Evaluation of altered cell–cell communication between glia and neurons in the hippocampus of 3xTg‐AD mice at two time points.

Authors: Soelter, Tabea M., Howton, Timothy C., Wilk, Elizabeth J., Whitlock, Jordan H., Clark, Amanda D., Birnbaum, Allison, Patterson, Dalton C., Cortes, Constanza J., Lasseigne, Brittany N.

Source: Journal of Cell Communication & Signaling; Mar2025, Vol. 19 Issue 1, p1-19, 19p

Nucleic acid liquid biopsies in Alzheimer's disease: current state, challenges, and opportunities

Authors: Soelter, Tabea M., Whitlock, Jordan H., Williams, Avery S., Hardigan, Andrew A., Lasseigne, Brittany N.

Source: In Heliyon April 2022 8(4)

A role for GLUT3 in glioblastoma cell invasion that is not recapitulated by GLUT1

Authors: Libby, Catherine J, Gc, Sajina, Benavides, Gloria A., Fisher, Jennifer L., Williford, Sarah E., Zhang, Sixue, Tran, Anh Nhat, Gordon, Emily R., Jones, Amber B., Tuy, Kaysaw, Flavahan, William, Gordillo, Juan, Long, Ashlee, Cooper, Sara J., Lasseigne, Brittany N., Augelli-Szafran, Corinne E., Darley-Usmar, Victor, Hjelmeland, Anita B.

Source: Cell adhesion & migration. 15(1):101-115

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136302937.0x000001&indx=1&recIds=ETOCvdc_100136302937.0x000001

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases

Authors: Cochran, J. Nicholas, Geier, Ethan G., Bonham, Luke W., Newberry, J. Scott, Amaral, Michelle D., Thompson, Michelle L., Lasseigne, Brittany N., Karydas, Anna M., Roberson, Erik D., Cooper, Gregory M., Rabinovici, Gil D., Miller, Bruce L., Myers, Richard M., Yokoyama, Jennifer S.

Source: In The American Journal of Human Genetics 7 May 2020 106(5):632-645

Evaluating cancer cell line and patient‐derived xenograft recapitulation of tumor and non‐diseased tissue gene expression profiles in silico

Authors: Williams, Avery S., Wilk, Elizabeth J., Fisher, Jennifer L., Lasseigne, Brittany N.

Source: Cancer reports. 6(9)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194164813.0x000001&indx=1&recIds=ETOCvdc_100194164813.0x000001

A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS

Authors: Gelfman, Sahar, Dugger, Sarah, de Araujo Martins Moreno, Cristiane, Ren, Zhong, Wolock, Charles J., Shneider, Neil A., Phatnani, Hemali, Cirulli, Elizabeth T., Lasseigne, Brittany N., Harris, Tim

Source: Genome research. 29(5):809-818

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620189067&indx=1&recIds=ETOCRN620189067

Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage.

Authors: Jones, Emma F., Howton, Timothy C., Flanary, Victoria L., Clark, Amanda D., Lasseigne, Brittany N.

Source: Molecular Brain; 6/20/2024, Vol. 17 Issue 1, p1-16, 16p

Subject Terms: GENE expression, RNA sequencing, LABORATORY mice, ALTERNATIVE RNA splicing, PHENOTYPES

Altered glia-neuron communication in Alzheimer's Disease affects WNT, p53, and NFkB Signaling determined by snRNA-seq.

Authors: Soelter, Tabea M., Howton, Timothy C., Clark, Amanda D., Oza, Vishal H., Lasseigne, Brittany N.

Source: Cell Communication & Signaling; 6/7/2024, Vol. 22 Issue 1, p1-16, 16p

Subject Terms: ALZHEIMER'S disease, DISEASE risk factors, TRANSCRIPTION factors, PI3K/AKT pathway, CELL populations, HOMEOSTASIS, PREFRONTAL cortex

Signature reversion of three disease‐associated gene signatures prioritizes cancer drug repurposing candidates.

Authors: Fisher, Jennifer L.¹, Wilk, Elizabeth J.¹, Oza, Vishal H.¹, Gary, Sam E.¹, Howton, Timothy C.¹, Flanary, Victoria L.¹, Clark, Amanda D.¹, Hjelmeland, Anita B.¹, Lasseigne, Brittany N.¹, bnp0001@uab.edu

Source: FEBS Open Bio; May2024, Vol. 14 Issue 5, p803-830, 28p

The Role of DNA Methylation in Renal Cell Carcinoma

Authors: Lasseigne, Brittany N., Brooks, James D.

Source: Molecular diagnosis & therapy. 22(4):431-442

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129498493.0x000001&indx=1&recIds=ETOCvdc_100129498493.0x000001

Quantifying transcriptome diversity: a review.

