Green Synthesis of Tetrahydropyrazino[2,1-a:5,4-a′]diisoquinolines as SARS-CoV‑2 Entry Inhibitors

Authors: Sowndarya Palla, Srinivasa Rao Palla, Jia-Jin Liu, Tai-Ling Chao, Ting-Hui Lee, Veerababurao Kavala, I-Chen Liu, Lily Hui-Ching Wang, Sui-Yuan Chang, Ching-Fa Yao, Po-Huang Liang

Source: ACS Omega, Vol 10, Iss 1, Pp 1164-1176 (2024)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/8ac03739c3f144c4aabb163c0413d350

Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2

Authors: Rong-Hsuan Wang, Pin-Ru Chen, Yue-Ting Chen, Yi-Chang Chen, Yu-Hsin Chu, Chia-Chen Chien, Po-Chen Chien, Shao-Yun Lo, Zhong-Liang Wang, Min-Chen Tsou, Ssu-Yu Chen, Guang-Shen Chiu, Wen-Ling Chen, Yi-Hsuan Wu, Lily Hui-Ching Wang, Wen-Ching Wang, Shu-Yi Lin, Hsing-Jien Kung, Lu-Hai Wang, Hui-Chun Cheng, Kai-Ti Lin

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/11ac430e3387400d8e564c205164f273

Precise Control of Intracellular Trafficking and Receptor‐Mediated Endocytosis in Living Cells and Behaving Animals

Authors: Shiau‐Chi Chen, Neng‐Jie Zeng, Grace Y. Liu, Hsien‐Chu Wang, Tzu‐Ying Lin, Yi‐Ling Tai, Chiao‐Yun Chen, Yin Fang, Yi‐Chien Chuang, Ching‐Lin Kao, Hsuan Cheng, Bing‐Huang Wu, Pin‐Chiao Sun, Odvogmed Bayansan, Yu‐Ting Chiu, Chi‐Hsuan Shih, Wen‐Hong Chung, Jia‐Bin Yang, Lily Hui‐Ching Wang, Po‐Han Chiang, Chun‐Hao Chen, Oliver I. Wagner, Yi‐Ching Wang, Yu‐Chun Lin

Source: Advanced Science, Vol 11, Iss 45, Pp n/a-n/a (2024)

Subject Terms: chemical‐inducible dimerization, cytoskeleton, optogenetics, receptor‐mediated endocytosis, vesicular trafficking, virus entry, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/f32706deda0442d0979c0a167f5bdc18

Systematic Studies on the Anti-SARS-CoV‑2 Mechanisms of Tea Polyphenol-Related Natural Products

Authors: Chen-Wei Li, Tai-Ling Chao, Chin-Lan Lai, Cheng-Chin Lin, Max Yu-Chen Pan, Chieh-Ling Cheng, Chih-Jung Kuo, Lily Hui-Ching Wang, Sui-Yuan Chang, Po-Huang Liang

Source: ACS Omega, Vol 9, Iss 22, Pp 23984-23997 (2024)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/4a531a3cc01746fb8eca7a593def9272

Development of a Novel Endometrial Signature Based on Endometrial microRNA for Determining the Optimal Timing for Embryo Transfer

Authors: Ching-Hung Chen, Farn Lu, Wen-Jui Yang, Wei-Ming Chen, Pok Eric Yang, Shih-Ting Kang, Tiffany Wang, Po-Chang Chang, Chi-Ting Feng, Jung-Hsuan Yang, Chen-Yu Liu, Chi-An Hsieh, Lily Hui-Ching Wang, Jack Yu-Jen Huang

Source: Biomedicines, Vol 12, Iss 3, p 700 (2024)

Subject Terms: non-coding RNA, microRNAs, endometrial receptivity, infertility, multi-gene analysis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/3/700; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/1d20aaa8d8e84f3caeb824458fca0804

Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model

Authors: Yun-Ti Chen, Yu-Hsiu Chang, Nikhil Pathak, Shey-Cherng Tzou, Yong-Chun Luo, Yen-Chao Hsu, Tian-Neng Li, Jung-Yu Lee, Yi-Cyun Chen, Yu-Wei Huang, Hsin-Ju Yang, Nung-Yu Hsu, Hui-Ping Tsai, Tein-Yao Chang, Shu-Chen Hsu, Ping-Cheng Liu, Yuan-Fan Chin, Wen-Chin Lin, Chuen-Mi Yang, Hsueh-Ling Wu, Chia-Ying Lee, Hui-Ling Hsu, Yi-Chun Liu, Jhih-Wei Chu, Lily Hui-Ching Wang, Jann-Yuan Wang, Chih-Heng Huang, Chi-Hung Lin, Po-Shiuan Hsieh, Yan-Hwa Wu Lee, Yi-Jen Hung, Jinn-Moon Yang

