Clinical Implications of Basic Research: Exploring the Transformative Potential of Spatial 'Omics in Uro-oncology

Authors: Figiel, Sandy ^a, Bates, Anthony ^b, Braun, David A. ^c, Eapen, Renu ^d, Eckstein, Markus ^e, Manley, Brandon J. ^f, Milowsky, Matthew I. ^g, Mitchell, Tom J. ^h, Bryant, Richard J. ^{a, b}, Sfakianos, John P. ⁱ, Lamb, Alastair D. ^{a, b, ⁎}

Source: In European Urology January 2025 87(1):8-14

Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics

Authors: Desai, Trishna A., Hedman, Åsa K., Dimitriou, Marios, Koprulu, Mine, Figiel, Sandy, Yin, Wencheng, Johansson, Mattias, Watts, Eleanor L., Atkins, Joshua R., Sokolov, Aleksandr V., Schiöth, Helgi B., Gunter, Marc J., Tsilidis, Konstantinos K., Martin, Richard M., Pietzner, Maik, Langenberg, Claudia, Mills, Ian G., Lamb, Alastair D., Mälarstig, Anders, Key, Tim J., Travis, Ruth C., Smith-Byrne, Karl

Source: In eBioMedicine July 2024 105

Clinical performance of magnetic resonance imaging and biomarkers for prostate cancer diagnosis in men at high genetic risk

Authors: Cussenot, Olivier, Renard‐Penna, Raphaele, Montagne, Sarah, Ondet, Valerie, Pilon, Antoine, Guechot, Jerome, Comperat, Eva, Hamdy, Freddie, Lamb, Alastair, Cancel‐Tassin, Geraldine

Source: BJU international. 131(6):745-754

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183599093.0x000001&indx=1&recIds=ETOCvdc_100183599093.0x000001

Protocol for the TRANSLATE prospective, multicentre, randomised clinical trial of prostate biopsy technique

Authors: Bryant, Richard J., Yamamoto, Hide, Eddy, Ben, Kommu, Sashi, Narahari, Krishna, Omer, Altan, Leslie, Tom, Catto, James W. F., Rosario, Derek J., Good, Daniel W., Gray, Rob, Liew, Matthew P. C., Lopez, J. Francisco, Campbell, Teresa, Reynard, John M., Tuck, Steve, Barber, Vicki S., Medeghri, Nadjat, Davies, Lucy, Parkes, Matthew, Hewitt, Aimi, Landeiro, Filipa, Wolstenholme, Jane, Macpherson, Ruth, Verrill, Clare, Marian, Ioana R., Williams, Roxanne, Hamdy, Freddie C., Lamb, Alastair D.

Source: BJU international. 131(6):694-704

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183599138.0x000001&indx=1&recIds=ETOCvdc_100183599138.0x000001

Total pelvic exenteration surgery for loco‐regionally advanced prostate cancer, is it justifiable?

Authors: Cussenot, Olivier, Cancel‐Tassin, Geraldine, Comperat, Eva, Benbouzid, Sabrina, Lamb, Alastair

Source: BJU international. 130(5):582-585

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169397860.0x000001&indx=1&recIds=ETOCvdc_100169397860.0x000001

The provision of prostate cancer patient information leaflets on an electronic tablet: A further step to paperless health-care provision

Authors: Miah, Saiful, Maw, Jonathon, Pang, Karl, Nair, Vineetha, Hori, Satoshi, Lamb, Alastair, Martin, Alexander, Bratt, Ola, Lamb, Benjamin, Shah, Nimish

Source: Urology annals. 14(2):156-161

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148869745.0x000001&indx=1&recIds=ETOCvdc_100148869745.0x000001

Feasibility and safety of radical prostatectomy for oligo‐metastatic prostate cancer: the Testing Radical prostatectomy in men with prostate cancer and oligo‐Metastases to the bone (TRoMbone) trial

Authors: Sooriakumaran, Prasanna, Wilson, Caroline, Rombach, Ines, Hassanali, Neelam, Aning, Jonathan, D. Lamb, Alastair, Cathcart, Paul, Eden, Christopher, Ahmad, Imran, Rajan, Prabhakar, Sridhar, Ashwin, Bryant, Richard J., Elhage, Oussama, Cook, Jonathan, Leung, Hing, Soomro, Naeem, Kelly, John, Nathan, Senthil, Donovan, Jenny L., Hamdy, Freddie C.

Source: BJU international. 130(1):43-53

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157748965.0x000001&indx=1&recIds=ETOCvdc_100157748965.0x000001

Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers.

Authors: Erickson, Andrew, Figiel, Sandy, Rajakumar, Timothy, Rao, Srinivasa, Yin, Wencheng, Doultsinos, Dimitrios, Magnussen, Anette, Singh, Reema, Poulose, Ninu, Bryant, Richard J., Cussenot, Olivier, Hamdy, Freddie C., Woodcock, Dan, Mills, Ian G., Lamb, Alastair D.

