Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis

Authors: Abdolahpur Monikh, Fazel, Lehtonen, Šárka, Kekäläinen, Jukka, Karkossa, Isabel, Auriola, Seppo, Schubert, Kristin, Zanut, Alessandra, Peltonen, Sanni, Niskanen, Jonna, Bandekar, Mandar, von Bergen, Martin, Leskinen, Jari T.T., Koistinen, Arto, Bogialli, Sara, Guo, Zhiling, Kukkonen, Jussi V.K., Chen, Chunying, Lynch, Iseult

Source: In Nano Today December 2024 59

Presenilin-1 ΔE9 mutation associated sarcoplasmic reticulum leak alters [Ca2+]i distribution in human iPSC-derived cardiomyocytes

Authors: Naumenko, Nikolay, Koivumäki, Jussi T., Lunko, Olesia, Tuomainen, Tomi, Leigh, Robert, Rabiee, Mina, Laurila, Jalmari, Oksanen, Minna, Lehtonen, Sarka, Koistinaho, Jari, Tavi, Pasi

Source: In Journal of Molecular and Cellular Cardiology August 2024 193:78-87

Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species- and Donor-Specific Manner

Authors: Räsänen, Noora, Tiihonen, Jari, Koskuvi, Marja, Lehtonen, Šárka, Jalkanen, Nelli, Karmila, Nelli, Weert, Isabelle, Vaurio, Olli, Ojansuu, Ilkka, Lähteenvuo, Markku, Pietiläinen, Olli, Koistinaho, Jari

Source: In Biological Psychiatry Global Open Science July 2024 4(4)

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes.

Authors: Wu, Ying-Chieh¹ (AUTHOR), Lehtonen, Šárka^1,2 (AUTHOR) sarka.lehtonen@uef.fi, Trontti, Kalevi¹ (AUTHOR), Kauppinen, Riitta¹ (AUTHOR), Kettunen, Pinja¹ (AUTHOR), Leinonen, Ville^3,4 (AUTHOR), Laakso, Markku⁴ (AUTHOR), Kuusisto, Johanna^4,5 (AUTHOR), Hiltunen, Mikko⁶ (AUTHOR), Hovatta, Iiris⁷ (AUTHOR), Freude, Kristine⁸ (AUTHOR), Dhungana, Hiramani¹ (AUTHOR), Koistinaho, Jari^9,10 (AUTHOR) jari.koistinaho@helsinki.fi, Rolova, Taisia¹ (AUTHOR) taisia.rolova@helsinki.fi

Source: Fluids & Barriers of the CNS. 9/27/2024, Vol. 21 Issue 1, p1-20. 20p.

Subject Terms: *INDUCED pluripotent stem cells, *AMYLOID beta-protein precursor, *DRUG discovery, *ALZHEIMER'S disease, *CEREBRAL circulation, *CEREBRAL amyloid angiopathy

Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia

Authors: Koskuvi, Marja, Lehtonen, Šárka, Trontti, Kalevi, Keuters, Meike, Wu, Ying‐Chieh, Koivisto, Hennariikka, Ludwig, Anastasia, Plotnikova, Lidiia, Virtanen, Pekka L. J., Räsänen, Noora, Kaipainen, Satu, Hyötyläinen, Ida, Dhungana, Hiramani, Giniatullina, Raisa, Ojansuu, Ilkka, Vaurio, Olli, Cannon, Tyrone D., Lönnqvist, Jouko, Therman, Sebastian, Suvisaari, Jaana, Kaprio, Jaakko, Lähteenvuo, Markku, Tohka, Jussi, Giniatullin, Rashid, Rivera, Claudio, Hovatta, Iiris, Tanila, Heikki, Tiihonen, Jari, Koistinaho, Jari

Source: Glia. 70(4):650-660

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140065687.0x000001&indx=1&recIds=ETOCvdc_100140065687.0x000001

Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice

Authors: Välimäki, Nelli-Noora, Bakreen, Abdulhameed, Häkli, Sara, Dhungana, Hiramani, Keuters, Meike H., Dunlop, Yannick, Koskuvi, Marja, Keksa-Goldsteine, Velta, Oksanen, Minna, Jäntti, Henna, Lehtonen, Šárka, Malm, Tarja, Koistinaho, Jari, Jolkkonen, Jukka

Source: Stroke. 53(10):3192-3201

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185420464.0x000001&indx=1&recIds=ETOCvdc_100185420464.0x000001

The iPSC perspective on schizophrenia

Authors: Räsänen, Noora, Tiihonen, Jari, Koskuvi, Marja, Lehtonen, Šárka, Koistinaho, Jari

Source: Trends in neurosciences. 45(1):8-26

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151175070.0x000001&indx=1&recIds=ETOCvdc_100151175070.0x000001

miRNA profiling of hiPSC-derived neurons from monozygotic twins discordant for schizophrenia.

Authors: Räsänen, Noora, Tiihonen, Jari, Koskuvi, Marja, Trontti, Kalevi, Cheng, Lesley, Hill, Andrew F., Lehtonen, Šárka, Vaurio, Olli, Ojansuu, Ilkka, Lähteenvuo, Markku, Pietiläinen, Olli, Koistinaho, Jari

Source: Schizophrenia; 2/18/2025, Vol. 11 Issue 1, p1-10, 10p

Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia.

