Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.

Authors: Yuan, Zheng^1,2, van Delft, Mark F.^1,2, Li, Mark Xiang³, Sumardy, Fransisca¹, Smith, Brian J.⁴, Huang, David C. S.^1,2, Lessene, Guillaume^1,2,5, Khakam, Yelena¹, Jin, Ruitao^4,6, He, Sitong⁴, Smith, Nicholas A.⁴, Birkinshaw, Richard W.^1,2, birkinshaw.r@wehi.edu.au, Czabotar, Peter E.^1,2, birkinshaw.r@wehi.edu.au, Dewson, Grant^1,2, birkinshaw.r@wehi.edu.au

Source: PLoS Biology; 5/2/2024, Vol. 22 Issue 5, p1-20, 20p

A new method for network bioinformatics identifies novel drug targets for mucinous ovarian carcinoma.

Authors: Craig, Olivia, Lee, Samuel, Pilcher, Courtney, Saoud, Rita, Abdirahman, Suad, Salazar, Carolina, Williams, Nathan, Ascher, David B, Vary, Robert, Luu, Jennii, Cowley, Karla J, Ramm, Susanne, Li, Mark Xiang, Thio, Niko, Li, Jason, Semple, Tim, Simpson, Kaylene J, Gorringe, Kylie L, Holien, Jessica K

Source: NAR Genomics & Bioinformatics; Sep2024, Vol. 6 Issue 3, p1-16, 16p

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

Authors: Li, Mark Xiang, Tan, Iris K. L., Ma, Stephen B., Hockings, Colin, Kratina, Tobias, Dengler, Michael A., Alsop, Amber E., Kluck, Ruth M., Dewson, Grant

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jul . 114(29), 7629-7634.

Access URL: https://www.jstor.org/stable/26486672

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