Evolutionary Conservation Predicts Function of Variants of the Human Organic Cation Transporter, OCT1

Authors: Shu, Yan, Leabman, Maya K., Feng, Bo, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, Kawamoto, Michiko, Johns, Susan J., DeYoung, Joseph, Carlson, Elaine, Ferrin, Thomas E., Herskowitz, Ira, Giacomini, Kathleen M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 May . 100(10), 5902-5907.

Access URL: https://www.jstor.org/stable/3147515

Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraints

Authors: Leabman, Maya K., Huang, Conrad C., DeYoung, Joseph, Carlson, Elaine J., Taylor, Travis R., de la Cruz, Melanie, Johns, Susan J., Stryke, Doug, Kawamoto, Michiko, Urban, Thomas J., Kroetz, Deanna L., Ferrin, Thomas E., Clark, Andrew G., Risch, Neil, Herskowitz, Ira, Giacomini, Kathleen M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 May . 100(10), 5896-5901.

Access URL: https://www.jstor.org/stable/3147514

Pharmacodynamics and Biomarker Correlates of Imvotamab (IGM-2323), the First-in-Class CD20xCD3 Bispecific IgM Antibody with Dual Mechanisms of Action, in Patients with Advanced B Cell Malignancies

Authors: Hernandez, Genevive H. ^*, So, John ^*, Logronio, Kathryn A. ^*, Kotturi, Maya F. ^*, Kim, Won Seog ^*, Armand, Philippe, Cheah, Chan Y., Gopal, Ajay K., Flinn, Ian W., Gregory, Gareth P., Matasar, Matthew J., Nastoupil, Loretta J., Diefenbach, Catherine S., Yoon, Sung-Soo, Ku, Matthew, Qazi, Ibrahim ^*, Leabman, Maya K. ^*, Sison, Iris ^*, Keyt, Bruce A., Takimoto, Chris H., Manley, Thomas J., Budde, Elizabeth L.

Source: In Blood 15 November 2022 140 Supplement 1:6436-6438

Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants

Authors: Fujita, Tomoe, Urban, Thomas J., Leabman, Maya K., Fujita, Kazumi, Giacomini, Kathleen M. ^*

Source: In Journal of Pharmaceutical Sciences January 2006 95(1):25-36

PharmGKB Update: I. Genetic Variants of the Organic Cation Transporter 2 (OCT2, SLC22A2)

Authors: Leabman, Maya K., Huang, Conrad C., Stryke, Doug, Johns, Susan J., Kawamoto, Michiko, Ferrin, Thomas E., DeYoung, Joseph, Taylor, Travis R., De La Cruz, Melanie, Herskowitz, Ira, Giacomini, Kathleen M.

Source: In Pharmacological Reviews September 2003 55(3):399-399

P815: HIGH VALENCY OF IGM-2644, A CD38XCD3 IGM BISPECIFIC T CELL ENGAGER, DISPLACES DARATUMUMAB BINDING AND INDUCES POTENT MULTIPLE MYELOMA CELL KILLING.

Authors: Hart, Kevin C., Santos, Daniel, Pandya, Deepal, Deng, Rong, LI, Keyu, Guan, Yinghui, Hernandez, Genevive, Manley, Thomas, Leabman, Maya K., Hinton, Paul R., Liu, Liqin, Sinclair, Angus M., Candia, Albert F., Carroll, Stephen F., Keyt, Bruce A., Kotturi, Maya F.

Source: HemaSphere; 2023 Supplement 3, Vol. 7, pe630565c-e630565c, 1p

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SNP ANALYSIS AND PRESENTATION IN THE PHARMACOGENETICS OF MEMBRANE TRANSPORTERS PROJECT.

Authors: STRYKE, DOUG, HUANG, CONRAD C., KAWAMOTO, MICHIKO, JOHNS, SUSAN J., CARLSON, ELAINE J., DEYOUNG, JOSEPH A., LEABMAN, MAYA K., HERSKOWITZ, IRA, GIACOMINI, KATHLEEN M., FERR1N, THOMAS E.

Source: Biocomputing 2003 - Proceedings of the Pacific Symposium; 2002, p535-547, 13p

Subject Terms: PHARMACOGENOMICS, MEMBRANE transport proteins, PHENOTYPES, BIOINFORMATICS, PYTHON programming language

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys.

Authors: Leabman, Maya K., Meng, Y. Gloria, Kelley, Robert F., DeForge, Laura E., Cowan, Kyra J., Iyer, Suhasini

Source: mAbs; Nov/Dec2013, Vol. 5 Issue 6, p896-903, 8p

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.

