DeepFDR: A Deep Learning-based False Discovery Rate Control Method for Neuroimaging Data

Authors: Kim, Taehyo, Shu, Hai, Jia, Qiran, de Leon, Mony J.

Source: Proceedings of The 27th International Conference on Artificial Intelligence and Statistics (AISTATS 2024), PMLR 238:946-954, 2024

Subject Terms: Statistics - Machine Learning, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning

Access URL: http://arxiv.org/abs/2310.13349

PET Imaging of Neurofluids

Authors: Zhou, Liangdong, Li, Yi, de Leon, Mony J. ^∗

Source: In Neuroimaging Clinics of North America May 2025 35(2):223-238

Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy

Authors: Weiner, Michael, Aisen, Paul, Petersen, Ronald, Jack, Clifford R., Jagust, William, Trojanowki, John Q., Toga, Arthur W., Beckett, Laurel, Green, Robert C., Saykin, Andrew J., Morris, John, Shaw, Leslie M., Liu, Enchi, Montine, Tom, Thomas, Ronald G., Donohue, Michael, Walter, Sarah, Gessert, Devon, Sather, Tamie, Jiminez, Gus, Harvey, Danielle, Bernstein, Matthew, Fox, Nick, Thompson, Paul, Schuff, Norbert, DeCarli, Charles, Borowski, Bret, Gunter, Jeff, Senjem, Matt, Vemuri, Prashanthi, Jones, David, Kantarci, Kejal, Ward, Chad, Koeppe, Robert A., Foster, Norm, Reiman, Eric M., Chen, Kewei, Mathis, Chet, Landau, Susan, Cairns, Nigel J., Householder, Erin, Reinwald, Lisa Taylor, Lee, Virginia, Korecka, Magdalena, Figurski, Michal, Crawford, Karen, Neu, Scott, Foroud, Tatiana M., Potkin, Steven, Shen, Li, Kelley, Faber, Kim, Sungeun, Nho, Kwangsik, Kachaturian, Zaven, Frank, Richard, Snyder, Peter J., Molchan, Susan, Kaye, Jeffrey, Quinn, Joseph, Lind, Betty, Carter, Raina, Dolen, Sara, Schneider, Lon S., Pawluczyk, Sonia, Beccera, Mauricio, Teodoro, Liberty, Spann, Bryan M., Brewer, James, Vanderswag, Helen, Fleisher, Adam, Heidebrink, Judith L., Lord, Joanne L., Mason, Sara S., Albers, Colleen S., Knopman, David, Johnson, Kris, Doody, Rachelle S., Meyer, Javier Villanueva, Chowdhury, Munir, Rountree, Susan, Dang, Mimi, Stern, Yaakov, Honig, Lawrence S., Bell, Karen L., Ances, Beau, Morris, John C., Carroll, Maria, Leon, Sue, Mintun, Mark A., Schneider, Stacy, Oliver, Angela, Marson, Daniel, Griffith, Randall, Clark, David, Geld-macher, David, Brockington, John, Roberson, Erik, Grossman, Hillel, Mitsis, Effie, Leyla deToledo-Morrell, Shah, Raj C., Duara, Ranjan, Varon, Daniel, Greig, Maria T., Roberts, Peggy, Albert, Marilyn, Onyike, Chiadi, D’Agostino, Daniel, Kielb, Stephanie, Galvin, James E., Pogorelec, Dana M., Cerbone, Brittany, Michel, Christina A., Rusinek, Henry, de Leon, Mony J., Glodzik, Lidia, De Santi, Susan, Doraiswamy, P. Murali, Petrella, Jeffrey R., Wong, Terence Z., Arnold, Steven E., Karlawish, Jason H., Wolk, David, Smith, Charles D., Jicha, Greg, Hardy, Peter, Sinha, Partha, Oates, Elizabeth, Conrad, Gary, Lopez, Oscar