Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotypeResearch in context

Authors: Manukumar Honnayakanahalli Marichannegowda, Saini Setua, Meera Bose, Eric Sanders-Buell, David King, Michelle Zemil, Lindsay Wieczorek, Felisa Diaz-Mendez, Nicolas Chomont, Rasmi Thomas, Leilani Francisco, Leigh Anne Eller, Victoria R. Polonis, Sodsai Tovanabutra, Alonso Heredia, Yutaka Tagaya, Nelson L. Michael, Merlin L. Robb, Hongshuo Song

Source: EBioMedicine, Vol 109, Iss , Pp 105410- (2024)

Subject Terms: HIV-1, CXCR4, Mucosal transmission, CD4 subset, Pathogenesis, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424004468; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/cb0d23262dfb444090a7d9f07063396f

Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG

Authors: Lindsay Wieczorek, David Chang, Eric Sanders-Buell, Michelle Zemil, Elizabeth Martinez, Jesse Schoen, Agnes-Laurence Chenine, Sebastian Molnar, Brittani Barrows, Kultida Poltavee, Man E. Charurat, Alash’le Abimiku, William Blattner, Michael Iroezindu, Afoke Kokogho, Nelson L. Michael, Trevor A. Crowell, Julie A. Ake, Sodsai Tovanabutra, Victoria R. Polonis, on behalf of the AFRICOS and TRUST/RV368 Study Groups

Source: Virology Journal, Vol 21, Iss 1, Pp 1-14 (2024)

Subject Terms: HIV, Envelope (Env), Antibody, Nigeria, West Africa, Subtype G, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1743-422X

Access URL: https://doaj.org/article/ddfeaaa90c034894b2a7019be230a0b6

Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding

Authors: Hongjun Bai, Eric Lewitus, Yifan Li, Paul V. Thomas, Michelle Zemil, Mélanie Merbah, Caroline E. Peterson, Thujitha Thuraisamy, Phyllis A. Rees, Agnes Hajduczki, Vincent Dussupt, Bonnie Slike, Letzibeth Mendez-Rivera, Annika Schmid, Erin Kavusak, Mekhala Rao, Gabriel Smith, Jessica Frey, Alicea Sims, Lindsay Wieczorek, Victoria Polonis, Shelly J. Krebs, Julie A. Ake, Sandhya Vasan, Diane L. Bolton, M. Gordon Joyce, Samantha Townsley, Morgane Rolland

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4aed98c53021448ba001318c61974fb7

Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

Authors: Rajeshwer S. Sankhala, Kerri G. Lal, Jaime L. Jensen, Vincent Dussupt, Letzibeth Mendez-Rivera, Hongjun Bai, Lindsay Wieczorek, Sandra V. Mayer, Michelle Zemil, Danielle A. Wagner, Samantha M. Townsley, Agnes Hajduczki, William C. Chang, Wei-Hung Chen, Gina C. Donofrio, Ningbo Jian, Hannah A. D. King, Cynthia G. Lorang, Elizabeth J. Martinez, Phyllis A. Rees, Caroline E. Peterson, Fabian Schmidt, Tricia J. Hart, Debra K. Duso, Lawrence W. Kummer, Sean P. Casey, Jazmean K. Williams, Shruthi Kannan, Bonnie M. Slike, Lauren Smith, Isabella Swafford, Paul V. Thomas, Ursula Tran, Jeffrey R. Currier, Diane L. Bolton, Edgar Davidson, Benjamin J. Doranz, Theodora Hatziioannou, Paul D. Bieniasz, Dominic Paquin-Proulx, William W. Reiley, Morgane Rolland, Nancy J. Sullivan, Sandhya Vasan, Natalie D. Collins, Kayvon Modjarrad, Gregory D. Gromowski, Victoria R. Polonis, Nelson L. Michael, Shelly J. Krebs, M. Gordon Joyce

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/61dc74f1c5d84f64ac1178c032cab9f4

Extracellular vesicle isolation methods identify distinct HIV‐1 particles released from chronically infected T‐cells

Authors: Sebastian M. Molnar, Yuriy Kim, Lindsay Wieczorek, Anastasia Williams, Kajal Ashok Patil, Pooja Khatkar, Mark F. Santos, Gifty Mensah, Aurelio Lorico, Victoria R. Polonis, Fatah Kashanchi

Source: Journal of Extracellular Vesicles, Vol 13, Iss 7, Pp n/a-n/a (2024)

Subject Terms: amphisomes, cART, exomeres, exosomes, extracellular particles, extracellular vesicles, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2001-3078

