Evaluation of prognostic scores in patients with HCC undergoing first-line immunotherapy with atezolizumab and bevacizumab

Authors: Gairing, Simon Johannes ¹, Mildenberger, Philipp ², Gile, Jennifer ³, Artusa, Fabian ⁴, Scheiner, Bernhard ⁵, Leyh, Catherine ⁶, Lieb, Sabine ⁷, Sinner, Friedrich ⁸, Jörg, Vincent ⁹, Fruendt, Thorben ⁹, Himmelsbach, Vera ¹⁰, Abedin, Nada ¹⁰, Sahin, Cennet ¹¹, Böttcher, Katrin ¹², Schuhbaur, Jasmin ¹³, Labuhn, Simon ¹⁴, Korolewicz, James ¹⁵, Fulgenzi, Claudia A.M. ¹⁵, D'Alessio, Antonio ¹⁵, Zanuso, Valentina ^{16, 17}, Hucke, Florian ¹⁸, Röhlen, Natascha ¹⁹, Ben Khaled, Najib ²⁰, Ramadori, Eleonora ²¹, Müller, Lukas ²², Weinmann, Arndt ¹, Kloeckner, Roman ²³, Galle, Peter Robert ¹, Tran, Nguyen H. ³, Venkatesh, Sudhakar K. ²⁴, Teufel, Andreas ^{25, 26}, Ebert, Matthias ^{26, 27}, De Toni, Enrico N. ²⁰, Waldschmidt, Dirk-Thomas ²¹, Marquardt, Jens U. ²⁸, Bettinger, Dominik ¹⁹, Peck-Radosavljevic, Markus ¹⁸, Geier, Andreas ²⁹, Reiter, Florian P. ²⁹, Rimassa, Lorenza ^{16, 17}, Pinato, David J. ^{15, 30}, Roderburg, Christoph ¹⁴, Ettrich, Thomas ¹³, Bitzer, Michael ³¹, Scheble, Veit ³¹, Ehmer, Ursula ¹², Berres, Marie-Luise ¹¹, Finkelmeier, Fabian ¹⁰, Gonzalez-Carmona, Maria Angeles ³², von Felden, Johann ⁹, Schulze, Kornelius ⁹, Venerito, Marino ⁸, van Bömmel, Florian ⁷, Jochheim, Leonie S. ⁶, Pinter, Matthias ⁵, Mohr, Raphael ⁴, Ilyas, Sumera I. ³³, Schmidtmann, Irene ², Foerster, Friedrich ^{1, ⁎}

Source: In JHEP Reports March 2025 7(3)

Atezolizumab/bevacizumab or lenvatinib in hepatocellular carcinoma: Multicenter real-world study with focus on bleeding and thromboembolic events

Authors: Ben Khaled, Najib ^{1, †, ‡}, Möller, Marie ^{2, †, ‡}, Jochheim, Leonie S. ³, Leyh, Catherine ³, Ehmer, Ursula ^{4, †, ‡}, Böttcher, Katrin ^{4, †, ‡}, Pinter, Matthias ⁵, Balcar, Lorenz ⁵, Scheiner, Bernhard ⁵, Weich, Alexander ^{6, †}, Leicht, Hans Benno ^{2, †, ‡}, Zarka, Valentina ^{2, †, ‡}, Ye, Liangtao ^{1, 7, †, ‡}, Schneider, Julia ^{1, †, ‡}, Piseddu, Ignazio ^{1, †, ‡}, Öcal, Osman ⁸, Rau, Monika ^{2, †, ‡}, Sinner, Friedrich ⁹, Venerito, Marino ⁹, Gairing, Simon Johannes ¹⁰, Förster, Friedrich ¹⁰, Mayerle, Julia ^{1, †, ‡}, De Toni, Enrico N. ^{1, †, ‡}, Geier, Andreas ^{2, †, ‡}, Reiter, Florian P. ^{2, ∗, †, ‡}

Source: In JHEP Reports June 2024 6(6)

Elevated HbA1c Levels Are Associated with a Risk of Pancreatic Cancer: A Case–Control Study.

