Gefapixant Citrate (MK-7264) Sulfonamide Step Speciation Study: Investigation into Precipitation—Dissolution Events during Addition of Chlorosulfonic Acid

Authors: Rivera, Nelo R., Cohen, Ryan D., Zhang, Si-Wei, Dance, Zachary E. X., Halsey, Holst M., Song, Siqing, Bu, Xiaodong, Reibarkh, Mikhail, Ren, Hong, Lee, Alfred Y.

Source: Organic process research & development. 27(2):286-294

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631915370&indx=1&recIds=ETOCRN631915370

Understanding crystal nucleation mechanisms: where do we stand? General discussion

Authors: Anderson, Michael W., Bennett, Matthew, Cedeno, Ruel, Cölfen, Helmut, Cox, Stephen J., Cruz-Cabeza, Aurora J., De Yoreo, James J., Drummond-Brydson, Rik, Dudek, Marta K., Fichthorn, Kristen A., Finney, Aaron R., Ford, Ian, Galloway, Johanna M., Gebauer, Denis, Grossier, Romain, Harding, John H., Hare, Alan, Horváth, Dezső, Hunter, Liam, Kim, Joonsoo, Kimura, Yuki, Kirschhock, Christine E. A., Kiselev, Alexei A., Kras, Weronika, Kuttner, Christian, Lee, Alfred Y., Liao, Zhiyu, Maini, Lucia, Nilsson Lill, Sten O., Pellens, Nick, Price, Sarah L., Rietveld, Ivo B., Rimer, Jeffrey D., Roberts, Kevin J., Rogal, Jutta, Salvalaglio, Matteo, Sandei, Ilaria, Schuszter, Gábor, Sefcik, Jan, Sun, Wenhao, ter Horst, Joop H., Ukrainczyk, Marko, Van Driessche, Alexander E. S., Veesler, Stéphane, Vekilov, Peter G., Verma, Vivek, Whale, Thomas, Wheatcroft, Helen P., Zeglinski, Jacek

Source: Faraday discussions. 235:219-272

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From Powders to Single Crystals: A Crystallographer's Toolbox for Small-Molecule Structure Determination

Authors: Newman, Justin A., Iuzzolino, Luca, Tan, Melissa, Orth, Peter, Bruhn, Jessica, Lee, Alfred Y.

Source: Molecular pharmaceutics. 19(7):2133-2141

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Advanced characterisation techniques: multi-scale, in situ, and time-resolved: general discussion

Authors: Brammer, Lee, Burrows, Andrew D., Chong, Samantha Yu-ling, Craig, Gavin, Evans, Jack, Farha, Omar, Farrusseng, David, Fischer, Michael, Goodwin, Andrew, Huang, Zhehao, Johnson, Ben, Kaskel, Stefan, Kitagawa, Susumu, Lavenn, Christophe, Lee, Alfred Y., Lee, Jet-Sing M., Matsuda, Ryotaro, Phillips, Anthony E., Rainer, Daniel N., Ryder, Matthew R., Schmid, Rochus, Shivanna, Mohana, Sumby, Christopher, Taddei, Marco, Terry, Lui, Ting, Valeska P., van der Veen, Monique A., West, Norton G.

Source: Faraday discussions. 225:152-167

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Bullet-Proofing Doravirine (MK-1439) Starting Material Supply: Rapid Identification and Response to a New Polymorph of Ethyl Ester

Authors: Larpent, Patrick, Iuzzolino, Luca, Schoell, Jochen, Codan, Lorenzo, Tan, Melissa, Newman, Justin A., Lee, Alfred Y.

Source: Crystal growth & design. 21(7):4207-4219

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Structure Elucidation of Pharmaceutically Relevant Compounds Within Pyrene‐Based Frameworks.

Authors: Chaudhry, Mohammad T.¹, mohammad.chaudhry1@merck.com, Newman, Justin A.¹, justin.newman@merck.com, Lee, Alfred Y.¹, Patel, Anisha¹

Source: Chemistry - A European Journal; 12/5/2024, Vol. 30 Issue 68, p1-6, 6p

Interrogating the Solid–Solid Phase Transition Behavior of a Molecular Crystal with a Diverse Range of Solid-State Analytical Techniques and Computational Predictions.

Authors: Zhu, Xiaolong, Kelly, Andrew W., Cao, Tuyen, Iuzzolino, Luca, Gozzo, Fabia, Reinle-Schmitt, Mathilde, Robison, Lee, Patel, Anisha, Lee, Alfred Y.

Source: Crystal Growth & Design; 10/16/2024, Vol. 24 Issue 20, p8174-8180, 7p

Revisiting the solid-state landscape of creatine citric acid: A salt or a cocrystal?