Access URL: https://doaj.org/article/0d50f727a4de4bc68d506b333862ef96

Innate immune cell activation after HIV-1 vaccine administration is associated with increased antibody production

Authors: Kombo F. N’guessan, Kawthar Machmach, Isabella Swafford, Margaret C. Costanzo, Lindsay Wieczorek, Dohoon Kim, Siriwat Akapirat, Victoria R. Polonis, Punnee Pitisuttithum, Sorachai Nitayaphan, Sanjay Gurunathan, Faruk Sinangil, Suwat Chariyalertsak, Julie A. Ake, Robert J. O’connell, Sandhya Vasan, Dominic Paquin-Proulx

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: MAIT (mucosal-associated invariant T) cell, iNKT cell, NK cell, gamma delta (γδ) T cells, HIV vaccine, immune activation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1339727/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b63b37f19fa546188d5104a25d963234

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity

Authors: Wei-Hung Chen, Agnes Hajduczki, Elizabeth J. Martinez, Hongjun Bai, Hanover Matz, Thomas M. Hill, Eric Lewitus, William C. Chang, Layla Dawit, Caroline E. Peterson, Phyllis A. Rees, Adelola B. Ajayi, Emily S. Golub, Isabella Swafford, Vincent Dussupt, Sapna David, Sandra V. Mayer, Sandrine Soman, Caitlin Kuklis, Courtney Corbitt, Jocelyn King, Misook Choe, Rajeshwer S. Sankhala, Paul V. Thomas, Michelle Zemil, Lindsay Wieczorek, Tricia Hart, Debora Duso, Larry Kummer, Lianying Yan, Spencer L. Sterling, Eric D. Laing, Christopher C. Broder, Jazmean K. Williams, Edgar Davidson, Benjamin J. Doranz, Shelly J. Krebs, Victoria R. Polonis, Dominic Paquin-Proulx, Morgane Rolland, William W. Reiley, Gregory D. Gromowski, Kayvon Modjarrad, Helen Dooley, M. Gordon Joyce

Source: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/898fe823bbf4468ea5527a2d0a41fa28

Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States.

Authors: Lindsay Wieczorek, Eric Sanders-Buell, Michelle Zemil, Eric Lewitus, Erin Kavusak, Jonah Heller, Sebastian Molnar, Mekhala Rao, Gabriel Smith, Meera Bose, Amy Nguyen, Adwitiya Dhungana, Katherine Okada, Kelly Parisi, Daniel Silas, Bonnie Slike, Anuradha Ganesan, Jason Okulicz, Tahaniyat Lalani, Brian K Agan, Trevor A Crowell, Janice Darden, Morgane Rolland, Sandhya Vasan, Julie Ake, Shelly J Krebs, Sheila Peel, Sodsai Tovanabutra, Victoria R Polonis

Source: PLoS Pathogens, Vol 19, Iss 12, p e1011780 (2023)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011780&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/81e83870173c4f2faaeff5746df525aa

ALVAC-HIV and AIDSVAX B/E vaccination induce improved immune responses compared with AIDSVAX B/E vaccination alone

Authors: Margaret C. Costanzo, Dominic Paquin-Proulx, Alexandra Schuetz, Siriwat Akapirat, Zhanna Shubin, Dohoon Kim, Lindsay Wieczorek, Victoria R. Polonis, Hung V. Trinh, Mangala Rao, Hanna Anenia, Michael D. Barrera, Jacob Boeckelman, Barbara Nails, Pallavi Thapa, Michelle Zemil, Carlo Sacdalan, Eugene Kroon, Boot Kaewboon, Somporn Tipsuk, Surat Jongrakthaitae, Sanjay Gurunathan, Faruk Sinangil, Jerome H. Kim, Merlin L. Robb, Julie A. Ake, Robert J. O’Connell, Punnee Pitisutthithum, Sorachai Nitayaphan, Suwat Chariyalertsak, Michael A. Eller, Nittaya Phanuphak, Sandhya Vasan, the RV, RV328 study groups

Source: JCI Insight, Vol 8, Iss 9 (2023)

Subject Terms: AIDS/HIV, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/54ea0fbbfd224eb79d9efe0dfded1c6a

Convalescent human IgG, but not IgM, from COVID-19 survivors confers dose-dependent protection against SARS-CoV-2 replication and disease in hamsters

