Persistent splenic-derived IgMs preferentially recognize factor VIII A2 and C2 domain epitopes but do not alter antibody production

Authors: York, Elizabeth S. ^{1, 2, 3}, Dratch, Benjamin D. ⁴, Ito, Jasmine ^{2, 3}, Horwitz, Samantha M. ⁴, Emamian, Sahand ⁵, Ambarian, Joseph A. ⁴, Gill, Surinder ^{2, 3}, Jones, Jayre ^{2, 3}, Chonat, Satheesh ^{2, 3}, Lollar, Pete ^{2, 3}, Meeks, Shannon L. ^{2, 3}, Davis, Katherine M. ^{4, ∗∗}, Batsuli, Glaivy ^{1, 2, 3, ∗}

Source: In Journal of Thrombosis and Haemostasis February 2025 23(2):440-457

Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain

Authors: Childers, Kenneth C., Cowper, Ben, Vaughan, Jordan D., McGill, Juliet R., Davulcu, Omar, Lollar, Pete, Doering, Christopher B., Coxon, Carmen H., Spiegel, Paul C., Jr.

Source: In Journal of Thrombosis and Haemostasis September 2024 22(9):2449-2459

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module

Authors: Arce, Nicholas A., Markham-Lee, Zoe, Liang, Qian, Najmudin, Shabir, Legan, Emily R., Dean, Gabrielle, Su, Ally J., Wilson, Moriah S., Sidonio, Robert F., Lollar, Pete, Emsley, Jonas, Li, Renhao

Source: In Blood 9 May 2024 143(19):1992-2004

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain

Authors: Legan, Emily R., Liu, Yi, Arce, Nicholas A., Parker, Ernest T., Lollar, Pete, Zhang, X. Frank, Li, Renhao

Source: In Blood 9 March 2023 141(10):1221-1232

SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa

Authors: Childers, Kenneth C., Peters, Shaun C., Lollar, Pete, Spencer, Harold Trent, Doering, Christopher B., Spiegel, Paul C., Jr ^*

Source: In Blood Advances 14 June 2022 6(11):3240-3254

Nonhuman glycans can regulate anti–factor VIII antibody formation in mice

Authors: Arthur, Connie M., Zerra, Patricia E., Shin, Sooncheon, Wang, Jianmei, Song, Xeuzheng, Doering, Christopher B., Lollar, Pete, Meeks, Shannon, Stowell, Sean R.

Source: Blood. 139(9):1312-1317

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183245077.0x000001&indx=1&recIds=ETOCvdc_100183245077.0x000001

Desialylation of O‐glycans activates von Willebrand factor by destabilizing its autoinhibitory module

Authors: Voos, Kayleigh M., Cao, Wenpeng, Arce, Nicholas A., Legan, Emily R., Wang, Yingchun, Shajahan, Asif, Azadi, Parastoo, Lollar, Pete, Zhang, Xiaohui Frank, Li, Renhao

Source: Journal of thrombosis and haemostasis. 20(1):196-207

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Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction

Authors: Knight, Kristopher A., Coyle, Christopher W., Radford, Caelan E., Parker, Ernest T., Fedanov, Andrew, Shields, Jordan M., Szlam, Fania, Purchel, Anatolii, Chen, Michelle, Denning, Gabriela, Sniecinski, Roman M., Lollar, Pete, Spencer, H. Trent, Gaucher, Eric A., Doering, Christopher B. ^*

Source: In Blood Advances 14 September 2021 5(17):3333-3343

Conformation of the von Willebrand factor/factor VIII complex in quasi-static flow

Authors: Parker, Ernest T., Lollar, Pete

Source: In Journal of Biological Chemistry January-June 2021 296

Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor

Authors: Gish, Joseph S., Jarvis, Lexi, Childers, Kenneth C., Peters, Shaun C., Garrels, Connor S., Smith, Ian W., Spencer, H. Trent, Doering, Christopher B., Lollar, Pete, Spiegel, P. Clint

Source: Blood. 137(21):2981-2986

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183251690.0x000001&indx=1&recIds=ETOCvdc_100183251690.0x000001

