Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

Authors: Bottomly, Daniel, Long, Nicola, Schultz, Anna Reister, Kurtz, Stephen E., Tognon, Cristina E., Johnson, Kara, Abel, Melissa, Agarwal, Anupriya, Avaylon, Sammantha, Benton, Erik, Blucher, Aurora, Borate, Uma, Braun, Theodore P., Brown, Jordana, Bryant, Jade, Burke, Russell, Carlos, Amy, Chang, Bill H., Cho, Hyun Jun, Christy, Stephen, Coblentz, Cody, Cohen, Aaron M., d’Almeida, Amanda, Cook, Rachel, Danilov, Alexey, Dao, Kim-Hien T., Degnin, Michie, Dibb, James, Eide, Christopher A., English, Isabel, Hagler, Stuart, Harrelson, Heath, Henson, Rachel, Ho, Hibery, Joshi, Sunil K., Junio, Brian, Kaempf, Andy, Kosaka, Yoko, Laderas, Ted, Lawhead, Matt, Lee, Hyunjung, Leonard, Jessica T., Lin, Chenwei, Lind, Evan F., Liu, Selina Qiuying, Lo, Pierrette, Loriaux, Marc M., Luty, Samuel, Maxson, Julia E., Macey, Tara, Martinez, Jacqueline, Minnier, Jessica, Monteblanco, Andrea, Mori, Motomi, Morrow, Quinlan, Nelson, Dylan, Ramsdill, Justin, Rofelty, Angela, Rogers, Alexandra, Romine, Kyle A., Ryabinin, Peter, Saultz, Jennifer N., Sampson, David A., Savage, Samantha L., Schuff, Robert, Searles, Robert, Smith, Rebecca L., Spurgeon, Stephen E., Sweeney, Tyler, Swords, Ronan T., Thapa, Aashis, Thiel-Klare, Karina, Traer, Elie, Wagner, Jake, Wilmot, Beth, Wolf, Joelle, Wu, Guanming, Yates, Amy, Zhang, Haijiao, Cogle, Christopher R., Collins, Robert H., Deininger, Michael W., Hourigan, Christopher S., Jordan, Craig T., Lin, Tara L., Martinez, Micaela E., Pallapati, Rachel R., Pollyea, Daniel A., Pomicter, Anthony D., Watts, Justin M., Weir, Scott J., Druker, Brian J., McWeeney, Shannon K., Tyner, Jeffrey W.

Source: In Cancer Cell 8 August 2022 40(8):850-864

Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia

Authors: Lamble, Adam J., Kosaka, Yoko, Laderas, Ted, Maffit, Allie, Kaempf, Andy, Brady, Lauren K., Wang, Weiwei, Long, Nicola, Saultz, Jennifer N., Mori, Motomi, Soong, David, LeFave, Clare V., Huang, Fei, Adams, Homer, Loriaux, Marc M., Tognon, Cristina E., Lo, Pierrette, Tyner, Jeffrey W., Fan, Guang, McWeeney, Shannon K., Druker, Brian J., Lind, Evan F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jun . 117(25), 14331-14341.

