A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease

Authors: Xu, Julia Z., Conrey, Anna, Frey, Ingrid, Gwaabe, Eveline, Menapace, Laurel A., Tumburu, Laxminath, Lundt, Maureen, Lequang, Timothy, Li, Quan, Glass, Kristen, Dunkelberger, Emily B., Iyer, Varsha, Mangus, Heidi, Kung, Charles, Dang, Lenny, Kosinski, Penelope A., Hawkins, Peter, Jeffries, Neal, Eaton, William A., Lay Thein, Swee

Source: In Blood 10 November 2022 140(19):2053-2062

Contributors

Authors: Abdel-Wahab, Omar, Abrahm, Janet L., Abutalib, Syed A., Adams, Sharon, Al Hadidi, Samer, Alcaide, Pilar, Allen, Carl E., Ambinder, Richard F., Amonoo, Hermioni L., Anderson, Julia A.M., Antin, Joseph H., Antony, Aśok C., Araten, David J., Arnold, Donald M., Awan, Farrukh T., Ayers, Emily C., Barth, Peter, Bates, Shannon M., Benz, Edward J., Berliner, Nancy, Bhardwaj, Nina, Bhatia, Smita, Bhatt, Mihir D., Bollard, Catherine M., Bowman, Mackenzie, Boyle, Eileen M., Braun, Benjamin S., Brenner, Malcolm K., Broccoli, Alessandro, Brodsky, Robert A., Brown, Myles, Broxmeyer, Hal E., Brummel-Ziedins, Kathleen, Brunner, Andrew M., Brunstein, Claudio G., Buadi, Francis K., Burkhardt, Birgit, Burns, Melissa A., Bussel, James B., Byrd, John C., Caimi, Paolo F., Camaschella, Clara, Canavan, Michelle, Cantor, Alan B., Capitano, Maegan L., Carcao, Manuel, Carrillo-Farga, Joaquin, Carroll, Michael C., Carson, William E., Carty, Shannon A., Castillo, Jorge J., Chakrabarti, Priyasmita, Chan, Anthony K.C., Chan, Noel C., Chhabra, Saurabh, Chute, John P., Cimen Bozkus, Cansu, Ciurea, Stefan O., Coates, Thomas D., Collins, Graham, Creager, Mark A., Cromwell, Caroline, Crowder, Lauren A., Cushing, Melissa M., Cutler, Corey, Dabaja, Bouthaina, Dave, Sandeep S., De, Caprio, James A., De, Carli, Kathryn, Deininger, Michael W., De, Simone, Robert A., Dinauer, Mary C., Dinner, Shira, Dixit, Karan S., Dogan, Ahmet, Dorshkind, Kenneth, Dotti, Gianpietro, Dror, Yigal, Dunleavy, Kieron, Dvorak, Christopher C., Ebert, Benjamin L., Eck, Michael J., Eckstein, Olive S., Eikelboom, John W., El Jamal, Siraj M., El-Jurdi, Najla, Kim El-Mallawany, Nader, Erba, Harry P., Evans, William E., Feld, Jonathan, Feldman, Alexander, Ferrara, James L., Fischer, Martin, Forbes, Lisa R., Franco, Idalid, Fredenburgh, James C., Frey, Noelle V., Friedman, Kenneth D., Fuller, Stephen J., Gabe, Caroline, Gailani, David, Gallagher, Patrick G., Gallardo-Grajeda, Andrea, Ganz, Tomas, Gee, Adrian P., George, Gemlyn, Gerson, Stanton L., Gertz, Morie A., Ghosh, Nilanjan, Gibson, Christopher J., Ginzburg, Yelena Z., Gomez, Keith, Gotlib, Jason, Grant, Shakira J., Graubert, Timothy A., Gregg, Xylina T., Gribben, John G., Gross, Peter L., Gulati, Nitya, Gurbuxani, Sandeep, Gutierrez, Alejandro, de Haan, Gerald, Haas-Kogan, Daphne, Haddad, Montaser, Halene, Stephanie, Hamadani, Mehdi, Hammond, Rebecca M., Hari, Parameswaran N., Hayman, Suzanne R., Hayward, Catherine, Hebbel, Robert P., Heidenreich, Olaf, Henkin, Stanislav, Hensch, Lisa, Hillis, Christopher, Hillyer, Christopher D., Hoffman, Ronald, Horny, Hans-Peter, Horowitz, Mia, Hsu, Katharine, Hub, Elin, Iancu-Rubin, Camelia, Isenman, David E., Israels, Sara J., Italiano, Joseph E., Jaffe, Elaine S., Jaffer, Iqbal H., Jäger, Ulrich, Jain, Nitin, James, Paula, Jimenez, Alexandra, Jordan, Michael B., Jung, Moonjung, Kager, Leo, Kanakry, Jennifer A., Kanate, Abraham S., Kelly, Kara M., Khandoga, Alexander G., Karsan, Aly, Kaufman, Richard M., Keyzner, Alla, Khanna-Gupta, Arati, Kharchenko, Evgeniya, Klein, Harvey