NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer

Authors: Miltiadis Tsesmelis, Ulrike F. G. Büttner, Melanie Gerstenlauer, Uta Manfras, Konstantinos Tsesmelis, Ziwei Du, Nadine Sperb, Stephanie Ellen Weissinger, Peter Möller, Thomas F. E. Barth, Harald J. Maier, Lap Kwan Chan, Thomas Wirth

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)

Subject Terms: PDAC, PanINs, NEMO, NF-κB, Senescence, Cerulein, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/d60de3829ea54fce943d4b1ee9fe0c20

Mcl-1 deficiency in murine livers leads to nuclear polyploidisation and mitotic errors: Implications for hepatocellular carcinoma

Authors: Laure-Alix Clerbaux, Pierre Cordier, Nina Desboeufs, Kristian Unger, Peter Leary, Gabriel Semere, Yannick Boege, Lap Kwan Chan, Chantal Desdouets, Massimo Lopes, Achim Weber

Source: JHEP Reports, Vol 5, Iss 10, Pp 100838- (2023)

Subject Terms: Liver, Polyploidy, Mcl-1, Chromosome segregation, Mutational signature, Hepatocarcinogenesis, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555923001696; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/5f8d2726cb3b4e978c92f8e81851c77a

Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis

Authors: Lap Kwan Chan, Miltiadis Tsesmelis, Melanie Gerstenlauer, Frank Leithäuser, Alexander Kleger, Lukas Daniel Frick, Harald Jacob Maier, Thomas Wirth

Source: Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/80177109f28e4bcf87f4e4ede8c9e652

JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.

Authors: MÃ?ller, Katrin, Honcharova-Biletska, Hanna, Koppe, Christiane, Egger, MichÃ?le, Lap Kwan Chan, Schneider, Anne T., KÃ?sgens, Lena, BÃ?hm, Friederike, Boege, Yannick, Healy, Marc E., Schmitt, Johannes, Comtesse, Sarah, Castoldi, Mirco, Preisinger, Christian, Szydlowska, Marta, Focaccia, Enrico, Gaisa, Nadine T., Loosen, Sven H., JÃ?rs, Simone, Tacke, Frank

Source: Proceedings of the National Academy of Sciences of the United States of America; 3/23/2021, Vol. 118 Issue 12, p1-11, 11p

Subject Terms: AGING, APOPTOSIS, LIVER cells, CURCUMIN, PROTEIN kinases, CELL death

Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis.

Authors: Lap Kwan Chan, Gerstenlauer, Melanie, Konukiewitz, Björn, Steiger, Katja, Weichert, Wilko, Wirth, Thomas, Maier, Harald Jakob

Source: Gut; Nov2017, Vol. 66 Issue 11, p1995-2007, 13p

Subject Terms: CHRONIC pancreatitis, NF-kappa B, EPITHELIAL cells, REGENERATION (Biology), METAPLASIA, LABORATORY mice