The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain

Authors: Smith, Ian W., d'Aquino, Anne E., Coyle, Christopher W., Fedanov, Andrew, Parker, Ernest T., Denning, Gabriela, Spencer, Harold Trent, Lollar, Pete, Doering, Christopher B., Spiegel, Paul Clint, Jr. ^*

Source: In Journal of Thrombosis and Haemostasis January 2020 18(1):57-69

Structural basis of transcriptional regulation by the HigA antitoxin

Authors: Schureck, Marc A., Meisner, Jeffrey, Hoffer, Eric D., Wang, Dongxue, Onuoha, Nina, Ei Cho, Shein, Lollar, Pete, Dunham, Christine M.

Source: Molecular microbiology. 111(6):1449-1462

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Marginal zone B cells are critical to factor VIII inhibitor formation in mice with hemophilia A

Authors: Zerra, Patricia E., Cox, Courtney, Baldwin, W. Hunter, Patel, Seema R., Arthur, Connie M., Lollar, Pete, Meeks, Shannon L., Stowell, Sean R.

Source: In Blood 7 December 2017 130(23):2559-2568

Frequency and epitope specificity of anti–factor VIII C1 domain antibodies in acquired and congenital hemophilia A

Authors: Kahle, Joerg, Orlowski, Aleksander, Stichel, Diana, Healey, John F., Parker, Ernest T., Jacquemin, Marc, Krause, Manuela, Tiede, Andreas, Schwabe, Dirk, Lollar, Pete, Königs, Christoph

Source: In Blood 10 August 2017 130(6):808-816

Nanobody activator improves sensitivity of the von Willebrand factor activity assay to multimer size

Authors: Liang, Qian, Parker, Ernest T., Dean, Gabrielle, Karpen, Matthew S., Wu, Yujia, Wang, Xuefeng, Di Paola, Jorge, Maier, Cheryl L., Meeks, Shannon L., Lollar, Pete, Sidonio, Robert F., Li, Renhao

Source: In Journal of Thrombosis and Haemostasis July 2024 22(7):2052-2058

Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate.

Authors: Sastre, Diego E., Sultana, Nazneen, V. A. S. Navarro, Marcos, Huliciak, Maros, Du, Jonathan, Cifuente, Javier O., Flowers, Maria, Liu, Xu, Lollar, Pete, Trastoy, Beatriz, Guerin, Marcelo E., Sundberg, Eric J.

Source: Nature Communications; 6/15/2024, Vol. 15 Issue 1, p1-17, 17p

Subject Terms: ENDOGLYCOSIDASES, X-ray crystallography, GUT microbiome, HUMAN microbiota, MICROORGANISMS, GLYCANS

High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

Authors: Batsuli, Glaivy, Deng, Wei, Healey, John F., Parker, Ernest T., Baldwin, W. Hunter, Cox, Courtney, Nguyen, Brenda, Kahle, Joerg, Königs, Christoph, Li, Renhao, Lollar, Pete, Meeks, Shannon L.

Source: In Blood 20 October 2016 128(16):2055-2067

Structure of coagulation factor VIII bound to a patient-derived anti–C1 domain antibody inhibitor

Authors: Childers, Kenneth C., Avery, Nathan G., Estrada Alamo, Kevin A., Davulcu, Omar, Haynes, Rose Marie, Lollar, Pete, Doering, Christopher B., Coxon, Carmen H., Spiegel, P. Clint, Jr.

Source: In Blood 13 July 2023 142(2):197-201

pH-dependent conformation of multimeric von Willebrand factor

Authors: Smith, Ian W., Parker, Ernest T., Lollar, Pete

Source: In Blood Advances 13 June 2023 7(11):2554-2557

Hydrogen-deuterium exchange of plasma-derived von Willebrand factor reveals similar dynamics to isolated A1 domain and autoinhibitory module

Authors: Legan, Emily R., Wilson, Moriah S., Arce, Nicholas A., Parker, Ernest T., Lollar, Pete, Li, Renhao

Source: Biophysical journal. 121(S1):337a-338a

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