The Molecular Landscape of Primary CNS Lymphomas (PCNSLs) in Children and Young Adults.

Authors: Shi, Zhi-Feng^1,2 (AUTHOR) shizhifeng@fudan.edu.cn, Li, Kay Ka-Wai³ (AUTHOR) kayli@cuhk.edu.hk, Liu, Anthony Pak-Yin^4,5 (AUTHOR), Chung, Nellie Yuk-Fei³ (AUTHOR) yf169chung@cuhk.edu.hk, Wong, Sze-Ching³ (AUTHOR) scwong@cuhk.edu.hk, Chen, Hong⁶ (AUTHOR) cherrychen30@126.com, Woo, Peter Yat-Ming⁷ (AUTHOR) peterwoo@surgery.cuhk.edu.hk, Chan, Danny Tat-Ming⁷ (AUTHOR) tmdanny@surgery.cuhk.edu.hk, Mao, Ying^1,2 (AUTHOR) maoying@fudan.edu.cn, Ng, Ho-Keung^2,3 (AUTHOR) maoying@fudan.edu.cn

Source: Cancers. May2024, Vol. 16 Issue 9, p1740. 15p.

Subject Terms: *GENE rearrangement, *LYMPHOMAS, *SYMPTOMS, *AGE distribution, *DESCRIPTIVE statistics, *GENE expression, *GENE expression profiling, *FLUORESCENCE in situ hybridization, *GENETIC mutation, *PHENOTYPES, *HLA-B27 antigen, *IMMUNOMODULATORS, *SEQUENCE analysis, *CHILDREN, *ADULTS, CENTRAL nervous system tumors

Rare Pediatric Cerebellar High-Grade Gliomas Mimic Medulloblastomas Histologically and Transcriptomically and Show p53 Mutations.

Authors: Shi, Zhi-Feng^1,2 (AUTHOR) shizhifeng@fudan.edu.cn, Li, Kay Ka-Wai³ (AUTHOR) kayli@cuhk.edu.hk, Liu, Anthony Pak-Yin^4,5 (AUTHOR) apyliu@hku.hk, Chung, Nellie Yuk-Fei³ (AUTHOR) yf169chung@cuhk.edu.hk, Chow, Chit³ (AUTHOR) chit@cuhk.edu.hk, Chen, Hong⁶ (AUTHOR) cherrychen30@126.com, Kan, Nim-Chi Amanda⁷ (AUTHOR) amandakan@yahoo.com, Zhu, Xian-Lun⁸ (AUTHOR) zhuxl@surgery.cuhk.edu.hk, Chan, Danny Tat-Ming⁸ (AUTHOR) tmdanny@surgery.cuhk.edu.hk, Mao, Ying^1,2 (AUTHOR) maoying@fudan.edu.cn, Ng, Ho-Keung^2,3 (AUTHOR) maoying@fudan.edu.cn

Source: Cancers. Jan2024, Vol. 16 Issue 1, p232. 12p.

Subject Terms: *GENETIC mutation, *SEQUENCE analysis, *IMMUNOHISTOCHEMISTRY, *HUMAN genome, *GLIOMAS, *DIFFERENTIAL diagnosis, *TUMORS in children, *BRAIN tumors, *CEREBELLUM, *DNA methylation, *GENE expression profiling, *RESEARCH funding, *TUMOR suppressor genes, *CLUSTER analysis (Statistics), *RARE diseases, *TUMOR grading

Molecular landscape of pediatric type IDH wildtype, H3 wildtype hemispheric glioblastomas

Authors: Hong, Liang, Shi, Zhi-Feng, Li, Kay Ka-Wai, Wang, Wei-Wei, Yang, Rui Ryan, Kwan, Johnny Sheung-Him, Chen, Hong, Li, Fang-Cheng, Liu, Xian-Zhi, Chan, Danny Tat-Ming, Li, Wen-Cai, Zhang, Zhen-Yu, Mao, Ying, Ng, Ho-Keung

Source: In Laboratory Investigation July 2022 102(7):731-740

The molecular history of IDH‐mutant astrocytomas without adjuvant treatment.

Authors: Shi, Zhi‐Feng^1,2 (AUTHOR), Li, Kay Ka‐Wai³ (AUTHOR), Kwan, Johnny Sheung‐Him^3,4 (AUTHOR), Chung, Nellie Yuk‐Fei³ (AUTHOR), Wong, Sze‐Ching³ (AUTHOR), Chu, Abby Wai‐Yan³ (AUTHOR), Chen, Hong⁵ (AUTHOR), Chan, Danny Tat‐Ming⁶ (AUTHOR), Mao, Ying^1,2 (AUTHOR) maoying@fudan.edu.cn, Ng, Ho‐Keung^2,3 (AUTHOR) hkng@cuhk.edu.hk

Source: Brain Pathology. Mar2025, Vol. 35 Issue 2, p1-11. 11p.

