Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites

Authors: Dayton, Talya L., Alcala, Nicolas, Moonen, Laura, den Hartigh, Lisanne, Geurts, Veerle, Mangiante, Lise, Lap, Lisa, Dost, Antonella F.M., Beumer, Joep, Levy, Sonja, van Leeuwaarde, Rachel S., Hackeng, Wenzel M., Samsom, Kris, Voegele, Catherine, Sexton-Oates, Alexandra, Begthel, Harry, Korving, Jeroen, Hillen, Lisa, Brosens, Lodewijk A.A., Lantuejoul, Sylvie, Jaksani, Sridevi, Kok, Niels F.M., Hartemink, Koen J., Klomp, Houke M., Borel Rinkes, Inne H.M., Dingemans, Anne-Marie, Valk, Gerlof D., Vriens, Menno R., Buikhuisen, Wieneke, van den Berg, José, Tesselaar, Margot, Derks, Jules, Speel, Ernst Jan, Foll, Matthieu, Fernández-Cuesta, Lynnette, Clevers, Hans

Source: In Cancer Cell 11 December 2023 41(12):2083-2099

Postoperative radiotherapy in stage I–III Merkel cell carcinoma

Authors: Levy, Sonja, Blankenstein, Stephanie A., Grünhagen, Dirk Jan, Jalving, Mathilde, Hamming-Vrieze, Olga, Been, Lukas B., Tans, Lisa, van Akkooi, Alexander C.J., Tesselaar, Margot E.T.

Source: Radiotherapy and oncology. 166:203-211

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155814981.0x000001&indx=1&recIds=ETOCvdc_100155814981.0x000001

Well-Differentiated Bronchopulmonary Neuroendocrine Tumors: More Than One Entity

Authors: de Herder, Wouter, Dekkers, Olaf, van de Ven, Annenienke, Havekes, Bas, Drent, Madeleine, Bisschop, Peter, Zandee, Wouter, Valk, Gerlof, van den Broek, Medard F.M., Levy, Sonja, Buikhuisen, Wieneke A., Dijke, Kim, Hartemink, Koen J., van Leeuwaarde, Rachel S., Vriens, Menno R., Tesselaar, Margot E.T., Valk, Gerlof D.

Source: In Journal of Thoracic Oncology November 2021 16(11):1810-1820

Driver mutations occur frequently in metastases of well‐differentiated small intestine neuroendocrine tumours

Authors: Samsom, Kris G, Levy, Sonja, Veenendaal, Linde M, Roepman, Paul, Kodach, Liudmila L, Steeghs, Neeltje, Valk, Gerlof D, Wouter Dercksen, M, Kuhlmann, Koert F D, Verbeek, Wieke H M, Meijer, Gerrit A, Tesselaar, Margot E T, Berg, José G

Source: Histopathology. 78(4):556-566

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115215230.0x000001&indx=1&recIds=ETOCvdc_100115215230.0x000001

Four decades of experience with carcinoid heart disease: An analysis of 84 patients.

Authors: Levy, Sonja¹ (AUTHOR) so.levy@nki.nl, Korse, Catherina E.² (AUTHOR), de Groot, Andre C. A.³ (AUTHOR), Meijer, Ronald C. A.⁴ (AUTHOR), Tesselaar, Margot E. T.¹ (AUTHOR), Valk, Gerlof D.⁵ (AUTHOR)

Source: Journal of Neuroendocrinology. Oct2022, Vol. 34 Issue 10, p1-9. 9p.

Subject Terms: *HEART diseases, *CARCINOID, *SEROTONIN syndrome, *NEUROENDOCRINE tumors, *HEART valves, *SURVIVAL rate

Elevated Serotonin and NT-proBNP Levels Predict and Detect Carcinoid Heart Disease in a Large Validation Study.

Authors: Levy, Sonja¹ (AUTHOR) m.tesselaar@nki.nl, Kilgallen, Aoife B.^2,3 (AUTHOR) a.kilgallen@umcutrecht.nl, Korse, Catharina M.⁴ (AUTHOR) t.korse@nki.nl, Oerlemans, Marish I. F. J.³ (AUTHOR), Sluijter, Joost P. G.^2,3,5 (AUTHOR) j.sluijter@umcutrecht.nl, van Laake, Linda W.^2,3 (AUTHOR) l.w.vanlaake@umcutrecht.nl, Valk, Gerlof D.⁶ (AUTHOR) g.d.valk@umcutrecht.nl, Tesselaar, Margot E. T.¹ (AUTHOR)

Source: Cancers. May2022, Vol. 14 Issue 10, p2361-N.PAG. 13p.

Subject Terms: *HEART disease diagnosis, *BIOMARKERS, *CONNECTIVE tissue growth factor, *PREDICTIVE tests, *RESEARCH methodology, *SEROTONIN, *METASTASIS, *DESCRIPTIVE statistics, *PEPTIDE hormones, *DATA analysis software

Avelumab treatment for patients with metastatic Merkel cell carcinoma can be safely stopped after 1 year and a PET/CT–confirmed complete response.

Authors: Zijlker, Lisanne P.^1,2 (AUTHOR), Levy, Sonja³ (AUTHOR), Wolters, Wendy³ (AUTHOR), van Thienen, Johannes V.³ (AUTHOR), van Akkooi, Alexander C. J.^2,4,5 (AUTHOR), Tesselaar, Margot E. T.^3,6 (AUTHOR) m.tesselaar@nki.nl

Source: Cancer (0008543X). Feb2024, Vol. 130 Issue 3, p433-438. 6p.

