Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy

Authors: Mengying Xia, Mahboubeh Varmazyad, Iris Pla-Palacín, Dillon C. Gavlock, Richard DeBiasio, Gregory LaRocca, Celeste Reese, Rodrigo M. Florentino, Lanuza A. P. Faccioli, Jacquelyn A. Brown, Lawrence A. Vernetti, Mark Schurdak, Andrew M. Stern, Albert Gough, Jaideep Behari, Alejandro Soto-Gutierrez, D. Lansing Taylor, Mark T. Miedel

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: metabolic dysfunction-associated steatotic liver disease, microphysiology systems, patatin-like phospholipase domain-containing protein 3, precision medicine, reproducibility, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1423936/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/ee7744aae33d4960a923808275c298d0

Modeling oxidative injury response in human kidney organoids

Authors: Aneta Przepiorski, Thitinee Vanichapol, Eugenel B. Espiritu, Amanda E. Crunk, Emily Parasky, Michael D. McDaniels, Dave R. Emlet, Ryan Salisbury, Cassandra L. Happ, Lawrence A. Vernetti, Matthew L. MacDonald, John A. Kellum, Thomas R. Kleyman, Catherine J. Baty, Alan J. Davidson, Neil A. Hukriede

Source: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Kidney organoids, iPSCs, Renal injury, ROS, Hemin, Mitochondria, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/ed6e39b445874502af0c45f7b56b6278

Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Authors: Josepmaria Argemi, Maria U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquin Cabezas, Juan J. Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan P. Arab, Meritxell Ventura-Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Odena, Juan L. Gomez, Tomas Aragon, Jose Altamirano, Juan Caballeria, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho-Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark R. Thursz, Jelena Mann, Matias A. Avila, Ramon Bataller

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/65a267dd546740ec9b7190c3e67982ab

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Authors: Josepmaria Argemi, Maria U. Latasa, Stephen R. Atkinson, Ilya O. Blokhin, Veronica Massey, Joel P. Gue, Joaquin Cabezas, Juan J. Lozano, Derek Van Booven, Aaron Bell, Sheng Cao, Lawrence A. Vernetti, Juan P. Arab, Meritxell Ventura-Cots, Lia R. Edmunds, Constantino Fondevila, Peter Stärkel, Laurent Dubuquoy, Alexandre Louvet, Gemma Odena, Juan L. Gomez, Tomas Aragon, Jose Altamirano, Juan Caballeria, Michael J. Jurczak, D. Lansing Taylor, Carmen Berasain, Claes Wahlestedt, Satdarshan P. Monga, Marsha Y. Morgan, Pau Sancho-Bru, Philippe Mathurin, Shinji Furuya, Carolin Lackner, Ivan Rusyn, Vijay H. Shah, Mark R. Thursz, Jelena Mann, Matias A. Avila, Ramon Bataller

Source: Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies

Authors: Daniel E. Lefever, Mark T. Miedel, Fen Pei, Johanna K. DiStefano, Richard Debiasio, Tong Ying Shun, Manush Saydmohammed, Maria Chikina, Lawrence A. Vernetti, Alejandro Soto-Gutierrez, Satdarshan P. Monga, Ramon Bataller, Jaideep Behari, Vijay K. Yechoor, Ivet Bahar, Albert Gough, Andrew M. Stern, D. Lansing Taylor

Source: Metabolites, Vol 12, Iss 6, p 528 (2022)

Subject Terms: liver, non-alcoholic fatty liver disease, NAFLD, metabolic-associated fatty liver disease, MAFLD, microphysiology systems, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/12/6/528; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/465968be7e9348c68b977f1cf547b02f

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.

Authors: Albert H Gough, Ning Chen, Tong Ying Shun, Timothy R Lezon, Robert C Boltz, Celeste E Reese, Jacob Wagner, Lawrence A Vernetti, Jennifer R Grandis, Adrian V Lee, Andrew M Stern, Mark E Schurdak, D Lansing Taylor

Source: PLoS ONE, Vol 9, Iss 7, p e102678 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4103836?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/073440165ed34f8b8cced8d70b8f685a