A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype

Authors: Jara Cárcel-Márquez, Elena Muiño, Cristina Gallego-Fabrega, Natalia Cullell, Miquel Lledós, Laia Llucià-Carol, Tomás Sobrino, Francisco Campos, José Castillo, Marimar Freijo, Juan Francisco Arenillas, Victor Obach, José Álvarez-Sabín, Carlos A. Molina, Marc Ribó, Jordi Jiménez-Conde, Jaume Roquer, Lucia Muñoz-Narbona, Elena Lopez-Cancio, Mònica Millán, Rosa Diaz-Navarro, Cristòfol Vives-Bauza, Gemma Serrano-Heras, Tomás Segura, Laura Ibañez, Laura Heitsch, Pilar Delgado, Rajat Dhar, Jerzy Krupinski, Raquel Delgado-Mederos, Luis Prats-Sánchez, Pol Camps-Renom, Natalia Blay, Lauro Sumoy, Rafael de Cid, Joan Montaner, Carlos Cruchaga, Jin-Moo Lee, Joan Martí-Fàbregas, Israel Férnandez-Cadenas

Source: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Subject Terms: polygenic risk score, GWAS, multi-trait analysis, stroke, ESUs, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2022.940696/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/59cc2ac670ff4756af4144e6cde2a58a

Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review

Authors: Nuria P Torres-Aguila, Caty Carrera, Elena Muiño, Natalia Cullell, Jara Cárcel-Márquez, Cristina Gallego-Fabrega, Jonathan González-Sánchez, Alejandro Bustamante, Pilar Delgado, Laura Ibañez, Laura Heitsch, Jerzy Krupinski, Joan Montaner, Joan Martí-Fàbregas, Carlos Cruchaga, Jin-Moo Lee, Israel Fernandez-Cadenas

Source: Journal of Stroke, Vol 21, Iss 3, Pp 276-289 (2019)

Subject Terms: stroke, outcome, clinical variables, genetics, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.j-stroke.org/upload/pdf/jos-2019-01522.pdf; https://doaj.org/toc/2287-6391; https://doaj.org/toc/2287-6405

Access URL: https://doaj.org/article/abcde46cee5342b881dc0c3ba4264269

Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease

Authors: Maria V. Fernández, John Budde, Jorge L. Del-Aguila, Laura Ibañez, Yuetiva Deming, Oscar Harari, Joanne Norton, John C. Morris, Alison M. Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga

Source: Frontiers in Neuroscience, Vol 12 (2018)

Subject Terms: gene-based, family-based, clustering, variance-component, transmission disequilibrium, rare variants, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fnins.2018.00209/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/00a49d322b4341eaa1660f0c536b517f

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.

Authors: Maria Victoria Fernández, Jong Hun Kim, John P Budde, Kathleen Black, Alexandra Medvedeva, Ben Saef, Yuetiva Deming, Jorge Del-Aguila, Laura Ibañez, Umber Dube, Oscar Harari, Joanne Norton, Rachel Chasse, John C Morris, Alison Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga

Source: PLoS Genetics, Vol 13, Iss 11, p e1007045 (2017)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5683650?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/c24c203611fa48d2b14d18c2f9324a8e

Circulating blood circular RNA in Parkinson’s Disease; from involvement in pathology to diagnostic tools in at-risk individuals

Authors: Aleksandra Beric, Yichen Sun, Santiago Sanchez, Charissa Martin, Tyler Powell, Ravindra Kumar, Jose Adrian Pardo, Gauri Darekar, Jessie Sanford, Devin Dikec, Bridget Phillips, Juan A. Botia, Carlos Cruchaga, Laura Ibanez

Source: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/006103c44a514c62bbe91c16b7cdf18e

Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease

Authors: Anna Hofmann, Lisa M. Häsler, Marius Lambert, Stephan A. Kaeser, Susanne Gräber-Sultan, Ulrike Obermüller, Elke Kuder-Buletta, Christian la Fougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Nick C. Fox, Natalie S. Ryan, Henrik Zetterberg, Jorge J. Llibre-Guerra, Richard J. Perrin, Laura Ibanez, Peter R. Schofield, William S. Brooks, Gregory S. Day, Martin R. Farlow, Ricardo F. Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, Jae-Hong Lee, Jee Hoon Roh, Hiroshi Mori, Francisco Lopera, Randall J. Bateman, Eric McDade, Brian A. Gordon, Jasmeer P. Chhatwal, Mathias Jucker, Stephanie A. Schultz, Dominantly Inherited Alzheimer Network

Source: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0a454b50306942c5b151db45a71682b3

Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center

Authors: Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John Budde, Pat Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Dan Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N. Do, Yun Ju Sung, Guoyan Zhao, John C. Morris, Krista Moulder, David M. Holtzman, Randall J. Bateman, Celeste Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E. Schindler, Joyce (Joy) Balls-Berry, Tammie L. S. Benzinger, Richard J. Perrin, Andrea Denny, B. Joy Snider, Susan L. Stark, Laura Ibanez, Carlos Cruchaga

Source: Scientific Data, Vol 11, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2052-4463

Access URL: https://doaj.org/article/1469c9617a64436fbff15b0d11b166cb

Predictive Models for Assessing Patients’ Response to Treatment in Metastatic Prostate Cancer: A Systematic Review

Authors: Ailbhe Lawlor, Carol Lin, Juan Gómez Rivas, Laura Ibáñez, Pablo Abad López, Peter-Paul Willemse, Muhammad Imran Omar, Sebastiaan Remmers, Philip Cornford, Pawel Rajwa, Rossella Nicoletti, Giorgio Gandaglia, Jeremy Yuen-Chun Teoh, Jesús Moreno Sierra, Asieh Golozar, Anders Bjartell, Susan Evans-Axelsson, James N'Dow, Jihong Zong, Maria J. Ribal, Monique J. Roobol, Mieke Van Hemelrijck, Katharina Beyer

