Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

Authors: Penkava, Frank, Velasco-Herrera, Martin Del Castillo, Young, Matthew D., Yager, Nicole, Nwosu, Lilian N., Pratt, Arthur G., Lara, Alicia Lledo, Guzzo, Charlotte, Maroof, Ash, Mamanova, Lira, Cole, Suzanne, Efremova, Mirjana, Simone, Davide, Filer, Andrew, Brown, Chrysothemis C., Croxford, Andrew L., Isaacs, John D., Teichmann, Sarah, Bowness, Paul, Behjati, Sam, Hussein Al-Mossawi, M.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174507088.0x000001&indx=1&recIds=ETOCvdc_100174507088.0x000001

Ex vivo mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluid.

Authors: Yager, Nicole, Cole, Suzanne, Lara, Alicia Lledo, Maroof, Ash, Penkava, Frank, Knight, Julian C., Bowness, Paul, Al-Mossawi, Hussein, Lledo Lara, Alicia

Source: Annals of the Rheumatic Diseases; Dec2021, Vol. 80 Issue 12, p1559-1567, 9p

Subject Terms: CELL metabolism, PROTEIN metabolism, DENDRITIC cells, PSORIATIC arthritis, PROTEINS, FLOW cytometry, RESEARCH, RESEARCH methodology, MACROPHAGES, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, ENZYME-linked immunosorbent assay, CELLS, GENE expression profiling, T cells, INFLAMMATORY mediators, CYTOLOGY, MONOCYTES, SYNOVIAL fluid