Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation

Authors: Rao, Satish S.C., Quigley, Eamonn M.M., Shiff, Steven J., Lavins, Bernard J., Kurtz, Caroline B., MacDougall, James E., Currie, Mark G., Johnston, Jeffrey M.

Source: In Clinical Gastroenterology and Hepatology April 2014 12(4):616-623

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

Authors: Castro, Joel, Harrington, Andrea M., Hughes, Patrick A., Martin, Christopher M., Ge, Pei, Shea, Courtney M., Jin, Hong, Jacobson, Sarah, Hannig, Gerhard, Mann, Elizabeth, Cohen, Mitchell B., MacDougall, James E., Lavins, Bernard J., Kurtz, Caroline B., Silos-Santiago, Inmaculada, Johnston, Jeffrey M., Currie, Mark G., Blackshaw, L. Ashley, Brierley, Stuart M.

Source: In Gastroenterology December 2013 145(6):1334-1346

Comparison of adequate relief with symptom, global, and responder endpoints in linaclotide phase 3 trials in IBS‐C

Authors: Camilleri, Michael, Lembo, Anthony J, Lavins, Bernard J, MacDougall, James E, Carson, Robyn T, Williams, Valerie SL, Nelson, Lauren M, Shiff, Steven J, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey M

Source: United European Gastroenterology journal. 3(1):53-62

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112782040.0x000001&indx=1&recIds=ETOCvdc_100112782040.0x000001

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation

Authors: Johnston, Jeffrey M., Kurtz, Caroline B., MacDougall, James E., Lavins, Bernard J., Currie, Mark G., Fitch, Donald A., O'Dea, Chris, Baird, Mollie, Lembo, Anthony J.

Source: In Gastroenterology 2010 139(6):1877-1886

Two Randomized Trials of Linaclotide for Chronic Constipation.

Authors: Lembo, Anthony J., Schneier, Harvey A., Shiff, Steven J., Kurtz, Caroline B., MacDougall, James E., Jia, Xinwei D., Shao, James Z., Lavins, Bernard J., Currie, Mark G., Fitch, Donald A., Jeglinski, Brenda I., Eng, Paul

Source: New England Journal of Medicine; August 11 2011, Vol. 365 Issue 6, p527-536, 10p

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′, 5′-Monophosphate

Authors: Castro, Joel, Harrington, Andrea M., Hughes, Patrick A., Martin, Christopher M., Ge, Pei, Shea, Courtney M., Jin, Hong, Jacobson, Sarah, Hannig, Gerhard, Mann, Elizabeth, Cohen, Mitchell B., MacDougall, James E., Lavins, Bernard J., Kurtz, Caroline B., Silos-Santiago, Inmaculada, Johnston, Jeffrey M., Currie, Mark G., Blackshaw, L. Ashley, Brierley, Stuart M.

Source: Gastroenterology. 145(6):1334-1346.e11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139499275.0x000001&indx=1&recIds=ETOCvdc_100139499275.0x000001

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Sa2008 Efficacy and Safety of Linaclotide in Chronic Idiopathic Constipation Patients With Abdominal Bloating: Phase 3b Trial Results

Authors: Lacy, Brian E., Lembo, Anthony, Schey, Ron, Lavins, Bernard J., Eng, Paul F., Fox, Susan M., Jia, Xinwei D., Hao, Xinming, Currie, Mark G., Kurtz, Caroline B., Johnston, Jeffrey, Shiff, Steven J.

Source: In Gastroenterology May 2014 146(5) Supplement 1:S

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Mo2054 Assessing Abdominal and Bowel Symptoms Using Adequate Relief Based Thresholds: Results From 2 Phase 3 Trials of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

Authors: Camilleri, Michael, Lembo, Anthony, Lavins, Bernard J., MacDougall, James E., Shiff, Steven J., Jia, Xinwei D., Currie, Mark G., Kurtz, Caroline B., Johnston, Jeffrey M.

Source: In Gastroenterology May 2013 144(5) Supplement 1:S

Su2033 Determining the Minimum Duration for Initial Treatment With Linaclotide in IBS-C Patients: Results From Pooled Phase 3 Trials

Authors: Chey, William D., Lavins, Bernard J., Shiff, Steven J., MacDougall, James E., Kurtz, Caroline B., Shi, Kelvin, Currie, Mark G., Johnston, Jeffrey M.

Source: In Gastroenterology May 2013 144(5) Supplement 1:S

Tu1423 Effects of Linaclotide on Straining Associated With Bowel Movements in Patients With Irritable Bowel Syndrome With Constipation (IBS-C): A Post Hoc Analysis of Pooled Data From Two Phase 3 Trials

Authors: Lembo, Anthony, Rao, Satish S., Shiff, Steven J., Lavins, Bernard J., MacDougall, James E., Shi, Kelvin, Schneier, Harvey, Currie, Mark G., Johnston, Jeffrey M.

Source: In Gastroenterology May 2012 142(5) Supplement 1:S

Tu1401 Factors Contributing to Treatment Satisfaction in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) Treated With Linaclotide vs Placebo

Authors: Lembo, Anthony, Carson, Robyn, Shiff, Steven J., Lavins, Bernard J., MacDougall, James E., Shi, Kelvin, Schneier, Harvey, Currie, Mark G., Johnston, Jeffrey M.

Source: In Gastroenterology May 2012 142(5) Supplement 1:S

Tu1381 Effects of 26 Weeks of Linaclotide Treatment on Adequate Relief and IBS Severity in Patients With Irritable Bowel Syndrome With Constipation

Authors: Chey, William D., Quigley, Eamonn M., Lavins, Bernard J., Baird, Mollie J., Fitch, Donald A., Hao, Xinming, Shi, Kelvin, Currie, Mark G., Schneier, Harvey, Johnston, Jeffrey M.

Source: In Gastroenterology May 2012 142(5) Supplement 1:S

Tu1380 Assessing the Percent of Days Linaclotide Improved Abdominal Symptoms and Stool Frequency in Patients With IBS-C: A Pooled Analysis of Two Phase 3 Trials

Authors: Rao, Satish S., Chang, Lin, Hao, Xinming, Lavins, Bernard J., Shiff, Steven J., Cao, Xiaofan, Schneier, Harvey, Currie, Mark G., Johnston, Jeffrey M.

Source: In Gastroenterology May 2012 142(5) Supplement 1:S

Tu1069 Do Baseline Factors Contribute to Treatment Satisfaction in Patients With Chronic Constipation Treated With Linaclotide vs Placebo?

Authors: Schoenfeld, Philip S., Chang, Lin, Carson, Robyn, Shiff, Steven J., Lavins, Bernard J., MacDougall, James E., Jia, Xinwei D., Schneier, Harvey, Currie, Mark G., Johnston, Jeffrey M.

Source: In Gastroenterology May 2012 142(5) Supplement 1:S

Mo1858 Characterization and Association of Abdominal Pain With Anxiety or Depression in Patients With Irritable Bowel Syndrome With Constipation

Authors: Quigley, Eamonn M., Lavins, Bernard J., Shiff, Steven J., Shi, Kelvin, Hao, Xinming, Kurtz, Caroline B., Currie, Mark G., Schneier, Harvey, Johnston, Jeffrey M.

Source: In Gastroenterology May 2012 142(5) Supplement 1:S