Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques

Authors: Irvine, Edward B. ^{1, 2}, Darrah, Patricia A. ³, Wang, Shu ⁴, Wang, Chuangqi ^{4, 6}, McNamara, Ryan P. ¹, Roederer, Mario ³, Seder, Robert A. ³, Lauffenburger, Douglas A. ^{4, 7}, Flynn, JoAnne L. ^{5, 7}, Fortune, Sarah M. ^{1, 2, 7, ∗}, Alter, Galit ^{1, 7, 8, ∗∗}

Source: In iScience 20 December 2024 27(12)

Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques

Authors: Wang, Shu, Myers, Amy J., Irvine, Edward B., Wang, Chuangqi, Maiello, Pauline, Rodgers, Mark A., Tomko, Jaime, Kracinovsky, Kara, Borish, H. Jacob, Chao, Michael C., Mugahid, Douaa, Darrah, Patricia A., Seder, Robert A., Roederer, Mario, Scanga, Charles A., Lin, Philana Ling, Alter, Galit, Fortune, Sarah M., Flynn, JoAnne L., Lauffenburger, Douglas A.

Source: In Cell Systems 18 December 2024 15(12):1278-1294

SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner

Authors: Jung, Wonyeong, Abdelnour, Arturo, Kaplonek, Paulina, Herrero, Rolando, Shih-Lu Lee, Jessica, Barbati, Domenic R., Chicz, Taras M., Levine, Kate S., Fantin, Romain Clement, Loria, Viviana, Porras, Carolina, Lauffenburger, Douglas A., Gail, Mitchell H., Aparicio, Amada, Hildesheim, Allan, Alter, Galit, McNamara, Ryan P.

Source: In Cell Reports 24 September 2024 43(9)

Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype

Authors: Barrett, Jordan R., Pipini, Dimitra, Wright, Nathan D., Cooper, Andrew J.R., Gorini, Giacomo, Quinkert, Doris, Lias, Amelia M., Davies, Hannah, Rigby, Cassandra A., Aleshnick, Maya, Williams, Barnabas G., Bradshaw, William J., Paterson, Neil G., Martinson, Thomas, Kirtley, Payton, Picard, Luc, Wiggins, Christine D., Donnellan, Francesca R., King, Lloyd D.W., Wang, Lawrence T., Popplewell, Jonathan F., Silk, Sarah E., de Ruiter Swain, Jed, Skinner, Katherine, Kotraiah, Vinayaka, Noe, Amy R., MacGill, Randall S., King, C. Richter, Birkett, Ashley J., Soisson, Lorraine A., Minassian, Angela M., Lauffenburger, Douglas A., Miura, Kazutoyo, Long, Carole A., Wilder, Brandon K., Koekemoer, Lizbé, Tan, Joshua, Nielsen, Carolyn M., McHugh, Kirsty, Draper, Simon J.

Source: In Cell 5 September 2024 187(18):4964-4980

Inference of drug off-target effects on cellular signaling using interactome-based deep learning

Authors: Meimetis, Nikolaos, Lauffenburger, Douglas A., Nilsson, Avlant

Source: In iScience 19 April 2024 27(4)

Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants

Authors: Lopez, Paola A., Nziza, Nadège, Chen, Tina, Shook, Lydia L., Burns, Madeleine D., Demidkin, Stepan, Jasset, Olyvia, Akinwunmi, Babatunde, Yonker, Lael M., Gray, Kathryn J., Elovitz, Michal A., Lauffenburger, Douglas A., Julg, Boris D., Edlow, Andrea G.

