COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions

Authors: Schrijver, Irene T., Théroude, Charlotte, Antonakos, Nikolaos, Regina, Jean, Le Roy, Didier, Bart, Pierre‐Alexandre, Chiche, Jean‐Daniel, Perreau, Matthieu, Pantaleo, Giuseppe, Calandra, Thierry, Roger, Thierry

Source: European journal of immunology. 52(10):1676-1679

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169746718.0x000001&indx=1&recIds=ETOCvdc_100169746718.0x000001

Stapled Porcine Pericardium Displays Lower Infectivity In Vitro Than Native and Sutured Porcine Pericardium

Authors: Del Tatto, Benjamin, Le Roy, Didier, Lambelet, Martine, Corpataux, Jean-Marc, Chakfé, Nabil, Giulieri, Stefano, Allagnat, Florent, Roger, Thierry, Saucy, François

Source: Journal of surgical research. 272:132-138

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Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing.

Authors: Chang, Tzu-Hsuan, Cardona Gloria, Yamel, Hellmann, Margareta J., Richardo, Timmy, Greve, Carsten Leo, Le Roy, Didier, Roger, Thierry, Bork, Francesca, Bugl, Stefanie, Jakob, Johanna, Sonnberger, Johannes, Kasper, Lydia, Hube, Bernhard, Pusch, Stefan, Gow, Neil A. R., Sørlie, Morten, Tøndervik, Anne, Moerschbacher, Bruno M., Weber, Alexander N. R.

Source: Frontiers in Immunology; 2025, p1-20, 020p

Development of Broad‐Spectrum β‐Cyclodextrins‐Based Nanomaterials Against Influenza Viruses.

Authors: Zwygart, Arnaud Charles‐Antoine, Medaglia, Chiara, Zhu, Yong, Bart Tarbet, E., Jonna, Westover, Fage, Clément, Le Roy, Didier, Roger, Thierry, Clément, Sophie, Constant, Samuel, Huang, Song, Stellacci, Francesco, Silva, Paulo Jacob, Tapparel, Caroline

Source: Journal of Medical Virology; Dec2024, Vol. 96 Issue 12, p1-12, 12p

Subject Terms: INFLUENZA B virus, VIRUS diseases, INFLUENZA viruses, SIALIC acids, DISEASE outbreaks

Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies.

Authors: Brochut, Maëlick, Heinonen, Tytti, Snäkä, Tiia, Gilbert, Charly, Le Roy, Didier, Roger, Thierry

Source: Scientific Reports; 9/10/2024, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: INFLUENZA A virus, H1N1 subtype, WEIGHT loss, STREPTOCOCCUS pneumoniae, LISTERIA monocytogenes, STATISTICAL power analysis, LISTERIOSIS, SEPSIS

Myeloid-Derived Suppressor-like Cells as a Prognostic Marker in Critically Ill Patients: Insights from Experimental Endotoxemia and Intensive Care Patients.

Authors: Schrijver, Irene T., Herderschee, Jacobus, Théroude, Charlotte, Kritikos, Antonios, Leijte, Guus, Le Roy, Didier, Brochut, Maelick, Chiche, Jean-Daniel, Perreau, Matthieu, Pantaleo, Giuseppe, Guery, Benoit, Kox, Matthijs, Pickkers, Peter, Calandra, Thierry, Roger, Thierry

Source: Cells (2073-4409); Feb2024, Vol. 13 Issue 4, p314, 16p

Subject Terms: NOSOCOMIAL infections, INTENSIVE care patients, ENDOTOXINS, PROGNOSIS, CRITICALLY ill, MYELOID-derived suppressor cells, ENDOTOXEMIA

Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis

Authors: Savva, Athina, Brouwer, Matthijs C., Roger, Thierry, Serón, Mercedes Valls, Le Roy, Didier, Ferwerda, Bart, van der Ende, Arie, Bochud, Pierre-Yves, van de Beek, Diederik, Calandra, Thierry

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Mar . 113(13), 3597-3602.

Access URL: https://www.jstor.org/stable/26468845

High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates

Authors: Roger, Thierry, Schneider, Anina, Weier, Manuela, Sweep, Fred C. G. J., Le Roy, Didier, Bernhagen, Jürgen, Calandra, Thierry, Giannoni, Eric

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Feb . 113(8), E997-E1005.

