Polydactyly and syndactyly linked to GLI3 and TBX5 mutations: A pediatric case report

Authors: R. Leonardi, G. Pellino, E. Floridia, M. Lo Bianco, M. Ruggieri, SY. Cho, V. Pavone, P. Pavone, A. Polizzi

Source: Global Medical Genetics, Vol 12, Iss 1, Pp 100033- (2025)

Subject Terms: Poly-syndactyly, Congenital Limb Malformations, Genetic Variants in Limb Development, Pediatric Orthopedics, Case reports, Genetics, QH426-470, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S269994042400033X; https://doaj.org/toc/2699-9404

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Evidence for Fgf and Wnt regulation of Lhx2 during limb development via two limb-specific Lhx2-associated cis-regulatory modules

Authors: Jessica C. Britton, Anett Somogyi-Leatigaga, Billy A. Watson, Endika Haro, Cassidy G. Mulder, Kari D. Kennedy, Allen M. Cooper, Kristen L. Whitley, Ruth-Love Yeboah, Jeanyoung Kim, Micah C. Yu, Jairo D. Campos, Japhet Amoah, Shimako Kawauchi, Eunyoung Kim, Charmaine U. Pira, Kerby C. Oberg

Source: Frontiers in Cell and Developmental Biology, Vol 13 (2025)

Subject Terms: Lhx2, vertebrate limb development, cis-regulatory module, gene regulation, FGFs, Wnt, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2025.1552716/full; https://doaj.org/toc/2296-634X

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Generation of a transgenic chicken line with reporters for limb bud mesenchyme and apical ectodermal ridge cells

Authors: Atsuta, Yuji ^{a, ⁎}, Chen, Yi-Chen ^b, Hattori, Yuna ^a, Takemoto, Tatsuya ^{b, c}, Saito, Daisuke ^a

Source: In Developmental Biology April 2025 520:53-61

Macrophages allocate before apoptosis initiation and produce reactive oxygen species during interdigital phagocytosis

Authors: David Hernández-García, Celina García-Meléndrez, Rocío Hernández-Martínez, Omar Collazo-Navarrete, Luis Covarrubias

Source: Biology Open, Vol 13, Iss 7 (2024)

Subject Terms: limb development, phagocytosis, macrophages, apoptosis, reactive oxygen species, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://bio.biologists.org/content/13/7/bio060492; https://doaj.org/toc/2046-6390

Access URL: https://doaj.org/article/2f66c51d58bb45368705e9b298e06279

Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing

Authors: Chao Tang, Jirong Wang, Minli Yao, Xing Ji, Wei Shi, Chengyun Xu, Ling-Hui Zeng, Ximei Wu

Source: Cell Regeneration, Vol 12, Iss 1, Pp 1-16 (2023)

Subject Terms: Hedgehog, Hippo, Taz, Gli, Limb development, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2045-9769

Access URL: https://doaj.org/article/8014d0a562fc4ed1b8a4075a336d350b

Air–breathing behavior underlies the cell death in limbs of Rana pirica tadpoles

Authors: Satomi F. Ono, Ingrid Rosenburg Cordeiro, Osamu Kishida, Haruki Ochi, Mikiko Tanaka

Source: Zoological Letters, Vol 9, Iss 1, Pp 1-9 (2023)

Subject Terms: Limb development, Interdigital cell death, Reactive oxygen species, Evolution, Zoology, QL1-991

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Relation: https://doaj.org/toc/2056-306X

Access URL: https://doaj.org/article/3423de572ce44b8cba83e47d614f2fa9

Morphology and ontogeny of carpus and tarsus in stereospondylomorph temnospondyls

Authors: Florian Witzmann, Nadia Fröbisch

Source: PeerJ, Vol 11, p e16182 (2023)

Subject Terms: Limb development, Ossification, Carpus, Tarsus, Tetrapod, Postaxial, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://peerj.com/articles/16182.pdf; https://peerj.com/articles/16182/; https://doaj.org/toc/2167-8359

Access URL: https://doaj.org/article/37e84bfc86114ebf9b4a46944ffedb2d

The role of timing in the development and evolution of the limb

Authors: Meng Zhu, Clifford J. Tabin

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: limb development, timing and tempo, evolution, developmental biology, morphogenesis and development, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1135519/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/8388c8fb0c054428a06f5be96a020cb0

Distinct patterning responses of wing and leg neuromuscular systems to different preaxial polydactylies

Authors: Maëva Luxey, Gabriela Stieger, Bianka Berki, Patrick Tschopp

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: neuromuscular system, limb development, developmental plasticity, polydactyly, Silkie chicken, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1154205/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/049d8c6beb214e25a6b50d4d48904481

How might we build limbs in vitro informed by the modular aspects and tissue-dependency in limb development?

