CD57⁺ EMRA CD8⁺ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy.

Authors: Gonnin, Cécile, Leemans, Michelle, Canoui-Poitrine, Florence, Lebraud, Morgane, Corneau, Aurélien, Roquebert, Louise, Caillet, Philippe, Gay, Pierre, Canovas, Johanna, Histe, Axelle, Blanc, Catherine, El-Sissy, Carine, Larbi, Anis, Poisson, Johanne, Ober, Pauline, Boudou-Rouquette, Pascaline, Natella, Pierre-André, Vallet, Hélène, Saadaoui, Besma, Layese, Richard

Source: Immunity & Ageing; 12/27/2024, Vol. 21 Issue 1, p1-12, 12p

Subject Terms: T-cell exhaustion, OLDER people, MEDICAL sciences, T cells, OLDER patients

Increased levels of GM-CSF and CXCL10 and low CD8⁺ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people.

Authors: Poisson, Johanne, El-Sissy, Carine, Serret-Larmande, Arnaud, Smith, Nikaïa, Lebraud, Morgane, Augy, Jean-Loup, Conti, Catherine, Gonnin, Cécile, Planquette, Benjamin, Arlet, Jean-Benoît, Hermann, Bertrand, Charbit, Bruno, Pastre, Jean, Devaux, Floriane, Ladavière, Cyrielle, Lim, Lydie, Ober, Pauline, Cannovas, Johanna, Biard, Lucie, Gulczynski, Marie-Christelle

Source: Immunity & Ageing; 5/7/2024, Vol. 21, p1-14, 14p

Subject Terms: OLDER people, IMMUNOLOGIC memory, CHEMOKINES, IMMUNOSENESCENCE, ELDER care