Access URL: https://www.jstor.org/stable/26467859

Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway

Authors: Ives, Annette, Le Roy, Didier, Théroude, Charlotte, Bernhagen, Jürgen, Roger, Thierry, Calandra, Thierry

Source: FASEB journal. 35(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134553285.0x000001&indx=1&recIds=ETOCvdc_100134553285.0x000001

The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock

Authors: Lugrin, Jérôme, Ciarlo, Eleonora, Santos, Alba, Grandmaison, Gaël, Dos Santos, Isis, Le Roy, Didier, Roger, Thierry

Source: In BBA - Molecular Cell Research June 2013 1833(6):1498-1510

Innate Immune Sensing of Fusarium culmorum by Mouse Dendritic Cells

Authors: Vacher, Gaëlle, Ciarlo, Eleonora, Savova-Bianchi, Dessislava, Le Roy, Didier, Hantier, Gregoire, Niculita-Hirzel, Hélène, Roger, Thierry

Source: Journal of toxicology and environmental health.Part A.Current issues. 78(13-14):871-885

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100032756699.0x000001&indx=1&recIds=ETOCvdc_100032756699.0x000001

Macrophage Migration Inhibitory Factor Deficiency Is Associated With Impaired Killing of Gram-Negative Bacteria by Macrophages and Increased Susceptibility to Klebsiella pneumoniae Sepsis

Authors: Roger, Thierry, Delaloye, Julie, Chanson, Anne-Laure, Giddey, Marlyse, Le Roy, Didier, Calandra, Thierry

Source: The Journal of Infectious Diseases, 2013 Jan . 207(2), 331-339.

Access URL: http://dx.doi.org/10.1093/infdis/jis673

Seasonal migration, site fidelity, and population structure of European seabass (Dicentrarchus labrax).

Authors: de Pontual, Helene, Heerah, Karine, Goossens, Jolien, Garren, François, Martin, Stephane, Le Ru, Loic, Le Roy, Didier, Woillez, Mathieu

Source: ICES Journal of Marine Science / Journal du Conseil; Aug2023, Vol. 80 Issue 6, p1606-1618, 13p

Subject Terms: FISH migration, EUROPEAN seabass, MIGRATORY animals, INTERNAL migration, FISHERY management, FISHERY policy

Geographic Terms: BAY of Biscay (France & Spain)

Species-Specific Recognition of Aspergillus fumigatus by Toll-like Receptor 1 and Toll-like Receptor 6

Authors: Rubino, Ivana, Coste, Alix, Le Roy, Didier, Roger, Thierry, Jaton, Katia, Boeckh, Michael, Monod, Michel, Latgé, Jean-Paul, Calandra, Thierry, Bochud, Pierre-Yves

Source: The Journal of Infectious Diseases, 2012 Mar . 205(6), 944-954.

Access URL: http://dx.doi.org/10.1093/infdis/jir882

Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF

Authors: Kerschbaumer, Randolf J., Rieger, Manfred, Völkel, Dirk, Le Roy, Didier, Roger, Thierry, Garbaraviciene, Jurate, Boehncke, Wolf-Henning, Müllberg, Jürgen, Hoet, Rene M., Wood, Clive R., Antoine, Gerhard, Thiele, Michael, Savidis-Dacho, Helga, Dockal, Michael, Ehrlich, Hartmut, Calandra, Thierry, Scheiflinger, Friedrich

Source: In Journal of Biological Chemistry 2 March 2012 287(10):7446-7455

Protection from Lethal Gram-Negative Bacterial Sepsis by Targeting Toll-Like Receptor 4

Authors: Roger, Thierry, Froidevaux, Céline, Le Roy, Didier, Reymond, Marlies Knaup, Chanson, Anne-Laure, Mauri, Davide, Burns, Kim, Riederer, Beat Michel, Akira, Shizuo, Calandra, Thierry, Dinarello, Charles A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2009 Feb . 106(7), 2348-2352.

Access URL: https://www.jstor.org/stable/40272674

Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

Authors: Roger, Thierry, Lugrin, Jérôme, Le Roy, Didier, Goy, Geneviève, Mombelli, Matteo, Koessler, Thibaud, Ding, Xavier C., Chanson, Anne-Laure, Reymond, Marlies Knaup, Miconnet, Isabelle, Schrenzel, Jacques, François, Patrice, Calandra, Thierry

Source: In Blood 27 January 2011 117(4):1205-1217

Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action

Authors: Ouertatani-Sakouhi, Hajer, El-Turk, Farah, Fauvet, Bruno, Cho, Min-Kyu, Pinar Karpinar, Damla, Le Roy, Didier, Dewor, Manfred, Roger, Thierry, Bernhagen, Jürgen, Calandra, Thierry, Zweckstetter, Markus, Lashuel, Hilal A.

Source: In Journal of Biological Chemistry 20 August 2010 285(34):26581-26598

Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation

Authors: Lugrin, Jérôme, Ding, Xavier C., Le Roy, Didier, Chanson, Anne-Laure, Sweep, Fred C.G.J., Calandra, Thierry, Roger, Thierry

Source: In BBA - Molecular Cell Research 2009 1793(11):1749-1758

Lipopolysaccharide-Binding Protein as a Major Plasma Protein Responsible for Endotoxemic Shock

Authors: Gallay, Philippe, Heumann, Didier, Le Roy, Didier, Barras, Catherine, Glauser, Michel Pierre

Source: Proceedings of the National Academy of Sciences of the United States of America, 1993 Nov 01. 90(21), 9935-9938.

Access URL: https://www.jstor.org/stable/2363376