L., Oakley, MaryAnn, Simpson, Donna M., Porsteinsson, Anton P., Goldstein, Bonnie S., Martin, Kim, Makino, Kelly M., Ismail, M. Saleem, Brand, Connie, Mulnard, Ruth A., Thai, Gaby, Adams Ortiz, Catherine Mc, Womack, Kyle, Mathews, Dana, Quiceno, Mary, Arrastia, Ramon Diaz, King, Richard, Weiner, Myron, Cook, Kristen Martin, DeVous, Michael, Levey, Allan I., Lah, James J., Cellar, Janet S., Burns, Jeffrey M., Anderson, Heather S., Swerdlow, Russell H., Apostolova, Liana, Tingus, Kathleen, Woo, Ellen, Silverman, Daniel H.S., Lu, Po H., Bartzokis, George, Graff Radford, Neill R., Parfitt, Francine, Kendall, Tracy, Johnson, Heather, Farlow, Martin R., Hake, AnnMarie, Matthews, Brandy R., Herring, Scott, Hunt, Cynthia, van Dyck, Christopher H., Carson, Richard E., MacAvoy, Martha G., Chertkow, Howard, Bergman, Howard, Hosein, Chris, Black, Sandra, Stefanovic, Bojana, Caldwell, Curtis, Robin Hsiung, Ging-Yuek, Feldman, Howard, Mudge, Benita, Assaly, Michele, Kertesz, Andrew, Rogers, John, Trost, Dick, Bernick, Charles, Munic, Donna, Kerwin, Diana, Mesulam, Marek Marsel, Lipowski, Kristine, Wu, Chuang Kuo, Johnson, Nancy, Sadowsky, Carl, Martinez, Walter, Villena, Teresa, Turner, Raymond Scott, Johnson, Kathleen, Reynolds, Brigid, Sperling, Reisa A., Johnson, Keith A., Marshall, Gad, Frey, Meghan, Yesavage, Jerome, Taylor, Joy L., Lane, Barton, Rosen, Allyson, Tinklenberg, Jared, Sabbagh, Marwan N., Belden, Christine M., Jacobson, Sandra A., Sirrel, Sherye A., Kowall, Neil, Killiany, Ronald, Budson, Andrew E., Norbash, Alexander, Johnson, Patricia Lynn, Obisesan, Thomas O., Wolday, Saba, Allard, Joanne, Lerner, Alan, Ogrocki, Paula, Hudson, Leon, Fletcher, Evan, Carmichael, Owen, Olichney, John, Kittur, Smita, Borrie, Michael, Lee, T.Y., Bartha, Rob, Johnson, Sterling, Asthana, Sanjay, Carlsson, Cynthia M., Potkin, Steven G., Preda, Adrian, Nguyen, Dana, Tariot, Pierre, Reeder, Stephanie, Bates, Vernice, Capote, Horacio, Rainka, Michelle, Scharre, Douglas W., Kataki, Maria, Adeli, Anahita, Zimmerman, Earl A., Celmins, Dzintra, Brown, Alice D., Pearlson, Godfrey D., Blank, Karen, Anderson, Karen, Santulli, Robert B., Kitzmiller, Tamar J., Schwartz, Eben S., Sink, Kaycee M., Williamson, Jeff D., Garg, Pradeep, Watkins, Franklin, Ott, Brian R., Querfurth, Henry, Tremont, Geoffrey, Salloway, Stephen, Malloy, Paul, Correia, Stephen, Rosen, Howard J., Miller, Bruce L., Mintzer, Jacobo, Spicer, Kenneth, Bachman, David, Finger, Elizabeth, Pasternak, Stephen, Rachinsky, Irina, Drost, Dick, Pomara, Nunzio, Hernando, Raymundo, Sarrael, Antero, Schultz, Susan K., Boles Ponto, Laura L., Shim, Hyungsub, Smith, Karen Elizabeth, Relkin, Norman, Chaing, Gloria, Raudin, Lisa, Smith, Amanda, Fargher, Kristin, Raj, Balebail Ashok, Barisano, Giuseppe ^{a, ∗}, Iv, Michael ^b, Choupan, Jeiran ^{c, d}, Hayden-Gephart, Melanie ^a