Authors: Grewe, Steven, Jördens, Markus S., Roderburg, Christoph, Leyh, Catherine, Labuhn, Simon, Luedde, Tom, Krieg, Sarah, Krieg, Andreas, Loosen, Sven H., Kostev, Karel

Source: Journal of Clinical Medicine; Sep2024, Vol. 13 Issue 18, p5584, 8p

Subject Terms: CANCER diagnosis, PANCREATIC cancer, EARLY detection of cancer, TYPE 2 diabetes, PROPENSITY score matching

LiMAx Prior to Radioembolization for Hepatocellular Carcinoma as an Additional Tool for Patient Selection in Patients with Liver Cirrhosis.

Authors: Leyh, Catherine¹ (AUTHOR), Heucke, Niklas² (AUTHOR), Schotten, Clemens¹ (AUTHOR), Büchter, Matthias¹ (AUTHOR), Bechmann, Lars P.³ (AUTHOR), Wichert, Marc⁴ (AUTHOR), Dechêne, Alexander⁵ (AUTHOR), Herrmann, Ken⁶ (AUTHOR), Heider, Dominik⁷ (AUTHOR), Sydor, Svenja³ (AUTHOR), Lemmer, Peter² (AUTHOR), Ludwig, Johannes M.⁸ (AUTHOR), Pospiech, Josef³ (AUTHOR), Theysohn, Jens⁸ (AUTHOR), Damm, Robert⁹ (AUTHOR), March, Christine⁹ (AUTHOR), Powerski, Maciej⁹ (AUTHOR), Pech, Maciej⁹ (AUTHOR), Özcürümez, Mustafa³ (AUTHOR), Weigt, Jochen² (AUTHOR)

Source: Cancers. Oct2022, Vol. 14 Issue 19, p4584. 14p.

Subject Terms: *LIVER function tests, *BIOMARKERS, *PREDICTIVE tests, *RADIOEMBOLIZATION, *PATIENT selection, *CIRRHOSIS of the liver, *CANCER patients, *PRE-tests & post-tests, *RECEIVER operating characteristic curves, *HEPATOCELLULAR carcinoma, *LONGITUDINAL method

Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma

Authors: Loosen, Sven H., Roderburg, Christoph, Kauertz, Katja L., Pombeiro, Inês, Leyh, Catherine, Benz, Fabian, Vucur, Mihael, Longerich, Thomas, Koch, Alexander, Braunschweig, Till, Ulmer, Tom F., Heidenhain, Christoph, Tacke, Frank, Binnebösel, Marcel, Schmeding, Maximilian, Trautwein, Christian, Neumann, Ulf P., Luedde, Tom

Source: In Journal of Hepatology October 2017 67(4):749-757

Sorafenib Versus Lenvatinib-Based Sequential Systemic Therapy for Advanced Hepatocellular Carcinoma: A Real-World Analysis.

Authors: Leyh, Catherine¹ (AUTHOR) catherine.leyh@uk-essen.de, Ehmer, Ursula² (AUTHOR) ursula.ehmer@mri.tum.de, Roessler, Daniel³ (AUTHOR) daniel.roessler@med.uni-muenchen.de, Philipp, Alexander B.³ (AUTHOR) alexander.philipp@med.uni-muenchen.de, Reiter, Florian P.⁴ (AUTHOR) reiter_f@ukw.de, Jeliazkova, Petia² (AUTHOR) petia.jeliazkova@mri.tum.de, Jochheim, Leonie S.¹ (AUTHOR) leonie.jochheim@uk-essen.de, Jeschke, Matthias¹ (AUTHOR) matthias.jeschke@uk-essen.de, Hammig, Janina¹ (AUTHOR) janina.hammig@uk-essen.de, Ludwig, Johannes M.⁵ (AUTHOR) johannes.ludwig@uk-essen.de, Theysohn, Jens M.⁵ (AUTHOR) jens.theysohn@uk-essen.de, Geier, Andreas⁴ (AUTHOR) geier_a2@ukw.de, Lange, Christian M.^1,3 (AUTHOR) christian.lange@med.uni-muenchen.de

Source: Cancers. Apr2022, Vol. 14 Issue 8, p1975. 13p.

