Practical considerations for the use of fenfluramine to manage patients with Dravet syndrome or Lennox–Gastaut syndrome in clinical practice

Authors: Elaine C. Wirrell, Lieven Lagae, Ingrid E. Scheffer, J. Helen Cross, Nicola Specchio, Adam Strzelczyk

Source: Epilepsia Open, Vol 9, Iss 5, Pp 1643-1657 (2024)

Subject Terms: antiseizure medications, Dravet syndrome, fenfluramine, Lennox–Gastaut syndrome, polytherapy, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2470-9239

Access URL: https://doaj.org/article/3dc1b09b0bfc46e7857e957e7df05a9b

Child outcomes after prenatal exposure to platinum and taxane-based chemotherapy: an unplanned interim analysis of the international network on cancer, infertility, and pregnancy studyResearch in context

Authors: Indra A. Van Assche, Kristel Van Calsteren, Evangeline A. Huis in ’t Veld, Mathilde van Gerwen, Laura Heylen, Charlotte L. LeJeune, Elyce Cardonick, Michael J. Halaska, Robert Fruscio, Monica Fumagalli, Elisabeth M. van Dijk-Lokkart, Jurgen Lemiere, Martine van Grotel, Lieven Lagae, Marry M. van den Heuvel-Eibrink, Frédéric Amant

Source: EClinicalMedicine, Vol 78, Iss , Pp 102922- (2024)

Subject Terms: Cancer during pregnancy, Prenatal chemotherapy exposure, Platinum-based chemotherapy, Taxane-based chemotherapy, Child development, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024005017; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/f5c3e461287c4daeb19e9e5593f787dc

Dravet syndrome: A systematic literature review of the illness burden

Authors: Adam Strzelczyk, Lieven Lagae, Jo M Wilmshurst, Andreas Brunklaus, Pasquale Striano, Felix Rosenow, Susanne Schubert‐Bast

Source: Epilepsia Open, Vol 8, Iss 4, Pp 1256-1270 (2023)

Subject Terms: caregiver burden, developmental and epileptic encephalopathy, direct costs, health‐related quality of life, indirect costs, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2470-9239

Access URL: https://doaj.org/article/1c4d31b23fcd4896a04ebb2d52b09c6c

Molecular EPISTOP, a comprehensive multi-omic analysis of blood from Tuberous Sclerosis Complex infants age birth to two years

Authors: Franz Huschner, Jagoda Głowacka-Walas, James D. Mills, Katarzyna Klonowska, Kathryn Lasseter, John M. Asara, Romina Moavero, Christoph Hertzberg, Bernhard Weschke, Kate Riney, Martha Feucht, Theresa Scholl, Pavel Krsek, Rima Nabbout, Anna C. Jansen, Bořivoj Petrák, Jackelien van Scheppingen, Josef Zamecnik, Anand Iyer, Jasper J. Anink, Angelika Mühlebner, Caroline Mijnsbergen, Lieven Lagae, Paolo Curatolo, Julita Borkowska, Krzysztof Sadowski, Dorota Domańska-Pakieła, Magdalena Blazejczyk, Floor E. Jansen, Stef Janson, Malgorzata Urbanska, Aleksandra Tempes, Bart Janssen, Kamil Sijko, Konrad Wojdan, Sergiusz Jozwiak, Katarzyna Kotulska, Karola Lehmann, Eleonora Aronica, Jacek Jaworski, David J. Kwiatkowski

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4ebd3a42e79a421f9ec149801b6df580

Automated sleep staging on reduced channels in children with epilepsy

Authors: Renee Proost, Elisabeth Heremans, Lieven Lagae, Wim Van Paesschen, Maarten De Vos, Katrien Jansen

Source: Frontiers in Neurology, Vol 15 (2024)

Subject Terms: children, epilepsy, REM sleep, automated sleep staging, machine learning, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2024.1390465/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/c78dbc550f6d4172a509766e3652b52a

Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children

Authors: Jo Sourbron, Stéphane Auvin, Alexis Arzimanoglou, J. Helen Cross, Hans Hartmann, Ronit Pressler, Kate Riney, Kenji Sugai, Jo M. Wilmshurst, Elissa Yozawitz, Lieven Lagae

Source: Epilepsia Open, Vol 8, Iss 1, Pp 77-89 (2023)

Subject Terms: children, epilepsy treatment, International League Against Epilepsy, off‐label, questionnaire, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2470-9239

Access URL: https://doaj.org/article/d7e8ed31b1b44f2d8effbe4dcf7b5c7a

Serotonin receptors in epilepsy: Novel treatment targets?

Authors: Jo Sourbron, Lieven Lagae

Source: Epilepsia Open, Vol 7, Iss 2, Pp 231-246 (2022)

Subject Terms: 5‐HT, antiseizure medication, epilepsy treatment, fenfluramine, SUDEP, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2470-9239

Access URL: https://doaj.org/article/ca8c88dcf51f4ef787b3f08847381e57

Fenfluramine: a plethora of mechanisms?