Authors: Rio Tsutsumi, Mototsugu Eiraku

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: limb organoid, stem cell engineering, limb development, pluripotent stem cells, morphogenesis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1135784/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/ae03c0e9718c4d00a40e933c45f79ad4

Genetic loss-of-function does not support gain-of-function studies suggesting retinoic acid controls limb bud timing and scaling

Authors: Marie Berenguer, Gregg Duester

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: retinoic acid signaling, limb development, genetic loss-of-function, gain-of-function, limb patterning, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1149009/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/c17781817fdb474f9a9c6851b25a0453

Look who’s TORking: mTOR-mediated integration of cell status and external signals during limb development and endochondral bone growth

Authors: Chee Ho H’ng, Ashwini Khaladkar, Alberto Rosello-Diez

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: mTOR, limb development, skeletal, appendicular, cartilage, endochondral ossification, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1153473/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/adb1f622f8144e2dae2a97fdfc834e26

Tissue-specific requirement of sodium channel and clathrin linker 1 (Sclt1) for ciliogenesis during limb development

Authors: Hankyu Lee, Kyeong-Hye Moon, Jieun Song, Suyeon Je, Jinwoong Bok, Hyuk Wan Ko

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: primary cilia, distal appendage, limb development, SCLT1, ciliogenesis, ciliopathy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.1058895/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/318ca573bd304b89ad05d928ac75d72e

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay

Authors: Jessica Cristina Marín-Llera, author¹, Jesús Chimal-Monroy, author¹

Source: Journal of Visualized Experiments. (179)

Availability: http://www.jove.com/video/63187

midline represses Dpp signaling and target gene expression in Drosophila ventral leg development

Authors: Lindsay A. Phillips, Markle L. Atienza, Jae-Ryeon Ryu, Pia C. Svendsen, Lynn K. Kelemen, William J. Brook

Source: Biology Open, Vol 11, Iss 5 (2022)

Subject Terms: tissue patterning, limb development, dpp-signaling, t-box transcription factors, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://bio.biologists.org/content/11/5/bio059206; https://doaj.org/toc/2046-6390

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Mab21l2 is required to promote cell proliferation in stylopods during early limb development

Authors: Huang, Yingyu ^{a, 1}, Tsang, Shun Wa ^{a, 1}, Tsang, Wai Hung ^a, Chow, King L. ^{a, b, c, ⁎}

Source: In Biochemical and Biophysical Research Communications 5 April 2025 756

Learning about Vertebrate Limb Development

Source: The American Biology Teacher, 2014 Sep . 76(7), 471-475.

Access URL: https://www.jstor.org/stable/10.1525/abt.2014.76.7.10

Sonic hedgehog is Essential for Proximal-Distal Outgrowth of the Limb Bud in Salamanders

Authors: Sruthi Purushothaman, Brianda B. Lopez Aviña, Ashley W. Seifert

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: limb development, salamander, Sonic hedgehog, zone of polarizing activity (ZPA), BMS-833923, CRISPR-Cas9, Biology (General), QH301-705.5

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Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.797352/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/e9b1799ea2754725a23fbd814a7b13a2

Recombinant Limb Assay as in Vivo Organoid Model

Authors: Roberto Damián García-García, Estefanía Garay-Pacheco, Jessica Cristina Marín-Llera, Jesús Chimal-Monroy

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: organoid, cell differentiation, patterning, recombinant limbs, limb development, limb organoid, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.863140/full; https://doaj.org/toc/2296-634X

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Wnt Signaling Coordinates the Expression of Limb Patterning Genes During Axolotl Forelimb Development and Regeneration

Authors: Alexander M. Lovely, Timothy J. Duerr, Qingchao Qiu, Santiago Galvan, S. Randal Voss, James R. Monaghan

Source: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Subject Terms: Wnt, limb regeneration, limb development, axolotl, Fgf, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.814250/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/f207f57fd0104f598e67e66a502394ac