Piezo1 activation augments sickling propensity and the adhesive properties of sickle red blood cells in a calcium‐dependent manner

Authors: Nader, Elie, Conran, Nicola, Leonardo, Flavia C., Hatem, Aline, Boisson, Camille, Carin, Romain, Renoux, Céline, Costa, Fernando F., Joly, Philippe, Brito, Pamela L., Esperti, Sofia, Bernard, Joelle, Gauthier, Alexandra, Poutrel, Solene, Bertrand, Yves, Garcia, Caroline, Saad, Sara T. O., Egée, Stéphane, Connes, Philippe

Source: British journal of haematology. 202(3):657-668

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187933396.0x000001&indx=1&recIds=ETOCvdc_100187933396.0x000001

Molecular and cellular effects of in vivo chronic intravascular hemolysis and anti-inflammatory therapeutic approaches

Authors: Gotardo, Érica M.F., Brito, Pamela L., Gushiken, Lucas F.S., Chweih, Hanan, Leonardo, Flavia C., Costa, Fernando F., Conran, Nicola

Source: In Vascular Pharmacology June 2023 150

Chronic treatment with resveratrol improves overactive bladder in obese mice via antioxidant activity

Authors: Alexandre, Eduardo C., Calmasini, Fabiano B., de Oliveira, Mariana G., Silva, Fábio H., da Silva, Carmem P.V., André, Diana M., Leonardo, Flávia C., Delbin, Maria A., Antunes, Edson

Source: In European Journal of Pharmacology 5 October 2016 788:29-36

Reduced plasma angiotensin II levels are reversed by hydroxyurea treatment in mice with sickle cell disease

Authors: dos Santos, Alisson F., Almeida, Camila B., Brugnerotto, Ana F., Roversi, Fernanda M., Pallis, Flávia R., Franco-Penteado, Carla F., Lanaro, Carolina, Albuquerque, Dulcinéia M., Leonardo, Flávia C., Costa, Fernando F., Conran, Nicola

Source: In Life Sciences 4 November 2014 117(1):7-12

Didox (3, 4-dihydroxybenzohydroxamic acid) reduces the vascular inflammation induced by acute intravascular hemolysis

Authors: Silva, Juliete A.F., Gotardo, Érica M.F., Chweih, Hanan, Miguel, Lediana I., Ferreira, Wilson A., Hedlund, Bo, Elford, Howard L., Leonardo, Flavia C., Costa, Fernando F., Conran, Nicola

Source: Blood cells, molecules & diseases. 81

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096995263.0x000001&indx=1&recIds=ETOCvdc_100096995263.0x000001

P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion

Authors: Gotardo, Erica M.F. ^*, Torres, Lidiane S. ^*, Gushiken, Lucas F.S. ^*, Brito, Pamela L. ^*, Leonardo, Flavia C. ^*, Agoulnik, Sergei ^*, Kovarik, Jiri ^*, Bruederle, Andreas ^*, Millholland, John ^*, Vitaliti, Alessandra ^*, Förster, Irmgard ^*, Costa, Fernando Ferreira, Conran, Nicola

Source: In Blood 15 November 2022 140 Supplement 1:8230-8232

Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease

Authors: Gotardo, Erica M.F., Gushiken, Lucas F.S., Brito, Pamela L, Leonardo, Flavia C., Torres, Lidiane S., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Costa, Fernando Ferreira, Conran, Nicola

Source: In Blood 2 November 2023 142 Supplement 1:2487-2487

Caspase-1 As a Therapeutic Target in Intravascular Hemolysis-Induced Microvascular Inflammation and Occlusive Processes

Authors: Brito, Pamela L, Gotardo, Erica M.F., Gushiken, Lucas F.S., Leonardo, Flavia C., Costa, Fernando Ferreira, Conran, Nicola

Source: In Blood 2 November 2023 142 Supplement 1:1078-1078

Didox (3,4-dihydroxybenzohydroxamic acid) reduces the vascular inflammation induced by acute intravascular hemolysis

Authors: Silva, Juliete A.F., Gotardo, Érica M.F., Chweih, Hanan, Miguel, Lediana I., Ferreira, Wilson A., Jr, Hedlund, Bo, Elford, Howard L., Leonardo, Flavia C., Costa, Fernando F., Conran, Nicola

Source: In Blood Cells, Molecules and Diseases March 2020 81

Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition.