Source: In eBioMedicine January 2025 111

Retrospective analysis of Braak stage– and APOE4 allele–dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly

Authors: Chen, Anna M. ^{a, b, c}, Gajdošík, Martin ^{a, b, d}, Ahmed, Wajiha ^e, Ahn, Sinyeob ^f, Babb, James S. ^{a, b}, Blessing, Esther M. ^{g, h}, Boutajangout, Allal ^{e, i}, de Leon, Mony J. ^{j, k}, Debure, Ludovic ^e, Gaggi, Naomi ^{g, h}, Gajdošík, Mia ^{a, b}, George, Ajax ^{a, b}, Ghuman, Mobeena ^e, Glodzik, Lidia ^k, Harvey, Patrick ^k, Juchem, Christoph ^{d, l}, Marsh, Karyn ^e, Peralta, Rosemary ^{a, b}, Rusinek, Henry ^{a, b}, Sheriff, Sulaiman ^m, Vedvyas, Alok ^e, Wisniewski, Thomas ^{e, g, n}, Zheng, Helena ^{a, b}, Osorio, Ricardo ^{g, h, ⁎}, Kirov, Ivan I. ^{a, b, c, e, o, ⁎}

Source: In NeuroImage 15 August 2024 297

Multimodal assessment of brain fluid clearance is associated with amyloid-beta deposition in humans

Authors: Zhou, Liangdong, Butler, Tracy A., Wang, Xiuyuan H., Xi, Ke, Tanzi, Emily B., Glodzik, Lidia, Chiang, Gloria C., de Leon, Mony J., Li, Yi

Source: In Journal of Neuroradiology June 2024 51(4)

Impaired sleep is associated with tau deposition on 18F-flortaucipir PET and accelerated cognitive decline, accounting for medications that affect sleep

Authors: Kim, Ryan T., Zhou, Liangdong, Li, Yi, Krieger, Ana C., Nordvig, Anna S., Butler, Tracy, de Leon, Mony J., Chiang, Gloria C.

Source: In Journal of the Neurological Sciences 15 March 2024 458

Thriving In and Out of the Reading Room: A Faculty Development Workshop

Authors: May, Benjamin J., Dodelzon, Katerina, Katzen, Janine, Lamparello, Nicole A., Legasto, Alan C., Chatterji, Manjil, Lo, Grace C., de Leon, Mony J., Schweitzer, Andrew D., Min, Robert J.

Source: In Academic Radiology March 2024 31(3):1141-1147

Association of liver fibrosis with cognitive test performance and brain imaging parameters in the UK Biobank study

Authors: Parikh, Neal S., Kamel, Hooman, Zhang, Cenai, Gupta, Ajay, Cohen, David E., Leon, Mony J., Gottesman, Rebecca F., Iadecola, Costantino

Source: Alzheimer's & dementia. 19(4):1518-1528

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179298084.0x000001&indx=1&recIds=ETOCvdc_100179298084.0x000001

Quadratic relationship between systolic blood pressure and white matter lesions in individuals with hypertension

Authors: Woldstad, Christopher, Rusinek, Henry, Sweeney, Elizabeth, Butler, Tracy, Li, Yi, Tanzi, Emily, Mardy, Christopher, Harvey, Patrick, de Leon, Mony J., Glodzik, Lidia

Source: Journal of hypertension. 41(1):35-43

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178861730.0x000001&indx=1&recIds=ETOCvdc_100178861730.0x000001

Association between lower body temperature and increased tau pathology in cognitively normal older adults

Authors: Blessing, Esther M., Parekh, Ankit, Betensky, Rebecca A., Babb, James, Saba, Natalie, Debure, Ludovic, Varga, Andrew W., Ayappa, Indu, Rapoport, David M., Butler, Tracy A., de Leon, Mony J., Wisniewski, Thomas, Lopresti, Brian J., Osorio, Ricardo S.

