Chronic glial activation and behavioral alterations induced by acute/subacute pioglitazone treatment in a mouse model of traumatic brain injury

Authors: Estrella, L. Daniel, Manganaro, Jane E., Sheldon, Lexi, Roland, Nashanthea, Snyder, Austin D., George, Joseph W., Emanuel, Katy, Lamberty, Benjamin G, Stauch, Kelly L. ^⁎

Source: In Brain Behavior and Immunity January 2025 123:64-80

Parkinson's disease relevant pathological features are manifested in male Pink1/Parkin deficient rats

Authors: Lamberty, Benjamin G., Estrella, L. Daniel, Mattingly, Jane E., Emanuel, Katy, Trease, Andrew, Totusek, Steven, Sheldon, Lexi, George, Joseph W., Almikhlafi, Mohannad A., Farmer, Trey, Stauch, Kelly L.

Source: In Brain, Behavior, & Immunity - Health August 2023 31

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaques.

Authors: Xu, Xiaoke¹, Niu, Meng¹, Lamberty, Benjamin G.¹, Emanuel, Katy¹, Ramachandran, Shawn¹, Trease, Andrew J.¹, Tabassum, Mehnaz², Lifson, Jeffrey D.³, Fox, Howard S.¹, hfox@unmc.edu

Source: PLoS Pathogens; 9/16/2024, Vol. 20 Issue 9, p1-33, 33p

Cryopreservation of microglia enables single-cell RNA sequencing with minimal effects on disease-related gene expression patterns

Authors: Morsey, Brenda, Niu, Meng, Dyavar, Shetty Ravi, Fletcher, Courtney V., Lamberty, Benjamin G., Emanuel, Katy, Fangmeier, Anna, Fox, Howard S.

Source: In iScience 23 April 2021 24(4)

Pink1/Parkin deficiency alters circulating lymphocyte populations and increases platelet-T cell aggregates in rats.

Authors: Manganaro, Jane E., Emanuel, Katy, Lamberty, Benjamin G., George, Joseph W., Stauch, Kelly L.

Source: Scientific Reports; 10/11/2024, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: MONONUCLEAR leukocytes, BLOOD platelets, PARKIN (Protein), T cells, B cells, BLOOD platelet aggregation

Creation of a long-acting rilpivirine prodrug nanoformulation

Authors: Hilaire, James R., Bade, Aditya N., Sillman, Brady, Gautam, Nagsen, Herskovitz, Jonathan, Dyavar Shetty, Bhagya Laxmi, Wojtkiewicz, Melinda S., Szlachetka, Adam, Lamberty, Benjamin G., Sravanam, Sruthi, Fox, Howard S., Alnouti, Yazen, Dash, Prasanta K., McMillan, JoEllyn M., Edagwa, Benson J., Gendelman, Howard E.

Source: In Journal of Controlled Release October 2019 311-312:201-211

CD8⁺ T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System

Authors: Cecilia, Maria, Marcondes, G., Morsey, Brenda, Emanuel, Katy, Lamberty, Benjamin G., Flynn, Claudia T., Fox, Howard S.

Source: The Journal of Infectious Diseases, 2015 Jan 01. 211(1), 40-44.

Access URL: http://www.jstor.org/stable/43708626

Deletion of DJ-1 in rats affects protein abundance and mitochondrial function at the synapse

Authors: Almikhlafi, Mohannad A., Stauch, Kelly L., Villeneuve, Lance M., Purnell, Phillip R., Lamberty, Benjamin G., Fox, Howard S.

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174661520.0x000001&indx=1&recIds=ETOCvdc_100174661520.0x000001

Morphine suppresses peripheral responses and transforms brain myeloid gene expression to favor neuropathogenesis in SIV infection.

Authors: Fox, Howard S., Meng Niu, Morsey, Brenda M., Lamberty, Benjamin G., Emanuel, Katy, Periyasamy, Palsamy, Callen, Shannon, Acharya, Arpan, Kubik, Gregory, Eudy, James, Guda, Chittibabu, Dyavar, Shetty Ravi, Fletcher, Courtney V., Byrareddy, Siddappa N., Buch, Shilpa

Source: Frontiers in Immunology; 11/16/2022, Vol. 13, p01-21, 21p

Subject Terms: GENE expression, MORPHINE, HIV infections, WHITE matter (Nerve tissue), OPIOID abuse

A Novel Parkinson's Disease Model: PINK1/PARKIN Double‐Knockout Rats

Authors: Almikhlafi, Mohannad A., Lamberty, Benjamin G., Totusek, Steven A., Fox, Howard S., Stauch, Kelly L.