Subject Terms: *THERAPEUTIC use of antineoplastic agents, *LIVER function tests, *RETROSPECTIVE studies, *ACQUISITION of data, *PROTEIN-tyrosine kinase inhibitors, *TREATMENT effectiveness, *CANCER patients, *SORAFENIB, *MEDICAL records, *HEPATOCELLULAR carcinoma, *LONGITUDINAL method, *EVALUATION

Long-Term Intake of Proton-Pump Inhibitors Could Be Associated with an Increased Incidence of Liver Cancer in Women.

Authors: Loosen, Sven H., Jördens, Markus S., Leyh, Catherine, Luedde, Tom, Roderburg, Christoph, Kostev, Karel

Source: Cancers; Apr2024, Vol. 16 Issue 8, p1517, 8p

Subject Terms: LIVER tumors, RISK assessment, STATISTICAL correlation, WOMEN, DATA analysis, SEX distribution, LOGISTIC regression analysis, CANCER patients, TREATMENT duration, AGE distribution, MULTIVARIATE analysis, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, STATISTICS, PROTON pump inhibitors, DATA analysis software, CONFIDENCE intervals, DISEASE risk factors

Geographic Terms: GERMANY

MASLD-Related HCC—Update on Pathogenesis and Current Treatment Options.

Authors: Leyh, Catherine¹ (AUTHOR), Coombes, Jason D.² (AUTHOR) jason.coombes@health.slu.edu, Schmidt, Hartmut H.³ (AUTHOR), Canbay, Ali⁴ (AUTHOR), Manka, Paul P.⁴ (AUTHOR), Best, Jan³ (AUTHOR) jan.best@uk-essen.de

Source: Journal of Personalized Medicine. Apr2024, Vol. 14 Issue 4, p370. 16p.

Subject Terms: *TYPE 2 diabetes, *LIVER diseases, *GUT microbiome, *HEPATOCELLULAR carcinoma, *CANCER-related mortality

Associating Appendicitis with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Novel Insight into an Unexpected Connection.

Authors: Roderburg, Christoph, Waldschmidt, Dirk, Leyh, Catherine, Krieg, Sarah, Krieg, Andreas, Luedde, Tom, Loosen, Sven H., Kostev, Karel

Source: Journal of Clinical Medicine; Mar2024, Vol. 13 Issue 5, p1319, 8p

Subject Terms: LIVER diseases, APPENDICITIS, GUT microbiome, INDIVIDUAL development, AGE groups, REGRESSION analysis

Geographic Terms: GERMANY

Liver transplantation meets gastrointestinal cancer.

Authors: Loosen, Sven H., Leyh, Catherine, Neumann, Ulf Peter, Bock, Hans, Weigel, Christian, Luedde, Tom, Roderburg, Christoph

Source: Zeitschrift für Gastroenterologie; Jan2024, Vol. 62 Issue 1, p62-72, 11p

Association between Helicobacter pylori and its eradication and the development of cancer.

Authors: Loosen, Sven Heiko, Mertens, Alexander, Klein, Isabel, Leyh, Catherine, Krieg, Sarah, Kandler, Jennis, Luedde, Tom, Roderburg, Christoph, Kostev, Karel

Source: BMJ Open Gastroenterology; 2024, Vol. 11 Issue 1, p1-7, 7p

Herpes zoster is not associated with subsequent gastrointestinal cancer: data from over 200,000 outpatients in Germany.