Authors: Yan Shu, Leabman, Maya K., Bo Feng, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, Kawamoto, Michiko, Johns, Susan J., DeYoung, Joseph, Carlson, Elaine, Ferrin, Thomas E., Herskowitz, Ira, Giacomini, Kathleen M.

Source: Proceedings of the National Academy of Sciences of the United States of America. 5/13/2003, Vol. 100 Issue 10, p5902. 6p. 8 Color Photographs, 1 Chart, 5 Graphs.

Subject Terms: *BIOLOGICAL transport, *ORGANIC compounds, *CATIONS, *XENOBIOTICS, *LIVER

Interactions of n-Tetraalkylammonium Compounds and Biguanides with a Human Renal Organic Cation Transporter (hOCT2).

Authors: Dresser, Mark J., Guangqing Xiao, Leabman, Maya K., Gray, Andrew T., Giacomini, Kathleen M.

Source: Pharmaceutical Research; Aug2002, Vol. 19 Issue 8, p1244, 4p, 2 Diagrams, 1 Chart, 2 Graphs

Subject Terms: CATIONS, BIGUANIDE, PHARMACOKINETICS

Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.

Authors: Leabman, Maya K., Huang, Conrad C., Kawamoto, Michiko, Johns, Susan J., Stryke, Douglas, Ferrin, Thomas E., Deyoung, Joseph, Taylor, Travis, Clark, Andrew G., Herskowitz, Ira, Giacomini, Kathleen M.

Source: Pharmacogenetics; Jul2002, Vol. 12 Issue 5, p395-405, 11p

Functional analysis of polymorphisms in the organic anion transporter, SLC22A6(OAT1)

Authors: Fujita, Tomoe, Brown, Chaline, Carlson, Elaine J., Taylor, Travis, de la Cruz, Melanie, Johns, Susan J., Stryke, Doug, Kawamoto, Michiko, Fujita, Kazumi, Castro, Richard, Chen, Chung-Wen, Lin, Emil T., Brett, Claire M., Burchard, Esteban Gonzalez, Ferrin, Thomas E., Huang, Conrad C., Leabman, Maya K., Giacomini, Kathleen M.

Source: Pharmacogenetics and Genomics; April 2005, Vol. 15 Issue: 4 p201-209, 9p

Estimating the contribution of genes and environment to variation in renal drug clearance

Authors: Leabman, Maya K, Giacomini, Kathleen M

Source: Pharmacogenetics; September 2003, Vol. 13 Issue: 9 p581-584, 4p

PharmGKB Submission Update: V. PMT Submissions of Genetic Variation in SLC22 Family Transporters

Authors: Shu, Yan, Urban, Thomas J., Leabman, Maya K., Fujita, Tomoe, Erdman, Andrew R., Lagpacan, Leah L., Brown, Chaline, Castro, Richard A., Huang, Conrad C., Stryke, Doug, Kawamoto, Michiko, Johns, Susan J., Taylor, Travis R., Chan, Wendy, De La Cruz, Melanie, Carlson, Elaine J., Ferrin, Thomas E., Brett, Claire M., Burchard, Esteban G., Herskowitz, Ira, Kroetz, Deanna L., Giacomini, Kathleen M.

Source: Pharmacological Reviews; March 2006, Vol. 58 Issue: 1 p3-4, 2p

PharmGKB Update: III. Genetic Variants of SLC22A1, Solute Carrier Family 22 (Organic Cation Transporter), Member 1

Authors: Shu, Yan, Leabman, Maya K., Feng, Bo, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, Kawamoto, Michiko, Johns, Susan J., DeYoung, Joseph, Carlson, Elaine, Ferrin, Thomas E., Herskowitz, Ira, Giacomini, Kathleen M.

Source: Pharmacological Reviews; June 2004, Vol. 56 Issue: 2 p161-161, 1p

Functional genomics of membrane transporters in human populations.

Authors: Urban, Thomas J.¹, Sebro, Ronnie², Hurowitz, Evan H.¹, Leabman, Maya K.¹, Badagnani, Ilaria¹, Lagpacan, Leah L.¹, Risch, Neil², Giacomini, Kathleen M.¹ kmg@itsa.ucsf.edu

Source: Genome Research. Feb2006, Vol. 16 Issue 2, p223-230. 8p. 1 Diagram, 3 Charts, 3 Graphs.

Subject Terms: *DNA, *GENES, *NUCLEOTIDE sequence, *NUCLEIC acids, *ORGANIC acids, *AMINO acids