Authors: Niskanen, Jonna, Peltonen, Sanni, Ohtonen, Sohvi, Fazaludeen, Mohammad Feroze, Luk, Kelvin C., Giudice, Luca, Koistinaho, Jari, Malm, Tarja, Goldsteins, Gundars, Albert, Katrina, Lehtonen, Šárka

Source: Glia; Jan2025, Vol. 73 Issue 1, p159-174, 16p

Molecular signaling pathways underlying schizophrenia

Authors: Tiihonen, Jari, Koskuvi, Marja, Lähteenvuo, Markku, Trontti, Kalevi, Ojansuu, Ilkka, Vaurio, Olli, Cannon, Tyrone D., Lönnqvist, Jouko, Therman, Sebastian, Suvisaari, Jaana, Cheng, Lesley, Tanskanen, Antti, Taipale, Heidi, Lehtonen, Šárka, Koistinaho, Jari

Source: In Schizophrenia Research June 2021 232:33-41

Metabolic and immune dysfunction of glia in neurodegenerative disorders: Focus on iPSC models

Authors: Rõlova, Taisia, Lehtonen, Šárka, Goldsteins, Gundars, Kettunen, Pinja, Koistinaho, Jari

Source: Stem cells. 39(3):256-265

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115947078.0x000001&indx=1&recIds=ETOCvdc_100115947078.0x000001

LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses.

Authors: Sonninen, Tuuli-Maria, Peltonen, Sanni, Niskanen, Jonna, Hämäläinen, Riikka H., Koistinaho, Jari, Lehtonen, Šárka

Source: International Journal of Molecular Sciences; Dec2024, Vol. 25 Issue 23, p12874, 21p

Subject Terms: PARKINSON'S disease, ENDOTHELIAL cells, WASTE products, CENTRAL nervous system, DARDARIN

Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells.

Authors: Peltonen, Sanni, Sonninen, Tuuli-Maria, Niskanen, Jonna, Koistinaho, Jari, Ruponen, Marika, Lehtonen, Šárka

Source: Fluids & Barriers of the CNS; 11/18/2024, Vol. 21 Issue 1, p1-12, 12p

Subject Terms: INDUCED pluripotent stem cells, PARKINSON'S disease, PERICYTES, GENE expression profiling, INFLAMMATORY mediators

The link between amyloid β and ferroptosis pathway in Alzheimer's disease progression.

Authors: Majerníková, Naďa, Marmolejo-Garza, Alejandro, Salinas, Casandra Salinas, Luu, Minh D. A., Zhang, Yuequ, Trombetta-Lima, Marina, Tomin, Tamara, Birner-Gruenberger, Ruth, Lehtonen, Šárka, Koistinaho, Jari, Wolters, Justina C., Ayton, Scott, den Dunnen, Wilfred F. A., Dolga, Amalia M.

Source: Cell Death & Disease; Oct2024, Vol. 15 Issue 10, p1-15, 15p

Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

Authors: Oikari, Lotta E., Pandit, Rucha, Stewart, Romal, Cuní-López, Carla, Quek, Hazel, Sutharsan, Ratneswary, Rantanen, Laura M., Oksanen, Minna, Lehtonen, Sarka, de Boer, Carmela Maria, Polo, Jose M., Götz, Jürgen, Koistinaho, Jari, White, Anthony R.

Source: In Stem Cell Reports 12 May 2020 14(5):924-939

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PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Authors: Konttinen, Henna, Cabral-da-Silva, Mauricio e Castro, Ohtonen, Sohvi, Wojciechowski, Sara, Shakirzyanova, Anastasia, Caligola, Simone, Giugno, Rosalba, Ishchenko, Yevheniia, Hernández, Damián, Fazaludeen, Mohammad Feroze, Eamen, Shaila, Budia, Mireia Gómez, Fagerlund, Ilkka, Scoyni, Flavia, Korhonen, Paula, Huber, Nadine, Haapasalo, Annakaisa, Hewitt, Alex W., Vickers, James, Smith, Grady C., Oksanen, Minna, Graff, Caroline, Kanninen, Katja M., Lehtonen, Sarka, Propson, Nicholas, Schwartz, Michael P., Pébay, Alice, Koistinaho, Jari, Ooi, Lezanne, Malm, Tarja

Source: In Stem Cell Reports 8 October 2019 13(4):669-683

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

Authors: Korhonen, Paula, Pollari, Eveliina, Kanninen, Katja M., Savchenko, Ekaterina, Lehtonen, Šárka, Wojciechowski, Sara, Pomeshchik, Yuriy, Van Den Bosch, Ludo, Goldsteins, Gundars, Koistinaho, Jari, Malm, Tarja

Source: In IBRO Reports June 2019 6:74-86

NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer's disease astrocytes

Authors: Oksanen, Minna, Hyötyläinen, Ida, Trontti, Kalevi, Rolova, Taisia, Wojciechowski, Sara, Koskuvi, Marja, Viitanen, Matti, Levonen, Anna‐Liisa, Hovatta, Iiris, Roybon, Laurent, Lehtonen, Šárka, Kanninen, Katja M., Hämäläinen, Riikka H., Koistinaho, Jari

Source: Glia. 68(3):589-599

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099832565.0x000001&indx=1&recIds=ETOCvdc_100099832565.0x000001

Glial cell transplant for brain diseases: the supportive saviours?

Authors: Albert, Katrina, Goldsteins, Gundars, Kälvälä, Sara, Jolkkonen, Jukka, Lehtonen, Šárka

Source: Translational Medicine Communications; 7/13/2024, Vol. 9 Issue 1, p1-12, 12p