Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation

Authors: Oana Hangiu, Rocío Navarro, Susana Frago, Laura Rubio-Pérez, Antonio Tapia-Galisteo, Laura Díez-Alonso, Marina Gómez-Rosel, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Kenneth A. Howard, Laura Sanz, Luis Álvarez-Vallina, Marta Compte

Source: Frontiers in Immunology, Vol 15 (2025)

Subject Terms: T-cell engager, costimulatory antibody, cancer immunotherapy, mRNA encoded bispecific antibodies, combined RNA, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1494206/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0672d849f30349ecbcacc307964727fc

Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2

Authors: Rodrigo Lázaro‐Gorines, Patricia Pérez, Ignacio Heras‐Murillo, Irene Adán‐Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L. Harwood, Alejandro Segura‐Tudela, Laura Rubio‐Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A. Adipietro, Dinendra L. Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D. MacKerell Jr, Laura Sanz, David J. Weber, Francisco J. Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy‐Ruiz, Inés G. Muñoz, Rafael Delgado, David Sancho, Juan García‐Arriaza, Luis Álvarez‐Vallina

Source: Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)

Subject Terms: bispecific trimerbody, cross‐priming, CTL responses, dendritic cells, neutralizing antibody, SARS‐CoV‐2, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/83ee823ecfc342e88a1c1efafa321622

A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response

Authors: Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz, Luis Álvarez-Vallina

Source: OncoImmunology, Vol 12, Iss 1 (2023)

Subject Terms: Cancer immunotherapy, bispecific antibody, dual action, epithelial growth factor receptor, immune checkpoint blockade, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/87732fe8a8464638935a3dfe1b8c3ab0

Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity

Authors: Laura Rubio-Pérez, Susana Frago, Marta Compte, Rocío Navarro, Seandean L. Harwood, Rodrigo Lázaro-Gorines, Marina Gómez-Rosel, Oana Hangiu, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Luis Álvarez-Vallina

Source: Antibodies, Vol 13, Iss 2, p 34 (2024)

Subject Terms: cancer immunotherapy, trispecific antibody, epithelial growth factor receptor, immune checkpoint blockade, 4-1BB costimulation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4468/13/2/34; https://doaj.org/toc/2073-4468

Access URL: https://doaj.org/article/f4146a3dc0ce4049b9e43fa900b61edb

Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity

Authors: Oana Hangiu, Marta Compte, Anders Dinesen, Rocio Navarro, Antonio Tapia-Galisteo, Ole A. Mandrup, Ainhoa Erce-Llamazares, Rodrigo Lázaro-Gorines, Daniel Nehme-Álvarez, Carmen Domínguez-Alonso, Seandean L. Harwood, Carlos Alfonso, Belen Blanco, Laura Rubio-Pérez, Anaïs Jiménez-Reinoso, Laura Díez-Alonso, Francisco J. Blanco, Laura Sanz, Kenneth A. Howard, Luis Álvarez-Vallina

Source: iScience, Vol 25, Iss 9, Pp 104958- (2022)

Subject Terms: Immunology, immunological methods, immune response, cancer, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222012305; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/c486f101097e4624bed914bc95a337c3

Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones.

Authors: Laura Rubio-Pérez¹, F. Javier Pérez-Flores¹, Pankaj Sharma¹, Luis Velasco¹, Armando Cabrera¹

Source: Organic Letters. Jan2009, Vol. 11 Issue 2, p265-268. 4p.

Subject Terms: *PALLADIUM catalysts, *ASYMMETRIC synthesis, *AMINATION, *KETONES, *CARBONYL compounds, *AMINES

Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations

Authors: Beatriz Martín-Antonio, Belén Blanco, África González-Murillo, Laura Hidalgo, Jordi Minguillón, Gema Pérez-Chacón, Next Generation CART MAD Consortium, Lucía Fernández, Halin Bareke, Andrés París-Muñoz, Adriana Mañas, Cristina Aguirre-Portolés, Alfonso Navarro-Zapata, Carmen Mestre-Durán, Marta Ibáñez-Navarro, Laura Clares-Villa, Sara Naharro, Antonio Perez-Martinez, Marcos Aldea, María Gaibar, Javier Ruiz-Navarro, Manuel Izquierdo, Juan M. Zapata, África González Murillo, Elena García Sánchez, Jorge García Martínez, Alba Rubio San Simón, Blanca Herrero, Gonzalo García Aguilera, Beatriz Horcajo Morera, Manuel Ramírez Orellana, Belén Blanco-Durango, Anais Jiménez-Reinoso, Rodrigo Lázaro-Gorines, Ivana Zagorac, Antonio Tapia Galisteo, Ángel Ramirez-Fernández, Laura Díez-Alonso, Carmen Dominguez-Alonso, Ainhoa Erce-Llamazares, Oana Hangiu, Laura Rubio Pérez, Marina Gómez Rosel, Alejandro Segura Tudela, Javier Arroyo-Ródena, Luis Álvarez-Vallina, Miguel Ángel Rodríguez Milla, Patricia García Rodríguez, Beatriz Somovilla Crespo, Javier García-Castro, Esperanza Esquinas Tarifa, Juana Serrano-López, Pilar Llamas-Sillero, Beatriz Martin-Antonio

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: CAR-T cells, NK cells, TILs, TCR therapy, immunological synapse, cancer, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1386856/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/49d95b3c222f4b7389eb0625d73c49df