T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

Authors: Philipp, Nora, Kazerani, Maryam, Nicholls, Alyssa, Vick, Binje, Wulf, Jan, Straub, Tobias, Scheurer, Michaela, Muth, Amelie, Hänel, Gerulf, Nixdorf, Daniel, Sponheimer, Monika, Ohlmeyer, Malte, Lacher, Sonja M., Brauchle, Bettina, Marcinek, Anetta, Rohrbacher, Lisa, Leutbecher, Alexandra, Rejeski, Kai, Weigert, Oliver, von Bergwelt-Baildon, Michael, Theurich, Sebastian, Kischel, Roman, Jeremias, Irmela, Bücklein, Veit, Subklewe, Marion

Source: Blood. 140(10):1104-1118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183236861.0x000001&indx=1&recIds=ETOCvdc_100183236861.0x000001

Combining venetoclax and azacytidine with T-cell bispecific antibodies for treatment of acute myeloid leukemia: a preclinical assessment

Authors: Hänel, Gerulf, Schönle, Anne, Neumann, Anne-Sophie, Nixdorf, Daniel, Philipp, Nora, Sponheimer, Monika, Leutbecher, Alexandra, Emhardt, Alica-Joana, Magno, Giulia, Bücklein, Veit, Eckmann, Jan, Dunshee, Diana, Kramar, Vesna, Korfi, Koorosh, Colombetti, Sara, Umaña, Pablo, Klein, Christian, Subklewe, Marion

Source: Leukemia; February 2024, Vol. 38 Issue: 2 p398-402, 5p

Impaired function and delayed regeneration of dendritic cells in COVID-19.

Authors: Winheim, Elena¹, Rinke, Linus¹, Lutz, Konstantin¹, Reischer, Anna^2,3, Leutbecher, Alexandra^2,3, Wolfram, Lina¹, Rausch, Lisa¹, Kranich, Jan¹, Wratil, Paul R.^4,5, Huber, Johanna E.¹, Baumjohann, Dirk^1,6, Rothenfusser, Simon^7,8, Schubert, Benjamin^9,10, Hilgendorff, Anne^11,12, Hellmuth, Johannes C.^2,13, Scherer, Clemens^13,14, Muenchhoff, Maximilian^4,5,13, von Bergwelt-Baildon, Michael^2,13,15, Stark, Konstantin^13,14, Straub, Tobias¹⁶

Source: PLoS Pathogens; 10/6/2021, Vol. 17 Issue 10, p1-30, 30p

Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.

Authors: Khatamzas, Elham, Antwerpen, Markus H., Rehn, Alexandra, Graf, Alexander, Hellmuth, Johannes Christian, Hollaus, Alexandra, Mohr, Anne-Wiebe, Gaitzsch, Erik, Weiglein, Tobias, Georgi, Enrico, Scherer, Clemens, Stecher, Stephanie-Susanne, Gruetzner, Stefanie, Blum, Helmut, Krebs, Stefan, Reischer, Anna, Leutbecher, Alexandra, Subklewe, Marion, Dick, Andrea, Zange, Sabine

Source: Nature Communications; 9/23/2022, Vol. 13 Issue 1, p1-12, 12p

Subject Terms: B cell lymphoma, SARS-CoV-2, T cells, CD8 antigen, IMMUNOGLOBULINS, B cells

SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells.

Authors: Tahk, Siret, Vick, Binje, Hiller, Björn, Schmitt, Saskia, Marcinek, Anetta, Perini, Enrico D., Leutbecher, Alexandra, Augsberger, Christian, Reischer, Anna, Tast, Benjamin, Humpe, Andreas, Jeremias, Irmela, Subklewe, Marion, Fenn, Nadja C., Hopfner, Karl-Peter

Source: Journal of Hematology & Oncology; 9/27/2021, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: ANTIBODY-dependent cell cytotoxicity, CHIMERIC proteins, ACUTE myeloid leukemia, IMMUNOGLOBULINS, SURFACE plasmon resonance, SINGLE molecules

Augmenting Efficacy of T-Cell Bispecific Antibodies in AML through a Tumor Stroma-Targeted 4-1BB Agonist

Authors: Hänel, Gerulf, Neumann, Anne-Sophie, Pulko, Vesna, Claus, Christina, Leutbecher, Alexandra, Marcinek, Anetta, Zieger, Nora, Buecklein, Veit L, Umana, Pablo, Klein, Christian, Subklewe, Marion

Source: In Blood 23 November 2021 138 Supplement 1:1178-1178

Treatment-Free Intervals during CD19xCD3 BiTE ® Construct-Mediated T-Cell Stimulation Induce Functional Reinvigoration and Transcriptional Reprogramming of Exhausted T Cells

Authors: Zieger, Nora, Kazerani Pasikhani, Maryam, Straub, Tobias, Nicholls, Alyssa, Hänel, Gerulf, Wulf, Jan, Scheurer, Michaela, Nixdorf, Daniel, Sponheimer, Monika, Lacher, Sonja M, Brauchle, Bettina, Marcinek, Anetta, Rohrbacher, Lisa, Leutbecher, Alexandra, von Bergwelt, Michael, Spiekermann, Karsten, Weigert, Oliver, Theurich, Sebastian, Buecklein, Veit L, Kischel, Roman, Subklewe, Marion

Source: In Blood 23 November 2021 138 Supplement 1:513-513

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