Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome

Authors: Shaocong Hou, Hengcai Yu, Caihong Liu, Andrew M.F. Johnson, Xingfeng Liu, Qian Jiang, Qijin Zhao, Lijuan Kong, Yanjun Wan, Xiaowei Xing, Yibing Chen, Jingwen Chen, Qing Wu, Peng Zhang, Changtao Jiang, Bing Cui, Pingping Li

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 12, Pp 5267-5285 (2024)

Subject Terms: Nuclear receptor co-repressor 1, Intestinal epithelium, Metabolic syndrome, PPAR alpha, Liver X receptor, Thermogenesis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524003848; https://doaj.org/toc/2211-3835

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Niacin-induced lysosomal free cholesterol efflux via LXRα-mediated signaling pathways in macrophages retards the progression of atherosclerosis

Authors: Hao Xu, Xueni Sun, Miaoru Peng, Yuanshu Zhao, Shuxian Li, Ping Li, Fan Zhang, Xiaodong Fu, Xiaoyang Xu

Source: Heliyon, Vol 11, Iss 5, Pp e42976- (2025)

Subject Terms: Atherosclerosis, Niacin, Macrophage, Lysosome, Free cholesterol, Liver X receptor α (LXRα), Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S240584402501357X; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/43a6563189fb4136a52d9186b9a69603

Liver-X receptor β-selective agonist CE9A215 regulates Alzheimer’s disease-associated pathology in a 3xTg-AD mouse model

Authors: Ban, So Young ^{a, b, 1}, Nam, Yunkwon ^{c, 1}, Do, Thi Thuong ^b, Kim, Byeong-Hyeon ^c, Shin, Soo Jung ^c, Thi Nguyen, My Tuyen ^{e, f}, Kim, Jaehan ^e, Moon, Minho ^{c, d, ⁎}, Park, Jong-Tae ^{a, b, ⁎⁎}

Source: In Biomedicine & Pharmacotherapy March 2025 184

LXRα agonist differentially regulates BAFF expression and biological effects in RAW264.7 cells depending on growth status: LXRα activation and BAFF signaling in RAW264.7 cells

Authors: Teng, Yisa, Xu, Haiyan ^⁎, He, Xiaozhou, Zhuang, Qianfeng, Lu, Hao, Xu, Renfang, Xue, Dong

Source: In Biochemical and Biophysical Research Communications January 2025 742

Cresyl diphenyl phosphate (a novel organophosphate ester) induces hepatic steatosis by directly binding to liver X receptor α: From molecule action to risk assessment

Authors: Xinya Liu, Lanchao Sun, Yongfeng Lin, Jingyue Du, Huizi Yang, Chuanhai Li

Source: Environment International, Vol 194, Iss , Pp 109168- (2024)

Subject Terms: Cresyl diphenyl phosphate (CDP), Liver X Receptor α (LXRα), Receptor-bound concentration, Hepatic steatosis, Health risk, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412024007542; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/3bf0316f365a4e628ff4fd979ce5715f

Pivotal role of intestinal cholesterol and nuclear receptor LXR in metabolic liver steatohepatitis and hepatocarcinoma

Authors: Elena Piccinin, Maria Arconzo, Emanuela Pasculli, Angela Fulvia Tricase, Silvia Cultrera, Justine Bertrand-Michel, Nicolas Loiseau, Gaetano Villani, Hervé Guillou, Antonio Moschetta

Source: Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)

Subject Terms: Non-alcoholic steatohepatitis, Hepatocellular carcinoma, Gut-liver axis, Lipid metabolism, Liver X receptor, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2045-3701

Access URL: https://doaj.org/article/7dd55390b72b4df984024c17956df33a

LXR agonism for CNS diseases: promises and challenges

Authors: Ruiyi Zhang, Emily Wuerch, V. Wee Yong, Mengzhou Xue

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-13 (2024)

Subject Terms: Liver X receptor, Neurological diseases, Neuroinflammation, Cholesterol metabolism, Tissue regeneration, Clinical translation, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/28fc2cc132ac453a943b5c9add5dc52a