Source: FASEB journal. 34(S1):1-1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140401814.0x000001&indx=1&recIds=ETOCvdc_100140401814.0x000001

MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease.

Authors: Yelamanchili, Sowmya V.¹ yelamanchili@unmc.edu, Lamberty, Benjamin G.¹, Rennard, Deborah A.¹, Morsey, Brenda M.¹, Hochfelder, Colleen G.¹, Meays, Brittney M.¹, Levy, Efrat², Fox, Howard S.¹

Source: PLoS Pathogens. 7/8/2015, Vol. 11 Issue 7, p1-22. 22p.

Subject Terms: *NEUROTOXICOLOGY, *TOXICOLOGY, *NEUROLOGY, *NEUROLOGICAL disorders, *RHESUS monkeys

Physiologically Relevant Concentrations of Dolutegravir, Emtricitabine, and Efavirenz Induce Distinct Metabolic Alterations in HeLa Epithelial and BV2 Microglial Cells.

Authors: George, Joseph W., Mattingly, Jane E., Roland, Nashanthea J., Small, Cassandra M., Lamberty, Benjamin G., Fox, Howard S., Stauch, Kelly L.

Source: Frontiers in Immunology; 05/20/2021, Vol. 12, p1-13, 13p

Subject Terms: INTEGRASE inhibitors, EMTRICITABINE, MICROGLIA, DRUG side effects, CENTRAL nervous system infections, CELL respiration, NUCLEOSIDE reverse transcriptase inhibitors

A year-long extended release nanoformulated cabotegravir prodrug

Authors: Kulkarni, Tanmay A., Bade, Aditya N., Sillman, Brady, Shetty, Bhagya Laxmi Dyavar, Wojtkiewicz, Melinda S., Gautam, Nagsen, Hilaire, James R., Sravanam, Sruthi, Szlachetka, Adam, Lamberty, Benjamin G., Morsey, Brenda M., Fox, Howard S., Alnouti, Yazen, McMillan, JoEllyn M., Mosley, R. Lee, Meza, Jane, Domanico, Paul L., Yue, Tai-Yuen, Moore, Gary, Edagwa, Benson J., Gendelman, Howard E.

Source: Nature Materials; August 2020, Vol. 19 Issue: 8 p910-920, 11p

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Correction: MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease.

Authors: Yelamanchili, Sowmya V., Lamberty, Benjamin G., Rennard, Deborah A., Morsey, Brenda M., Hochfelder, Colleen G., Meays, Brittney M., Levy, Efrat, Fox, Howard S.

Source: PLoS Pathogens. 5/14/2018, Vol. 14 Issue 5, p1-1. 1p.

Subject Terms: *NEUROLOGICAL disorders, *NEUROTOXICOLOGY

Correction: MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease.

Authors: Yelamanchili, Sowmya V., Lamberty, Benjamin G., Rennard, Deborah A., Morsey, Brenda M., Hochfelder, Colleen G., Meays, Brittney M., Levy, Efrat, Fox, Howard S.

Source: PLoS Pathogens. 9/1/2015, Vol. 11 Issue 9, p1-1. 1p.

Subject Terms: *NEUROLOGICAL disorders, *NEUROTOXICOLOGY

Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis.

Authors: Niu, Meng, Morsey, Brenda, Lamberty, Benjamin G., Emanuel, Katy, Yu, Fang, León-Rivera, Rosiris, Berman, Joan W., Gaskill, Peter J., Matt, Stephanie M., Ciborowski, Pawel S., Fox, Howard S.

Source: Viruses (1999-4915); Nov2020, Vol. 12 Issue 11, p1297, 1p

Subject Terms: CELL death, PHARMACOLOGY, METHAMPHETAMINE, MACROPHAGES, CELL physiology, MICROGLIA