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: methotrexate, SARS-CoV-2, multi-target drugs, drug repurposing, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1080897/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e0d9b744dc564e78affee0cda9c37a2a

Heparan sulfate targeting strategy for enhancing liposomal drug accumulation and facilitating deep distribution in tumors

Authors: Ping-Hsueh Kuo, Yi-Hsien Teng, Ann-Lun Cin, Wen Han, Pei-Wan Huang, Lily Hui-Ching Wang, Yu-Ting Chou, Jia-Ling Yang, Yun-Long Tseng, Minhsiung Kao, Margaret Dah-Tsyr Chang

Source: Drug Delivery, Vol 27, Iss 1, Pp 542-555 (2020)

Subject Terms: desmoplastic stroma, extracellular matrix, heparan sulfate, tumor penetration, drug delivery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464

Access URL: https://doaj.org/article/e52312b323f24bb8aa40cd945a0e992d

Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2.

Authors: Yi-Hsuan Wu, Yi Yang, Ching-Hung Chen, Chia-Jen Hsiao, Tian-Neng Li, Kuan-Ju Liao, Koichi Watashi, Bor-Sen Chen, Lily Hui-Ching Wang

Source: PLoS Pathogens, Vol 17, Iss 3, p e1008866 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008866&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/a4eb130c894c4ebfbd51e33694dc0183

Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets

Authors: Pei-Chen Yu, Chen-Hao Huang, Chih-Jung Kuo, Po-Huang Liang, Lily Hui-Ching Wang, Max Yu-Chen Pan, Sui-Yuan Chang, Tai-Ling Chao, Si-Man Ieong, Jun-Tung Fang, Hsuan-Cheng Huang, Hsueh-Fen Juan

Source: Pharmaceutics, Vol 14, Iss 1, p 176 (2022)

Subject Terms: docking simulation, severe acute respiratory syndrome coronavirus 2, transmembrane protease serine 2 (TMPRSS2), 3C-like protease (3CLpro/Mpro), papain-like protease (PLpro), tamoxifen, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/1/176; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/389f653d4421491599f82db2b3519755

Ground glass hepatocytes provide targets for therapy or prevention of hepatitis B virus-related hepatocellular carcinoma

Authors: Hong-Yi Chang, Hung-Wen Tsai, Chiao-Fang Teng, Lily Hui-Ching Wang, Wenya Huang, Ih-Jen Su

Source: AIMS Medical Science, Vol 5, Iss 2, Pp 90-101 (2018)

Subject Terms: ground glass hepatocyte, pre-S mutant, endoplasmic reticulum stress, therapy, hepatocellular carcinoma, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.aimspress.com/medicalScience/article/1869/fulltext.html; https://doaj.org/toc/2375-1576

Access URL: https://doaj.org/article/dbe08fe3d2d540c0aa1430939009da45

Development and Evaluation of Vero Cell-Derived Master Donor Viruses for Influenza Pandemic Preparedness

Authors: Po-Ling Chen, Tsai-Teng Tzeng, Alan Yung-Chih Hu, Lily Hui-Ching Wang, Min-Shi Lee

Source: Vaccines, Vol 8, Iss 4, p 626 (2020)

Subject Terms: pandemic preparedness, Vero cell-derived influenza vaccine, master donor virus, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/8/4/626; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/adb51df2af734a539fdadd5598f15150

Investigating Core Signaling Pathways of Hepatitis B Virus Pathogenesis for Biomarkers Identification and Drug Discovery via Systems Biology and Deep Learning Method

Authors: Shen Chang, Lily Hui-Ching Wang, Bor-Sen Chen

Source: Biomedicines, Vol 8, Iss 9, p 320 (2020)

Subject Terms: hepatitis B virus infection, pathogenesis, host/pathogen interspecies genetic and epigenetic network (HPI-GEN), systems medicine discovery, drug-target interaction (DTI) model, deep learning, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/8/9/320; https://doaj.org/toc/2227-9059

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Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications

Authors: Tse-Kai Fu, Ping-Hsueh Kuo, Yen-Chang Lu, Hsing-Ni Lin, Lily Hui-Ching Wang, Yu-Chun Lin, Yu-Chen Kao, Huey-Min Lai, Margaret Dah-Tsyr Chang

