, Allerton, Rozenn, Burcombe, Russell, Davis, Ruth, Narayanan, Sankaran, Chandrasekharan, Sankaran, Vesty, Sarah, Seetharam, Seema, Ledwidge, Serena, Iqbal, Shabana, Wahee, Shamaela, Silva, Shobha, Pain, Simon, Holt, Simon, Thomson, Simon, Smith, Simon, Ellenbogen, Simon, Laws, Siobhan, Chan, Stephen, Johnston, Stephen, Holt, Steve, Thrush, Steven, McIntosh, Stuart, Chatterjee, Sumohan, Cleator, Susan, Usman, Tamoor, Johnson, Tayo, Kovacs, Tibor, Irvine, Tracey, Barthkur, Urmila, Pope, Vanessa, Brown, Victoria Alexandra, Muralikrishna, Vummiti, Samra, Walid, Maxwell, William, Winters, Zoe, Bergamino, Milana A., López-Knowles, Elena, Morani, Gabriele, Tovey, Holly, Kilburn, Lucy, Schuster, Eugene F., Alataki, Anastasia, Hills, Margaret, Xiao, Hui, Holcombe, Chris, Robertson, John F., Smith, Ian E., Bliss, Judith M., Dowsett, Mitch, Cheang, Maggie C.U.

Source: In eBioMedicine September 2022 83

Molecular characterisation of aromatase inhibitor-resistant advanced breast cancer: the phenotypic effect of ESR1 mutations

Authors: Lopez-Knowles, Elena, Pearson, Alex, Schuster, Gene, Gellert, Pascal, Ribas, Ricardo, Yeo, Belinda, Cutts, Ros, Buus, Richard, Garcia-Murillas, Isaac, Haynes, Ben, Martin, Lesley-Ann, Smith, Ian, Turner, Nick, Dowsett, Mitch

Source: British journal of cancer. 120(2):247-255

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193490299.0x000001&indx=1&recIds=ETOCvdc_100193490299.0x000001

Clinical and molecular predictors of very late recurrence in oestrogen receptor-positive breast cancer patients.

Authors: Richman, Juliet, Schuster, Gene, Buus, Richard, Lopez-Knowles, Elena, Dowsett, Mitch

Source: Breast Cancer Research & Treatment; Jul2024, Vol. 206 Issue 1, p195-205, 11p

Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population

Authors: Sgroi, Dennis C, Sestak, Ivana, Cuzick, Jack, Zhang, Yi, Schnabel, Catherine A, Schroeder, Brock, Erlander, Mark G, Dunbier, Anita, Sidhu, Kally, Lopez-Knowles, Elena, Goss, Paul E, Dowsett, Mitch

Source: In The Lancet Oncology October 2013 14(11):1067-1076

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

Authors: Fedele, Clare G., Ooms, Lisa M., Ho, Miriel, Vieusseux, Jessica, O'Toole, Sandra A., Millar, Ewan K., Lopez-Knowles, Elena, Sriratana, Absorn, Gurung, Rajendra, Baglietto, Laura, Giles, Graham G., Bailey, Charles G., Rasko, John E. J., Shields, Benjamin J., Price, John T., Majerus, Philip W., Sutherland, Robert L., Tiganis, Tony, McLean, Catriona A., Mitchell, Christina A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Dec . 107(51), 22231-22236.

Access URL: https://www.jstor.org/stable/25757046

Oncogenic PIK3CA Mutations Occur in Epidermal Nevi and Seborrheic Keratoses with a Characteristic Mutation Pattern

Authors: Hafner, Christian, López-Knowles, Elena, Luis, Nuno M., Toll, Agustí, Baselga, Eulàlia, Fernández-Casado, Alex, Hernández, Silvia, Ribé, Adriana, Mentzel, Thomas, Stoehr, Robert, Hofstaedter, Ferdinand, Landthaler, Michael, Vogt, Thomas, Pujol, Ramòn M., Hartmann, Arndt, Real, Francisco X.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2007 Aug . 104(33), 13450-13454.

Access URL: https://www.jstor.org/stable/25436504

Molecular profiling of aromatase inhibitor sensitive and resistant ER+HER2- postmenopausal breast cancers.

Authors: Schuster, Eugene F., Lopez-Knowles, Elena, Alataki, Anastasia, Zabaglo, Lila, Folkerd, Elizabeth, Evans, David, Sidhu, Kally, Cheang, Maggie Chon U., Tovey, Holly, Salto-Tellez, Manuel, Maxwell, Perry, Robertson, John, Smith, Ian, Bliss, Judith M., Dowsett, Mitch

Source: Nature Communications; 7/7/2023, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: AROMATASE inhibitors, BREAST cancer, TUMOR-infiltrating immune cells, BIOMARKERS, BREAST, ESTRADIOL

Relationship between ER expression by IHC or mRNA with Ki67 response to aromatase inhibition: a POETIC study.

Authors: Lopez-Knowles, Elena, Detre, Simone, Hills, Margaret, Schuster, Eugene F., Cheang, Maggie C. U., Tovey, Holly, Kilburn, Lucy S., Bliss, Judith M., Robertson, John, Mallon, Elizabeth, Skene, Anthony, Evans, Abigail, Smith, Ian, Dowsett, Mitch

Source: Breast Cancer Research; 9/12/2022, Vol. 24 Issue 1, p1-10, 10p

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41. Differences in cell cycle and apoptotic biomarker expression between molecular subtypes of invasive ductal breast carcinoma

Authors: McNeil, Catriona M., O’Toole, Sandra A., Millar, Ewan K.A., Kench, James G., Segara, Davendra, Morey, Adrienne L., Lopez-Knowles, Elena, Crea, Paul, Henshall, Susan M., Musgrove, Elizabeth A., Sutherland, Robert L.

Source: Pathology. 43:S101-S102

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100054070915.0x000001&indx=1&recIds=ETOCvdc_100054070915.0x000001

29. c-MYC gene amplification is associated with a poor prognosis in invasive ductal carcinoma

Authors: O’Toole, Sandra A., McNeil, Catriona M., Morey, Adrienne L., Millar, Ewan K., Lopez-Knowles, Elena, Musgrove, Elizabeth A., Sutherland, Robert L.

Source: Pathology. 42:S89-S90

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100059167751.0x000001&indx=1&recIds=ETOCvdc_100059167751.0x000001

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Tumor PIK3CAG enotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data.

Authors: Zardavas, Dimitrios, te Marvelde, Luc, Milne, Roger L., Fumagalli, Debora, Fountzilas, George, Kotoula, Vassiliki, Razis, Evangelia, Papaxoinis, George, Joensuu, Heikki, Moynahan, Mary Ellen, Hennessy, Bryan T., Bieche, Ivan, Saal, Lao H., Stal, Olle, Iacopetta, Barry, Jensen, Jeanette Dupont, O’Toole, Sandra, Lopez-Knowles, Elena, Barbaraeschi, Mattia, Noguchi, Shinzaburo

Source: Journal of Clinical Oncology; 4/1/2018, Vol. 36 Issue 10, p981-990, 12p

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