Subject Terms: *ASTROCYTOMAS, *TEMOZOLOMIDE, *DNA sequencing, *DISEASE relapse, *ISOCITRATE dehydrogenase, *MOLECULAR evolution, *DNA copy number variations, *GENETIC mutation

Mismatch repair proteins PMS2 and MLH1 can further refine molecular stratification of IDH-mutant lower grade astrocytomas

Authors: Yang, Rui Ryan, Li, Kay Ka-Wai, Zhang, Zhen-Yu, Chan, Aden Ka-Yin, Wang, Wei-Wei, Chan, Danny Tat-Ming, Li, Wen-Cai, Liu, Xian-Zhi, Li, Fang-Cheng, Chen, Hong, Ng, Ho-Keung, Mao, Ying, Shi, Zhi-Feng

Source: In Clinical Neurology and Neurosurgery September 2021 208

Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas

Authors: Wong, Queenie Hoi-Wing, Li, Kay Ka-Wai, Wang, Wei-Wei, Malta, Tathiane M., Noushmehr, Houtan, Grabovska, Yura, Jones, Chris, Chan, Aden Ka-Yin, Kwan, Johnny Sheung-Him, Huang, Queenie Jun-Qi, Wong, Gabriel Chun-Hei, Li, Wen-Cai, Liu, Xian-Zhi, Chen, Hong, Chan, Danny Tat-Ming, Mao, Ying, Zhang, Zhen-Yu, Shi, Zhi-Feng, Ng, Ho-Keung

Source: In Modern Pathology July 2021 34(7):1245-1260

Low‐grade BRAF V600E mutant oligodendroglioma‐like tumors of children may show EGFR and MET amplification

Authors: Yang, Rui Ryan, Li, Kay Ka‐Wai, Liu, Anthony P.Y., Chen, Hong, Chung, Nellie Yuk‐Fei, Chan, Aden K.Y., Li, Fangcheng, Chan, Danny Tat‐Ming, Mao, Ying, Shi, Zhi‐Feng, Ng, Ho‐Keung

Source: Brain pathology. 31(1):211-214

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132304237.0x000001&indx=1&recIds=ETOCvdc_100132304237.0x000001

Incremental prognostic value and underlying biological pathways of radiomics patterns in medulloblastoma

Authors: Yan, Jing, Zhang, Shenghai, Li, Kay Ka-Wai, Wang, Weiwei, Li, Ke, Duan, Wenchao, Yuan, Binke, Wang, Li, Liu, Lei, Zhan, Yunbo, Pei, Dongling, Zhao, Haibiao, Sun, Tao, Sun, Chen, Wang, Wenqing, Liu, Zhen, Hong, Xuanke, Wang, Xiangxiang, Guo, Yu, Li, Wencai, Cheng, Jingliang, Liu, Xianzhi, Ng, Ho-Keung, Li, Zhicheng, Zhang, Zhenyu

Source: In EBioMedicine November 2020 61

Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

Authors: Nobre, Liana, Zapotocky, Michal, Khan, Sara, Fukuoka, Kohei, Fonseca, Adriana, McKeown, Tara, Sumerauer, David, Vicha, Ales, Grajkowska, Wieslawa A., Trubicka, Joanna, Li, Kay Ka Wai, Ng, Ho-Keung, Massimi, Luca, Lee, Ji Yeoun, Kim, Seung-Ki, Zelcer, Shayna, Vasiljevic, Alexandre, Faure-Conter, Cécile, Hauser, Peter, Lach, Boleslaw, van Veelen-Vincent, Marie-Lise, French, Pim J., Van Meir, Erwin G., Weiss, William A., Gupta, Nalin, Pollack, Ian F., Hamilton, Ronald L., Nageswara Rao, Amulya A., Giannini, Caterina, Rubin, Joshua B., Moore, Andrew S., Chambless, Lola B., Vibhakar, Rajeev, Ra, Young Shin, Massimino, Maura, McLendon, Roger E., Wheeler, Helen, Zollo, Massimo, Ferruci, Veronica, Kumabe, Toshihiro, Faria, Claudia C., Sterba, Jaroslav, Jung, Shin, López-Aguilar, Enrique, Mora, Jaume, Carlotti, Carlos G., Olson, James M., Leary, Sarah, Cain, Jason, Krskova, Lenka, Zamecnik, Josef, Hawkins, Cynthia E., Tabori, Uri, Huang, Annie, Bartels, Ute, Northcott, Paul A., Taylor, Michael D., Yip, Stephen, Hansford, Jordan R., Bouffet, Eric, Ramaswamy, Vijay