Authors: Hannah A. D. King, Vincent Dussupt, Letzibeth Mendez-Rivera, Bonnie M. Slike, Ursula Tran, Nathan D. Jackson, Erica Barkei, Michelle Zemil, Emily Tourtellott-Fogt, Caitlin H. Kuklis, Sandrine Soman, Aslaa Ahmed, Maciel Porto, Christopher Kitajewski, Brittany Spence, Dalia Benetiene, Lindsay Wieczorek, Swagata Kar, Gregory Gromowski, Victoria R. Polonis, Shelly J. Krebs, Kayvon Modjarrad, Diane L. Bolton

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: SARS-CoV-2, antibody, passive transfer, IgM, IgG, hamster, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1138629/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c52c6e6701da487ba8ca0ca3fe209401

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

Authors: Brittani M. Barrows, Shelly J. Krebs, Ningbo Jian, Michelle Zemil, Bonnie M. Slike, Vincent Dussupt, Ursula Tran, Letzibeth Mendez-Rivera, David Chang, Anne Marie O’Sullivan, Brendan Mann, Eric Sanders-Buell, Zhanna Shubin, Matt Creegan, Dominic Paquin-Proulx, Philip Ehrenberg, Agnes Laurence-Chenine, Kriengkrai Srithanaviboonchai, Rasmi Thomas, Michael A. Eller, Guido Ferrari, Merlin Robb, Venigalla Rao, Sodsai Tovanabutra, Victoria R. Polonis, Lindsay Wieczorek

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: vertical transmission, antibody dependent cellular cytotoxicity, neonatal Fc receptor, passive immunity, CRF01_AE HIV, Thailand, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051501/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/cf38bdf7a92d429dbb06fe53fdb887b3

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Authors: Kathryn McGuckin Wuertz, Erica K. Barkei, Wei-Hung Chen, Elizabeth J. Martinez, Ines Lakhal-Naouar, Linda L. Jagodzinski, Dominic Paquin-Proulx, Gregory D. Gromowski, Isabella Swafford, Akshaya Ganesh, Ming Dong, Xiankun Zeng, Paul V. Thomas, Rajeshwer S. Sankhala, Agnes Hajduczki, Caroline E. Peterson, Caitlin Kuklis, Sandrine Soman, Lindsay Wieczorek, Michelle Zemil, Alexander Anderson, Janice Darden, Heather Hernandez, Hannah Grove, Vincent Dussupt, Holly Hack, Rafael de la Barrera, Stasya Zarling, James F. Wood, Jeffrey W. Froude, Matthew Gagne, Amy R. Henry, Elham Bayat Mokhtari, Prakriti Mudvari, Shelly J. Krebs, Andrew S. Pekosz, Jeffrey R. Currier, Swagata Kar, Maciel Porto, Adrienne Winn, Kamil Radzyminski, Mark G. Lewis, Sandhya Vasan, Mehul Suthar, Victoria R. Polonis, Gary R. Matyas, Eli A. Boritz, Daniel C. Douek, Robert A. Seder, Sharon P. Daye, Mangala Rao, Sheila A. Peel, M. Gordon Joyce, Diane L. Bolton, Nelson L. Michael, Kayvon Modjarrad

Source: npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/3d4762c8ae9d4d3e8004ffeb07a8b88e

Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 Infection

Authors: Lindsay Wieczorek, Michelle Zemil, Mélanie Merbah, Vincent Dussupt, Erin Kavusak, Sebastian Molnar, Jonah Heller, Bradley Beckman, Suzanne Wollen-Roberts, Kristina K. Peachman, Janice M. Darden, Shelly Krebs, Morgane Rolland, Sheila A. Peel, Victoria R. Polonis

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: SARS-CoV-2, coronavirus – COVID-19, variant of concern, antibody dependent enhancement, neutralization, pseudovirus, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.901217/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/3fd69905fb6740eda97934e127cb2d8a

Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection

Authors: Julie L. Mitchell, Justin Pollara, Kenneth Dietze, R. Whitney Edwards, Junsuke Nohara, Kombo F. N’guessan, Michelle Zemil, Supranee Buranapraditkun, Hiroshi Takata, Yifan Li, Roshell Muir, Eugene Kroon, Suteeraporn Pinyakorn, Shalini Jha, Sopark Manasnayakorn, Suthat Chottanapund, Pattarawat Thantiworasit, Peeriya Prueksakaew, Nisakorn Ratnaratorn, Bessara Nuntapinit, Lawrence Fox, Sodsai Tovanabutra, Dominic Paquin-Proulx, Lindsay Wieczorek, Victoria R. Polonis, Frank Maldarelli, Elias K. Haddad, Praphan Phanuphak, Carlo P. Sacdalan, Morgane Rolland, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Guido Ferrari, Lydie Trautmann, on behalf of the RV254 and RV304 Study Groups

Source: The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)

Subject Terms: AIDS/HIV, Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/cc859e1a16824f2a979382eb4e0ca583

Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.

