Safety run-in and part 1 of GIMEMA AML1718: venetoclax combined with FLAI as induction treatment in non–low-risk AML

Authors: Marconi, Giovanni ^{1, 2, ∗}, Piciocchi, Alfonso ³, Audisio, Ernesta ⁴, Papayannidis, Cristina ⁵, Cerrano, Marco ⁴, Minotti, Clara ⁶, Paoloni, Francesca ³, Guolo, Fabio ^{7, 8}, Bocchia, Monica ⁹, Rondoni, Michela ¹⁰, Lico, Albana ¹¹, Carrabba, Matteo G. ¹², Della Porta, Matteo Giovanni ^{13, 14}, Frigeni, Marco ¹⁵, Giaccone, Luisa ¹⁶, Beltrami, Germana ¹⁷, Cattaneo, Chiara ¹⁸, Di Chio, Maria Chiara ¹⁹, Serio, Bianca ²⁰, Crea, Enrico ³, Freilone, Roberto ⁴, Capria, Saveria ⁶, Curti, Antonio ⁵, Minetto, Paola ⁷, la Sala, Edoardo ³, Nanni, Jacopo ²¹, Zannetti, Beatrice Anna ¹⁰, Simonetti, Giorgia ²², Bochicchio, Maria Teresa ²², Saglio, Giuseppe ¹⁶, Lemoli, Roberto M. ⁷, Venditti, Adriano ²³, Vignetti, Marco ³, Fazi, Paola ³, Martinelli, Giovanni ^{5, 21, ∗∗}

Source: In Blood Advances January 2025

Up-front blinatumomab improves MRD clearance and outcome in adult Ph– B-lineage ALL: the GIMEMA LAL2317 phase 2 study

Authors: Bassan, Renato ^{1, ∗}, Chiaretti, Sabina ², Della Starza, Irene ^{2, 3}, Santoro, Alessandra ⁴, Spinelli, Orietta ⁵, Tosi, Manuela ⁵, Elia, Loredana ², Cardinali, Deborah ², De Propris, Maria Stefania ², Piccini, Matteo ⁶, Lussana, Federico ^{5, 7}, Annunziata, Mario ⁸, Chiusolo, Patrizia ^{9, 10}, Zappasodi, Patrizia ¹¹, Borlenghi, Erika ¹², Leoncin, Matteo ¹, Califano, Catello ¹³, Bocchia, Monica ¹⁴, Di Raimondo, Francesco ¹⁵, Grimaldi, Francesco ¹⁶, Tiribelli, Mario ¹⁷, Candoni, Anna ^{17, 18}, Lico, Albana ¹⁹, Audisio, Ernesta ²⁰, Lunghi, Monia ²¹, Mianulli, Anna Maria ²², Di Trani, Mariangela ², Arena, Valentina ²³, Messina, Monica ²³, Piciocchi, Alfonso ²³, Fazi, Paola ²³, Rambaldi, Alessandro ^{5, 7}, Foà, Robin ²

Source: In Blood January 2025

Venetoclax in combination with hypomethylating agents in previously untreated patients with acute myeloid leukemia ineligible for intensive treatment: a real-life multicenter experience

Authors: De Bellis, Eleonora, Imbergamo, Silvia, Candoni, Anna, Liço, Albana, Tanasi, Ilaria, Mauro, Endri, Mosna, Federico, Leoncin, Matteo, Stulle, Manuela, Griguolo, Davide, Pravato, Stefano, Trentin, Livio, Lazzarotto, Davide, Di Bona, Eros, Bassan, Renato, Lucchini, Elisa, Poiani, Monica, Palmieri, Clara, Zaja, Francesco

Source: In Leukemia Research March 2022 114

Efficacy and safety of venetoclax plus hypomethylating agents in relapsed/refractory acute myeloid leukemia: a multicenter real-life experience.