Source: In Neurobiology of Disease September 2022 171

Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease

Authors: Mehta, Neel H., Suss, Richard A., Dyke, Jonathan P., Theise, Neil D., Chiang, Gloria C., Strauss, Sara, Saint-Louis, Leslie, Li, Yi, Pahlajani, Silky, Babaria, Vivek, Glodzik, Lidia, Carare, Roxana O., de Leon, Mony J.

Source: In Neurobiology of Disease August 2022 170

Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta‐analysis.

Authors: Khalafi, Mohammad, Dartora, William J., McIntire, Laura Beth J., Butler, Tracy A., Wartchow, Krista M., Hojjati, Seyed Hani, Razlighi, Qolamreza R., Shirbandi, Kiarash, Zhou, Liangdong, Chen, Kewei, Xi, Ke, Banerjee, Samprit, Foldi, Nancy, Pahlajani, Silky, Glodzik, Lidia, Li, Yi, de Leon, Mony J., Chiang, Gloria C.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Feb2025, Vol. 21 Issue 2, p1-22, 22p

Association between liver fibrosis and incident dementia in the UK Biobank study

Authors: Parikh, Neal S., Kamel, Hooman, Zhang, Cenai, Kumar, Sonal, Rosenblatt, Russell, Spincemaille, Pascal, Gupta, Ajay, Cohen, David E., Leon, Mony J., Gottesman, Rebecca F., Iadecola, Costantino

Source: European journal of neurology. 29(9):2622-2630

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165329887.0x000001&indx=1&recIds=ETOCvdc_100165329887.0x000001

Diffusion tensor-based analysis of white matter in the healthy aging canine brain

Authors: Barry, Erica F., Loftus, John P., Luh, Wen-Ming, de Leon, Mony J., Niogi, Sumit N., Johnson, Philippa J.

Source: In Neurobiology of Aging September 2021 105:129-136

Rationale, study design and implementation of the LUCINDA Trial: Leuprolide plus Cholinesterase Inhibition to reduce Neurologic Decline in Alzheimer's

Authors: Butler, Tracy, Goldberg, Judith D., Galvin, James E., Maloney, Thomas, Ravdin, Lisa, Glodzik, Lidia, de Leon, Mony J., Hochman, Tsivia, Bowen, Richard L., Atwood, Craig S.

