Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex

Authors: Somsen, Bente A., Sijbesma, Eline, Leysen, Seppe, Honzejkova, Karolina, Visser, Emira J., Cossar, Peter J., Obšil, Tomáš, Brunsveld, Luc, Ottmann, Christian

Source: In Journal of Biological Chemistry July 2023 299(7)

Molecular glues to stabilise protein–protein interactions

Authors: Soini, Lorenzo, Leysen, Seppe, Davis, Jeremy, Ottmann, Christian

Source: In Current Opinion in Chemical Biology August 2022 69

A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

Authors: Leysen, Seppe, Burnley, Rebecca Jane, Rodriguez, Elizabeth, Milroy, Lech-Gustav, Soini, Lorenzo, Adamski, Carolyn J., Nitschke, Larissa, Davis, Rachel, Obsil, Tomas, Brunsveld, Lucas, Crabbe, Tom, Zoghbi, Huda Yahya, Ottmann, Christian, Davis, Jeremy Martin

Source: In Journal of Molecular Biology 17 September 2021 433(19)

The identification and structural analysis of potential 14‐3‐3 interaction sites on the bone regulator protein Schnurri‐3

Authors: Soini, Lorenzo, Leysen, Seppe, Crabbe, Tom, Davis, Jeremy, Ottmann, Christian

Source: Acta crystallographica.Section F.Structural biology communications. 77(8):254-261

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125466244.0x000001&indx=1&recIds=ETOCvdc_100125466244.0x000001

Identification of molecular glues of the SLP76/14-3-3 protein–protein interactionElectronic supplementary information (ESI) available. See DOI: 10.1039/d1md00172h

Authors: Soini, Lorenzo, Redhead, Martin, Westwood, Marta, Leysen, Seppe, Davis, Jeremy, Ottmann, Christian

Source: RSC medicinal chemistry. 12(9):1555-1564

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130251272.0x000001&indx=1&recIds=ETOCvdc_100130251272.0x000001

The 14‐3‐3/SLP76 protein–protein interaction in T‐cell receptor signalling: a structural and biophysical characterization

Authors: Soini, Lorenzo, Leysen, Seppe, Davis, Jeremy, Westwood, Marta, Ottmann, Christian

Source: FEBS letters. 595(3):404-414

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120086129.0x000001&indx=1&recIds=ETOCvdc_100120086129.0x000001

Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold enabled the discovery of antibodies, which recognized native receptor.

Authors: Barrett, Janine, Leysen, Seppe, Galmiche, Cécile, Al-Mossawi, Hussein, Bowness, Paul, Edwards, Thomas E., Lawson, Alastair D.G.

Source: Bioengineered; Dec2024, Vol. 15 Issue 1, p1-12, 12p

A biophysical and structural analysis of the interaction of BLNK with 14-3-3 proteins

Authors: Soini, Lorenzo, Leysen, Seppe, Davis, Jeremy, Ottmann, Christian

Source: In Journal of Structural Biology 1 December 2020 212(3)

Site-Directed Fragment-Based Screening for the Discovery of Protein—Protein Interaction Stabilizers

Authors: Sijbesma, Eline, Hallenbeck, Kenneth K., Leysen, Seppe, de Vink, Pim J., Skóra, Lukasz, Jahnke, Wolfgang, Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian

Source: Journal of the American Chemical Society. 141(8):3524-3531

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN619364077&indx=1&recIds=ETOCRN619364077

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR

Authors: Stevers, Loes M., Lam, Chan V., Leysen, Seppe F. R., Meijer, Femke A., van Scheppingen, Daphne S., de Vries, Rens M. J. M., Carlile, Graeme W., Milroy, Lech G., Thomas, David Y., Brunsveld, Luc, Ottmann, Christian

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Mar 01. 113(9), E1152-E1161.

Access URL: https://www.jstor.org/stable/26468560

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening

Authors: Sijbesma, Eline, Skora, Lukasz, Leysen, Seppe, Brunsveld, Luc, Koch, Uwe, Nussbaumer, Peter, Jahnke, Wolfgang, Ottmann, Christian

Source: Biochemistry. 56(30):3972-3982

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612403075&indx=1&recIds=ETOCRN612403075

Stabilizer‐Guided Inhibition of Protein–Protein Interactions

Authors: Milroy, Lech‐Gustav, Bartel, Maria, Henen, Morkos A., Leysen, Seppe, Adriaans, Joris M. C., Brunsveld, Luc, Landrieu, Isabelle, Ottmann, Christian

Source: Angewandte Chemie. 127(52):15946-15950

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128627336.0x000001&indx=1&recIds=ETOCvdc_100128627336.0x000001

Structural characterization of the PliG lysozyme inhibitor family

Authors: Leysen, Seppe, Vanderkelen, Lise, Van Asten, Kathleen, Vanheuverzwijn, Steven, Theuwis, Veronique, Michiels, Chris W., Strelkov, Sergei V.

Source: In Journal of Structural Biology October 2012 180(1):235-242

Guards of the great wall: bacterial lysozyme inhibitors

Authors: Callewaert, Lien, Van Herreweghe, Joris M., Vanderkelen, Lise, Leysen, Seppe, Voet, Arnout, Michiels, Chris W.

Source: In Trends in Microbiology October 2012 20(10):501-510

Fragment-based Differential Targeting of PPI Stabilizer Interfaces.

Authors: Guillory, Xavier, Wolter, Madita, Leysen, Seppe, Neves, João Filipe, Kuusk, Ave, Genet, Sylvia, Somsen, Bente, Morrow, John Kenneth, Rivers, Emma, van Beek, Lotte, Patel, Joe, Goodnow, Robert, Schoenherr, Heike, Fuller, Nathan, Cao, Qing, Doveston, Richard G., Brunsveld, Luc, Arkin, Michelle R., Castaldi, Paola, Boyd, Helen

Source: Journal of Medicinal Chemistry; 7/9/2020, Vol. 63 Issue 13, p6694-6707, 14p

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Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

Authors: Meijer, Femke A., Doveston, Richard G., de Vries, Rens M.J.M., Vos, Gaël M., Vos, Alex A.A., Leysen, Seppe, Scheepstra, Marcel, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc

Source: Journal of Medicinal Chemistry; May 2020, Vol. 63 Issue: 1 p241-259, 19p

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