G., Klepin, Heidi D., Anders Kolb, E., Kollet, Orit, Konopleva, Marina, Kontoyiannis, Dimitrios P., Koreth, John, Koretzky, Gary A., Kozieł-Siołkowska, Monika, Kremyanskaya, Marina, Kucine, Nicole, Kumar, Shaji, Küppers, Ralf, Lacy, Martha Q., Ola Landgren, C., Landier, Wendy, Lane, Andrew A., Lane, William J., Langer, Arielle L., Lapidot, Tsvee, Laureano, Marissa, Leblanc, Francis R., Le, Blanc, Thomas W., La, Casce, Ann S., Lee, Daniel W., Lee, Kathleen A., Leung, Wingchi, Levi, Marcel, Lewis, Russell E., Lichtman, Eben I., Lin, Judith C., Lin, Richard J., Lip, Gregory, Poh Loh, Kah, López, José A., Zoref Lorenz, Adi, Loughran, Thomas P., Lu, Sydney X., Lukas, Rimas V., Lulla, Premal, Luscinskas, Francis W., Ma, Alice D., Maakaron, Joseph E., Machlus, Kellie R., Maciejewski, Jaroslaw P., Magenau, John, Majhail, Navneet, Malek, Ehsan, Manis, John P., Mann, Kenneth G., Manno, Catherine S., Marcellino, Bridget K., Marcogliese, Andrea N., Marincola, Francesco M., Mascarenhas, John, Massberg, Steffen, Matino, Davide, Mc, Ever, Rodger P., Mc, Grath, Emer, Mc, Guire, Hilary, S. Mc, Kinney, Matthew, Mehta, Atul, A. Menapace, Laurel, Mentzer, William C., Michel, Marc, Rita Migliaccio, Anna, Mims, Martha P., Moffat, Karen A., Morgan, Gareth J., Najfeld, Vesna, Naymagon, Leonard, Ness, Paul M., Ng, Andrea K., Ning, Shuoyan, Notarangelo, Luigi D., O'Donnell, Martin, Ollila, Thomas A., Ordonez-Moreno, Alejandra, Own, Maryam, Pai, Menaka, Pai, Sung-Yun, Paidas, Michael, Papa, Luena, Papayannopoulou, Thalia, Peng, Cynthia S., Wang Petersdorf, Effie, Pickard, Lucy, Pierce, Glenn F., Pittaluga, Stefania, Porteus, Matthew, Potpara, Tatjana S., Prchal, Josef T., Puigserver, Pere, Vincent Rajkumar, S., Rak, Janusz, Ramos, Carlos A., Rand, Jacob H., Rand, Margaret L., Rao, Dinesh S., Rappazzo, Katherine C., Rau, Rachel E., Ravandi, Farhad, Rawley, Orla, Rawlings, David J., Reddy, Pavan, Reiter, Andreas, Reville, Barbara, Rice, Lawrence, Riese, Matthew J., Rippel, Noa, Riwes, Mary, Roberts, David J., Rodrigue, Bentley B., Rojek, Alexandra E., Roman, Elizabeth, Rossmann, Marlies P., Rot, Antal, Rouce, Rayne H., Rowley, Scott D., Rustad, Even H., Sahni, Gagan, Sahoo, Daisy, Salama, Mohamed E., Samji, Nasrin, Scadden, David, Schiffman, Fred J., Schipperus, Martin R., Schrier, Stanley L., Shaz, Beth H., Shelburne, Samuel A., Sheth, Sujit, Sholevar, Roxanne, Silberstein, Lev, Silverman, Lewis B., Silverstein, Roy L., Skeith, Leslie, Sloan, Steven R., Douglas Smith, Stephen, Steensma, David P., Steinberg, Martin H., Stieglitz, Elliot, Stock, Wendy, Storry, Jill R., Stramer, Susan L., Strati, Paolo, Stroncek, David F., Flohr Svendsen, Arthur, Sweetenham, John W., Tebaldi, Toma, Teegavarapu, Sravanti P., Tewari, Alok, Lay Thein, Swee, Tillman, Benjamin F., Tomlinson, Benjamin, Tremblay, Douglas, Treon, Steven P., Tsai, Frederick D., Tsang, Mazie, Tzannou, Ifigeneia, Usmani, Saad Z., Valent, Peter, Venkataraman, Girish, Venugopal, Sangeetha, M. Vercellotti, Gregory, Viero, Gabriella, von Andrian, Ulrich H., Vose, Julie M., Wagner, Andrew J., Wang, Ena, Wang, Jia-huai, Warkentin, Theodore E., Weitz, Jeffrey I., West, Kamille A., Westhoff, Connie M., Wheeler, Allison P., Wierda, William, Wiersum-Osselton, Johanna C., Wiley, James S., Williams, David A., Wolgast, Lucia R., Yang, Daozheng, Yang, Moua, Younes, Anas, Young, Neal S., Zayac, Adam S., Zeller, Michelle P., Zieske, Arthur W., Zimran, Ari, Luigi Zinzani, Pier, C. Zubair, Abba, Michel Zwaan, C.

