Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats

Authors: Hsueh, Henry T., Chou, Renee Ti, Rai, Usha, Kolodziejski, Patricia, Liyanage, Wathsala, Pejavar, Jahnavi, Mozzer, Ann, Davison, Charlotte, Appell, Matthew B., Kim, Yoo Chun, Leo, Kirby T., Kwon, HyeYoung, Sista, Maanasa, Anders, Nicole M., Hemingway, Avelina, Rompicharla, Sri Vishnu Kiran, Pitha, Ian, Zack, Donald J., Hanes, Justin, Cummings, Michael P., Ensign, Laura M.

Source: In Journal of Controlled Release October 2023 362:371-380

A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data.

Authors: Poll, Brian G.¹ (AUTHOR), Leo, Kirby T.¹ (AUTHOR), Deshpande, Venky¹ (AUTHOR), Jayatissa, Nipun¹ (AUTHOR), Pisitkun, Trairak^1,2 (AUTHOR), Park, Euijung¹ (AUTHOR), Yang, Chin-Rang¹ (AUTHOR), Raghuram, Viswanathan¹ (AUTHOR), Knepper, Mark A.¹ (AUTHOR) knepperm@nhlbi.nih.gov

Source: Cell Communication & Signaling. 2/19/2024, Vol. 22 Issue 1, p1-12. 12p.

Subject Terms: *DATABASES, *PROTEOMICS, *RECOMBINANT proteins, *MASS spectrometry, *POST-translational modification, *KINASES, *PROTEIN kinases

'ADPKD-omics': determinants of cyclic AMP levels in renal epithelial cells

Authors: Mehta, Yash R., Lewis, Spencer A., Leo, Kirby T., Chen, Lihe, Park, Euijung, Raghuram, Viswanathan, Chou, Chung-Lin, Yang, Chin-Rang, Kikuchi, Hiroaki, Khundmiri, Syed, Poll, Brian G., Knepper, Mark A.

Source: Kidney international. 101(1):47-62

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180894007.0x000001&indx=1&recIds=ETOCvdc_100180894007.0x000001

Bayesian analysis of dynamic phosphoproteomic data identifies protein kinases mediating GPCR responses.

Authors: Leo, Kirby T.¹ (AUTHOR), Chou, Chung-Lin¹ (AUTHOR), Yang, Chin-Rang¹ (AUTHOR), Park, Euijung¹ (AUTHOR), Raghuram, Viswanathan¹ (AUTHOR), Knepper, Mark A.¹ (AUTHOR) knepperm@nhlbi.nih.gov

Source: Cell Communication & Signaling. 6/3/2022, Vol. 20 Issue 1, p1-17. 17p.

Subject Terms: *PROTEIN kinases, *BAYESIAN analysis, *MITOGEN-activated protein kinases, *BAYES' theorem, *G protein coupled receptors, *AQUAPORINS, *CALMODULIN, *VASOPRESSIN

Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung

Authors: Kim, Yoo C., Hsueh, Henry T., Kim, Namho, Rodriguez, Jason, Leo, Kirby T., Rao, Divya, West, Natalie E., Hanes, Justin, Suk, Jung Soo

Source: Advanced therapeutics. 4(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115825183.0x000001&indx=1&recIds=ETOCvdc_100115825183.0x000001

Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung

Authors: Kim, Yoo C., Hsueh, Henry T., Kim, Namho, Rodriguez, Jason, Leo, Kirby T., Rao, Divya, West, Natalie E., Hanes, Justin, Suk, Jung Soo

Source: Advanced therapeutics. 3(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107960786.0x000001&indx=1&recIds=ETOCvdc_100107960786.0x000001

Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery.

Authors: Hsueh, Henry T., Chou, Renee Ti, Rai, Usha, Liyanage, Wathsala, Kim, Yoo Chun, Appell, Matthew B., Pejavar, Jahnavi, Leo, Kirby T., Davison, Charlotte, Kolodziejski, Patricia, Mozzer, Ann, Kwon, HyeYoung, Sista, Maanasa, Anders, Nicole M., Hemingway, Avelina, Rompicharla, Sri Vishnu Kiran, Edwards, Malia, Pitha, Ian, Hanes, Justin, Cummings, Michael P.

Source: Nature Communications; 5/2/2023, Vol. 14 Issue 1, p1-19, 19p

Subject Terms: PEPTIDES, INTRAOCULAR pressure, PATIENT compliance, DISEASE management, THERAPEUTICS

Data resource: vasopressin-regulated protein phosphorylation sites in the collecting duct.

Authors: Euijung Park, Chin-Rang Yang, Raghuram, Viswanathan, Deshpande, Venkatesh, Datta, Arnab, Poll, Brian G., Leo, Kirby T., Hiroaki Kikuchi, Lihe Chen, Chung-Lin Chou, Knepper, Mark A.