Authors: Kier Om, Dominic Paquin-Proulx, Maria Montero, Kristina Peachman, Xiaoying Shen, Lindsay Wieczorek, Zoltan Beck, Joshua A Weiner, Dohoon Kim, Yifan Li, Thembi Mdluli, Zhanna Shubin, Christopher Bryant, Vishakha Sharma, Andrey Tokarev, Peter Dawson, Yohann White, Oliver Appelbe, Nichole R Klatt, Sodsai Tovanabutra, Jacob D Estes, Gary R Matyas, Guido Ferrari, Carl R Alving, Georgia D Tomaras, Margaret E Ackerman, Nelson L Michael, Merlin L Robb, Victoria Polonis, Morgane Rolland, Michael A Eller, Mangala Rao, Diane L Bolton

Source: PLoS Pathogens, Vol 16, Iss 9, p e1008764 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/7a6c977bbc934d51bd9ae6ad3d6245bd

Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5

Authors: Sebastian Molnar, Lindsay Wieczorek, Michelle Zemil, Bianca Schulte, Elizabeth Martinez, Syna Gift, Lan Tang, Hendrik Streeck, Robert A. Gramzinski, Nelson L. Michael, Gordon Joyce, Victoria R. Polonis

Source: mAbs, Vol 12, Iss 1 (2020)

Subject Terms: SERINC5, HIV-1 restriction factor, monoclonal antibody, multi-pass transmembrane protein, serine incorporator, immunocytochemistry, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/b3e84ef4f2da4c3b815fad227abff309

Detection of HIV-1 neutralizing antibodies in a human CD4⁺/CXCR4⁺/CCR5⁺ T-lymphoblastoid cell assay system.

Authors: Robert J McLinden, Celia C Labranche, Agnès-Laurence Chenine, Victoria R Polonis, Michael A Eller, Lindsay Wieczorek, Christina Ochsenbauer, John C Kappes, Stephen Perfetto, David C Montefiori, Nelson L Michael, Jerome H Kim

Source: PLoS ONE, Vol 8, Iss 11, p e77756 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3842913?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f43d34812b084bf68bedf541c1faccd3

Impact of HIV-1 backbone on neutralization sensitivity: neutralization profiles of heterologous envelope glycoproteins expressed in native subtype C and CRF01_AE backbone.

Authors: Agnès-Laurence Chenine, Lindsay Wieczorek, Eric Sanders-Buell, Maggie Wesberry, Teresa Towle, Devin M Pillis, Sebastian Molnar, Robert McLinden, Tara Edmonds, Ivan Hirsch, Robert O'Connell, Francine E McCutchan, David C Montefiori, Christina Ochsenbauer, John C Kappes, Jerome H Kim, Victoria R Polonis, Sodsai Tovanabutra

Source: PLoS ONE, Vol 8, Iss 11, p e76104 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3843658?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c0b36090a11d4ac489e4bbf4ec7be29c

The role of natural killer (NK) cells and NK cell receptor polymorphisms in the assessment of HIV-1 neutralization.

Authors: Bruce K Brown, Lindsay Wieczorek, Gustavo Kijak, Kara Lombardi, Jeffrey Currier, Maggie Wesberry, John C Kappes, Viseth Ngauy, Mary Marovich, Nelson Michael, Christina Ochsenbauer, David C Montefiori, Victoria R Polonis

Source: PLoS ONE, Vol 7, Iss 4, p e29454 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3324450?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b5f086f9b94e4f6eba28e2bf1757d8b0

Phase I study of safety and immunogenicity of an Escherichia coli-derived recombinant protective antigen (rPA) vaccine to prevent anthrax in adults.

Authors: Bruce K Brown, Josephine Cox, Anita Gillis, Thomas C VanCott, Mary Marovich, Mark Milazzo, Tanya Santelli Antonille, Lindsay Wieczorek, Kelly T McKee, Karen Metcalfe, Raburn M Mallory, Deborah Birx, Victoria R Polonis, Merlin L Robb

Source: PLoS ONE, Vol 5, Iss 11, p e13849 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2974626?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/536b9783e5ae44dbbd58d330690a4703