The synergistic tumor growth-inhibitory effect of probiotic Lactobacillus on transgenic mouse model of pancreatic cancer treated with gemcitabine

Authors: Shan-Ming Chen, Wee-Wei Chieng, Szu-Wei Huang, Li-Jin Hsu, Ming-Shiou Jan

Source: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/15cf03039bce4227a77ea1f341924212

Functional role of WW domain‐containing proteins in tumor biology and diseases: Insight into the role in ubiquitin‐proteasome system

Authors: Shenq‐Shyang Huang, Li‐Jin Hsu, Nan‐Shan Chang

Source: FASEB BioAdvances, Vol 2, Iss 4, Pp 234-253 (2020)

Subject Terms: degradation, neural diseases, proteasome, tumorigenesis, ubiquitination, WW domain, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2573-9832

Access URL: https://doaj.org/article/681549f851c04a2e93b05cbbafe321ae

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Authors: Ya-Yun Cheng, Ying-Tsen Chou, Feng-Jie Lai, Ming-Shiou Jan, Tsung-Hao Chang, I-Ming Jou, Pei-Shiuan Chen, Jui-Yen Lo, Shiang-Suo Huang, Nan-Shan Chang, Yung-Tsai Liou, Po-Chih Hsu, Hui-Ching Cheng, Yee-Shin Lin, Li-Jin Hsu

Source: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)

Subject Terms: Common chromosomal fragile site, Brain malformations, Neuronal degeneration, Schwann cell apoptosis, Epilepsy, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/eb7e53c62cb94d12a058fc878897c937

Wwox Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

Authors: Ying-Tsen Chou, Feng-Jie Lai, Nan-Shan Chang, Li-Jin Hsu

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: WWOX, tumor suppressor, keratinocyte proliferation, keratinocyte differentiation, stem cells, adipocytes, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2020.558432/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/ebf22210ee454309b089fff71085db6c

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

Authors: Ying-Da Chen, Yi-Ting Fang, Yi-Lin Cheng, Chiou-Feng Lin, Li-Jin Hsu, Shu-Ying Wang, Robert Anderson, Chih-Peng Chang, Yee-Shin Lin

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/bc911b52e59b49cab717a6b1e9b33d46

WWOX and Its Binding Proteins in Neurodegeneration

Authors: Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I. Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chang

Source: Cells, Vol 10, Iss 7, p 1781 (2021)

Subject Terms: tumor suppressor, p53, WWOX, TRAPPC6A, TIAF1, SH3GLB2, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/7/1781; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/7f0544b21fce4d64aa60078d5fbcc9a8

Antitumor Activity of the Chinese Medicine JC-001 Is Mediated by Immunomodulation in a Murine Model of Hepatocellular Carcinoma

Authors: Meng-Hsien Chuang, Jinghua Tsai Chang PhD, Li-Jin Hsu PhD, Ming-Shiou Jan PhD, Fung-Jou Lu

Source: Integrative Cancer Therapies, Vol 16 (2017)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1534-7354; https://doaj.org/toc/1552-695X

Access URL: https://doaj.org/article/806fa279ea764b548f50312e276c92c7

HYAL-2–WWOX–SMAD4 signaling in cell death and anticancer response

Authors: Li-Jin Hsu, Ming-Fu Chiang, Chun-I Sze, Wan-Pei Su, Ye Vone Yap, I-Ting Lee, Hsiang-Ling Kuo, Nan-Shan Chang

Source: Frontiers in Cell and Developmental Biology, Vol 4 (2016)

Subject Terms: Peptides, Polymerization, Cancer, Treatment, prevention, Hyaluronidase, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00141/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/bd7d93a771c04d61bf73fdf89bc61fae

Autophagy facilitates antibody-enhanced dengue virus infection in human pre-basophil/mast cells.

Authors: Yi-Ting Fang, Shu-Wen Wan, Yi-Tien Lu, Ju-Han Yao, Chiou-Feng Lin, Li-Jin Hsu, Michael G Brown, Jean S Marshall, Robert Anderson, Yee-Shin Lin

Source: PLoS ONE, Vol 9, Iss 10, p e110655 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4199741?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f7e2ba90df25423ba6009e57f55217d5

Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats.

Authors: Meng-Yen Li, Feng-Jie Lai, Li-Jin Hsu, Chen-Peng Lo, Ching-Li Cheng, Sing-Ru Lin, Ming-Hui Lee, Jean-Yun Chang, Dudekula Subhan, Ming-Shu Tsai, Chun-I Sze, Subbiah Pugazhenthi, Nan-Shan Chang, Shur-Tzu Chen

Source: PLoS ONE, Vol 4, Iss 11, p e7820 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2771921?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e8ad8510e32742c084acdf100de87cf6

Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells.

Authors: Qunying Hong, Chun-I Sze, Sing-Ru Lin, Ming-Hui Lee, Ruei-Yu He, Lori Schultz, Jean-Yun Chang, Shean-Jen Chen, Robert J Boackle, Li-Jin Hsu, Nan-Shan Chang

Source: PLoS ONE, Vol 4, Iss 6, p e5755 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2685983?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6d7963a0d3494e5ca77d9aa642a3dd79

Postnatal Dexamethasone Therapy Impairs Brown Adipose Tissue Thermogenesis and Autophagy Flux in Neonatal Rat Pups.

Authors: Yu-Shan Chang, Shun-Yun Hou, Shang-Shiuan Yu, Shin-Yu Tsai, Ying-Yi Chen, Li-Jin Hsu, Pei-Jane Tsai, Hui-Kuan Lin, Chyi-Her Lin, Yau-Sheng Tsai

Source: Theranostics; 2022, Vol. 12 Issue 13, p5803-5819, 17p

Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response.