Access URL: https://www.jstor.org/stable/26934962

An expanded universe of cancer targets

Authors: Dancik, Vlado, Gill, Shubhroz, Hua, Bruce, Sharifnia, Tanaz, Viswanathan, Vasanthi, Zou, Yilong, Dela Cruz, Filemon, Kung, Andrew, Stockwell, Brent, Boehm, Jesse, Dempster, Josh, Manguso, Robert, Vazquez, Francisca, Cooper, Lee A.D., Du, Yuhong, Ivanov, Andrey, Lonial, Sagar, Moreno, Carlos S., Niu, Qiankun, Owonikoko, Taofeek, Ramalingam, Suresh, Reyna, Matthew, Zhou, Wei, Grandori, Carla, Shmulevich, Ilya, Swisher, Elizabeth, Cai, Jitong, Chan, Issac S., Dunworth, Matthew, Ge, Yuchen, Georgess, Dan, Grasset, Eloïse M., Henriet, Elodie, Knútsdóttir, Hildur, Lerner, Michael G., Padmanaban, Veena, Perrone, Matthew C., Suhail, Yasir, Tsehay, Yohannes, Warrier, Manisha, Morrow, Quin, Nechiporuk, Tamilla, Long, Nicola, Saultz, Jennifer, Kaempf, Andy, Minnier, Jessica, Tognon, Cristina E., Kurtz, Stephen E., Agarwal, Anupriya, Brown, Jordana, Watanabe-Smith, Kevin, Vu, Tania Q., Jacob, Thomas, Yan, Yunqi, Robinson, Bridget, Lind, Evan F., Kosaka, Yoko, Demir, Emek, Estabrook, Joseph, Grzadkowski, Michael, Nikolova, Olga, Chen, Ken, Deneen, Ben, Liang, Han, Bassik, Michael C., Bhattacharya, Asmita, Brennan, Kevin, Curtis, Christina, Gevaert, Olivier, Ji, Hanlee P., Karlsson, Kasper A.J., Karagyozova, Kremena, Lo, Yuan-Hung, Liu, Katherine, Nakano, Michitaka, Sathe, Anuja, Smith, Amber R., Spees, Kaitlyn, Wong, Wing Hing, Yuki, Kanako, Hangauer, Matt, Kaufman, Dan S., Balmain, Allan, Bollam, Saumya R., Chen, Wei-Ching, Fan, QiWen, Kersten, Kelly, Krummel, Matthew, Li, Yun Rose, Menard, Marie, Nasholm, Nicole, Schmidt, Christin, Serwas, Nina K., Yoda, Hiroyuki, Ashworth, Alan, Bandyopadhyay, Sourav, Bivona, Trevor, Eades, Gabriel, Oberlin, Stefan, Tay, Neil, Wang, Yuhao, Weissman, Jonathan, Hahn, William C., Bader, Joel S., Braun, Theodore P., Califano, Andrea, Clemons, Paul A., Druker, Brian J., Ewald, Andrew J., Fu, Haian, Jagu, Subhashini, Kemp, Christopher J., Kim, William, Kuo, Calvin J., McManus, Michael T., B. Mills, Gordon, Mo, Xiulei, Sahni, Nidhi, Schreiber, Stuart L., Talamas, Jessica A., Tamayo, Pablo, Tyner, Jeffrey W., Wagner, Bridget K., Weiss, William A., Gerhard, Daniela S.

Source: In Cell 4 March 2021 184(5):1142-1155

Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway

Authors: Moshofsky, Kaycee B., Cho, Hyun J., Wu, Guanming, Romine, Kyle A., Newman, Matthew T., Kosaka, Yoko, McWeeney, Shannon K., Lind, Evan F.

Source: In Blood Advances 22 October 2019 3(20):3038-3051

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Authors: Edwards, David K., V, Watanabe-Smith, Kevin, Rofelty, Angela, Damnernsawad, Alisa, Laderas, Ted, Lamble, Adam, Lind, Evan F., Kaempf, Andy, Mori, Motomi, Rosenberg, Mara, d'Almeida, Amanda, Long, Nicola, Agarwal, Anupriya, Sweeney, David Tyler, Loriaux, Marc, McWeeney, Shannon K., Tyner, Jeffrey W. ^*

Source: In Blood 7 February 2019 133(6):588-599

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation

Authors: Dimitriou, Ioannis D., Lee, Korris, Akpan, Itoro, Lind, Evan F., Barr, Valarie A., Ohashi, Pamela S., Samelson, Lawrence E., Rottapel, Robert

Source: In Cell Reports 31 July 2018 24(5):1123-1135

Integrated functional and mass spectrometry-based flow cytometric phenotyping to describe the immune microenvironment in acute myeloid leukemia

Authors: Lamble, Adam J., Dietz, Matthew, Laderas, Ted, McWeeney, Shannon, Lind, Evan F.

Source: In Journal of Immunological Methods February 2018 453:44-52

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2

Authors: Inoue, Satoshi, Li, Wanda Y., Tseng, Alan, Beerman, Isabel, Elia, Andrew J., Bendall, Sean C., Lemonnier, François, Kron, Ken J., Cescon, David W., Hao, Zhenyue, Lind, Evan F., Takayama, Naoya, Planello, Aline C., Shen, Shu Yi, Shih, Alan H., Larsen, Dana M., Li, Qinxi, Snow, Bryan E., Wakeham, Andrew, Haight, Jillian, Gorrini, Chiara, Bassi, Christian, Thu, Kelsie L., Murakami, Kiichi, Elford, Alisha R., Ueda, Takeshi, Straley, Kimberly, Yen, Katharine E., Melino, Gerry, Cimmino, Luisa, Aifantis, Iannis, Levine, Ross L., De Carvalho, Daniel D., Lupien, Mathieu, Rossi, Derrick J., Nolan, Garry P., Cairns, Rob A., Mak, Tak W.

Source: In Cancer Cell 8 August 2016 30(2):337-348

Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency.

Authors: Flynn, Patrick A., Long, Mark D., Yoko Kosaka, Long, Nicola, Mulkey, Jessica S., Coy, Jesse L., Agarwal, Anupriya, Lind, Evan F.

