Qualification of the human Reconstructed Intestine Micronuclei Cytome assay for site-of-contact genotoxic hazard identification

Authors: Lim, Hui Kheng ^{a, ⁎}, Hughes, Christopher Owen ^a, Landry, Timothy ^c, Tan, Choon Wee Joseph ^a, Ayehunie, Seyoum ^c, Smith, Benjamin Paul Chapman ^{a, b}

Source: In NAM Journal 2025 1

Assessing nanotoxicity of food-relevant particles: A comparative analysis of cellular responses in cell monolayers versus 3D gut epithelial cultures

Authors: Gautam, Archana, Lim, Hui Kheng, Li, Jasmine Jia’En, Hughes, Christopher Owen, Yeo, Calvin Wee Sing, Rakshit, Moumita, Leavesley, David Ian, Lim, Michelle Jing Sin, Tan, Joseph Choon Wee, Tan, Li Yi, Chan, Joanne Sheot Harn, Smith, Benjamin Paul Chapman, Ng, Kee Woei

Source: In Food and Chemical Toxicology November 2024 193

The Polyamine Regulator AMD1 Upregulates Spermine Levels to Drive Epidermal Differentiation

Authors: Rahim, Anisa B., Lim, Hui Kheng, Tan, Christina Yan Ru, Jia, Li, Leo, Vonny Ivon, Uemura, Takeshi, Hardman-Smart, Jonathan, Common, John E.A., Lim, Thiam Chye, Bellanger, Sophie, Paus, Ralf, Igarashi, Kazuei, Yang, Henry, Vardy, Leah A.

Source: In Journal of Investigative Dermatology September 2021 141(9):2178-2188

Polyamine Regulator AMD1 Promotes Cell Migration in Epidermal Wound Healing

Authors: Lim, Hui Kheng, Rahim, Anisa B., Leo, Vonny Ivon, Das, Shatarupa, Lim, Thiam Chye, Uemura, Takeshi, Igarashi, Kazuei, Common, John, Vardy, Leah A.

Source: In Journal of Investigative Dermatology December 2018 138(12):2653-2665

DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells

Authors: Lim, Hui Kheng, Gurung, Resham Lal, Hande, M. Prakash

Source: In Mutation Research - Genetic Toxicology and Environmental Mutagenesis December 2017 824:32-41

Reconstructed human intestinal comet assay, a possible alternative in vitro model for genotoxicity assessment.

Authors: Hughes, Christopher Owen^1,2,3 (AUTHOR) christopher.hughes@ntu.edu.sg, Lim, Hui Kheng^1,2,3 (AUTHOR), Tan, Joseph Choon Wee³ (AUTHOR), Leavesley, David Ian^1,2 (AUTHOR), Smith, Benjamin Paul Chapman^1,3,4 (AUTHOR)

Source: Mutagenesis. May2023, Vol. 38 Issue 3, p139-150. 12p.

Subject Terms: *GENETIC toxicology, *INTESTINES, *CHEMICAL testing, *COMETS, *CELL proliferation, *DNA damage

Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances.

Authors: Lim, Hui Kheng^1,2,3 (AUTHOR) huikheng.lim@ntu.edu.sg, Hughes, Christopher Owen^1,2 (AUTHOR), Lim, Michelle Jing Sin^1,4 (AUTHOR), Li, Jia'En Jasmine⁵ (AUTHOR), Rakshit, Moumita⁶ (AUTHOR), Yeo, Calvin⁵ (AUTHOR), Chng, Kern Rei⁵ (AUTHOR), Li, Angela⁵ (AUTHOR), Chan, Joanne Sheot Harn⁵ (AUTHOR), Ng, Kee Woei^6,7,8 (AUTHOR), Leavesley, David Ian^1,2 (AUTHOR), Smith, Benjamin Paul Chapman^1,3,4 (AUTHOR)

Source: Archives of Toxicology. May2022, Vol. 96 Issue 5, p1455-1471. 17p.

Subject Terms: *NUCLEOLUS, *GENETIC toxicology, *BIOTRANSFORMATION (Metabolism), *INTESTINES, *SMALL intestine, *CELL death, *MATRIX effect

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Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells.

Authors: AshaRani, P. V., Sethu, Swaminathan, Lim, Hui Kheng, Balaji, Ganapathy, Valiyaveettil, Suresh, Hande, M. Prakash

Source: Genome Integrity; 2012, Vol. 3 Issue 1, p1-14, 14p, 6 Charts, 5 Graphs

Subject Terms: DNA repair, SILVER nanoparticles, INFLAMMATION, EUKARYOTIC cells, CANCER cells