Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics

Authors: Nye, Taylor M., Tükenmez, Hasan, Singh, Pardeep, Flores-Mireles, Ana L., Obernuefemann, Chloe L. P., Pinkner, Jerome S., Sarkar, Souvik, Bonde, Mari, Lindgren, Anders E. G., Dodson, Karen W., Johansson, Jörgen, Almqvist, Fredrik, Caparon, Michael G., Hultgren, Scott J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Oct . 119(43), 1-10.

Access URL: https://www.jstor.org/stable/27208914

THCz : Small molecules with antimicrobial activity that block cell wall lipid intermediates

Authors: Reithuber, Elisabeth, Wixe, Torbjörn, Ludwig, Kevin C., Müller, Anna, Uvell, Hanna, Grein, Fabian, Lindgren, Anders E. G., Muschiol, Sandra, Nannapaneni, Priyanka, Eriksson, Anna, Schneider, Tanja, Normark, Staffan, Henriques-Normark, Birgitta, Almqvist, Fredrik, Mellroth, Peter

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Nov . 118(47), 1-12.

Access URL: https://www.jstor.org/stable/27094014

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

Authors: Flentie, Kelly, Harrison, Gregory A., Tükenmez, Hasan, Livny, Jonathan, Good, James A. D., Sarkar, Souvik, Zhu, Dennis X., Kinsella, Rachel L., Weiss, Leslie A., Solomon, Samantha D., Schene, Miranda E., Hansen, Mette R., Cairns, Andrew G., Kulén, Martina, Wixe, Torbjörn, Lindgren, Anders E. G., Chorell, Erik, Bengtsson, Christoffer, Krishnan, K. Syam, Hultgren, Scott J., Larsson, Christer, Almqvist, Fredrik, Stallings, Christina L.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 May . 116(21), 10510-10517.

Access URL: https://www.jstor.org/stable/26706280

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

Authors: KulénThese authors contributed equally., Martina, Núñez-Otero, Carlos, Cairns, Andrew G., Silver, Jim, Lindgren, Anders E. G., Wede, Emma, Singh, Pardeep, Vielfort, Katarina, BahnanDivision of Infection Medicine, BMC, Lund University, Sweden., Wael, GoodReViral Ltd, NETpark Plexus, Thomas Wright Way, Sedgefield, TS21 3FD, United Kingdom., James A. D., Svensson, Richard, Bergström, Sven, Gylfe, Åsa, Almqvist, Fredrik

Source: MedChemComm. 10(11):1966-1987

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100092288292.0x000001&indx=1&recIds=ETOCvdc_100092288292.0x000001

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2‑Pyridone Polyheterocycles Binding to α‑Synuclein and Amyloid‑β Fibrils.

Authors: Adolfsson, Dan E., Tyagi, Mohit, Singh, Pardeep, Deuschmann, Adrian, Ådén, Jörgen, Gharibyan, Anna L., Jayaweera, Sanduni Wasana, Lindgren, Anders E. G., Olofsson, Anders, Almqvist, Fredrik

Source: Journal of Organic Chemistry; 11/6/2020, Vol. 85 Issue 21, p14174-14189, 16p

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.

Authors: Kulén, Martina, Núñez-Otero, Carlos, Cairns, Andrew G., Silver, Jim, Lindgren, Anders E. G., Wede, Emma, Singh, Pardeep, Vielfort, Katarina, Bahnan, Wael, Good, James A. D., Svensson, Richard, Bergström, Sven, Gylfe, Åsa, Almqvist, Fredrik

Source: MedChemComm; Nov2019, Vol. 10 Issue 11, p1966-1987, 22p

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Total Synthesis of the Resveratrol Oligomers (±)-Ampelopsin B and (±)-ϵ-Viniferin.

Authors: Lindgren, Anders E. G.¹, Öberg, Christopher T.¹, Hillgren, J. Mikael¹, Elofsson, Mikael¹, mikael.elofsson@chem.umu.se

Source: European Journal of Organic Chemistry; Jan2016, Vol. 2016 Issue 3, p426-429, 4p

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Statistical Molecular Design: A Tool to Follow Up Hits from Small-Molecule Screening.

Authors: Lindgren, Anders E. G., Larsson, Andreas, Linusson, Anna, Elofsson, Mikael

Source: Plant Chemical Genomics; 2014, p169-188, 20p

Chemical Probes to Study ADP-Ribosylation:Synthesisand Biochemical Evaluation of Inhibitors of the Human ADP-RibosyltransferaseARTD3/PARP3.

Authors: Lindgren, Anders E. G., Karlberg, Tobias, Ekblad, Torun, Spjut, Sara, Thorsell, Ann-Gerd, Andersson, C. David, Nhan, Ton Tong, Hellsten, Victor, Weigelt, Johan, Linusson, Anna, Schüler, Herwig, Elofsson, Mikael

Source: Journal of Medicinal Chemistry; Dec2013, Vol. 56 Issue 23, p9556-9568, 13p

Discovery of Ligands forADP-Ribosyltransferases viaDocking-Based Virtual Screening.

Authors: Andersson, C. David, Karlberg, Tobias, Ekblad, Torun, Lindgren, Anders E. G., Thorsell, Ann-Gerd, Spjut, Sara, Uciechowska, Urszula, Niemiec, Moritz S., Wittung-Stafshede, Pernilla, Weigelt, Johan, Elofsson, Mikael, Schüler, Herwig, Linusson, Anna

Source: Journal of Medicinal Chemistry; Sep2012, Vol. 55 Issue 17, p7706-7718, 13p

The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism

Authors: Reithuber, Elisabeth, Nannapaneni, Priyanka, Rzhepishevska, Olena, Lindgren, Anders E. G., Ilchenko, Oleksandr, Normark, Staffan, Almqvist, Fredrik, Henriques-Normark, Birgitta, Mellroth, Peter

Source: mBio; December 2020, Vol. 11 Issue: 6

ChemInform Abstract: Total Synthesis of the Resveratrol Oligomers (.+-.)-Ampelopsin B and (.+-.)-ε-Viniferin.

Authors: Lindgren, Anders E. G.¹, Oeberg, Christopher T.¹, Hillgren, J. Mikael¹, Elofsson, Mikael¹

Source: ChemInform. Mar2016, Vol. 47 Issue 12, pno-no. 1p.

Subject Terms: *RESVERATROL, *OLIGOMERS, *CHEMICAL synthesis