Source: Frontiers in Immunology; 2024, p1-15, 15p

Subject Terms: DENDRITIC cells, BONE marrow cells, PRELEUKEMIA, T helper cells, ACUTE myeloid leukemia, T cells, MYELOID differentiation factor 88

HUNK Suppresses Metastasis of Basal Type Breast Cancers by Disrupting the Interaction between PP2A and Cofilin-1

Authors: Quintela-Fandino, Miguel, Arpaia, Enrico, Brenner, Dirk, Goh, Theo, Yeung, Faith Au, Blaser, Heiko, Alexandrova, Roumiana, Lind, Evan F., Tusche, Mike W., Wakeham, Andrew, Ohashi, Pamela S., Mak, Tak W.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Feb 01. 107(6), 2622-2627.

Access URL: https://www.jstor.org/stable/40536634

The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation

Authors: Lu, Li-Fan, Ahonen, Cory L., Lind, Evan F., Raman, Vanitha S., Cook, W. James, Lin, Ling-Li, Noelle, Randolph J. ^*

Source: In Blood 1 July 2007 110(1):193-200

Strategies for selective priming of memory B cells

Authors: Raman, Vanitha S., Lind, Evan F., Benson, Micah J., Noelle, Randolph J.

Source: In Immunology Letters 2007 109(2):93-100

Prognostic Significance of NCAM1 (CD56) Expression in AML Patients Treated with HMA+Venetoclax

Authors: Saultz, Jennifer N., Rai, Manoj, Burns, Faith, Chandra, Daniel J, Joshi, Sunil K, Lachowiez, Curtis A., Kaempf, Andy, Nemecek, Andrew N, Kosaka, Yoko, Lind, Evan F., Kurtz, Stephen E., Long, Nicola, Cook, Rachel, Meyers, Gabrielle, Gandhi, Arpita, Leonard, Jessica T., Hayes-Lattin, Brandon, Newell, Laura F., Maziarz, Richard T, Traer, Elie, Swords, Ronan T., Braun, Theodore P, Tognon, Cristina, Tyner, Jeffrey W

Source: In Blood 2 November 2023 142 Supplement 1:5762-5762

High Dimensional Clustering and Identification of Immune Cell Hybrid Populations in B-ALL across the Disease Continuum

Authors: Newman, Matthew, De Sa, Hong, Byrd, Kaelan, Patel, Ranish, Parappilly, Michael S., Kosaka, Yoko, Lind, Evan F., Leonard, Jessica T.

Source: In Blood 2 November 2023 142 Supplement 1:5627-5627

Combined Single Cell Flow Cytometry and Imaging Analyses Reveal Immunomodulatory Effects Exerted By Targeted Phospho-SYK Inhibitors with Elevated Sensitivity in NPM1 Mutated AML

Authors: Robinson, Bridget A, Sergeev, Philipp, Kosaka, Yoko, Jacob, Thomas, Kaempf, Andy, Lind, Evan F., Tognon, Cristina, Carvajal, Luis A., DiMartino, Jorge F., Heckman, Caroline A., Vu, Tania Q

Source: In Blood 2 November 2023 142 Supplement 1:5037-5037

Mast cells are essential intermediaries in regulatory T-cell tolerance.

Authors: Lu, Li-Fan, Lind, Evan F., Gondek, David C.

Source: Nature; August 31 2006, Vol. 442, p997-1002, 6p

The Aryl Hydrocarbon Receptor Defines a Unique Genomic and Immune Signature in AML Characterized By Monocytic Differentiation, Venetoclax Resistance and Is Targetable By Ahr Antagonist

Authors: Saultz, Jennifer N., Bottomly, Daniel ^*, Burns, Faith ^*, Byrd, Kaelan ^*, Kosaka, Yoko ^*, McWeeney, Shannon K. ^*, Kurtz, Stephen E. ^*, Fan, Guang, Kaempf, Andy ^*, McGovern, Karen ^*, Wang, Lei ^*, Sanchez-Martin, Marta ^*, Kaufman, Dan S, Lind, Evan F., Tyner, Jeffrey W.

Source: In Blood 15 November 2022 140 Supplement 1:3071-3072

Aryl Hydrocarbon Receptor (AHR) Gene Expression in AML Is Associated with FLT3-ITD+ AML and HLA-E Induced Immune Resistance Reversed By Ik-364

Authors: Saultz, Jennifer N., Lind, Evan F., Tyner, Jeffrey W., Byrd, Kaelan, McWeeney, Shannon K., Kosaka, Yoko, McGovern, Karen, Wang, Lei, Sanchez-Martin, Marta

Source: In Blood 23 November 2021 138 Supplement 1:1161-1161

CD40/CD154 Interactions at the Interface of Tolerance and Immunity.

Authors: Quezada, Sergio A., Jarvinen, Lamis Z., Lind, Evan F.

Source: Annual Review of Immunology; 2004, Vol. 22, p307-328, 22p

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