Source: American Journal of Physiology: Renal Physiology; Jan2023, Vol. 324 Issue 1, pF43-F55, 13p

Subject Terms: CYTOSKELETAL proteins, PHOSPHORYLATION, PROTEIN kinases, PHOSPHOPROTEINS, WEBSITES, DESMOPRESSIN, AQUAPORINS

A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells.

Authors: Kim, Yoo Chun, Hsueh, Henry T., Shin, Matthew D., Berlinicke, Cynthia A., Han, Hyounkoo, Anders, Nicole M., Hemingway, Avelina, Leo, Kirby T., Chou, Renee Ti, Kwon, HyeYoung, Appell, Matthew B., Rai, Usha, Kolodziejski, Patricia, Eberhart, Charles, Pitha, Ian, Zack, Donald J., Hanes, Justin, Ensign, Laura M.

Source: Drug Delivery & Translational Research; Apr2022, Vol. 12 Issue 4, p826-837, 12p

Systems Biology of the Vasopressin V2 Receptor: New Tools for Discovery of Molecular Actions of a GPCR.

Authors: Chen, Lihe, Jung, Hyun Jun, Datta, Arnab, Park, Euijung, Poll, Brian G., Kikuchi, Hiroaki, Leo, Kirby T., Mehta, Yash, Lewis, Spencer, Khundmiri, Syed J., Khan, Shaza, Chou, Chung-Lin, Raghuram, Viswanathan, Yang, Chin-Rang, Knepper, Mark A.

Source: Annual Review of Pharmacology & Toxicology; Jan2022, Vol. 62, p595-616, 18p

Subject Terms: SEQUENCE analysis, MOLECULAR biology, GENE expression profiling, MASS spectrometry, VASOPRESSIN

Caregiver Preferences for Three-Dimensional Printed or Augmented Reality Craniosynostosis Skull Models: A Cross-Sectional Survey.

Authors: Chen, Jonlin, Kumar, Sahana, Shallal, Christopher, Leo, Kirby T., Girard, Alisa, Bai, Yunong, Li, Yukang, Jackson, Eric M., Cohen, Alan R., Yang, Robin

Source: Journal of Craniofacial Surgery; Jan/Feb2022, Vol. 33 Issue 1, p151-155, 5p

Bayesian identification of candidate transcription factors for the regulation of Aqp2 gene expression.

Authors: Hiroaki Kikuchi, Hyun Jun Jung, Raghuram, Viswanathan, Leo, Kirby T., Euijung Park, Chin-Rang Yang, Chun-Lin Chou, Lihe Chen, Knepper, Mark A.

Source: American Journal of Physiology: Renal Physiology; Sep2021, Vol. 321 Issue 3, pF389-F401, 13p

Subject Terms: GENETIC regulation, TRANSCRIPTION factors, BAYES' theorem, RNA sequencing, STAT proteins

Bayesian identification of candidate transcription factors for the regulation of Aqp2gene expression

Authors: Kikuchi, Hiroaki, Jung, Hyun Jun, Raghuram, Viswanathan, Leo, Kirby T., Park, Euijung, Yang, Chin-Rang, Chou, Chun-Lin, Chen, Lihe, Knepper, Mark A.

Source: American Journal of Physiology - Renal Physiology; September 2021, Vol. 321 Issue: 3 pF389-F401, 13p

Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells.

Authors: Hsueh, Henry T., Kim, Yoo-Chun, Pitha, Ian, Shin, Matthew D., Berlinicke, Cynthia A., Chou, Renee Ti, Kimball, Elizabeth, Schaub, Julie, Quillen, Sarah, Leo, Kirby T., Han, Hyounkoo, Xiao, Amy, Kim, Youngwook, Appell, Matthew, Rai, Usha, Kwon, HyeYoung, Kolodziejski, Patricia, Ogunnaike, Laolu, Anders, Nicole M., Hemingway, Avelina

Source: Pharmaceutics; May2021, Vol. 13 Issue 5, p647, 1p

Subject Terms: RETINAL ganglion cells, KINASE inhibitors, PROTEIN kinase inhibitors, OPTIC nerve injuries, ANIMAL disease models

Data Resource: Vasopressin-Regulated Protein Phosphorylation Sites in Collecting Duct

Authors: Park, Euijung, Yang, Chin-Rang, Raghuram, Viswanathan, Deshpande, Venkatesh, Datta, Arnab, Poll, Brian G., Leo, Kirby T., Kikuchi, Hiroaki, Chen, Lihe, Chou, Chung-Lin, Knepper, Mark A.

Source: American Journal of Physiology - Renal Physiology; 20220101, Issue: Preprints

A Cartilage Dicing Tool for Rapid Preparation of Rhinoplasty Grafts

Authors: Stephanian, Brooke A., Karki, Sabin, Sharma, Paarth, Leo, Kirby T., Di Meo, Marc A., Ota, Mitsuki, Patel, Millan, Byrne, Patrick J., Durr, Nicholas J.

Source: Journal of Medical Devices; December 2020, Vol. 14 Issue: 4 p045002-045002, 1p