BCL-2 Modulates IRE1α Activation to Attenuate Endoplasmic Reticulum Stress and Pulmonary Fibrosis.

Authors: Le Saux, Claude Jourdan, Ho, Tsung Che, Brumwell, Alexis M., Kathiriya, Jaymin J., Wei, Ying, Hughes, Jun-Wei B., Garakani, Kiana, Atabai, Kamran, Auyeung, Vincent C., Papa, Ferroz R., Chapman, Harold A.

Source: American Journal of Respiratory Cell & Molecular Biology; Apr2024, Vol. 70 Issue 4, p247-258, 12p

Subject Terms: PULMONARY fibrosis, ENDOPLASMIC reticulum, LUNGS, EXTRACELLULAR matrix, BLEOMYCIN, SOFT tissue injuries

Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction

Authors: Shivshankar, Pooja, Halade, Ganesh V., Calhoun, Cheresa, Escobar, Gladys P., Mehr, Ali J., Jimenez, Fabio, Martinez, Cindy, Bhatnagar, Harshita, Mjaatvedt, Corey H., Lindsey, Merry L., Le Saux, Claude Jourdan

Source: In Journal of Molecular and Cellular Cardiology November 2014 76:84-93

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+basal cells

Authors: Kathiriya, Jaymin J., Wang, Chaoqun, Zhou, Minqi, Brumwell, Alexis, Cassandras, Monica, Le Saux, Claude Jourdan, Cohen, Max, Alysandratos, Kostantinos-Dionysios, Wang, Bruce, Wolters, Paul, Matthay, Michael, Kotton, Darrell N., Chapman, Harold A., Peng, Tien

Source: Nature Cell Biology; 20240101, Issue: Preprints p1-14, 14p

Respiratory Infections in the Aging Lung: Implications for Diagnosis, Therapy, and Prevention.

Authors: Häder, Antje, Köse-Vogel, Nilay, Schulz, Luise, Mlynska, Lucja, Hornung, Franziska, Hagel, Stefan, Teichgräber, Ulf, Lang, Susanne M., Pletz, Mathias W., Le Saux, Claude Jourdan, Löffler, Bettina, Deinhardt-Emmer, Stefanie

Source: Aging & Disease; Aug2023, Vol. 14 Issue 4, p1091-1104, 14p

Subject Terms: RESPIRATORY infections in old age, COVID-19 pandemic, MOTOR ability, CELLULAR aging, PHYSIOLOGICAL aspects of aging

Caveolin-1 modulates TGF-β1 signaling in cardiac remodeling

Authors: Miyasato, Shelley K., Loeffler, Jorik, Shohet, Ralph, Zhang, Jianhua, Lindsey, Merry, Le Saux, Claude Jourdan

Source: In Matrix Biology June 2011 30(5-6):318-329

Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases

Authors: Royce, Simon G, Le Saux, Claude Jourdan

Source: Expert review of respiratory medicine. 8(3):339-347

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106836838.0x000001&indx=1&recIds=ETOCvdc_100106836838.0x000001

Down-regulation of Caveolin-1, an Inhibitor of Transforming Growth Factor-β Signaling, in Acute Allergen-induced Airway Remodeling

Authors: Le Saux, Claude Jourdan, Teeters, Kelsa, Miyasato, Shelley K., Hoffmann, Peter R., Bollt, Oana, Douet, Vanessa, Shohet, Ralph V., Broide, David H., Tam, Elizabeth K.

Source: In Journal of Biological Chemistry 29 February 2008 283(9):5760-5768

Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis.

Authors: Wei, Ying, Dong, Wenting, Jackson, Julia, Ho, Tsung-Che, Le Saux, Claude Jourdan, Brumwell, Alexis, Li, Xiaopeng, Klesney-Tait, Julia, Cohen, Max L, Wolters, Paul J, Chapman, Harold A

Source: Thorax; Jul2021, Vol. 76 Issue 7, p729-732, 4p

Subject Terms: COLLAGEN, RESEARCH, IDIOPATHIC pulmonary fibrosis, CELL culture, GROWTH factors, LUNGS, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, CELLULAR signal transduction, IMMUNOBLOTTING, COMPARATIVE studies, OXIDOREDUCTASES, METABOLISM

Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans.

Authors: Chung, Liam, Maestas, David R., Lebid, Andriana, Mageau, Ashlie, Rosson, Gedge D., Wu, Xinqun, Wolf, Matthew T., Tam, Ada J., Vanderzee, Isabel, Wang, Xiaokun, Andorko, James I., Zhang, Hong, Narain, Radhika, Sadtler, Kaitlyn, Fan, Hongni, Čiháková, Daniela, Le Saux, Claude Jourdan, Housseau, Franck, Pardoll, Drew M., Elisseeff, Jennifer H.

Source: Science Translational Medicine; 4/15/2020, Vol. 12 Issue 539, p1-12, 12p

Subject Terms: FOREIGN bodies, T cells, INTERLEUKIN-17, BREAST implants, INNATE lymphoid cells, STROMAL cells, SCARS, MYOFIBROBLASTS

A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic Pulmonary Fibrosis.

Authors: Le Saux, Claude Jourdan¹, Davy, Philip², Brampton, Christopher², Ahuja, Seema S.¹, Fauce, Steven^3,4, Shivshankar, Pooja¹, Nguyen, Hieu², Ramaseshan, Mahesh³, Tressler, Robert^3,5, Pirot, Zhu³, Harley, Calvin B.³, Allsopp, Richard² allsopp@hawaii.edu

Source: PLoS ONE. Mar2013, Vol. 8 Issue 3, p1-12. 12p.

Subject Terms: *TELOMERASE, *LUNG diseases, *IDIOPATHIC pulmonary fibrosis, *AIDS, *APLASTIC anemia, *PULMONARY fibrosis, *BIOTECHNOLOGY, *CYTOLOGY, *LABORATORY mice

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A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis.

Authors: Cohen, Max L., Brumwell, Alexis N., Tsung Che Ho, Garakani, Kiana, Montas, Genevieve, Leong, Darren, Ding, Vivianne W., Golden, Jeffrey A., Trinh, Binh N., Jablons, David M., Matthay, Michael A., Jones, Kirk D., Wolters, Paul J., Ying Wei, Chapman, Harold A., Le Saux, Claude Jourdan

Source: Journal of Clinical Investigation. 9/17/2024, Vol. 134 Issue 18, p1-14. 14p.

Subjects: WNT signal transduction, INTERSTITIAL lung diseases, METAPLASIA, EPIGALLOCATECHIN gallate, EPITHELIAL cells, PULMONARY fibrosis, IDIOPATHIC pulmonary fibrosis

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Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation.

Authors: Feng Wan, Letavernier, Emmanuel, Le Saux, Claude Jourdan, Houssaini, Amal, Abid, Shariq, Czibik, Gabor, Daigo Sawaki, Marcos, Elisabeth, Dubois-Rande, Jean-Luc, Baud, Laurent, Adnot, Serge, Derumeaux, Geneviève, Gellen, Barnabas

Source: American Journal of Physiology: Heart & Circulatory Physiology; Dec2015, Vol. 309 Issue 11, pH1883-H1893, 11p

Subject Terms: CALPAIN regulation, CALPASTATIN, HEART rupture, SCARS, MACROPHAGE activation, GENETIC overexpression, INFLAMMATION, GENETICS, THERAPEUTICS

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