Authors: Angotzi, Francesco, Lessi, Federica, Leoncin, Matteo, Filì, Carla, Endri, Mauro, Lico, Albana, Visentin, Andrea, Pravato, Stefano, Candoni, Anna, Trentin, Livio, Gurrieri, Carmela

Source: Frontiers in Oncology; 2024, p1-11, 11p

Subject Terms: ACUTE myeloid leukemia, VENETOCLAX, STEM cell transplantation, PROGNOSIS, SURVIVAL rate

A real‐world retrospective–prospective analysis of efficacy and safety of combined ixazomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma: The northern Italy experience.

Authors: Furlan, Anna, Cea, Michele, Pavan, Laura, Galli, Monica, Clissa, Cristina, Mangiacavalli, Silvia, Cafro, Anna Maria, Girlanda, Stefania, Patriarca, Francesca, Minotto, Claudia, Bertoldero, Giovanni, Barilà, Gregorio, Pascarella, Anna, Lico, Albana, Paolini, Rossella, Rabassi, Nicholas, Pescosta, Norbert, Porrazzo, Marika, De Sabbata, Giovanni, Pompa, Alessandra

Source: Cancer Medicine; Apr2024, Vol. 13 Issue 7, p1-14, 14p

Subject Terms: MULTIPLE myeloma, LENALIDOMIDE, DEXAMETHASONE, PERIPHERAL neuropathy, EXANTHEMA

Geographic Terms: NORTHERN Italy, ITALY

Whole-body low-dose CT recognizes two distinct patterns of lytic lesions in multiple myeloma patients with different disease metabolism at PET/MRI

Authors: Zambello, Renato, Crimì, Filippo, Lico, Albana, Barilà, Gregorio, Branca, Antonio, Guolo, Annamaria, Varin, Cristiano, Vezzaro, Roberto, Checuz, Lucia, Scapin, Vanna, Berno, Tamara, Pizzi, Marco, Ponzoni, Alberto, De Biasi, Ercole, Vio, Stefania, Semenzato, Gianpietro, Zucchetta, Pietro, Lacognata, Carmelo

Source: Annals of hematology. 98(3):679-689

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125400014.0x000001&indx=1&recIds=ETOCvdc_100125400014.0x000001

A real-life study of daratumumab-bortezomib-dexamethasone (D-VD) in lenalidomide exposed/refractory multiple myeloma patients: a report from the Triveneto Myeloma Working Group.

Authors: Barilà, Gregorio, Quaglia, Francesca Maria, Furlan, Anna, Pescosta, Norbert, Bonalumi, Angela, Marcon, Chiara, Pascarella, Anna, Tinelli, Martina, De March, Elena, Lico, Albana, Sartori, Roberto, Clissa, Cristina, De Sabbata, Giovanni, Nappi, Davide, Porrazzo, Marika, De Marchi, Roberta, Pavan, Laura, Tosetto, Alberto, Gherlinzoni, Filippo, Krampera, Mauro

Source: Annals of Hematology; Jan2024, Vol. 103 Issue 1, p125-132, 8p

Subject Terms: MULTIPLE myeloma, LENALIDOMIDE, REFRACTORY materials, PROGRESSION-free survival

Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia

Authors: Teramo, Antonella, Gattazzo, Cristina, Passeri, Francesca, Lico, Albana, Tasca, Giulia, Cabrelle, Anna, Martini, Veronica, Frezzato, Federica, Trimarco, Valentina, Ave, Elisa, Boscaro, Elisa, Piazza, Francesco, Facco, Monica, Trentin, Livio, Semenzato, Gianpietro ^*, Zambello, Renato

Source: In Blood 9 May 2013 121(19):3843-3854

Gimema ALL2418: Interim Analysis of a Phase Iia Study of Feasibility and Effectiveness of Inotuzumab Ozogamicin in Adult Patients with B-Cell Acute Lymphoblastic Leukemia with Positive Minimal Residual Disease before Any Hematopoietic Stem Cell Transplantation