Authors: Brito, Pamela L., dos Santos, Alisson F., Chweih, Hanan, Favero, Maria E., Gotardo, Erica M. F., Silva, Juliete A. F., Leonardo, Flavia C., Franco-Penteado, Carla F., de Oliveira, Mariana G., Ferreira Jr., Wilson A., Zaidan, Bruna C., Billis, Athanase, Baldanzi, Giorgio, Mashima, Denise A., Antunes, Edson, Saad, Sara T. Olalla, Costa, Fernando F., Conran, Nicola

Source: PLoS ONE; 2/3/2022, Vol. 17 Issue 2, p1-19, 19p

Subject Terms: ANGIOTENSIN converting enzyme, SICKLE cell anemia, BLOOD pressure, ACE inhibitors, ANGIOTENSIN II, HYPOTENSION

Acute intravascular haemolysis rapidly shifts the balance of angiogenic factors and accelerates neovascularization in vivo.

Authors: Gotardo, Erica M. F.¹ (AUTHOR) erikinha_gotardo@yahoo.com.br, Brito, Pamela L.¹ (AUTHOR), Leonardo, Flavia C.¹ (AUTHOR), Costa, Raquel² (AUTHOR), Soares, Raquel² (AUTHOR), Costa, Fernando F.¹ (AUTHOR), Conran, Nicola¹ (AUTHOR) conran@unicamp.br

Source: British Journal of Haematology. Mar2025, p1. 5p. 2 Illustrations.

P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In VivoModel of Acute Sickle Cell Vaso-Occlusion

Authors: Gotardo, Erica M.F., Torres, Lidiane S., Gushiken, Lucas F.S., Brito, Pamela L., Leonardo, Flavia C., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Vitaliti, Alessandra, Förster, Irmgard, Costa, Fernando Ferreira, Conran, Nicola

Source: Blood; November 2022, Vol. 140 Issue: 1, Number 1 Supplement 1 p8230-8232, 3p

Anti-Inflammatory Effects of Hydroxyurea in a Murine Model of Chronic Intravascular Hemolysis

Authors: Gotardo, Erica M.F. ^*, Brito, Pamela L. ^*, Chweih, Hanan ^*, Leonardo, Flavia C. ^*, Costa, Fernando Ferreira, Conran, Nicola

Source: In Blood 13 November 2019 134 Supplement 1:2263-2263

Heme Induces Significant Neutrophil Adhesion in Vitro Via an Nfκb-Dependent Pathway

Authors: Miguel, Lediana I. ^*, Torres, Lidiane S. ^*, Ferreira, Wilson A., Jr. ^*, Fabris, Fernanda C.Z. ^*, Leonardo, Flavia C. ^*, Costa, Fernando F., Conran, Nicola

Source: In Blood 29 November 2018 132 Supplement 1:3610-3610

Acute Hemolysis Induces Pro-Angiogenic Molecule Production and Neovascularization In Vivo

Authors: Gotardo, Erica M.F. ^*, Chweih, Hanan ^*, Brito, Pamela L. ^*, Leonardo, Flavia C. ^*, Costa, Raquel ^*, Soares, Raquel ^*, Costa, Fernando F., Conran, Nicola

Source: In Blood 29 November 2018 132 Supplement 1:3608-3608

Combined Administration of Recombinant TGF-β1 and DMSO Decreases the in Vitro Inflammatory Properties of Neutrophils from Sickle Cell Anemia Individuals

Authors: Torres, Lidiane S. ^*, Miguel, Lediana I. ^*, Shaul, Merav E. ^*, Fridlender, Zvi G. ^*, Ferreira, Wilson A., Jr. ^*, Leonardo, Flavia C. ^*, Olalla Saad, Sara T., Costa, Fernando F., Conran, Nicola

Source: In Blood 29 November 2018 132 Supplement 1:2366-2366

Glomerular Hypertrophy and Alterations in Renin-Angiotensin System Activation Are Associated with Diminished Systemic Blood Pressure in Aging Mice with Sickle Cell Anemia

Authors: Brito, Pamela L. ^*, Gotardo, Erica M.F. ^*, Chweih, Hanan ^*, Ferreira, Wilson A., Jr. ^*, Leonardo, Flavia C. ^*, Franco-Penteado, Carla F., Oliveira, Mariana Gonçalves ^*, Antunes, Edson ^*, Costa, Fernando F., Conran, Nicola

Source: In Blood 29 November 2018 132 Supplement 1:2362-2362

TNF-Induced Vaso-Occlusive and Inflammatory Processes in Mice with Sickle Cell Anemia Are Abrogated By the Platelet Activation Inhibitor, Prasugrel

Authors: Chweih, Hanan ^*, Silva, Juliete A.F. ^*, Gotardo, Erica M.F. ^*, Brito, Pamela L. ^*, Barbosa, Guilherme G.O. ^*, Garcia, Flavia ^*, Ferreira, Wilson A., Jr. ^*, Leonardo, Flavia C. ^*, Franco-Penteado, Carla F., Costa, Fernando F., Conran, Nicola

Source: In Blood 29 November 2018 132 Supplement 1:2354-2354

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