Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma

Authors: Macowan, Matthew ^{a, ∗}, Pattaroni, Céline ^{a, ∗, ∗}, Bonner, Katie ^b, Chatzis, Roxanne ^a, Daunt, Carmel ^a, Gore, Mindy ^b, Custovic, Adnan ^{b, c}, Shields, Michael D. ^c, Power, Ultan F. ^c, Grigg, Jonathan ^d, Roberts, Graham ^{e, f, g}, Ghazal, Peter ^h, Schwarze, Jürgen ⁱ, Turner, Steve ^{j, k}, Bush, Andrew ^b, Saglani, Sejal ^{l, m}, Lloyd, Clare M. ^m, Marsland, Benjamin J. ^a

Source: In The Journal of Allergy and Clinical Immunology January 2025 155(1):94-106

Airway extracellular LTA4H concentrations are governed by release from liver hepatocytes and changes in lung vascular permeability

Authors: Mincham, Kyle T. ¹, Akthar, Samia ¹, Patel, Dhiren F. ^{1, 2}, Meyer, Garance F. ¹, Lloyd, Clare M. ¹, Gaggar, Amit ^{3, 4, 5, 6}, Blalock, James E. ^{3, 4, 5}, Snelgrove, Robert J. ^{1, 7, ∗}

Source: In Cell Reports 27 August 2024 43(8)

Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen

Authors: Albers, Gesa J., Michalaki, Christina, Ogger, Patricia P., Lloyd, Amy F., Causton, Benjamin, Walker, Simone A., Caldwell, Anna, Halket, John M., Sinclair, Linda V., Forde, Sarah H., McCarthy, Cormac, Hinks, Timothy S.C., Lloyd, Clare M., Byrne, Adam J.

Source: In Mucosal Immunology October 2024

Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1

Authors: Stölting, Helen, Baillon, Laury, Frise, Rebecca, Bonner, Katie, Hewitt, Richard J., Molyneaux, Philip L., Gore, Mindy L., Barclay, Wendy S., Saglani, Sejal ¹⁷, Lloyd, Clare M. ¹⁷

Source: In Mucosal Immunology August 2022 15(5):952-963

Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma.

Authors: Joulia, Régis¹ (AUTHOR) r.joulia@imperial.ac.uk, Lloyd, Clare M.¹ (AUTHOR) c.lloyd@imperial.ac.uk

Source: Immunological Reviews. Mar2025, Vol. 330 Issue 1, p1-13. 13p.

Subject Terms: *ASTHMA, *IMMUNE response, *AIRWAY (Anatomy), *BLOOD vessels, *EXTRACELLULAR matrix, *TISSUE remodeling, *INVESTIGATIONAL therapies

Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen.

Authors: Albers, Gesa J., Michalaki, Christina, Ogger, Patricia P., Lloyd, Amy F., Causton, Benjamin, Walker, Simone A., Caldwell, Anna, Halket, John M., Sinclair, Linda V., Forde, Sarah H., McCarthy, Cormac, Hinks, Timothy S.C., Lloyd, Clare M., Byrne, Adam J.

Source: Mucosal Immunology (1933-0219); Feb2025, Vol. 18 Issue 1, p121-134, 14p

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease

Authors: Vijayakumar, Bavithra, Boustani, Karim, Ogger, Patricia P., Papadaki, Artemis, Tonkin, James, Orton, Christopher M., Ghai, Poonam, Suveizdyte, Kornelija, Hewitt, Richard J., Desai, Sujal R., Devaraj, Anand, Snelgrove, Robert J., Molyneaux, Philip L., Garner, Justin L., Peters, James E., Shah, Pallav L., Lloyd, Clare M., Harker, James A.

Source: In Immunity 8 March 2022 55(3):542-556

Breathing easy: Dopamine quenches the ILC2 flame

Authors: Puttur, Franz, Lloyd, Clare M.

Source: Immunity. 56(2):229-231

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189638397.0x000001&indx=1&recIds=ETOCvdc_100189638397.0x000001

Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early-life allergen exposure

Authors: Branchett, William J., Cook, James, Oliver, Robert A., Bruno, Nicoletta, Walker, Simone A., Stölting, Helen, Mack, Matthias, O’Garra, Anne, Saglani, Sejal, Lloyd, Clare M.