Authors: Jo Sourbron, Lieven Lagae

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: fintepla, pathways, serotonin, sigma, disease modification, epilepsy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1192022/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/aff4b99698f445948668628c8d783e8c

Guidance on Dravet syndrome from infant to adult care: Road map for treatment planning in Europe

Authors: Elena Cardenal‐Muñoz, Stéphane Auvin, Vicente Villanueva, J. Helen Cross, Sameer M. Zuberi, Lieven Lagae, José Ángel Aibar

Source: Epilepsia Open, Vol 7, Iss 1, Pp 11-26 (2022)

Subject Terms: antiseizure medication, comorbidities, epilepsy, genetic diagnosis, treatment algorithm, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2470-9239

Access URL: https://doaj.org/article/6f738f3396a94d8e9441daf564c14571

Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

Authors: Anatoly Korotkov, Mark J. Luinenburg, Alessia Romagnolo, Till S. Zimmer, Jackelien van Scheppingen, Anika Bongaarts, Diede W. M. Broekaart, Jasper J. Anink, Caroline Mijnsbergen, Floor E. Jansen, Wim van Hecke, Wim G. Spliet, Peter C. van Rijen, Martha Feucht, Johannes A. Hainfellner, Pavel Krsek, Josef Zamecnik, Peter B. Crino, Katarzyna Kotulska, Lieven Lagae, Anna C. Jansen, David J. Kwiatkowski, Sergiusz Jozwiak, Paolo Curatolo, Angelika Mühlebner, Erwin A. van Vliet, James D. Mills, Eleonora Aronica

Source: Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-16 (2022)

Subject Terms: Cerebral cortex development, Neurodevelopmental disorders, Cell adhesion, mTORopathies, Epilepsy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://doaj.org/toc/1866-1947; https://doaj.org/toc/1866-1955

Access URL: https://doaj.org/article/9e33560efb00425a8bb93db1a513ea16

A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies

Authors: Tobias Baumgartner, Mar Carreño, Rodrigo Rocamora, Francesca Bisulli, Antonella Boni, Milan Brázdil, Ondrej Horak, Dana Craiu, Cristina Pereira, Renzo Guerrini, Victoria San Antonio‐Arce, Andreas Schulze‐Bonhage, Sameer M. Zuberi, Tove Hallböök, Reetta Kalviainen, Lieven Lagae, Sylvie Nguyen, Sofia Quintas, Ana Franco, J. Helen Cross, Matthew Walker, Alexis Arzimanoglou, Sylvain Rheims, Tiziana Granata, Laura Canafoglia, Cecilie Johannessen Landmark, Arjune Sen, Rohini Rattihalli, Rima Nabbout, Elena Tartara, Manuela Santos, Rui Rangel, Pavel Krsek, Petr Marusic, Nicola Specchio, Kees P. J. Braun, Patricia Smeyers, Vicente Villanueva, Katarzyna Kotulska, Rainer Surges

Source: Epilepsia Open, Vol 6, Iss 1, Pp 160-170 (2021)

Subject Terms: autoimmune encephalitis, Dravet syndrome, orphan disease, progressive myoclonic epilepsy, targeted therapies, tuberous sclerosis complex, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2470-9239

Access URL: https://doaj.org/article/69517d96215647e1a494c4132cfe2998

Is autism driven by epilepsy in infants with Tuberous Sclerosis Complex?

Authors: Romina Moavero, Katarzyna Kotulska, Lieven Lagae, Arianna Benvenuto, Leonardo Emberti Gialloreti, Bernhard Weschke, Kate Riney, Martha Feucht, Pavel Krsek, Rima Nabbout, Anna C. Jansen, Konrad Wojdan, Julita Borkowska, Krzysztof Sadowski, Christoph Hertzberg, Monique M. Van Schooneveld, Sharon Samueli, Alice Maulisovà, Eleonora Aronica, David J. Kwiatkowski, Floor E. Jansen, Sergiusz Jozwiak, Paolo Curatolo, the EPISTOP Consortium

Source: Annals of Clinical and Translational Neurology, Vol 7, Iss 8, Pp 1371-1381 (2020)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/9ee0ecd1135c49efbd34863b65289943

Treatment of Focal-Onset Seizures in Children: Should This Be More Etiology-Driven?

