A multi-modal molecular characterization of the Philadelphia translocation featuring long read sequencing

Authors: Yin Law, Janet Hei ^a, Au, Chun Hang ^a, Leung, Amy Wing-Sze ^a, Leung, Henry C.M. ^a, Wong, Elaine Y.L. ^a, Ip, Beca B.K. ^a, Ho, Dona N.Y. ^a, Ma, Shing Yan ^b, Chan, Helen M.H. ^b, Chiu, Edmond K.W. ^b, Chim, James C.S. ^c, Liang, Raymond H.S. ^c, Wan, Thomas S.K. ^a, Ma, Edmond S.K. ^{a, ⁎}

Source: In Gene 20 May 2025 950

Applications and potentials of nanopore sequencing in the (epi)genome and (epi)transcriptome era

Authors: Xie, Shangqian, Leung, Amy Wing-Sze, Zheng, Zhenxian, Zhang, Dake, Xiao, Chuanle, Luo, Ruibang, Luo, Ming, Zhang, Shoudong

Source: In The Innovation 28 November 2021 2(4)

Duet: SNP-assisted structural variant calling and phasing using Oxford nanopore sequencing.

Authors: Zhou, Yekai¹ (AUTHOR), Leung, Amy Wing-Sze¹ (AUTHOR), Ahmed, Syed Shakeel¹ (AUTHOR), Lam, Tak-Wah¹ (AUTHOR), Luo, Ruibang¹ (AUTHOR) rbluo@cs.hku.hk

Source: BMC Bioinformatics. 11/7/2022, Vol. 23 Issue 1, p1-12. 12p.

Subject Terms: *NUCLEOTIDE sequencing, *WHOLE genome sequencing, *SINGLE nucleotide polymorphisms, *HAPLOTYPES

ECNano: A cost-effective workflow for target enrichment sequencing and accurate variant calling on 4800 clinically significant genes using a single MinION flowcell.

Authors: Leung, Amy Wing-Sze¹ (AUTHOR), Leung, Henry Chi-Ming¹ (AUTHOR), Wong, Chak-Lim¹ (AUTHOR), Zheng, Zhen-Xian¹ (AUTHOR), Lui, Wui-Wang¹ (AUTHOR), Luk, Ho-Ming² (AUTHOR), Lo, Ivan Fai-Man² (AUTHOR), Luo, Ruibang¹ (AUTHOR) rbluo@cs.hku.hk, Lam, Tak-Wah¹ (AUTHOR) twlam@cs.hku.hk

Source: BMC Medical Genomics. 3/4/2022, Vol. 15 Issue 1, p1-14. 14p.

Subject Terms: *TURNAROUND time, *WORKFLOW, *GENES, *WORKFLOW software, *MEDICAL screening, *THERAPEUTICS, *NUCLEOTIDE sequencing

ETV:SGSH, a brain-penetrant enzyme transport vehicle for SGSH, improves lysosomal and microglial morphology, degeneration and cognitive behavior in MPS IIIA mice

Authors: Masoud, Shababa T., Nguyen, Hoang, Discenza, Claire, Joy, David, Simms, Jeffrey, Lo, Iris, Chun, You Young, Holtzman, Julia, Tsogtbaatar, Khishig, Leung, Amy Wing-Sze, Becerra, Isabel, Thomsen, Elliot, Gill, Audrey, Rajendra, Yashas, Seay, Alexander, Jafarnejad, Mohammad, Bakardjiev, Anna, Calvert, Meredith E.K., Mahon, Cathal S., Thorne, Robert, Chessler, Steven, Henne, Kirk, Sanchez, Pascal, Arguello, Annie

Source: In Molecular Genetics and Metabolism February 2024 141(2)

Evaluation of Mycobacterium tuberculosis enrichment in metagenomic samples using ONT adaptive sequencing and amplicon sequencing for identification and variant calling.

Authors: Su, Junhao, Lui, Wui Wang, Lee, YanLam, Zheng, Zhenxian, Siu, Gilman Kit-Hang, Ng, Timothy Ting-Leung, Zhang, Tong, Lam, Tommy Tsan-Yuk, Lao, Hiu-Yin, Yam, Wing-Cheong, Tam, Kingsley King-Gee, Leung, Kenneth Siu-Sing, Lam, Tak-Wah, Leung, Amy Wing-Sze, Luo, Ruibang

Source: Scientific Reports; 3/31/2023, Vol. 13 Issue 1, p1-10, 10p

Subject Terms: MYCOBACTERIUM tuberculosis, DRUG resistance in microorganisms, METAGENOMICS, DETECTION limit, BACTERIAL cultures, TUBERCULOSIS, IDENTIFICATION

Company/Entity: UNIVERSITY of Oxford

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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.

Authors: Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung H., Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E., DeVos, Sarah L., Earr, Timothy K., Lin, Chia-Ching, Davis, Sonnet, Ha, Connie, Leung, Amy Wing-Sze, Nguyen, Hoang, Chau, Roni, Yulyaningsih, Ernie, Lopez, Isabel, Solanoy, Hilda, Masoud, Shababa T.

Source: Molecular Neurodegeneration; 6/11/2022, Vol. 17 Issue 1, p1-29, 29p

Subject Terms: AMYLOID plaque, MICROGLIA, LABORATORY mice, ANIMAL disease models, PATHOLOGY, AMYLOID, ALZHEIMER'S disease

HKG: an open genetic variant database of 205 Hong Kong cantonese exomes.

Authors: Ou, Min, Leung, Henry Chi-Ming, Leung, Amy Wing-Sze, Luk, Ho-Ming, Yan, Bin, Liu, Chi-Man, Tong, Tony Ming-For, Mok, Myth Tsz-Shun, Ko, Wallace Ming-Yuen, Law, Wai-Chun, Lam, Tak-Wah, Lo, Ivan Fai-Man, Luo, Ruibang

Source: NAR Genomics & Bioinformatics; Mar2022, Vol. 4 Issue 1, p1-13, 13p

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