Source: In iScience 15 March 2024 27(3)

Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis

Authors: Bowman, Kathryn A. ^{1, 2, 9}, Wiggins, Christine D. ^{3, 9}, DeRiso, Elizabeth ¹, Paul, Steffan ⁴, Strle, Klemen ⁵, Branda, John A. ⁶, Steere, Allen C. ^{7, ∗}, Lauffenburger, Douglas A. ^{3, 10, ∗∗}, Alter, Galit ^{1, 8, ∗∗∗}

Source: In iScience 16 February 2024 27(2)

Enhanced placental antibody transfer efficiency with longer interval between maternal respiratory syncytial virus vaccination and birth

Authors: Jasset, Olyvia J., Lopez Zapana, Paola Andrea, Bahadir, Zeynep, Shook, Lydia, Dennis, Maria, Gilbert, Emily, Liu, Zhaojing Ariel, Yinger, Rachel V., Bald, Caroline, Bradford, Caroline G., Silfen, Alexa H., Klein, Sabra L., Pekosz, Andrew, Permar, Sallie, Konnikova, Liza, Yonker, Lael M., Lauffenburger, Douglas, Nelson, Ashley, Elovitz, Michal A., Edlow, Andrea G.

Source: In American Journal of Obstetrics and Gynecology October 2024

Beta-spike-containing boosters induce robust and functional antibody responses to SARS-CoV-2 in macaques primed with distinct vaccines

Authors: Deng, Yixiang, Atyeo, Caroline, Yuan, Dansu, Chicz, Taras M., Tibbitts, Timothy, Gorman, Matthew, Taylor, Sabian, Lecouturier, Valerie, Lauffenburger, Douglas A., Chicz, Roman M., Alter, Galit, McNamara, Ryan P.

Source: In Cell Reports 28 November 2023 42(11)

Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition

Authors: Netterfield, Tatiana S., Ostheimer, Gerard J., Tentner, Andrea R., Joughin, Brian A., Dakoyannis, Alexandra M., Sharma, Charvi D., Sorger, Peter K., Janes, Kevin A., Lauffenburger, Douglas A., Yaffe, Michael B.

Source: In Cell Systems 19 July 2023 14(7):582-604

Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques

Authors: Darrah, Patricia A., Zeppa, Joseph J., Wang, Chuangqi, Irvine, Edward B., Bucsan, Allison N., Rodgers, Mark A., Pokkali, Supriya, Hackney, Joshua A., Kamath, Megha, White, Alexander G., Borish, H. Jacob, Frye, L. James, Tomko, Jaime, Kracinovsky, Kara, Lin, Philana Ling, Klein, Edwin, Scanga, Charles A., Alter, Galit, Fortune, Sarah M., Lauffenburger, Douglas A., Flynn, JoAnne L., Seder, Robert A., Maiello, Pauline, Roederer, Mario

Source: In Cell Host & Microbe 14 June 2023 31(6):962-977

Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling

Authors: Berard, Alicia R. ^{1, 2}, Brubaker, Douglas K. ³, Birse, Kenzie ^{1, 2}, Lamont, Alana ¹, Mackelprang, Romel D. ⁴, Noël-Romas, Laura ^{1, 2}, Perner, Michelle ⁵, Hou, Xuanlin ⁴, Irungu, Elizabeth ⁶, Mugo, Nelly ^{4, 6}, Knodel, Samantha ^{1, 2}, Muwonge, Timothy R. ⁷, Katabira, Elly ⁷, Hughes, Sean M. ⁸, Levy, Claire ⁸, Calienes, Fernanda L. ⁹, Lauffenburger, Douglas A. ¹¹, Baeten, Jared M. ^{4, 12, 13, 14}, Celum, Connie ^{4, 12, 13}, Hladik, Florian ^{8, 9, 12}, Lingappa, Jairam ^{4, 12, 15}, Burgener, Adam D. ^{1, 2, 10, 16, ∗}

Source: In Cell Reports 30 May 2023 42(5)

Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates

Authors: Gunn, Bronwyn M., McNamara, Ryan P., Wood, Lianna, Taylor, Sabian, Devadhasan, Anush, Guo, Wenyu, Das, Jishnu, Nilsson, Avlant, Shurtleff, Amy, Dubey, Sheri, Eichberg, Michael, Suscovich, Todd J., Saphire, Erica Ollmann, Lauffenburger, Douglas, Coller, Beth-Ann, Simon, Jakub K., Alter, Galit