Authors: Leyh, Catherine^1,2 (AUTHOR), Roderburg, Christoph^1,2 (AUTHOR) Christoph.Roderburg@med.uni-duesseldorf.de, Luedde, Tom^1,2 (AUTHOR), Loosen, Sven H.^1,2 (AUTHOR) Sven.Loosen@med.uni-duesseldorf.de, Kostev, Karel³ (AUTHOR)

Source: Journal of Cancer Research & Clinical Oncology. Dec2023, Vol. 149 Issue 19, p17115-17121. 7p.

Subject Terms: *HERPES zoster, *GASTROINTESTINAL cancer, *VARICELLA-zoster virus, *VIRUS diseases, *PROPENSITY score matching, *VIRUS reactivation

Geographic Terms: GERMANY

Prevalence of and factors associated with a treatment delay due to the COVID-19 pandemic in patients with gastrointestinal cancer in Europe.

Authors: Roderburg, Christoph, Loosen, Sven H., Leyh, Catherine, Joerdens, Markus S., Mohr, Raphael, Luedde, Tom, Alymova, Svetlana, Klein, Isabel, Kostev, Karel

Source: Journal of Cancer Research & Clinical Oncology; Oct2023, Vol. 149 Issue 13, p11849-11856, 8p

Subject Terms: TREATMENT delay (Medicine), COVID-19 pandemic, GASTROINTESTINAL cancer, CANCER patients, ASYMPTOMATIC patients

Geographic Terms: ITALY, SPAIN

Are sleep disorders associated with the risk of gastrointestinal cancer?—A case–control study.

Authors: Loosen, Sven, Krieg, Sarah, Krieg, Andreas, Leyh, Catherine, Luedde, Tom, Vetter, Céline, Kostev, Karel, Roderburg, Christoph

Source: Journal of Cancer Research & Clinical Oncology; Oct2023, Vol. 149 Issue 13, p11369-11378, 10p

Subject Terms: SLEEP disorders, GASTROINTESTINAL cancer, DISEASE risk factors, MENTAL illness, CASE-control method

Bilobar Radioembolization Carries the Risk of Radioembolization-Induced Liver Disease in the Treatment of Advanced Hepatocellular Carcinoma: Safety and Efficacy Comparison to Systemic Therapy with Atezolizumab/Bevacizumab.

Authors: Jeschke, Matthias, Ludwig, Johannes M., Leyh, Catherine, Pabst, Kim M., Weber, Manuel, Theysohn, Jens M., Lange, Christian M., Herrmann, Ken, Schmidt, Hartmut H. -J., Jochheim, Leonie S.

Source: Cancers; Sep2023, Vol. 15 Issue 17, p4274, 13p

Subject Terms: THERAPEUTIC use of monoclonal antibodies, DRUG efficacy, STATISTICS, CONFIDENCE intervals, RADIOEMBOLIZATION, ANTINEOPLASTIC agents, RETROSPECTIVE studies, MANN Whitney U Test, TUMOR classification, LIVER diseases, RISK assessment, T-test (Statistics), DESCRIPTIVE statistics, KAPLAN-Meier estimator, BEVACIZUMAB, DATA analysis software, HEPATOCELLULAR carcinoma, PATIENT safety, DISEASE risk factors

OS-079-YI Development and validation of the CABLE score to estimate individual prognosis of patients with hepatocellular carcinoma treated with 1L atezolizumab and bevacizumab

Authors: Gairing, Simon Johannes, Mildenberger, Philipp, Gile, Jennifer, Artusa, Fabian, Scheiner, Bernhard, Leyh, Catherine, Lieb, Sabine, Sinner, Friedrich, Jörg, Vincent, Fruendt, Thorben, Himmelsbach, Vera, Abedin, Nada, Sahin, Cennet, Boettcher, Katrin, Schuhbaur, Jasmin, Labuhn, Simon, Korolewicz, James, Fulgenzi, Claudia, D'Alessio, Antonio, Zanuso, Valentina, Hucke, Florian, Röhlen, Natascha, Khaled, Najib Ben, Ramadori, Eleonora, Müller, Lukas, Weinmann, Arndt, Kloeckner, Roman, Galle, Peter R., Tran, Nguyen H., Venkatesh, Sudhakar, Teufel, Andreas, de Toni, Enrico, Waldschmidt, Dirk-Thomas, Marquardt, Jens U., Bettinger, Dominik, Peck-Radosavljevic, Markus, Geier, Andreas, Reiter, Florian P, Rimassa, Lorenza, Pinato, David J., Roderburg, Christoph, Ettrich, Thomas, Bitzer, Michael, Scheble, Veit, Ehmer, Ursula, Berres, Marie-Luise, Finkelmeier, Fabian, Gonzalez-Carmona, Maria Angeles, von Felden, Johann, Schulze, Kornelius, Venerito, Marino, van Bömmel, Florian, Jochheim, Leonie, Pinter, Matthias, Mohr, Raphael, Ilyas, Sumera I., Schmidtmann, Irene, Foerster, Friedrich