Source: In Contemporary Clinical Trials August 2021 107

Tau‐Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease

Authors: Das, Sandhitsu R., Lyu, Xueying, Duong, Michael Tran, Xie, Long, McCollum, Lauren, Flores, Robin, DiCalogero, Michael, Irwin, David J., Dickerson, Bradford C., Nasrallah, Ilya M., Yushkevich, Paul A., Wolk, David A., Weiner, Michael, Aisen, Paul, Petersen, Ronald, Jack, Clifford R., Jagust, William, Trojanowki, John Q., Toga, Arthur W., Beckett, Laurel, Green, Robert C., Saykin, Andrew J., Morris, John, Shaw, Leslie M., Liu, Enchi, Montine, Tom, Thomas, Ronald G., Donohue, Michael, Walter, Sarah, Gessert, Devon, Sather, Tamie, Jiminez, Gus, Harvey, Danielle, Bernstein, Matthew, Fox, Nick, Thompson, Paul, Schuff, Norbert, DeCArli, Charles, Borowski, Bret, Gunter, Jeff, Senjem, Matt, Vemuri, Prashanthi, Jones, David, Kantarci, Kejal, Ward, Chad, Koeppe, Robert A., Foster, Norm, Reiman, Eric M., Chen, Kewei, Mathis, Chet, Landau, Susan, Cairns, Nigel J., Householder, Erin, Reinwald, Lisa Taylor, Lee, Virginia, Korecka, Magdalena, Figurski, Michal, Crawford, Karen, Neu, Scott, Foroud, Tatiana M., Potkin, Steven, Shen, Li, Kelley, Faber, Kim, Sungeun, Nho, Kwangsik, Kachaturian, Zaven, Frank, Richard, Snyder, Peter J., Molchan, Susan, Kaye, Jeffrey, Quinn, Joseph, Lind, Betty, Carter, Raina, Dolen, Sara, Schneider, Lon S., Pawluczyk, Sonia, Beccera, Mauricio, Teodoro, Liberty, Spann, Bryan M., Brewer, James, Vanderswag, Helen, Fleisher, Adam, Heidebrink, Judith L., Lord, Joanne L., Mason, Sara S., Albers, Colleen S., Knopman, David, Johnson, Kris, Doody, Rachelle S., Meyer, Javier Villanueva, Chowdhury, Munir, Rountree, Susan, Dang, Mimi, Stern, Yaakov, Honig, Lawrence S., Bell, Karen L., Ances, Beau, Morris, John C., Carroll, Maria, Leon, Sue, Mintun, Mark A., Schneider, Stacy, Oliver, Angela, Marson, Daniel, Griffith, Randall, Clark, David, Geld‐Macher, David, Brockington, John, Roberson, Erik, Grossman, Hillel, Mitsis, Effie, Toledo‐Morrell, Leyla, Shah, Raj C., Duara, Ranjan, Varon, Daniel, Greig, Maria T., Roberts, Peggy, Albert, Marilyn, Onyike, Chiadi, D'Agostino, Daniel, Kielb, Stephanie, Galvin, James E., Pogorelec, Dana M., Cerbone, Brittany, Michel, Christina A., Rusinek, Henry, Leon, Mony J, Glodzik, Lidia, De Santi, Susan, Doraiswamy, P. Murali, Petrella, Jeffrey R., Wong, Terence Z., Arnold, Steven E., Karlawish, Jason H., Wolk, David, Smith, Charles D., Jicha, Greg, Hardy, Peter, Sinha, Partha, Oates, Elizabeth, Conrad, Gary, Lopez, Oscar L., Oakley, MaryAnn, Simpson, Donna M., Porsteinsson, Anton P., Goldstein, Bonnie S., Martin, Kim, Makino, Kelly M., Ismail, M. Saleem, Brand, Connie, Mulnard, Ruth A., Thai, Gaby, Ortiz, Catherine Mc Adams, Womack, Kyle, Mathers, Dana, Quiceno, Mary, Arrastia, Ramon Diaz, King, Richard, Weiner, Myron, Martin Cook, Kristen, DeVous, Michael, Levey, Allan I., Lah, James J., Cellar, Janet S., Bums, Jeffrey M., Anderson, Heather S., Swerdlow, Russell H., Apostolova, Liana, Tingus, Kathleen, Woo, Ellen, Silverman, Daniel H.S., Lu, Po H., Bartzokis, George, Graff Radford, Neill R, Parfitt, Francine, Kendall, Tracy, Johnson, Heather, Farlow, Martin R., Hake, Ann Marie, Matthews, Brandy R., Herring, Scott, Hunt, Cynthia, Dyck, Christopher H., Carson, Richard E., MacAvoy, Martha G., Chertkow, Howard, Bergman, Howard, Hosein, Chris, Black, Sandra, Stefanovic, Bojana, Caldwell, Curtis, Hsiung, Ging Yuek Robin, Feldman, Howard, Mudge, Benita, Assaly, Michele, Kertesz, Andrew, Rogers, John, Trost, Dick, Bernick, Charles, Munic, Donna, Kerwin, Diana, Mesulam, Marek Marsel, Lipowski, Kristine, Wu, Chuang Kuo, Johnson, Nancy, Sadowsky, Carl, Martinez, Walter, Villena, Teresa, Turner, Raymond Scott, Kathleen Johnson, NP, Brigid Reynolds, NP, Sperling, Reisa A., Johnson, Keith A., Marshall, Gad, Frey, Meghan, Yesavage, Jerome, Taylor, Joy L., Lane, Barton, Rosen, Allison, Tinklenberg, Jared, Sabbagh, Marwan N., Belden, Christine M., Jacobson, Sandra A., Sirrel, Sherye A., Kowall, Neil, Killiany, Ronald, Budson, Andrew E., Norbash, Alexan, Johnson, Patricia Lynn, Obisesan, Thomas O., Wolday, Saba, Allard, Joanne, Lerner, Alan, Ogrocki, Paula, Hudson, Leon, Fletcher, Evan, Carmichael, Owen, Olichney, John, DeCarli, Charles, Kittur, Smita, Borrie, Michael, Lee, T Y, Bartha, Rob, Johnson, Sterling, Asthana, Sanjay, Carlsson, Cynthia M., Potkin, Steven G., Preda, Adrian, Nguyen, Dana, Tariot, Pierre, Reeder, Stephanie, Bates, Vemice, Capote, Horacio, Rainka, Michelle, Scharre, Douglas W., Kataki, Maria, Adeli, Anahita, Zimmerman, Earl A., Celmins, Dzintra, Brown, Alice D., Pearlson, Godfrey D., Blank, Karen, Anderson, Karen, Santulli, Robert B., Kitzmiller, Tamar J., Schwartz, Eben S., Sink, Kaycee M., Williamson, Jeff D., Garg, Pradeep, Watkins, Franklin, Ott, Brian R., Querfurth, Henry, Tremont, Geoffrey, Salloway, Stephen, Malloy, Paul, Correia, Stephen, Rosen, Howard J., Miller, Bruce L., Mintzer, Jacobo, Spicer, Kenneth, Bachman, David, Finger, Elizabether, Pasternak, Stephen, Rachinsky, Irina, Drost, Dick, Pomara, Nunzio, Hernando, Raymundo, Sarrael, Antero, Schultz, Susan K., Boles Ponto, Laura L., Shim, Hyungsub, Smith, Karen Elizabeth, Relkin, Norman, Chaing, Gloria, Raudin, Lisa, Smith, Amanda, Fargher, Kristin, Raj, Balebail Ashok