Source: In Cell Reports 25 April 2023 42(4)

Antibody effector functions are associated with protection from respiratory syncytial virus

Authors: Bartsch, Yannic C., Cizmeci, Deniz, Kang, Jaewon, Zohar, Tomer, Periasamy, Sivakumar, Mehta, Nickita, Tolboom, Jeroen, Van der Fits, Leslie, Sadoff, Jerry, Comeaux, Christy, Callendret, Benoit, Bukreyev, Alexander, Lauffenburger, Douglas A., Bastian, Arangassery Rosemary, Alter, Galit

Source: In Cell 22 December 2022 185(26):4873-4886

A multifaceted high-throughput assay for probing antigen-specific antibody-mediated primary monocyte phagocytosis and downstream functions

Authors: Zohar, Tomer, Atyeo, Caroline, Wolf, Caitlin R., Logue, Jennifer K., Shuey, Kiel, Franko, Nicholas, Choi, Robert Y., Wald, Anna, Koelle, David M., Chu, Helen Y., Lauffenburger, Douglas A., Alter, Galit

Source: In Journal of Immunological Methods November 2022 510

Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data

Authors: Melas, Ioannis N., Lauffenburger, Douglas A., Alexopoulos, Leonidas G.

Source: 13th IEEE International Conference on BioInformatics and BioEngineering Bioinformatics and Bioengineering (BIBE), 2013 IEEE 13th International Conference on. :1-4 Nov, 2013

Relation: 2013 IEEE 13th International Conference on Bioinformatics and Bioengineering (BIBE)

Endometrial cytokines in patients with and without endometriosis evaluated for infertility

Authors: Jørgensen, Hilde, Fedorcsak, Peter, Isaacson, Keith, Tevonian, Erin, Xiao, Amy, Beste, Michael, Qvigstad, Erik, Lauffenburger, Douglas, Griffith, Linda

Source: In Fertility and Sterility March 2022 117(3):629-640

Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates

Authors: Zohar, Tomer, Hsiao, Jeff C., Mehta, Nickita, Das, Jishnu, Devadhasan, Anush, Karpinski, Wiktor, Callahan, Cheryl, Citron, Michael P., DiStefano, Daniel J., Touch, Sinoeun, Wen, Zhiyun, Sachs, Jeffrey R., Cejas, Pedro J., Espeseth, Amy S., Lauffenburger, Douglas A., Bett, Andrew J., Alter, Galit

Source: In Cell Host & Microbe 12 January 2022 30(1):41-52

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation

Authors: Suarez-Lopez, Lucia, Shui, Bing, Brubaker, Douglas K., Hill, Marza, Bergendorf, Alexander, Changelian, Paul S., Laguna, Aisha, Starchenko, Alina, Lauffenburger, Douglas A., Haigis, Kevin M.

Source: In iScience 17 December 2021 24(12)

Reduced antibody activity against SARS-CoV-2 B.1.617.2 delta virus in serum of mRNA-vaccinated individuals receiving tumor necrosis factor-α inhibitors

Authors: Chen, Rita E., Gorman, Matthew J., Zhu, Daniel Y., Carreño, Juan Manuel, Yuan, Dansu, VanBlargan, Laura A., Burdess, Samantha, Lauffenburger, Douglas A., Kim, Wooseob, Turner, Jackson S., Droit, Lindsay, Handley, Scott A., Chahin, Salim, Deepak, Parakkal, O’Halloran, Jane A., Paley, Michael A., Presti, Rachel M., Wu, Gregory F., Krammer, Florian, Alter, Galit, Ellebedy, Ali H., Kim, Alfred H.J., Diamond, Michael S.

Source: In Med 10 December 2021 2(12):1327-1341