Source: In Cell Reports Medicine 23 June 2020 1(3)

Molecular landscapes of longitudinal NF2/22q and non‐NF2/22q meningiomas show different life histories

Authors: Ng, Ho‐Keung, Li, Kay Ka‐Wai, Chung, Nellie Yuk‐Fei, Chan, Janice Yuen‐Tung, Poon, Manix Fung‐Man, Wong, Queenie Hoi‐Wing, Kwan, Johnny Sheung‐Him, Poon, Wai‐Sang, Chen, Hong, Chan, Danny Tat‐Ming, Shi, Zhi‐Feng, Mao, Ying

Source: Brain pathology. 33(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181625902.0x000001&indx=1&recIds=ETOCvdc_100181625902.0x000001

IDH mutant lower grade (WHO Grades II/III) astrocytomas can be stratified for risk by CDKN2A, CDK4 and PDGFRA copy number alterations

Authors: Yang, Rui Ryan, Shi, Zhi‐feng, Zhang, Zhen‐yu, Chan, Aden Ka‐Yin, Aibaidula, Abudumijiti, Wang, Wei‐wei, Kwan, Johnny Sheung Him, Poon, Wai Sang, Chen, Hong, Li, Wen‐cai, Chung, Nellie Yuk‐Fei, Punchhi, Gopika, Chu, William Ching‐Yuen, Chan, Ivan Sik‐Hei, Liu, Xian‐zhi, Mao, Ying, Li, Kay Ka‐Wai, Ng, Ho‐Keung

Source: Brain pathology. 30(3):541-553

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108209510.0x000001&indx=1&recIds=ETOCvdc_100108209510.0x000001

Whole‐exome sequencing revealed mutational profiles of giant cell glioblastomas

Authors: Shi, Zhi‐feng, Li, Kay Ka‐Wai, Kwan, Johnny Sheung Him, Yang, Rui Ryan, Aibaidula, Abudumijiti, Tang, Qisheng, Bao, Yifeng, Mao, Ying, Chen, Hong, Ng, Ho‐Keung

Source: Brain pathology. 29(6):782-792

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091055993.0x000001&indx=1&recIds=ETOCvdc_100091055993.0x000001

Molecular landscape of IDH‐wild type, pTERT‐wild type adult glioblastomas

Authors: Liu, Emma Munan, Shi, Zhi‐Feng, Li, Kay Ka‐Wai, Malta, Tathiane M., Chung, Nellie Yuk‐Fei, Chen, Hong, Chan, Janice Yuen‐Tung, Poon, Manix Fung‐Man, Kwan, Johnny Sheung‐Him, Chan, Danny Tat‐Ming, Noushmehr, Houtan, Mao, Ying, Ng, Ho‐Keung

Source: Brain pathology. 32(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100177028742.0x000001&indx=1&recIds=ETOCvdc_100177028742.0x000001

Molecular landscape of IDH‐wild‐type, H3‐wild‐type glioblastomas of adolescents and young adults

Authors: Shi, Zhi‐Feng, Li, Kay Ka‐Wai, Huang, Queenie Jun‐Qi, Wang, Wei‐Wei, Kwan, Johnny Sheung‐Him, Chen, Hong, Liu, Xiang‐Zhi, Li, Wen‐Cai, Chan, Danny Tat‐Ming, Zhang, Zhen‐Yu, Mao, Ying, Ng, Ho‐Keung

Source: Neuropathology & applied neurobiology. 48(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152446287.0x000001&indx=1&recIds=ETOCvdc_100152446287.0x000001

Cover Image, Volume 48, Issue 4

Authors: Shi, Zhi‐Feng, Li, Kay Ka‐Wai, Huang, Queenie Jun‐Qi, Wang, Wei‐Wei, Kwan, Johnny Sheung‐Him, Chen, Hong, Liu, Xiang‐Zhi, Li, Wen‐Cai, Chan, Danny Tat‐Ming, Zhang, Zhen‐Yu, Mao, Ying, Ng, Ho‐Keung

Source: Neuropathology & applied neurobiology. 48(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149275934.0x000001&indx=1&recIds=ETOCvdc_100149275934.0x000001

An Unusual Combination of Mirror-Image Dextrocardia with Familial Medulloblastoma: Is There a Histogenetic Relationship?