Source: Annals of neurology. 90(5):751-762

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132377664.0x000001&indx=1&recIds=ETOCvdc_100132377664.0x000001

The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people.

Authors: Jacobs, Tovia, Jacobson, Sean R, Fortea, Juan, Berger, Jeffrey S, Vedvyas, Alok, Marsh, Karyn, Gonzalez, Moses, Figueredo, Luisa F, Plaska, Chelsea Reichert, Blessing, Esther M, Betensky, Rebecca A, Rusinek, Henry, Glodzik, Lidia, Wisniewski, Thomas, Osorio, Ricardo S., de Leon, Mony J., Cejudo, Jaime Ramos

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2024 Supplement 1, Vol. 20, p1-4, 4p

Synthesis of [1–11C]Butanol via a facile solid phase extraction protocol

Authors: Waterhouse, Nicole N., Kothari, Paresh J., Dooley, Marybeth, Hu, Bao, de Leon, Mony J., Babich, John, Qu, Wenchao

Source: In Applied Radiation and Isotopes May 2020 159

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Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research

Authors: Bubu, Omonigho M., Andrade, Andreia G., Umasabor-Bubu, Ogie Q., Hogan, Megan M., Turner, Arlener D., de Leon, Mony J., Ogedegbe, Gbenga, Ayappa, Indu, Jean-Louis G, Girardin, Jackson, Melinda L., Varga, Andrew W., Osorio, Ricardo S.

Source: In Sleep Medicine Reviews April 2020 50