Authors: Marconi, Giovanni, Piciocchi, Alfonso ^*, Chiaretti, Sabina, Papayannidis, Cristina, Lunghi, Monia ^*, Salutari, Prassede ^*, Zappasodi, Patrizia ^*, Rambaldi, Alessandro, Olivieri, Attilio, Cavallari, Maurizio ^*, Soddu, Stefano ^*, Fracchiolla, Nicola S ^*, Gigli, Federica ^*, Cattaneo, Chiara ^*, Mattei, Daniele Giovanni, Candoni, Anna ^*, Grillo, Giovanni ^*, Abbenante, Maria Chiara ^*, Audisio, Ernesta ^*, Bonifacio, Massimiliano ^*, Lico, Albana ^*, Lemoli, Roberto Massimo ^*, De Fabritiis, Paolo ^*, Ferrara, Felicetto ^*, Marino, Martina Rachele ^*, Messina, Monica ^*, Ferrari, Anna ^*, Robustelli, Valentina ^*, Nanni, Jacopo ^*, Della Starza, Irene ^*, Simonetti, Giorgia ^*, De Propris, Maria Stefania ^*, Bochicchio, Maria Teresa ^*, Vignetti, Marco ^*, Fazi, Paola ^*, Martinelli, Giovanni

Source: In Blood 15 November 2022 140 Supplement 1:6119-6121

Gimema AML1718 Part 1: Planned Interim Analysis of a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Authors: Marconi, Giovanni, Piciocchi, Alfonso ^*, Audisio, Ernesta ^*, Priolo, Giorgio ^*, Papayannidis, Cristina, Martelli, Maurizio ^*, Paoloni, Francesca ^*, Lemoli, Roberto Massimo ^*, Bocchia, Monica ^*, Lanza, Francesco ^*, Lico, Albana ^*, Ciceri, Fabio ^*, Della Porta, Matteo G. ^*, Frigeni, Marco ^*, Giaccone, Luisa ^*, Beltrami, Germana ^*, Borlenghi, Erika ^*, Di Chio, Maria Chiara ^*, Selleri, Carmine, Crea, Enrico ^*, Urbino, Irene ^*, Sartor, Chiara ^*, Minotti, Clara ^*, Guolo, Fabio ^*, La Sala, Edoardo ^*, Nanni, Jacopo ^*, Simonetti, Giorgia ^*, Bochicchio, Maria Teresa ^*, Saglio, Giuseppe, Venditti, Adriano, Vignetti, Marco ^*, Fazi, Paola ^*, Martinelli, Giovanni

Source: In Blood 15 November 2022 140 Supplement 1:1705-1707

Corrigendum to “Venetoclax in combination with hypomethylating agents in previously untreated patients with acute myeloid leukemia ineligible for intensive treatment: a real-life multicenter experience” [Leukemia Res. 114 (March 2022) 106803]

Authors: De Bellis, Eleonora, Imbergamo, Silvia, Candoni, Anna, Liço, Albana, Tanasi, Ilaria, Mauro, Endri, Mosna, Federico, Leoncin, Matteo, Stulle, Manuela, Griguolo, Davide, Pravato, Stefano, Trentin, Livio, Lazzarotto, Davide, Di Bona, Eros, Sancetta, Rosaria, Lucchini, Elisa, Poiani, Monica, Palmieri, Clara, Zaja, Francesco

Source: In Leukemia Research April 2022 115

Centralized MRD Assessment at Early Timepoints in Gimema AML1718 Trial, a Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk AML

Authors: Minetto, Paola, Guolo, Fabio, Rosellini, Sara, Piciocchi, Alfonso, Marconi, Giovanni, Audisio, Ernesta, Priolo, Giorgio, Papayannidis, Cristina, Martelli, Maurizio, Paoloni, Francesca Paola, Bocchia, Monica, Lanza, Francesco, Lico, Albana, Ciceri, Fabio, Della Porta, Matteo Giovanni, Frigeni, Marco, Giaccone, Luisa, Beltrami, Germana, Borlenghi, Erika, Di Chio, Maria Chiara, Selleri, Carmine, Crea, Enrico, Urbino, Irene, Sartor, Chiara, Minotti, Clara, Arena, Valentina, Nanni, Jacopo, Simonetti, Giorgia, Bochicchio, Maria Teresa, Saglio, Giuseppe, Venditti, Adriano, Vignetti, Marco, Fazi, Paola, Tedone, Elisabetta, Martinelli, Giovanni, Lemoli, Roberto M.

