Effectiveness of lanadelumab for preventing hereditary angioedema attacks: Subgroup analyses from the HELP study

Authors: Johnston, Douglas T., Busse, Paula J., Riedl, Marc A., Maurer, Marcus, Anderson, John, Nurse, Christina, Inhaber, Neil, Yu, Ming, Banerji, Aleena, Hébert, J., Ritchie, B., Sussman, G., Yang, W. H., Escuriola Ettingshausen, C., Magerl, M., Martinez‐Saguer, I., Maurer, M., Staubach, P., Zimmer, S., Cicardi, M., Perego, F., Wu, M. A., Zanichelli, A., Al‐Ghazawi, A., Shennak, M., Zaragoza‐Urdaz, R. H., Ghurye, R., Longhurst, H. J., Zinser, E., Anderson, J., Banerji, A., Baptist, A. P., Bernstein, J. A., Boggs, P. B., Busse, P. J., Christiansen, S., Craig, T., Davis‐Lorton, M., Gierer, S., Gower, R. G., Harris, D., Hong, D. I., Jacobs, J., Johnston, D. T., Levitch, E. S., Li, H. H., Lockey, R. F., Lugar, P., Lumry, W. R., Manning, M. E., McNeil, D. L., Melamed, I., Mostofi, T., Nickel, T., Otto, W. R., Petrov, A. A., Poarch, K., Radojicic, C., Rehman, S. M., Riedl, M. A., Schwartz, L. B., Shapiro, R., Sher, E., Smith, A. M., Smith, T. D., Soteres, D., Tachdjian, R., Wedner, H. J., Weinstein, M. E., Zafra, H., Zuraw, B. L.

Source: Clinical & experimental allergy. 51(10):1391-1395

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132306207.0x000001&indx=1&recIds=ETOCvdc_100132306207.0x000001

CRISPR.-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema.

Authors: Longhurst, H. J.^1,2 hilarylo@adhb.govt.nz, Lindsay, K.¹, Petersen, R. S.³, Fijen, L. M.³, Gurugama, P.⁴, Maag, D.⁵, Butler, J. S.⁵, Shah, M. Y.⁵, Golden, A.⁵, Xu, Y.⁵, Boiselle, C.⁵, Vogel, J. D.⁵, Abdelhady, A. M.⁵, Maitland, M. L.⁵, McKee, M. D.⁵, Seitzer, J.⁵, Han, B. W.⁵, Soukamneuth, S.⁵, Leonard, J.⁵, Sepp-Lorenzino, L.⁵

Source: New England Journal of Medicine. 2/1/2024, Vol. 390 Issue 5, p432-441. 10p.

Subject Terms: *GENOME editing, *ANGIONEUROTIC edema, *POISONS, *URTICARIA, *BLOOD proteins, *GENETIC disorders

Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor

Authors: Longhurst, H.

Source: New England journal of medicine. 376(12):1131-1140

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN610343375&indx=1&recIds=ETOCRN610343375

Long-term safety of icatibant treatment of patients with angioedema in real-world clinical practice

Authors: Zanichelli, A., Maurer, M., Aberer, W., Caballero, T., Longhurst, H. J., Bouillet, L., Fabien, V., Andresen, I.

Source: ALLERGY -COPENHAGEN-. 72(6):994-998

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The Icatibant Outcome Survey: experience of hereditary angioedema management from six European countries

Authors: Caballero, T., Aberer, W., Longhurst, H. J., Maurer, M., Zanichelli, A., Perrin, A., Bouillet, L., Andresen, I.

Source: JOURNAL- EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 31(7):1214-1222

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IN VIVO CRISPR/CAS9 EDITING OF KLKB1 IN PATIENTS WITH HEREDITARY ANGIOEDEMA: A FIRST-IN-HUMAN STUDY

Authors: Longhurst, H., Fijen, L., Lindsay, K., Butler, J., Golden, A., Maag, D., Xu, Y., Cohn, D.

Source: Annals of allergy, asthma & immunology. 129(5):S10-S11

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An Antisense Oligonucleotide for Hereditary Angioedema

Authors: Longhurst, H. J., Ameratunga, R.

Source: New England journal of medicine. 386(11):1083-1084

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628804575&indx=1&recIds=ETOCRN628804575

Misdiagnosis trends in patients with hereditary angioedema from the real-world clinical setting

Authors: Zanichelli, A., Longhurst, H. J., Maurer, M., Bouillet, L., Aberer, W., Fabien, V., Andresen, I., Caballero, T.

Source: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 117(4):394-398

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The Humanistic, Societal, and Pharmaco-economic Burden of Angioedema

Authors: Longhurst, H., Bygum, A.