Source: European Urology Open Science, Vol 63, Iss , Pp 126-135 (2024)

Subject Terms: Adverse events, Disease progression, Metastatic prostate cancer, Overall survival, Predictive models, Treatment discontinuation, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666168324003513; https://doaj.org/toc/2666-1683

Access URL: https://doaj.org/article/f90407ad2903422cb93f320090476c89

Spatio-Temporal Analysis of Drought with SPEI in the State of Mexico and Mexico City

Authors: Mauricio Carrillo-Carrillo, Laura Ibáñez-Castillo, Ramón Arteaga-Ramírez, Gustavo Arévalo-Galarza

Source: Atmosphere, Vol 16, Iss 2, p 202 (2025)

Subject Terms: meteorological drought index, SPEI, central Mexico, CHIRPS, DAYMET, Meteorology. Climatology, QC851-999

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4433/16/2/202; https://doaj.org/toc/2073-4433

Access URL: https://doaj.org/article/b34d24a2071a40eeacf8c30e688368de

SU96PHARMACOGENETICS MAY IMPROVE THE SAFETY PROFILE OF ANTIPSYCHOTIC TREATMENTS

Authors: Arranz, MJ, Gonzalez-Rodriguez, Alex, Perez-Blanco, Josefina, Penadés, Rafael, Gutierrez, Blanca, Laura, Ibañez, Arias, Barbara, Brunet, Mercè, Ballesteros, Jorge Cervilla, Salazar, Juliana, Campos, Rosa Catalan

Source: European neuropsychopharmacology. 29(S4):S1316-S1317

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111184710.0x000001&indx=1&recIds=ETOCvdc_100111184710.0x000001

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

Authors: Peter R Millar, Brian A Gordon, Julie K Wisch, Stephanie A Schultz, Tammie LS Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Ricardo F Allegri, Sarah B Berman, Jasmeer P Chhatwal, Patricio A Chrem Mendez, Gregory S Day, Anna Hofmann, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Johannes Levin, Francisco Lopera, Yoshiki Niimi, Victor J Sánchez-González, Peter R Schofield, Ana Luisa Sosa-Ortiz, Jonathan Vöglein, for the Dominantly Inherited Alzheimer Network, Randall J Bateman, Beau M Ances, Eric M McDade

Source: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-17 (2023)

Subject Terms: Brain aging, Alzheimer disease, Structural MRI, Machine learning, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/8a99db29ec9940cf80f47b491f9d122f

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Authors: Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga

Source: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/1615926b14294de6baba893a22aea0f8

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Cell-free RNA signatures predict Alzheimer’s disease

Authors: Alejandro Cisterna-García, Aleksandra Beric, Muhammad Ali, Jose Adrian Pardo, Hsiang-Han Chen, Maria Victoria Fernandez, Joanne Norton, Jen Gentsch, Kristy Bergmann, John Budde, Joel S. Perlmutter, John C. Morris, Carlos Cruchaga, Juan A. Botia, Laura Ibanez

Source: iScience, Vol 26, Iss 12, Pp 108534- (2023)

Subject Terms: Clinical finding, Disease, Biochemistry, Molecular biology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223026111; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/c673195ebc334bbf8769a800749ab69e

Editorial: Molecular and cellular mechanisms of synaptopathies: emerging synaptic aging-related molecular pathways in neurological disorders

Authors: Hector Ramiro Quintá, Laura Ibanez, Carlos Cruchaga, Dario Maschi

Source: Frontiers in Aging Neuroscience, Vol 15 (2023)

Subject Terms: neurodegenerative diseases, synaptopathies, synaptic aging, Alzheimer's disease, biomarkers, therapeutic targets, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2023.1267033/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/30bdfa33638a4b79b52faff1a1e2d8fa

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Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease

Authors: Hsiang-Han Chen, Abdallah Eteleeb, Ciyang Wang, Maria Victoria Fernandez, John P. Budde, Kristy Bergmann, Joanne Norton, Fengxian Wang, Curtis Ebl, John C. Morris, Richard J. Perrin, Randall J. Bateman, Eric McDade, Chengjie Xiong, Alison Goate, Martin Farlow, Jasmeer Chhatwal, Peter R. Schofield, Helena Chui, Oscar Harari, Carlos Cruchaga, Laura Ibanez, Dominantly Inherited Alzheimer Network

Source: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-11 (2022)

Subject Terms: Autosomal-dominant Alzheimer's disease, Circular RNA, Circular PSEN1, Differential expression, In-silico functional analysis, Pathway analysis, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/bf883b27c2594839a9332c5dd57be351

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Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Authors: Laura Ibanez, Jorge A. Bahena, Chengran Yang, Umber Dube, Fabiana H. G. Farias, John P. Budde, Kristy Bergmann, Carol Brenner-Webster, John C. Morris, Richard J. Perrin, Nigel J. Cairns, John O’Donnell, Ignacio Álvarez, Monica Diez-Fairen, Miquel Aguilar, Rebecca Miller, Albert A. Davis, Pau Pastor, Paul Kotzbauer, Meghan C. Campbell, Joel S. Perlmutter, Herve Rhinn, Oscar Harari, Carlos Cruchaga, Bruno A. Benitez

Source: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)

Subject Terms: Parkinson disease, GWAS, Alpha-synuclein, Amyloid beta, APOE, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-020-01072-8; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/2077762f363c437892ba2473c6937bd7

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