Authors: York, Gregory ^{a, 1}, Kelly, Andrew W. ^{a, 1}, Robison, Lee ^{a, ⁎}, Iuzzolino, Luca ^b, Lee, Alfred Y. ^{a, ⁎}

Source: In Journal of Pharmaceutical Sciences April 2025 114(4)

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process

Authors: Di Maso, Michael J., Ren, Hong, Zhang, Si-Wei, Liu, Wenjun, Desmond, Richard, Alwedi, Embarek, Narsimhan, Karthik, Kalinin, Alexei, Larpent, Patrick, Lee, Alfred Y.

Source: Organic process research & development. 24(11):2491-2497

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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process

Authors: Maloney, Kevin M., Zhang, Si-Wei, Mohan, Anne E., Lee, Alfred Y., Larpent, Patrick, Ren, Hong, Humphrey, Guy R., Desmond, Richard, DiBenedetto, Michael, Liu, Wenjun

Source: Organic process research & development. 24(11):2498-2504

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Unprecedented Packing Polymorphism of Oxindole: An Exploration Inspired by Crystal Structure Prediction.

Authors: Wu, Emily J.¹, Kelly, Andrew W.¹, Iuzzolino, Luca², Lee, Alfred Y.¹, alfred.lee@merck.com, Zhu, Xiaolong¹, xiaolong.zhu@merck.com

Source: Angewandte Chemie International Edition; 8/19/2024, Vol. 63 Issue 34, p1-7, 7p

Formation, Selective Encapsulation, and Tautomerization Control of Isoindolone Utilizing Guanidinium Sulfonate Frameworks.

Authors: Chaudhry, Mohammad T.¹, mohammad.chaudhry1@merck.com, Newman, Justin A.¹, justin.newman@merck.com, Lee, Alfred Y.¹

Source: Chemistry - A European Journal; Jun2024, Vol. 30 Issue 33, p1-5, 5p

Benchmarking Guanidinium Organosulfonate Hydrogen-Bonded Frameworks for Structure Determination of Encapsulated Guests.

Authors: Yusov, Anna, Dillon, Alexandra M., Chaudhry, Mohammad T., Newman, Justin A., Lee, Alfred Y., Ward, Michael D.

Source: ACS Materials Letters; 5/6/2024, Vol. 6 Issue 5, p1906-1912, 7p

Supramolecular Mille-Feuille: Adaptive Guest Inclusion in a New Aliphatic Guanidinium Monosulfonate Hydrogen-Bonded Framework.

Authors: Dillon, Alexandra M., Yusov, Anna, Chaudhry, Mohammad T., Newman, Justin A., Demkiw, Krystyna M., Woerpel, K. A., Lee, Alfred Y., Ward, Michael D.

Source: Crystal Growth & Design; 4/17/2024, Vol. 24 Issue 8, p3483-3490, 8p

Process Development of the HCV NS5B Site D Inhibitor MK-8876

Authors: Williams, Michael J., Chen, Qinghao, Codan, Lorenzo, Dermenjian, Renee K., Dreher, Spencer, Gibson, Andrew W., He, Xianliang, Jin, Yan, Keen, Stephen P., Lee, Alfred Y.

Source: Organic process research & development. 20(7):1227-1238

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Predicting crystal form stability under real-world conditions.

Authors: Firaha, Dzmitry, Liu, Yifei Michelle, van de Streek, Jacco, Sasikumar, Kiran, Dietrich, Hanno, Helfferich, Julian, Aerts, Luc, Braun, Doris E., Broo, Anders, DiPasquale, Antonio G., Lee, Alfred Y., Le Meur, Sarah, Nilsson Lill, Sten O., Lunsmann, Walter J., Mattei, Alessandra, Muglia, Pierandrea, Putra, Okky Dwichandra, Raoui, Mohamed, Reutzel-Edens, Susan M., Rome, Sandrine

Source: Nature; Nov2023, Vol. 623 Issue 7986, p324-328, 5p

Cocrystal Synthesis through Crystal Structure Prediction.

Authors: Abramov, Yuriy A., Iuzzolino, Luca, Jin, Yingdi, York, Gregory, Chen, Chien-Hung, Shultz, C. Scott, Yang, Zhuocen, Chang, Chao, Shi, Baimei, Zhou, Tian, Greenwell, Chandler, Sekharan, Sivakumar, Lee, Alfred Y.

Source: Molecular Pharmaceutics; 7/3/2023, Vol. 20 Issue 7, p3380-3392, 13p

One-phase crystal disorder in pharmaceutical solids and its implication for solid-state stability

Authors: Clawson, Jacalyn S. ^*, Kennedy-Gabb, Sonya, Lee, Alfred Y., Copley, Royston C.B.

Source: In Journal of Pharmaceutical Sciences October 2011 100(10):4302-4316

From Powders to Single Crystals: A Crystallographer's Toolbox for Small-Molecule Structure Determination.

Authors: Newman, Justin A., Iuzzolino, Luca, Tan, Melissa, Orth, Peter, Bruhn, Jessica, Lee, Alfred Y.

Source: Molecular Pharmaceutics; 5/1/2023, Vol. 20 Issue 5, p2133-2141, 9p

Method for screening crystallization conditions using multifunctional substrates