Source: In Journal of Hepatology June 2024 80 Supplement 1:S52-S52

OS-057 - Risk of bleeding and thromboembolic events with atezolizumab/bevacizumab or lenvatinib in patients with hepatocellular carcinoma: a multicenter, retrospective study

Authors: Khaled, Najib Ben, Möller, Marie, Jochheim, Leonie, Leyh, Catherine, Ehmer, Ursula, Böttcher, Katrin, Leicht, Hans Benno, Rau, Monika, Sinner, Friedrich, Venerito, Marino, Gairing, Simon Johannes, Foerster, Friedrich, de Toni, Enrico, Geier, Andreas, Reiter, Florian P

Source: In Journal of Hepatology June 2023 78 Supplement 1:S51-S51

Real-World Data for Lenvatinib in Hepatocellular Carcinoma (ELEVATOR): A Retrospective Multicenter Study.

Authors: Welland, Sabrina, Leyh, Catherine, Finkelmeier, Fabian, Jefremow, André, Shmanko, Kateryna, Gonzalez-Carmona, Maria A., Kandulski, Arne, Jeliazkova, Petia, Best, Jan, Fründt, Thorben W., Djanani, Angela, Pangerl, Maria, Maieron, Andreas, Greil, Richard, Fricke, Christina, Sookthai, Disorn, Günther, Rainer, Schmiderer, Andreas, Wege, Henning, Venerito, Marino

Source: Liver Cancer (2235-1795); 2022, Vol. 11 Issue 3, p219-232, 14p

Subject Terms: HEPATOCELLULAR carcinoma, PROGRESSION-free survival, ELEVATORS, OVERALL survival

Geographic Terms: AUSTRIA

[⁶⁸Ga]Ga-PSMA-11 PET/CT improves tumor detection and impacts management in patients with hepatocellular carcinoma .

Authors: Hirmas, Nader, Leyh, Catherine, Sraieb, Miriam, Barbato, Francesco, Schaarschmidt, Benedikt M., Umutlu, Lale, Nader, Michael, Wedemeyer, Heiner, Ferdinandus, Justin, Rischpler, Christoph, Herrmann, Ken, Costa, Pedro Fragoso, Lange, Christian M., Weber, Manuel, Fendler, Wolfgang P.

Source: Journal of Nuclear Medicine; Dec2021, Vol. 62 Issue 12, p1-45, 45p

THU579 - LiMAx faciliates patient selection prior radioembolization for patients with hepatocellular carcinoma in liver cirrhosis

Authors: Leyh, Catherine, Heucke, Niklas, Schotten, Clemens, Buechter, Matthias, Bechmann, Lars, Wichert, Marc, Dechene, Alexander, Hermann, Ken, Katsounas, Antonios, Özcürümez, Mustafa, Heider, Dominik, Sydor, Svenja, Ludwig, Johannes M., Theysohn, Jens, Damm, Robert, Powerski, Maciej, Pech, Maciej, Canbay, Ali, Weigt, Jochen, Keitel-Anselmino, Verena, Lange, Christian, Best, Jan, Manka, Paul

Source: In Journal of Hepatology July 2022 77 Supplement 1:S378-S379