Liver X receptor α contribution to neuroinflammation and glial cells activation induced by MPTP: Implications for Parkinson’s disease

Authors: Mao, Zhihao ^{a, b, 1}, Zhang, Yuning ^{c, 1}, Liang, Yirong ^d, Xia, Chenglai ^{a, b, ⁎}, Tang, Lan ^{b, ⁎}

Source: In Neuroscience 12 November 2024 560:109-119

Cholesterol-dependent LXR transcription factor activity represses pronociceptive effects of estrogen in sensory neurons and pain induced by myelin basic protein fragments

Authors: Swathi K. Hullugundi, Jennifer Dolkas, Andrei V. Chernov, Tony L. Yaksh, Kelly A. Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y. Strongin, Patrick M. Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I. Shubayev

Source: Brain, Behavior, & Immunity - Health, Vol 38, Iss , Pp 100757- (2024)

Subject Terms: Neuropathic pain, Oxysterol, Cholesterol, Liver x receptor, LXR, Myelin basic protein, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666354624000358; https://doaj.org/toc/2666-3546

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Diisodecyl phenyl phosphate promotes foam cell formation by antagonizing Liver X receptor alpha

Authors: Shen, Xinming ^{a, b}, Li, Qiang ^a, Huang, Chong ^a, Xu, Cheng ^a, Hu, Jianying ^{a, ⁎}

Source: In Journal of Hazardous Materials 5 September 2024 476

The Liver X Receptor Promotes Immune Homeostasis via Controlled Activation of the Innate Immune System in the Liver

Authors: Hiroyuki Nakashima, Bradley M. Kearney, Manabu Kinoshita

Source: Biomolecules, Vol 15, Iss 1, p 25 (2024)

Subject Terms: liver X receptor, Kupffer cells, apoptosis, cholesterol, hepatocyte, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/1/25; https://doaj.org/toc/2218-273X

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Danlou Recipe promotes cholesterol efflux in macrophages RAW264.7 and reverses cholesterol transport in mice with hyperlipidemia induced by P407

Authors: Wenrun Han, Dandan Zhang, Peng Zhang, Qianqian Tao, Xiaoli Du, Chunquan Yu, Pengzhi Dong, Yan Zhu

Source: BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-14 (2023)

Subject Terms: Ethanol extract of Danlou tablet, Liver X receptor, Reverse cholesterol transport, Hyperlipidemia, Traditional Chinese Medicine, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: https://doaj.org/toc/2662-7671

Access URL: https://doaj.org/article/f8d8d2e2ae794c06b5f0dcf89b94eb02

Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearance

Authors: Beibei Wu, Yuqing Liu, Hongli Li, Lemei Zhu, Lingfeng Zeng, Zhen Zhang, Weijun Peng

Source: Neural Regeneration Research, Vol 20, Iss 3, Pp 695-714 (2023)

Subject Terms: abca1, alzheimer’s disease, amyloid-beta, apolipoprotein e, cholesterol metabolism, liver, liver x receptor, low-density lipoprotein receptor-related protein 1, peripheral clearance, tauroursodeoxycholic acid, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/1673-5374.391305; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958

Access URL: https://doaj.org/article/548fec7ed7264a1f9707fc01ec234d71

Liver X receptor activation in chronic myelogenous leukemia cells yields distinct mass fingerprints by whole cell MALDI-TOF MS, which correspond to changes in cell viability, gene expression, and differentiation markers

Authors: Catherine J. Andersen, Aaron R. Van Dyke, Lydia Dupree, Layra Cintrón-Rivera, Adam Doerr, Kaley McMullen, Kristina Murray, Nicholas Ragonesi, Alexander Gaito, Tyler Lyons, Eunsun Hong, Justin Gilbertson, Matthew Little, Justin Mercado, Margaret Rzucidlo, John Godwin

Source: Journal of Agriculture and Food Research, Vol 16, Iss , Pp 101202- (2024)