Authors: Alec Aeby, Berten Ceulemans, Lieven Lagae

Source: Frontiers in Neurology, Vol 13 (2022)

Subject Terms: focal-onset seizure, epilepsy, children, antiseizure medication, syndrome, etiology, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2022.842276/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/cce70c07827842ddb19604bbc887ffc3

Clinical Assessment of Visual Motion Perception in Children With Brain Damage: A Comparison With Base Rates and Control Sample

Authors: Ymie J. van der Zee, Peter L. J. Stiers, Lieven Lagae, Heleen M. Evenhuis

Source: Frontiers in Human Neuroscience, Vol 15 (2021)

Subject Terms: motion perception assessment, global motion, motion defined form, motion speed, performance age, PIQ, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnhum.2021.733054/full; https://doaj.org/toc/1662-5161

Access URL: https://doaj.org/article/256f7d453aca4cf9b383a4c426b857da

Subtraction Ictal SPECT coregistered to MRI (SISCOM) as a guide in localizing childhood epilepsy

Authors: Thomas Foiadelli, Lieven Lagae, Karolien Goffin, Tom Theys, Mara De Amici, Lucia Sacchi, Johannes Van Loon, Salvatore Savasta, Katrien Jansen

Source: Epilepsia Open, Vol 5, Iss 1, Pp 61-72 (2020)

Subject Terms: epilepsy, epilepsy surgery, focal cortical dysplasia, focal seizures, SISCOM, SPECT, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2470-9239

Access URL: https://doaj.org/article/7251836f6f204641a5e5965cdd4d23ed

A novel missense variant in SLC18A2 causes recessive brain monoamine vesicular transport disease and absent serotonin in platelets

Authors: Manisha Padmakumar, Jaak Jaeken, Vincent Ramaekers, Lieven Lagae, Daniel Greene, Chantal Thys, Chris Van Geet, NIHR BioResource, Kathleen Stirrups, Kate Downes, Ernest Turro, Kathleen Freson

Source: JIMD Reports, Vol 47, Iss 1, Pp 9-16 (2019)

Subject Terms: epilepsy, platelet dense granules, serotonin, vesicular monoamine transporter 2, whole genome sequencing, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2192-8312

Access URL: https://doaj.org/article/fc61d66386ba4d82840c3f4a32dfd91f

The Ketogenic Diet Revisited: Beyond Ketones

Authors: Jo Sourbron, Karin Thevissen, Lieven Lagae

Source: Frontiers in Neurology, Vol 12 (2021)

Subject Terms: epilepsy, ketogenic diet, mechanism, endocrine system, epigenetics, gut microbiome, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2021.720073/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/d9b2326a81754c52b93fa5dd183fa206

Author Correction: Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment

Authors: James D. Mills, Anand M. Iyer, Jackelien van Scheppingen, Anika Bongaarts, Jasper J. Anink, Bart Janssen, Till S. Zimmer, Wim G. Spliet, Peter C. van Rijen, Floor E. Jansen, Martha Feucht, Johannes A. Hainfellner, Pavel Krsek, Josef Zamecnik, Katarzyna Kotulska, Sergiusz Jozwiak, Anna Jansen, Lieven Lagae, Paolo Curatolo, David J. Kwiatkowski, R. Jeroen Pasterkamp, Ketharini Senthilkumar, Lars von Oerthel, Marco F. Hoekman, Jan A. Gorter, Peter B. Crino, Angelika Mühlebner, Brendon P. Scicluna, Eleonora Aronica

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/de7a426cad954b378ca437aa8208234a

miRNAs and isomiRs: Serum-Based Biomarkers for the Development of Intellectual Disability and Autism Spectrum Disorder in Tuberous Sclerosis Complex

Authors: Mirte Scheper, Alessia Romagnolo, Zein Mersini Besharat, Anand M. Iyer, Romina Moavero, Christoph Hertzberg, Bernhard Weschke, Kate Riney, Martha Feucht, Theresa Scholl, Borivoj Petrak, Alice Maulisova, Rima Nabbout, Anna C. Jansen, Floor E. Jansen, Lieven Lagae, Malgorzata Urbanska, Elisabetta Ferretti, Aleksandra Tempes, Magdalena Blazejczyk, Jacek Jaworski, David J. Kwiatkowski, Sergiusz Jozwiak, Katarzyna Kotulska, Krzysztof Sadowski, Julita Borkowska, Paolo Curatolo, James D. Mills, Eleonora Aronica, EPISTOP Consortium Members

Source: Biomedicines, Vol 10, Iss 8, p 1838 (2022)

Subject Terms: epilepsy, tuberous sclerosis complex, biomarkers, serum, autism spectrum disorder, intellectual disability, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/8/1838; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/f771935c50eb4ff39dc3c5c38aa4acd0

PPFIA4 mutation: A second hit in POLG related disease?

Authors: Jo Sourbron, Katrien Jansen, Nele Aerts, Lieven Lagae

Source: Epilepsy & Behavior Reports, Vol 16, Iss , Pp 100455- (2021)

Subject Terms: Epilepsy, Case report, PPFIA4, POLG, Mitochondria, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589986421000290; https://doaj.org/toc/2589-9864

Access URL: https://doaj.org/article/4af7efb0468d46f49f044622dabe9985