Authors: Jones, Emma F¹, Haldar, Anisha¹, Oza, Vishal H¹, Lasseigne, Brittany N¹, bnp0001@uab.edu

Source: Briefings in Functional Genomics; Mar2024, Vol. 23 Issue 2, p83-94, 12p

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Authors: FALS Sequencing Consortium, Cirulli, Elizabeth T., Lasseigne, Brittany N., Petrovski, Slavé, Sapp, Peter C., Dion, Patrick A., Leblond, Claire S., Couthouis, Julien, Lu, Yi-Fan, Wang, Quanli, Krueger, Brian J., Ren, Zhong, Keebler, Jonathan, Han, Yujun, Levy, Shawn E., Boone, Braden E., Wimbish, Jack R., Waite, Lindsay L., Jones, Angela L., Carulli, John P., Day-Williams, Aaron G., Staropoli, John F., Xin, Winnie W., Chesi, Alessandra, Raphael, Alya R., McKenna-Yasek, Diane, Cady, Janet, de Jong, J. M. B. Vianney, Kenna, Kevin P., Smith, Bradley N., Topp, Simon, Miller, Jack, Gkazi, Athina, Al-Chalabi, Ammar, van den Berg, Leonard H., Veldink, Jan, Silani, Vincenzo, Ticozzi, Nicola, Shaw, Christopher E., Baloh, Robert H., Appel, Stanley, Simpson, Ericka, Lagier-Tourenne, Clotilde, Pulst, Stefan M., Gibson, Summer, Trojanowski, John Q., Elman, Lauren, McCluskey, Leo, Grossman, Murray, Shneider, Neil A., Chung, Wendy K., Ravits, John M., Glass, Jonathan D., Sims, Katherine B., Van Deerlin, Vivianna M., Maniatis, Tom, Hayes, Sebastian D., Ordureau, Alban, Swarup, Sharan, Landers, John, Baas, Frank, Allen, Andrew S., Bedlack, Richard S., Harper, J. Wade, Gitler, Aaron D., Rouleau, Guy A., Brown, Robert, Harms, Matthew B., Cooper, Gregory M., Harris, Tim, Myers, Richard M., Goldstein, David B.

Source: Science, 2015 Mar . 347(6229), 1436-1441.

Access URL: http://www.jstor.org/stable/24746614

Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes.

Authors: Fisher, Jennifer L., Clark, Amanda D., Jones, Emma F., Lasseigne, Brittany N.

Source: BMC Pharmacology & Toxicology; 1/2/2024, Vol. 25 Issue 1, p1-19, 19p

Subject Terms: DRUG side effects, DRUG metabolism, DRUG target, GENE expression, ENZYME metabolism

Company/Entity: UNITED States. Food & Drug Administration

The landscape of SETBP1 gene expression and transcription factor activity across human tissues.

Authors: Whitlock, Jordan H., Wilk, Elizabeth J., Howton, Timothy C., Clark, Amanda D., Lasseigne, Brittany N.

Source: PLoS ONE; 1/2/2024, Vol. 19 Issue 1, p1-15, 15p

Subject Terms: GENE expression, TRANSCRIPTION factors, WEB-based user interfaces, K-means clustering, GENETIC transcription regulation

CoSIA: an R Bioconductor package for CrOss Species Investigation and Analysis.

Authors: Haldar, Anisha¹, Oza, Vishal H¹, DeVoss, Nathaniel S¹, Clark, Amanda D¹, Lasseigne, Brittany N¹, bnp0001@uab.edu

Source: Bioinformatics; Dec2023, Vol. 39 Issue 12, p1-4, 4p

Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers.

Authors: Taluri, Sasha, Oza, Vishal H., Soelter, Tabea M., Fisher, Jennifer L., Lasseigne, Brittany N.

Source: Cancer Reports; Dec2023, Vol. 6 Issue 12, p1-9, 9p

Cell‐type‐specific gene expression and regulation in the cerebral cortex and kidney of atypical Setbp1^S858R Schinzel Giedion Syndrome mice.

Authors: Whitlock, Jordan H., Soelter, Tabea M., Howton, Timothy C., Wilk, Elizabeth J., Oza, Vishal H., Lasseigne, Brittany N.

Source: Journal of Cellular & Molecular Medicine; Nov2023, Vol. 27 Issue 22, p3565-3577, 13p

Subject Terms: GENETIC regulation, KIDNEY cortex, CEREBRAL cortex, GENE expression, GENE regulatory networks

Computational Advancements in Cancer Combination Therapy Prediction.

Authors: Flanary, Victoria L., Fisher, Jennifer L., Wilk, Elizabeth J., Howton, Timothy C., Lasseigne, Brittany N.

Source: JCO Precision Oncology; 10/12/2023, Vol. 7, p1-10, 10p

Subject Terms: MACHINE learning, CANCER treatment, COMBINATION drug therapy, DRUG discovery, DRUG repositioning

CINmetrics: an R package for analyzing copy number aberrations as a measure of chromosomal instability.

Authors: Oza, Vishal H., Fisher, Jennifer L., Darji, Roshan, Lasseigne, Brittany N.

Source: PeerJ; Apr2023, p1-11, 11p

Subject Terms: CHROMOSOME abnormalities, BREAST cancer

Ten simple rules for using public biological data for your research.

Authors: Oza, Vishal H., Whitlock, Jordan H., Wilk, Elizabeth J., Uno-Antonison, Angelina, Wilk, Brandon, Gajapathy, Manavalan, Howton, Timothy C., Trull, Austyn, Ianov, Lara, Worthey, Elizabeth A., Lasseigne, Brittany N.

Source: PLoS Computational Biology; 1/5/2023, Vol. 19 Issue 1, p1-14, 14p, 1 Diagram

Subject Terms: DOWNLOADING, DATA plans, DATA modeling, PIPELINE inspection, EMBARGO