Subject Terms: Liver X receptor, Oxysterols, Anti-cancer bioactives, MALDI-TOF MS, Whole cell mass fingerprinting, Agriculture (General), S1-972, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666154324002394; https://doaj.org/toc/2666-1543

Access URL: https://doaj.org/article/fc3b77badc614b69a15f7dca8038368a

Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis

Authors: Brian Kleiboeker, Anyuan He, Min Tan, Dongliang Lu, Donghua Hu, Xuejing Liu, Parniyan Goodarzi, Fong-Fu Hsu, Babak Razani, Clay F. Semenkovich, Irfan J. Lodhi

Source: Molecular Metabolism, Vol 82, Iss , Pp 101913- (2024)

Subject Terms: Adipose tissue, Cholesterol, De novo lipogenesis, Diabetes, Plasmalogen, Liver X receptor, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877824000449; https://doaj.org/toc/2212-8778

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Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a stem cell model of neurodevelopmental disorder

Authors: De La Fuente, Daniel Cabezas ^{1, 7}, Tamburini, Claudia ^{1, 7}, Stonelake, Emily ⁵, Andrews, Robert ³, Hall, Jeremy ^{1, 2}, Owen, Michael J. ^{1, 2}, Linden, David E.J. ^{1, 2, 6}, Pocklington, Andrew ², Li, Meng ^{1, 2, 4, 8, ∗}

Source: In Cell Reports 26 March 2024 43(3)

Liver X Receptor Agonist 4β‐Hydroxycholesterol as a Prognostic Factor in Coronary Artery Disease

Authors: Roosa Rahunen, Mikko Tulppo, Valtteri Rinne, Samuli Lepojärvi, Juha S. Perkiömäki, Heikki V. Huikuri, Olavi Ukkola, Juhani Junttila, Janne Hukkanen

Source: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 5 (2024)

Subject Terms: 4β‐hydroxycholesterol, coronary artery disease, liver X receptor, death, sudden cardiac death, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2047-9980

Access URL: https://doaj.org/article/26ddd68e90bb4540a1fd71b46df9d022

Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation

Authors: Enchen Zhou, Xiaoke Ge, Hiroyuki Nakashima, Rumei Li, Hendrik J P van der Zande, Cong Liu, Zhuang Li, Christoph Müller, Franz Bracher, Yassene Mohammed, Jan Freark de Boer, Folkert Kuipers, Bruno Guigas, Christopher K Glass, Patrick C N Rensen, Martin Giera, Yanan Wang

Source: EMBO Molecular Medicine, Vol 15, Iss 8, Pp 1-15 (2023)

Subject Terms: desmosterol, Kupffer cell, liver X receptor, nonalcoholic steatohepatitis, Δ24‐dehydrocholesterol reductase, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

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Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder

Authors: Tuğba Menteşe Babayiğit, Güvem Gümüş-Akay, Merve Çikili Uytun, Özlem Doğan, Muhittin A. Serdar, Gökçe Yağmur Efendi, Ayşe Gökçe Erman, Esra Yürümez, Didem Behice Öztop

Source: Children, Vol 11, Iss 5, p 551 (2024)

Subject Terms: autism spectrum disorder, cholesterol, NR1H2, oxysterol, liver X receptor, single nucleotide polymorphism, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9067/11/5/551; https://doaj.org/toc/2227-9067

Access URL: https://doaj.org/article/b62dbb8bfd424f95b5ab9d030f60df1a

LXR Agonist T0901317′s Hepatic Impact Overrules Its Atheroprotective Action in Macrophages, Driving Early Atherogenesis in Chow-Diet-Fed Male Apolipoprotein E Knockout Mice

Authors: Menno Hoekstra, Laura M. de Jong, Rick van der Geest, Lidewij R. de Leeuw, Rani Krisnamurthi, Janine J. Geerling, Miranda Van Eck

Source: Biomolecules, Vol 14, Iss 4, p 429 (2024)

Subject Terms: liver X receptor, atherosclerosis, lipid metabolism, liver, macrophage, cholesterol efflux, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/4/429; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/81278c42970048989268f38ff1cfb5fb