Authors: Ke, Chao, Wang, Jing, Xi, Shaoyan, Li, Kay Ka-Wai, Luo, Junran, Chen, Zhenghe, Wang, Jian, Chen, Zhong-Ping

Source: In World Neurosurgery November 2017 107:860-867

The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis

Authors: Li, Kay Ka-Wai, Qi, Yan, Xia, Tian, Chan, Aden Ka-Yin, Zhang, Zhen-Yu, Aibaidula, Abudumijiti, Zhang, Rong, Zhou, Liangfu, Yao, Yu, Ng, Ho-Keung

Source: In Laboratory Investigation August 2017 97(8):946-961

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Authors: Cavalli, Florence M.G., Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David J.H., Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A. Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M., Farooq, Hamza, Isaev, Keren, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A., Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Nageswara Rao, Amulya A., Li, Kay Ka Wai, Ng, Ho-Keung, Eberhart, Charles G., Pollack, Ian F., Hamilton, Ronald L., Gillespie, G. Yancey, Olson, James M., Leary, Sarah, Weiss, William A., Lach, Boleslaw, Chambless, Lola B., Thompson, Reid C., Cooper, Michael K., Vibhakar, Rajeev, Hauser, Peter, van Veelen, Marie-Lise C., Kros, Johan M., French, Pim J., Ra, Young Shin, Kumabe, Toshihiro, López-Aguilar, Enrique, Zitterbart, Karel, Sterba, Jaroslav, Finocchiaro, Gaetano, Massimino, Maura, Van Meir, Erwin G., Osuka, Satoru, Shofuda, Tomoko, Klekner, Almos, Zollo, Massimo, Leonard, Jeffrey R., Rubin, Joshua B., Jabado, Nada, Albrecht, Steffen, Mora, Jaume, Van Meter, Timothy E., Jung, Shin, Moore, Andrew S., Hallahan, Andrew R., Chan, Jennifer A., Tirapelli, Daniela P.C., Carlotti, Carlos G., Fouladi, Maryam, Pimentel, José, Faria, Claudia C., Saad, Ali G., Massimi, Luca, Liau, Linda M., Wheeler, Helen, Nakamura, Hideo, Elbabaa, Samer K., Perezpeña-Diazconti, Mario, Chico Ponce de León, Fernando, Robinson, Shenandoah, Zapotocky, Michal, Lassaletta, Alvaro, Huang, Annie, Hawkins, Cynthia E., Tabori, Uri, Bouffet, Eric, Bartels, Ute, Dirks, Peter B., Rutka, James T., Bader, Gary D., Reimand, Jüri, Goldenberg, Anna, Ramaswamy, Vijay, Taylor, Michael D.

Source: In Cancer Cell 12 June 2017 31(6):737-754

Pediatric low-grade gliomas can be molecularly stratified for risk

Authors: Yang, Rui Ryan, Aibaidula, Abudumijiti, Wang, Wei-wei, Chan, Aden Ka-Yin, Shi, Zhi-feng, Zhang, Zhen-yu, Chan, Danny Tat Ming, Poon, Wai Sang, Liu, Xian-zhi, Li, Wen-cai, Zhang, Rui-qi, Li, Yan-Xi, Chung, Nellie Yuk-Fei, Chen, Hong, Wu, Jingsong, Zhou, Liangfu, Li, Kay Ka-Wai, Ng, Ho-Keung

Source: Acta neuropathologica. 136(4):641-655

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141526062.0x000001&indx=1&recIds=ETOCvdc_100141526062.0x000001

Oligodendrogliomas in pediatric and teenage patients only rarely exhibit molecular markers and patients have excellent survivals

Authors: Li, Yan-Xi, Aibaidula, Abudumijiti, Shi, Zhifeng, Chen, Hong, Li, Kay Ka-Wai, Chung, Nellie Yuk-Fei, Yang, Ryan Rui, Chan, Danny Tat-Ming, Poon, Wai Sang, Lee, Ka Lok Ryan, Mao, Ying, Wu, Jinsong, Chan, Aden Ka-yin, Zhou, Liangfu, Ng, Ho-Keung

Source: Journal of neuro-oncology. 139(2):307-322

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118723296.0x000001&indx=1&recIds=ETOCvdc_100118723296.0x000001