Source: Biomolecules, Vol 10, Iss 1, p 101 (2020)

Subject Terms: cell-penetrating peptides, cosmeceutical peptides, anti-inflammation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/10/1/101; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/adcbfbdcd5f24750a153d5acf491c83b

Pathogenesis of virus-associated human cancers: Epstein–Barr virus and hepatitis B virus as two examples

Authors: Kung-Chao Chang, Yao Chang, Lily Hui-Ching Wang, Hung-Wen Tsai, Wenya Huang, Ih-Jen Su

Source: Journal of the Formosan Medical Association, Vol 113, Iss 9, Pp 581-590 (2014)

Subject Terms: Epstein–Barr virus, hepatitis B virus, hepatocellular carcinoma, Hodgkin lymphoma, nasopharyngeal carcinoma, therapeutic implications, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0929664613003008; https://doaj.org/toc/0929-6646

Access URL: https://doaj.org/article/c77f0e75261c461393f4838d32ae8c28

Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells.

Authors: Jui-Hsiang Hung, Yen-Ni Teng, Lily Hui-Ching Wang, Ih-Jen Su, Clay C C Wang, Wenya Huang, Kuan-Han Lee, Kuan-Ying Lu, Lyu-Han Wang

Source: PLoS ONE, Vol 6, Iss 12, p e28977 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3245229?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a56e360a66b14670ab1252aab9fb6bc9

Cep57 regulates human centrosomes through multivalent interactions.

Authors: Hung-Wei Yeh, Po-Pang Chen, Tzu-Chen Yeh, Shiou-Lan Lin, Yue-Ting Chen, Wan-Ping Lin, Ting Chen, Jia Meng Pang, Kai-Ti Lin, Lily Hui-Ching Wang, Yu-Chun Lin, Orion Shih, U-Ser Jeng, Kuo-Chiang Hsia, Hui-Chun Cheng

Source: Proceedings of the National Academy of Sciences of the United States of America; 6/18/2024, Vol. 121 Issue 25, p1-12, 33p

Subject Terms: CENTROSOMES, SCAFFOLD proteins, CELL division, GENETIC mutation, MICROTUBULES

The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesis.

Authors: Ih-Jen Su^1,2 suihjen@nhri.org.tw, Lily Hui-Ching Wang³ lilywang@life.nthu.edu.tw, Wen-Chuan Hsieh¹ wenchuan@nhri.org.tw, Han-Chieh Wu¹ hanjie@nhri.org.tw, Chiao-Fang Teng¹ chiaofangteng@nhri.org.tw, Hung-Wen Tsai² hungwen@mail.ncku.edu.tw, Wenya Huang⁴ whuang@mail.ncku.edu.tw

Source: Journal of Biomedical Science. 2014, Vol. 21 Issue 1, p1-19. 19p. 2 Diagrams, 1 Graph.

Subject Terms: *HEPATITIS B, *VIRAL hepatitis, *PROTEINS, *BIOMOLECULES, *GENETIC mutation

Ground-glass hepatocytes co-expressing hepatitis B virus X protein and surface antigens exhibit enhanced oncogenic effects and tumorigenesis.

Authors: Han-Chieh Wu, Hung-Wen Tsai, Chiao-Fang Teng, Wen-Chuan Hsieh, Yih-Jyh Lin, Lily Hui-Ching Wang, Quan Yuan, Ih-Jen Su

Source: Human Pathology; 2014, Vol. 45 Issue 6, p1294-1301, 8p

The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities.

Authors: Hung-Ju Shih, Kang-Lin Chu, Meng-Hsun Wu, Pei-Hsuan Wu, Wei-Wen Chang, Jan-Show Chu, Lily Hui-Ching Wang, Hideki Takeuchi, Toru Ouchi, Hsin-Ling Hsu

Source: Cell Cycle; Mar2012, Vol. 11 Issue 5, p934-952, 19p

Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation.

Authors: Lily Hui-Ching Wang¹, Schwarzbraun, Thomas², Speicher, Michael R.² Michael.speicher@meduni-graz.at, Nigg, Erich A.¹ nigg@biochem.mpg.de

Source: Chromosoma. Mar2008, Vol. 117 Issue 2, p123-135. 13p. 3 Diagrams, 2 Graphs.

Subject Terms: *DNA helicases, *CHROMOSOMES, *CHROMATIN, *IN situ hybridization, *CHROMOSOME replication, *CELL division