Source: In The Journal of Allergy and Clinical Immunology May 2021 147(5):1892-1906

Overlapping and distinct features of viral and allergen immunity in the human lung

Authors: Harker, James A., Lloyd, Clare M.

Source: In Immunity 13 April 2021 54(4):617-631

Mechanistic modelling of allergen-induced airways disease in early life.

Authors: Pybus, Hannah J., Dangarh, Prakrati, Ng, Man Yin Melanie, Lloyd, Clare M., Saglani, Sejal, Tanaka, Reiko J.

Source: Scientific Reports; 1/2/2025, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: HOUSE dust mites, MEDICAL sciences, ASTHMA in children, LUNGS, ALLERGENS, ASTHMA

Experimental Mouse Models of Asthma and Analysis of CD4 T Cells

Authors: Branchett, William J., Walker, Simone A., Lloyd, Clare M.

Source: Methods in molecular biology. 2285:329-348

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626428822&indx=1&recIds=ETOCRN626428822

Recurrent Severe Preschool Wheeze: From Prespecified Diagnostic Labels to Underlying Endotypes

Authors: Robinson, Polly F. M., Fontanella, Sara, Ananth, Sachin, Alonso, Aldara Martin, Cook, James, Vries, Daphne Kaya-de, Silveira, Luisa Polo, Gregory, Lisa, Lloyd, Clare, Fleming, Louise

Source: American journal of respiratory and critical care medicine. 204(5):523-535

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627463467&indx=1&recIds=ETOCRN627463467

A T cell–myeloid IL-10 axis regulates pathogenic IFN-γ–dependent immunity in a mouse model of type 2–low asthma

Authors: Branchett, William J., Stölting, Helen, Oliver, Robert A., Walker, Simone A., Puttur, Franz, Gregory, Lisa G., Gabryšová, Leona, Wilson, Mark S., O'Garra, Anne, Lloyd, Clare M.

Source: In The Journal of Allergy and Clinical Immunology February 2020 145(2):666-678

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis

Authors: Turnbull, Andrew R., Pyle, Chloe J., Patel, Dhiren F., Jackson, Patricia L., Hilliard, Tom N., Regamey, Nicolas, Tan, Hui-Leng, Brown, Sarah, Thursfield, Rebecca, Short, Christopher, Mc Fie, Megan, Alton, Eric W.F.W., Gaggar, Amit, Blalock, J. Edwin, Lloyd, Clare M., Bush, Andrew, Davies, Jane C., Snelgrove, Robert J.

Source: In Journal of Cystic Fibrosis January 2020 19(1):40-48

Pseudomonas aeruginosa: a pathogen making itself at home

Authors: Stölting, Helen, Lloyd, Clare M.

Source: Trends in immunology. 43(7):497-499

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190024246.0x000001&indx=1&recIds=ETOCvdc_100190024246.0x000001

Immunoregulation of asthma by type 2 cytokine therapies: Treatments for all ages?

Authors: Saglani, Sejal, Yates, Laura, Lloyd, Clare M.

Source: European journal of immunology. 53(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190080546.0x000001&indx=1&recIds=ETOCvdc_100190080546.0x000001

Opening the Window of Immune Opportunity: Treating Childhood Asthma

Authors: Lloyd, Clare M., Saglani, Sejal

Source: In Trends in Immunology September 2019 40(9):786-798

Regulatory cytokine function in the respiratory tract

Authors: Branchett, William J., Lloyd, Clare M.

Source: In Mucosal Immunology May 2019 12(3):589-600

Enhanced frequency and function of follicular T cells in the tonsils of house dust mite‐sensitized children

Authors: Foster, William S., Grime, Christopher J., Tan, Hui‐Leng, Williams, Geoffrey S., Robinson, Matthew J., Carlesso, Gianluca, Saglani, Sejal, Lloyd, Clare M., Harker, James A.

Source: Allergy. 75(5):1240-1243

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131886457.0x000001&indx=1&recIds=ETOCvdc_100131886457.0x000001