Non‐canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure

Authors: Benčić, Patricia, Keppler, Michael, Kuge, Marco, Qiu, Danye, Schütte, Lena M., Häner, Markus, Strack, Katharina, Jessen, Henning J., Andexer, Jennifer N., Loenarz, Christoph

Source: FEBS journal. 290(20):4899-4920

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Biomimetic S‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes**

Authors: Gericke, Lukas, Mhaindarkar, Dipali, Karst, Lukas C., Jahn, Sören, Kuge, Marco, Mohr, Michael K. F., Gagsteiger, Jana, Cornelissen, Nicolas V., Wen, Xiaojin, Mordhorst, Silja, Jessen, Henning J., Rentmeister, Andrea, Seebeck, Florian P., Layer, Gunhild, Loenarz, Christoph, Andexer, Jennifer N.

Source: Chembiochem. 24(9)

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Ein Gespür für Sauerstoff: Entdeckung des molekularen Mechanismus der zellulären Sauerstoffregulation rückt die Hydroxylierung von Makromolekülen in den Blickpunkt

Authors: Loenarz, Christoph

Source: Angewandte Chemie. 132(10):3804-3809

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An Oxygen Sensation: Progress in Macromolecule Hydroxylation Triggered by the Elucidation of Cellular Oxygen Sensing

Authors: Loenarz, Christoph

Source: Angewandte Chemie international edition. 59(10):3776-3780

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A Cobalamin‐Dependent Radical SAM Enzyme Catalyzes the Unique Cα‐Methylation of Glutamine in Methyl‐Coenzyme M Reductase

Authors: Gagsteiger, Jana, Jahn, Sören, Heidinger, Lorenz, Gericke, Lukas, Andexer, Jennifer N., Friedrich, Thorsten, Loenarz, Christoph, Layer, Gunhild

Source: Angewandte Chemie. 134(32)

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YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase

Authors: Sekirnik, Rok, Wilkins, Sarah E., Bush, Jacob, Tarhonskaya, Hanna, Münzel, Martin, Hussein, Aayan, Flashman, Emily, Mohammed, Shabaz, McDonough, Michael A., Loenarz, Christoph, Schofield, Christopher J.

Source: Extremophiles. 22(3):553-562

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Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases

Authors: Horita, Shoichiro, Scotti, John S., Thinnes, Cyrille, Mottaghi-Taromsari, Yousef S., Thalhammer, Armin, Ge, Wei, Aik, WeiShen, Loenarz, Christoph, Schofield, Christopher J., McDonough, Michael A.

Source: In Structure 7 April 2015 23(4):639-652

Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2)

Authors: Davydova, Erna, Ho, Angela Y.Y., Malecki, Jedrzej, Moen, Anders, Enserink, Jorrit M., Jakobsson, Magnus E., Loenarz, Christoph, Falnes, Pål Ø.

Source: In Journal of Biological Chemistry 31 October 2014 289(44):30499-30510

Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth

Authors: Katz, Maximiliano J., Acevedo, Julieta M., Loenarz, Christoph, Galagovsky, Diego, Liu-Yi, Phebee, Pérez-Pepe, Marcelo, Thalhammer, Armin, Sekirnik, Rok, Ge, Wei, Melani, Mariana, Thomas, María G., Simonetta, Sergio, Boccaccio, Graciela L., Schofield, Christopher J., Cockman, Matthew E., Ratcliffe, Peter J., Wappner, Pablo

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Mar . 111(11), 4025-4030.

Access URL: https://www.jstor.org/stable/23770977

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

Authors: Loenarz, Christoph, Sekirnik, Rok, Thalhammer, Armin, Ge, Wei, Spivakovsky, Ekaterina, Mackeen, Mukram M., McDonough, Michael A., Cockman, Matthew E., Kessler, Benedikt M., Ratcliffe, Peter J., Wolf, Alexander, Schofield, Christopher J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Mar . 111(11), 4019-4024.

Access URL: https://www.jstor.org/stable/23770976

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

Authors: Singleton, Rachelle S., Liu-Yi, Phebee, Formenti, Fabio, Ge, Wei, Sekirnik, Rok, Fischer, Roman, Adam, Julie, Pollard, Patrick J., Wolf, Alexander, Thalhammer, Armin, Loenarz, Christoph, Flashman, Emily, Yamamoto, Atsushi, Coleman, Mathew L., Kessler, Benedikt M., Wappner, Pablo, Schofield, Christopher J., Ratcliffe, Peter J., Cockman, Matthew E.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Mar . 111(11), 4031-4036.

Access URL: https://www.jstor.org/stable/23770978

A mechanism for induction of a hypoxic response by vaccinia virus

Authors: Mazzon, Michela, Peters, Nicholas E., Loenarz, Christoph, Krysztofinska, Ewelina M., Ember, Stuart W. J., Ferguson, Brian J., Smith, Geoffrey L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Jul . 110(30), 12444-12449.

Access URL: https://www.jstor.org/stable/42712610

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

Authors: Longbotham, James E., Levy, Colin, Johannissen, Linus O., Tarhonskaya, Hanna, Jiang, Shuo, Loenarz, Christoph, Flashman, Emily, Hay, Sam, Schofield, Christopher J., Scrutton, Nigel S.

Source: Biochemistry. 54(39):6093-6105

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β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1-and oxygen-dependent manner.

Authors: Eisenbeis, Verena B., Danye Qiu, Gorka, Oliver, Strotmann, Lisa, Guizhen Liu, Prucker, Isabel, Su, Xue Bessie, Wilson, Miranda S. C., Ritter, Kevin, Loenarz, Christoph, Groß, Olaf, Saiardi, Adolfo, Jessen, Henning J.

Source: Proceedings of the National Academy of Sciences of the United States of America; 8/22/2023, Vol. 120 Issue 34, p1-9, 28p

Subject Terms: ELECTROSPRAY ionization mass spectrometry, INOSITOL, REACTIVE oxygen species, CAPILLARY electrophoresis, TYPE 2 diabetes

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

Authors: Hillringhaus, Lars, Yue, Wyatt W., Rose, Nathan R., Ng, Stanley S., Gileadi, Carina, Loenarz, Christoph, Bello, Simon H., Bray, James E., Schofield, Christopher J., Oppermann, Udo

Source: In Journal of Biological Chemistry 2 December 2011 286(48):41616-41625

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

Authors: Loenarz, Christoph, Schofield, Christopher J.

Source: In Trends in Biochemical Sciences 2011 36(1):7-18

Method for assaying OGFOD1 activity

Structural studies on human 2-oxoglutarate dependent oxygenases

Authors: McDonough, Michael A, Loenarz, Christoph, Chowdhury, Rasheduzzaman, Clifton, Ian J, Schofield, Christopher J

Source: In Current Opinion in Structural Biology December 2010 20(6):659-672

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

Authors: Chowdhury, Rasheduzzaman, McDonough, Michael A., Mecinović, Jasmin, Loenarz, Christoph, Flashman, Emily, Hewitson, Kirsty S., Domene, Carmen, Schofield, Christopher J.

Source: In Structure 15 July 2009 17(7):981-989

Oxygenase Catalyzed 5-Methylcytosine Hydroxylation

Authors: Loenarz, Christoph, Schofield, Christopher J.

Source: In Chemistry & Biology 2009 16(6):580-583