Source: CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY. 51(2):230-239

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN379196870&indx=1&recIds=ETOCRN379196870

Amélioration à long terme de la qualité de vie et des résultats rapportés par les patients avec garadacimab dans le traitement de l’angio-œdème héréditaire : étude d’extension de phase 3 en ouvert

Authors: Chapdelaine, H., Sitz, K., Karelaris, C.H., Guilarte, M., Longhurst, H., Lawo, J.P., Braverman, J., Lumry, W.R.

Source: In La revue de médecine interne December 2024 45 Supplement 2:A551-A552

CORRELATION OF TIME TO TREATMENT WITH ATTACK DURATION IN THE SEBETRALSTAT PHASE 3 KONFIDENT TRIAL

Authors: Craig, T., Bernstein, J., Longhurst, H., Hao, J., Smith, M., Audhya, P., Yea, C., Maurer, M.

Source: In Annals of Allergy, Asthma & Immunology November 2024 133(6) Supplement:S29-S29

RESULTS FROM A PHASE 2, RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF CRISPR-BASED THERAPY NTLA-2002 FOR HEREDITARY ANGIOEDEMA

Authors: Cohn, D., Gurugama, P., Magerl, M., Katelaris, C., Golden, A., Shah, M., Maag, D., Longhurst, H.

Source: In Annals of Allergy, Asthma & Immunology November 2024 133(6) Supplement:S6-S7

Phase II study results of a replacement therapy for hereditary angioedema with subcutaneous C1-inhibitor concentrate

Authors: Zuraw, B. L., Cicardi, M., Longhurst, H. J., Bernstein, J. A., Li, H. H., Magerl, M., Martinez-Saguer, I., Rehman, S. M., Staubach, P., Feuersenger, H.

Source: ALLERGY -COPENHAGEN-. 70(10):1319-1328

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Inherited human group IVA cytosolic phospholipase A~2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation

Authors: Kirkby, N. S., Reed, D. M., Edin, M. L., Rauzi, F., Mataragka, S., Vojnovic, I., Bishop-Bailey, D., Milne, G. L., Longhurst, H., Zeldin, D. C.

Source: FASEB journal. 29(11):4568-4578

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN603348642&indx=1&recIds=ETOCRN603348642

Pegylated interferon-α-2b reduces corticosteroid requirement in patients with Behçet's disease with upregulation of circulating regulatory T cells and reduction of Th17

Authors: Lightman, S., Taylor, S. R. J., Bunce, C., Longhurst, H., Lynn, W., Moots, R., Stanford, M., Tomkins-Netzer, O., Yang, D., Calder, V. L.

Source: Annals of the rheumatic diseases. 74(6):1138-1144

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Elevated D-dimers in attacks of hereditary angioedema are not associated with increased thrombotic risk

Authors: Reshef, A., Zanichelli, A., Longhurst, H., Relan, A., Hack, C. E.

Source: ALLERGY -COPENHAGEN-. 70(5):506-513

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN376189350&indx=1&recIds=ETOCRN376189350

Treatment of HAE Attacks in the Icatibant Outcome Survey: An Analysis of Icatibant Self-Administration versus Administration by Health Care Professionals

Authors: Hernández Fernandez de Rojas, D., Ibañez, E., Longhurst, H., Maurer, M., Fabien, V., Aberer, W., Bouillet, L., Zanichelli, A., Caballero, T.

Source: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 167(1):21-28

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN371125723&indx=1&recIds=ETOCRN371125723

Mullins’ syndrome: a new gammopathy-related autoinflammatory syndrome resistant to anakinra

Authors: Longhurst, H. J., Yong, P. F., Manson, A. L., Cavenagh, J. D., Grigoriadou, S., Buckland, M. S.

Source: QJM -OXFORD-. 108(6):497-501

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Hypogammaglobulinaemia after rituximab treatment—incidence and outcomes

Authors: Makatsori, M., Kiani-Alikhan, S., Manson, A. L., Verma, N., Leandro, M., Gurugama, N. P., Longhurst, H. J., Grigoriadou, S., Buckland, M., Kanfer, E.

Source: QJM -OXFORD-. 107(10):821-828

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN361279412&indx=1&recIds=ETOCRN361279412

Open-label, multicenter study of self-administered icatibant for attacks of hereditary angioedema

Authors: Aberer, W., Maurer, M., Reshef, A., Longhurst, H., Kivity, S., Bygum, A., Caballero, T., Bloom, B., Nair, N., Malbrn, A.

Source: ALLERGY -COPENHAGEN-. 69(3):305-314

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN347998046&indx=1&recIds=ETOCRN347998046