A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Authors: Yered Pita-Juarez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C. Melms, Sebastian Niezen, Toni M. Delorey, Adam L. Essene, Olga R. Brook, Deepti Pant, Disha Skelton-Badlani, Pourya Naderi, Pinzhu Huang, Liuliu Pan, Tyler Hether, Tallulah S. Andrews, Carly G. K. Ziegler, Jason Reeves, Andriy Myloserdnyy, Rachel Chen, Andy Nam, Stefan Phelan, Yan Liang, Mark Gregory, Shanshan He, Michael Patrick, Tushar Rane, Aster Wardhani, Amit Dipak Amin, Jana Biermann, Hanina Hibshoosh, Molly Veregge, Zachary Kramer, Christopher Jacobs, Yusuf Yalcin, Devan Phillips, Michal Slyper, Ayshwarya Subramanian, Orr Ashenberg, Zohar Bloom-Ackermann, Victoria M. Tran, James Gomez, Alexander Sturm, Shuting Zhang, Stephen J. Fleming, Sarah Warren, Joseph Beechem, Deborah Hung, Mehrtash Babadi, Robert F. Padera, Sonya A. MacParland, Gary D. Bader, Nasser Imad, Isaac H. Solomon, Eric Miller, Stefan Riedel, Caroline B. M. Porter, Alexandra-Chloé Villani, Linus T.-Y. Tsai, Winston Hide, Gyongyi Szabo, Jonathan Hecht, Orit Rozenblatt-Rosen, Alex K. Shalek, Benjamin Izar, Aviv Regev, Yury V. Popov, Z. Gordon Jiang, Ioannis S. Vlachos

Source: Genome Biology, Vol 26, Iss 1, Pp 1-46 (2025)

Subject Terms: SARS-CoV-2, COVID-19, Spatial transcriptomics, Single-nucleus sequencing, Liver, Single-cell sequencing, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/5a3d94b9a9fb4b6ab7dd3d80ab4f997e

Single cell spatial profiling of FFPE splenic tissue from a humanized mouse model of HIV infection

Authors: Guoxin Wu, Samuel H. Keller, Luca Sardo, Brian Magliaro, Paul Zuck, Carl J. Balibar, Claire Williams, Liuliu Pan, Mark Gregory, Kathy Ton, Jill Maxwell, Carol Cheney, Tom Rush, Bonnie J. Howell

Source: Biomarker Research, Vol 12, Iss 1, Pp 1-13 (2024)

Subject Terms: FFPE, CosMx SMI, HIV, Single cell, Transcriptomic profiling, SYK, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2050-7771

Access URL: https://doaj.org/article/01fa0f698e854c8984b8df83b5423713

DDOST is associated with tumor immunosuppressive microenvironment in cervical cancer

Authors: Jie Mei, Liuliu Pan, Min Huang, Dandan Bao, Hui Gao, Danhan Wang

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Cervical cancer, DDOST, TME, Biomarker, Treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/66850ff220354fb4a13f63544518bca9

In situ single-cell profiling sheds light on IFI27 localisation during SARS-CoV-2 infection

Authors: Chin Wee Tan, Jinjin Chen, Ning Liu, Dharmesh D. Bhuva, Tony Blick, James Monkman, Caroline Cooper, Malvika Kharbanda, Kristen Feher, Belinda Phipson, Emily E. Killingbeck, Liuliu Pan, Youngmi Kim, Yan Liang, Andy Nam, Michael Leon, Paulo Souza-Fonseca-Guimaraes, Seigo Nagashima, Ana Paula Camargo Martins, Cleber Machado-Souza, Lucia de Noronha, Benjamin Tang, Kirsty Short, John Fraser, Gabrielle T. Belz, Fernando Souza-Fonseca-Guimaraes, Arutha Kulasinghe, Melissa J. Davis

Source: EBioMedicine, Vol 101, Iss , Pp 105016- (2024)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424000513; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/4f2fdb2f06f84144987d21c5de056820

Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures

Authors: Nataly Stylianou, Ismail Sebina, Nicholas Matigian, James Monkman, Hadeel Doehler, Joan Röhl, Mark Allenby, Andy Nam, Liuliu Pan, Anja Rockstroh, Habib Sadeghirad, Kimberly Chung, Thais Sobanski, Ken O'Byrne, Ana Clara Simoes Florido Almeida, Patricia Zadorosnei Rebutini, Cleber Machado‐Souza, Emanuele Therezinha Schueda Stonoga, Majid E Warkiani, Carlos Salomon, Kirsty Short, Lana McClements, Lucia deNoronha, Ruby Huang, Gabrielle T Belz, Fernando Souza‐Fonseca‐Guimaraes, Vicki Clifton, Arutha Kulasinghe

Source: Clinical & Translational Immunology, Vol 13, Iss 2, Pp n/a-n/a (2024)

Subject Terms: COVID‐19, digital spatial profiling, gene expression profiling, placental dysfunction, SARS‐CoV‐2, trophoblasts, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/c26444dbfdab4c58aeeef3df629fe26a

In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting

Authors: Wen Juan Tu, Michelle Melino, Jenny Dunn, Robert D. McCuaig, Helle Bielefeldt-Ohmann, Sofiya Tsimbalyuk, Jade K. Forwood, Taniya Ahuja, John Vandermeide, Xiao Tan, Minh Tran, Quan Nguyen, Liang Zhang, Andy Nam, Liuliu Pan, Yan Liang, Corey Smith, Katie Lineburg, Tam H. Nguyen, Julian D. J. Sng, Zhen Wei Marcus Tong, Keng Yih Chew, Kirsty R. Short, Roger Le Grand, Nabila Seddiki, Sudha Rao

Source: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c807331d48fd44e7b2a60c1357a9b798

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution

Authors: Ann-Marie Baker, Weini Huang, Xiao-Ming Mindy Wang, Marnix Jansen, Xiao-Jun Ma, Jeffrey Kim, Courtney M. Anderson, Xingyong Wu, Liuliu Pan, Nan Su, Yuling Luo, Enric Domingo, Timon Heide, Andrea Sottoriva, Annabelle Lewis, Andrew D. Beggs, Nicholas A. Wright, Manuel Rodriguez-Justo, Emily Park, Ian Tomlinson, Trevor A. Graham

Source: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/04a8b784261d4d7da0ef04bead32687f

β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells.

Authors: Liuliu Pan, Hilary A North, Vibhu Sahni, Su Ji Jeong, Tammy L Mcguire, Eric J Berns, Samuel I Stupp, John A Kessler

Source: PLoS ONE, Vol 9, Iss 8, p e104335 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4123915?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/77810a875a8b49d7aa16c51a273f1c98

Generation of Mouse Spinal Cord Injury

Authors: Oneil Bhalala, Liuliu Pan, Hilary North, Tammy McGuire, John Kessler

Source: Bio-Protocol, Vol 3, Iss 17 (2013)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://bio-protocol.org/en/bpdetail?id=886&type=0; https://doaj.org/toc/2331-8325

Access URL: https://doaj.org/article/df64d0e9694f4048ab7d580de945f8ef

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Authors: Baker, Ann-Marie, Weini Huang, Xiao-Ming Mindy Wang, Jansen, Marnix, Xiao-Jun Ma, Kim, Jeffrey, Anderson, Courtney M., Xingyong Wu, Liuliu Pan, Nan Su, Yuling Luo, Domingo, Enric, Heide, Timon, Sottoriva, Andrea, Lewis, Annabelle, Beggs, Andrew D., WrightA, Nicholas A., Rodriguez-Justo, Manuel, Park, Emily, Tomlinson, Ian

Source: Nature Communications; 12/8/2017, Vol. 8 Issue 1, p1-8, 8p

Subject Terms: COLON cancer, TUMOR growth, CANCER treatment, DISEASE relapse, POINT mutation (Biology)

Human Pluripotent Stem Cell-Derived Radial Glia Recapitulate Developmental Events and Provide Real-Time Access to Cortical Neurons and Astrocytes.

Authors: LISHU DUAN, CHIAN-YU PENG, LIULIU PAN, KESSLER, JOHN A.

Source: Stem Cells Translational Medicine; May2015, Vol. 4 Issue 5, p437-447, 11p

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