Authors: Qunying Hong¹ qyhong68@hotmail.com, Li-Jin Hsu^1,2,3 lijin.hsu@gmail.com, Schultz, Lori¹ schultz_lori@guthrie.org, Pratt, Nicole¹, Mattison, Jeffrey³, Nan-Shan Chang^1,3,4 nschang13827@gmail.com

Source: BMC Molecular Biology. 2007, Vol. 8, p50-17. 17p. 4 Diagrams, 8 Graphs.

Subject Terms: *CELL death, *TUMOR necrosis factors, *PROTEIN kinases, *PHOSPHORYLATION, *MESSENGER RNA, *PROTEIN binding, *AMINO acids, *MOLECULAR biology

CCAAT/Enhancer Binding Protein δ in Macrophages Contributes to Immunosuppression and Inhibits Phagocytosis in Nasopharyngeal Carcinoma.

Authors: Yu-Wei Hsiao, Chien-Feng Li, Jhih-Ying Chi, Tseng, Joseph T., Yao Chang, Li-Jin Hsu, Chien-Hsun Lee, Tsung-Hao Chang, Shao-Ming Wang, Dennis Ding Hwa Wang, Hung-Chi Cheng, Ju-Ming Wang

Source: Science Signaling; 7/16/2013, Vol. 6 Issue 284, p1-12, 12p

Transforming Growth Factor γ1 Signaling via Interaction with Cell Surface Hyal-2 and Recruitment of WWOX/WOX1.

Authors: Li-Jin Hsu^1,2,3, Schultz, Lori³, Qunying Hong³, van Moer, Kris³, Heath, John³, Meng-Yen Li⁴, Feng-Jie Lai⁵, Sing-Ru Lin⁶, Ming-Hui Lee⁶, Cheng-Peng Lo², Yee-Shin Lin^1,2, Shur-Tzu Chen⁴, Nan-Shan Chang^2,3,7 wox1world@gmail.com

Source: Journal of Biological Chemistry. 6/5/2009, Vol. 284 Issue 23, p16049-16059. 11p. 10 Graphs.

Subject Terms: *GROWTH factors, *CELL membranes, *PROTEIN kinases, *PROTEIN binding, *CELL death, *FIBROBLAST growth factors

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VP1 codon deoptimization and high-fidelity substitutions in 3D polymerase as potential vaccine strategies for eliciting immune responses against enterovirus A71.

Authors: Wen-Sheng Hsieh¹, Chiao-Hsuan Chao¹, Chun-Yu Shen¹, Dayna Cheng², Sheng-Wen Huang³, Ya-Fang Wang³, Chien-Chin Chen^4,5,6, Shun-Hua Chen^7,8, Li-Jin Hsu^1,2,8 ljhsu@mail.ncku.edu.tw, Jen-Ren Wang^1,2,8,9 jrwang@mail.ncku.edu.tw

Source: Journal of Virology. Jan2024, Vol. 98 Issue 1, p1-15. 15p.

Subject Terms: *IMMUNE response, *REVERSE genetics, *GENOME editing, *CHILD mortality, *VACCINES

Geographic Terms: TAIWAN

Zfra invokes a novel mitochondrial pathway of cell death bypassing cytochrome c release.

Authors: Li-Jin Hsu¹, Nan-Shan Chang²

Source: FASEB Journal. Apr2007, Vol. 21 Issue 6, pA1345-A1345. 1/5p.

Subject Terms: *PROTEINS, *AMINO acids, *CELL death, *MITOCHONDRIA, *CYTOCHROME c, *MITOCHONDRIAL membranes, *PHOSPHORYLATION, *CELL growth

WOX1 Is Essential for Tumor Necrosis Factor-, UV Light-, Staurosporine-, and p53-mediated Cell Death, and Its Tyrosine 33-phosphorylated Form Binds and Stabilizes Serine 46-phosphorylated p53.

Authors: Nan-Shan Chang¹ chang_nanshan@guthrie.org, Doherty, Joan¹, Ensign, Amy¹, Schultz, Lori¹, Li-Jin Hsu¹, Qunying Hong¹

Source: Journal of Biological Chemistry. 12/30/2005, Vol. 280 Issue 52, p43100-43109. 9p. 8 Diagrams, 2 Graphs.

Subject Terms: *OXIDOREDUCTASES, *TUMOR necrosis factors, *CELL death, *PHOSPHORYLATION, *P53 protein, *DNA-binding proteins, *PHOSPHOPROTEINS, *STEROID hormones

Bcl-2 Rescues Ceramide- and Etoposide-induced Mitochondrial Apoptosis through Blockage of Caspase-2 Activation.

Authors: Chiou-Feng Lin¹, Chia-Ling Chen^1,2 yslin1@mail.ncku.edu.tw, Wen-Tsan Chang³, Ming-Shiou Jan⁴, Li-Jin Hsu¹, Ren-Huang Wu³, Yi-Ting Fang¹, Ming-Jer Tang⁵, Wen-Chang Chang⁶, Yee-Shin Lin¹ yslin1@mail.ncku.edu.tw

Source: Journal of Biological Chemistry. 6/24/2005, Vol. 280 Issue 25, p23758-23765. 8p. 25 Graphs.

Subject Terms: *CERAMIDES, *GLYCOSPHINGOLIPIDS, *ETOPOSIDE, *PODOPHYLLOTOXIN, *MITOCHONDRIA, *APOPTOSIS