Source: In Blood 2 November 2023 142 Supplement 1:1567-1567

Final Analysis for the Primary End-Point of Gimema AML1718, a Safety Run-in and Phase 2 Open-Label Study of Venetoclax, Fludarabine, Idarubicin and Cytarabine (V-FLAI) in the Induction Therapy of Non Low-Risk Acute Myeloid Leukemia

Authors: Marconi, Giovanni, Piciocchi, Alfonso, Audisio, Ernesta, Papayannidis, Cristina, Guolo, Fabio, Cerrano, Marco, Arena, Valentina, Saveria, Capria, Rondoni, Michela, Della Porta, Matteo Giovanni, Beltrami, Geramana, Bocchia, Monica, Lico, Albana, Giaccone, Luisa, Rossi, Marianna, Califano, Catello, Carrabba, Matteo Giovanni, Cattaneo, Chiara, Frigeni, Marco, Di Chio, Maria Chiara, Serio, Bianca, Freilone, Roberto, Curti, Antonio, Minetto, Paola, Marsili, Giovanni, Minotti, Clara, Zannetti, Beatrice, Cotugno, Francesca, Nanni, Jacopo, Simonetti, Giorgia, Bochicchio, Maria Teresa, Rosellini, Sara, Tedone, Elisabetta, Venditti, Adriano, Lemoli, Roberto Massimo, Vignetti, Marco, Fazi, Paola, Martinelli, Giovanni

Source: In Blood 2 November 2023 142 Supplement 1:1536-1536

Real World Outcome of Unfit Patients with Acute Myeloid Leukemia Treated with the Combination Venetoclax Plus Hypomethylating Agents in the Gimema AML2320 Observational Trial

Authors: Venditti, Adriano, Piciocchi, Alfonso, Soddu, Stefano, Frigeni, Marco, Palmieri, Raffaele, Borlenghi, Erika, Fracchiolla, Nicola, Martelli, Maria Paola, Audisio, Ernesta, Gianfaldoni, Giacomo, Vetro, Calogero, di Rienzo, Nicola, Esposito, Daniela, Di Veroli, Ambra, Selleri, Carmine, Gigli, Federica, Curti, Antonio, Mulè, Antonino, Califano, Catello, Bigliardi, Sara, Breccia, Massimo, Fozza, Claudio, Bocchia, Monica, Lico, Albana, Simonetti, Federico, Pierdomenico, Elisabetta, Buccisano, Francesco, Del Principe, Maria Ilaria, Maurillo, Luca, Fazi, Paola, Vignetti, Marco, Ferrara, Felicetto, Cairoli, Roberto, Rossi, Giuseppe, Rambaldi, Alessandro

Source: In Blood 2 November 2023 142 Supplement 1:1514-1514

Sequential Chemotherapy and Blinatumomab to Improve Minimal Residual Disease in Adult Ph- B-Lineage Acute Lymphoblastic Leukemia. Final Results of the Phase II Gimema LAL2317 Trial

Authors: Chiaretti, Sabina, Della Starza, Irene, Santoro, Alessandra, Spinelli, Orietta, Elia, Loredana, De Propris, Maria Stefania, Piccini, Matteo, Chiusolo, Patrizia, Ferrara, Felicetto, Zappasodi, Patrizia, Borlenghi, Erika, Califano, Catello, Bocchia, Monica, Mauro, Elisa, Pane, Fabrizio, Candoni, Anna, Lico, Albana, Audisio, Ernesta, Lunghi, Monia, Mianulli, Anna Maria, Di Trani, Mariangela, Arena, Valentina, Messina, Monica, Piciocchi, Alfonso, Fazi, Paola, Rambaldi, Alessandro, Foà, Robin, Bassan, Renato