Surgical Management of the Primary Tumor in Stage IV Small Intestinal Neuroendocrine Tumors: To Operate or Not to Operate, That Is the Question.

Authors: Dijke, Kim, Kuhlmann, Koert F.D., Levy, Sonja, Tesselaar, Margot E.T.

Source: Current Oncology Reports; Jun2023, Vol. 25 Issue 6, p679-688, 10p

Primary Tumor Resection is Associated with Improved Disease-Specific Mortality in Patients with Stage IV Small Intestinal Neuroendocrine Tumors (NETs): A Comparison of Upfront Surgical Resection Versus a Watch and Wait Strategy in Two Specialist NET Centers

Authors: Levy, Sonja, Arthur, James D., Banks, Melissa, Kok, Niels F. M., Fenwick, Stephen W., Diaz-Nieto, Rafael, van Leerdam, Monique E., Cuthbertson, Daniel J., Valk, Gerlof D., Kuhlmann, Koert F. D., Tesselaar, Margot E. T.

Source: Annals of Surgical Oncology: An Oncology Journal for Surgeons; Nov2022, Vol. 29 Issue 12, p7822-7832, 11p

Postoperative radiotherapy in Merkel cell carcinoma (MCC).

Authors: Levy, Sonja, Blankenstein, Stephanie, Grunhagen, Dirk J., Jalving, Mathilde, Hamming-Vrieze, Olga, Been, Lukas B., Tans, Lisa, Van Akkooi, Alexander Christopher Jonathan, Tesselaar, Margot Et

Source: Journal of clinical oncology. 39(15 suppl):9575-9575

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173224001.0x000001&indx=1&recIds=ETOCvdc_100173224001.0x000001

First-line everolimus and cisplatin in patients with advanced extrapulmonary neuroendocrine carcinoma: a nationwide phase 2 single-arm clinical trial.

Authors: Levy, Sonja, Verbeek, Wieke H.M., Eskens, Ferry A.L.M., van den Berg, José G., de Groot, Derk Jan A., van Leerdam, Monique E., Tesselaar, Margot E.T.

Source: Therapeutic Advances in Medical Oncology; 2/27/2022, p1-12, 12p

Well-Differentiated Bronchopulmonary Neuroendocrine Tumors: More Than One Entity.

Authors: van den Broek, Medard F.M., Levy, Sonja, Buikhuisen, Wieneke A., Dijke, Kim, Hartemink, Koen J., van Leeuwaarde, Rachel S., Vriens, Menno R., Tesselaar, Margot E.T., Valk, Gerlof D., DutchMEN Study Group

Source: Journal of Thoracic Oncology; Nov2021, Vol. 16 Issue 11, p1810-1820, 11p

Sudden cardiac death in families with premature cardiovascular disease.

Authors: Bruikman, Caroline, de Ronde, Maurice W. J., Amin, Ahmed, Levy, Sonja, Lof, Pien, de Ruijter, Ursula, Hovingh, Kees, Tan, Hanno L., Pinto-Sietsma, Sara-Joan

Source: Heart; Feb2020, Vol. 106 Issue 3, p228-232, 5p

Subject Terms: CARDIAC arrest, BRUGADA syndrome, CARDIOVASCULAR diseases, EARLY death, ACADEMIC medical centers, FAMILIAL hypercholesterolemia

ASO Visual Abstract: Primary Tumour Resection is Associated with Improved Disease-Specific Mortality in Patients with Stage IV Small Intestinal Neuroendocrine Tumours (NET)—A Comparison of Upfront Surgical Resection versus a Watch-and-Wait Strategy in Two Specialist NET Centres

Authors: Levy, Sonja, Arthur, James D., Banks, Melissa, Kok, Niels F. M., Fenwick, Stephen W., Diaz-Nieto, Rafael, van Leerdam, Monique E., Cuthbertson, Daniel J., Valk, Gerlof D., Kuhlmann, Koert F. D., Tesselaar, Margot E. T.

Source: Annals of Surgical Oncology: An Oncology Journal for Surgeons; Nov2022, Vol. 29 Issue 12, p7833-7834, 2p

Survival in Patients with Neuroendocrine Tumours of the Small Intestine: Nomogram Validation and Predictors of Survival.

Authors: Levy, Sonja¹ (AUTHOR) l.v.veenendaal@nki.nl, van Veenendaal, Linde M.¹ (AUTHOR) emilie.breekveldt@gmail.com, Korse, Catharina M.² (AUTHOR) t.korse@nki.nl, Breekveldt, Emilie C.H.¹ (AUTHOR) m.tesselaar@nki.nl, Verbeek, Wieke H.M.³ (AUTHOR) w.verbeek@nki.nl, Vriens, Menno R.⁴ (AUTHOR) mvriens@umcutrecht.nl, Kuhlmann, Koert F.D.⁵ (AUTHOR) k.kuhlmann@nki.nl, van den Berg, José G.⁶ (AUTHOR) j.vd.berg@nki.nl, Valk, Gerlof D.⁷ (AUTHOR) g.d.valk@umcutrecht.nl, Tesselaar, Margot E.T.¹ (AUTHOR)

Source: Journal of Clinical Medicine. Aug2020, Vol. 9 Issue 8, p2502. 1p.

Subject Terms: *SMALL intestine, *NOMOGRAPHY (Mathematics), *TUMORS, *DISEASE progression