Source: In Hematology Edition: Eighth Edition. 2023:vii-xxviii

Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia

Authors: Makani, Julie, Menzel, Stephan, Nkya, Siana, Cox, Sharon E., Drasar, Emma, Soka, Deogratius, Komba, Albert N., Mgaya, Josephine, Rooks, Helen, Vasavda, Nisha, Fegan, Gregory, Newton, Charles R., Farrall, Martin, Lay Thein, Swee

Source: In Blood 27 January 2011 117(4):1390-1392

IS IT DOMINANTLY INHERITED β THALASSAEMIA OR JUST A β-CHAIN VARIANT THAT IS HIGHLY UNSTABLE?

Authors: Thein, Swee Lay, Lay Thein, Swee

Source: British Journal of Haematology. Oct99, Vol. 107 Issue 1, p12-21. 10p. 2 Diagrams.

Subject Terms: *THALASSEMIA, *HEMOGLOBINOPATHY, *DISEASE management, *MOLECULES

A major quantitative trait locus on chromosome 6q23 for HbF levels – An update

Authors: Lay Thein, Swee, Menzel, Stephan, Peng, Xu, Best, Steve, Jiang, Jie, Close, James, Silver, Nicholas, Gerovasilli, Ageliki, Ping, Chen, Yamaguchi, Masao, Wahlberg, Karin, Muller, Heike, Spector, Tim D., Garner, Chad, Matsuda, Fumihiko, Farrall, Martin, Lathrop, Mark

Source: In Blood Cells, Molecules and Diseases March-April 2007 38(2):181-181

Prenatal Diagnosis in Combined Antithrombin and Factor V Gene Mutation.

Authors: Lane, David A., Auberger, Karin, Ireland, Helen, Roscher, Adelbert A., Lay Thein, Swee

Source: British Journal of Haematology; Sep1996, Vol. 94 Issue 4, p753-755, 3p

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