Source: In Blood 2 November 2023 142 Supplement 1:826-826

Hyperammonemic Encephalopathy as Initial Presentation of Multiple Myeloma

Authors: Lico, Albana, Barilà, Gregorio, Gaiani, Alessandra, Pompanin, Sara, Berno, Tamara, Ammirati, Lucia, Leoncin, Matteo, Branca, Antonio, De March, Elena, Briani, Chiara, Cagnin, Annachiara, Semenzato, Gianpietro, Zambello, Renato

Source: Clinical lymphoma, myeloma & leukemia. 17(1):e102-e103

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100047527151.0x000001&indx=1&recIds=ETOCvdc_100047527151.0x000001

P970: A REAL‐WORLD RETROSPECTIVE‐PROSPECTIVE ANALYSIS OF EFFICACY AND SAFETY OF COMBINED IXAZOMIB, LENALIDOMIDE AND DEXAMETHASONE IN RELAPSED/REFRACTORY MULTIPLE MYELOMA: THE NORTHERN ITALY EXPERIENCE.

Authors: Furlan, Anna, Cea, Michele, Zambello, Renato, Pavan, Laura, Galli, Monica, Clissa, Cristina, Mangiacavalli, Silvia, Maria Cafro, Anna, Girlanda, Stefania, Patriarca, Francesca, Minotto, Claudia, Bertoldero, Giovanni, Barilà, Gregorio, Pascarella, Anna, Lico, Albana, Paolini, Rossella, Rabassi, Nicholas, Pescosta, Norbert, Porrazzo, Marika, Gherlinzoni, Filippo

Source: HemaSphere; 2023 Supplement 3, Vol. 7, p1-2, 2p

Infections in Multiple Myeloma: An Understimate Risk Factor of Comorbidity

Authors: Barilà, Gregorio, Compagno, Nicolo', Lico, Albana, Cinetto, Francesco, Berno, Tamara, De March, Elena, Branca, Antonio, Ammirati, Lucia, Leoncin, Matteo, Agostini, Carlo, Semenzato, Gianpietro, Zambello, Renato

Source: Clinical lymphoma, myeloma & leukemia. 17(1):e30-e30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100047774614.0x000001&indx=1&recIds=ETOCvdc_100047774614.0x000001

Diffusion Weighted Whole Body MRI for Evaluation of Early Response in Multiple Myeloma

Authors: Zambello, Renato, Barilà, Gregorio, Crimì, Filippo, Annamaria, Guolo, Vio, Stefania, Ponzoni, Alberto, Lico, Albana, Branca, Antonio, Berno, Tamara, De March, Elena, Ammirati, Lucia, Leoncin, Matteo, De Biasi, Ercole, Semenzato, Gianpietro, Lacognata, Carmelo

Source: Clinical lymphoma, myeloma & leukemia. 17(1):e118-e118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100047526728.0x000001&indx=1&recIds=ETOCvdc_100047526728.0x000001

Whole-body low-dose CT recognizes two distinct patterns of lytic lesions in multiple myeloma patients with different disease metabolism at PET/MRI.

Authors: Zambello, Renato, Crimì, Filippo, Lico, Albana, Barilà, Gregorio, Branca, Antonio, Guolo, Annamaria, Varin, Cristiano, Vezzaro, Roberto, Checuz, Lucia, Scapin, Vanna, Berno, Tamara, Pizzi, Marco, Ponzoni, Alberto, De Biasi, Ercole, Vio, Stefania, Semenzato, Gianpietro, Zucchetta, Pietro, Lacognata, Carmelo

Source: Annals of Hematology; Mar2019, Vol. 98 Issue 3, p679-689, 11p