Source: PLoS ONE; 1/3/2025, Vol. 20 Issue 1, p1-14, 14p

Subject Terms: DNA copy number variations, CANCER genetics, PROSTATE cancer, SPATIAL resolution, MACHINE learning

Risks and Benefits of Live Surgical Broadcast: A Systematic Review

Authors: Carbonara, Umberto, Crocerossa, Fabio, Novara, Giacomo, Ditonno, Pasquale, Pansadoro, Vito, Breda, Alberto, Rocco, Bernardo, Cacciamani, Giovanni E., Lamb, Alastair D., Kaouk, Jihad, Porpiglia, Francesco, Autorino, Riccardo

Source: In European Urology Focus May 2022 8(3):870-881

Ductal variant prostate carcinoma is associated with a significantly shorter metastasis-free survival

Authors: Chow, Ken, Bedő, Justin, Ryan, Andrew, Agarwal, Dinesh, Bolton, Damien, Chan, Yee, Dundee, Philip, Frydenberg, Mark, Furrer, Marc A., Goad, Jeremy, Gyomber, Dennis, Hanegbi, Uri, Harewood, Laurence, King, Dennis, Lamb, Alastair D., Lawrentschuk, Nathan, Liodakis, Peter, Moon, Daniel, Murphy, Declan G., Peters, Justin S., Ruljancich, Paul, Verrill, Clare L., Webb, David, Wong, Lih-Ming, Zargar, Homayoun, Costello, Anthony J., Papenfuss, Anthony T., Hovens, Christopher M., Corcoran, Niall M.

Source: In European Journal of Cancer May 2021 148:440-450

Local anaesthetic transperineal (LATP) prostate biopsy using a probe‐mounted transperineal access system: a multicentre prospective outcome analysis

Authors: Lopez, J. Francisco, Campbell, Angus, Omer, Altan, Stroman, Luke, Bondad, Jasper, Austin, Tom, Reeves, Thomas, Phelan, Curtis, Leiblich, Aaron, Philippou, Yiannis, Lovegrove, Catherine E., Ranasinha, Nithesh, Bryant, Richard J., Leslie, Tom, Hamdy, Freddie C., Brewster, Simon, Bell, C. Richard, Popert, Rick, Hodgson, Dominic, Elsaghir, Mohammed, Eddy, Ben, Bolomytis, Stefanos, Persad, Raj, Reddy, Utsav D., Foley, Charlotte, Rij, Simon, Lam, Wayne, Lamb, Alastair D.

Source: BJU international. 128(3):311-318

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128673964.0x000001&indx=1&recIds=ETOCvdc_100128673964.0x000001

Ductal adenocarcinoma of the prostate: A systematic review and meta‐analysis of incidence, presentation, prognosis, and management

Authors: Ranasinha, Nithesh, Omer, Altan, Philippou, Yiannis, Harriss, Eli, Davies, Lucy, Chow, Ken, Chetta, Paolo M., Erickson, Andrew, Rajakumar, Timothy, Mills, Ian G., Bryant, Richard J., Hamdy, Freddie C., Murphy, Declan G., Loda, Massimo, Hovens, Christopher M., Corcoran, Niall M., Verrill, Clare, Lamb, Alastair D.

Source: BJUI Compass. 2(1):13-23

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118303477.0x000001&indx=1&recIds=ETOCvdc_100118303477.0x000001

A cross‐section of UK prostate cancer diagnostics during the coronavirus disease 2019 (COVID‐19) era – a shifting paradigm?

Authors: Stroman, Luke, Cathcart, Paul, Lamb, Alastair, Challacombe, Ben, Popert, Rick

Source: BJU international. 127(1):30-34

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114002009.0x000001&indx=1&recIds=ETOCvdc_100114002009.0x000001

Use of intraoperative fluorescence to enhance robot-assisted radical prostatectomy

Authors: Rajakumar, Timothy, Yassin, Musaab, Musbahi, Omar, Harris, Eli, Lopez, J Francisco, Bryant, Richard J, Tullis, Iain DC, Vojnovic, Borivoj, Hamdy, Freddie C, Lamb, Alastair D

Source: Future oncology. 17(9):1083-1095

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187515553.0x000001&indx=1&recIds=ETOCvdc_100187515553.0x000001

Evidence for local anaesthetic transperineal biopsy versus transrectal prostate biopsy.

Authors: Lamb, Alastair D., Landeiro, Filipa, Marian, Ioana R., Tuck, Steve, Bryant, Richard J.

Source: BMJ: British Medical Journal; 12/7/2024, Vol. 387 Issue 8451, p1-5, 5p

Subject Terms: BIOPSY, LOCAL anesthetics, MEDICAL care use, PATIENT safety, EARLY detection of cancer, PROSTATE tumors, INFECTION, MAGNETIC resonance imaging, NEEDLE biopsy, RECTUM

Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in the Detection of Clinically Significant Prostate Cancer in the Prostate Imaging Reporting and Data System Era: A Systematic Review and Meta-analysis

Authors: Sathianathen, Niranjan J. ^⁎, Omer, Altan, Harriss, Eli, Davies, Lucy, Kasivisvanathan, Veeru, Punwani, Shonit, Moore, Caroline M., Kastner, Christof, Barrett, Tristan, Van Den Bergh, Roderick CN, Eddy, Ben A., Gleeson, Fergus, Macpherson, Ruth, Bryant, Richard J., Catto, James W.F., Murphy, Declan G., Hamdy, Freddie C., Ahmed, Hashim U., Lamb, Alastair D.

Source: In European Urology September 2020 78(3):402-414

Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration

Authors: Rao, Srinivasa R., Alham, Nasullah K., Upton, Elysia, McIntyre, Stacey, Bryant, Richard J., Cerundolo, Lucia, Bowes, Emma, Jones, Stephanie, Browne, Molly, Mills, Ian, Lamb, Alastair, Tomlinson, Ian, Wedge, David, Browning, Lisa, Sirinukunwattana, Korsuk, Palles, Claire, Hamdy, Freddie C., Rittscher, Jens, Verrill, Clare

Source: In The Journal of Molecular Diagnostics May 2020 22(5):652-669

First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy.

Authors: Hamdy, Freddie C.^1,2 (AUTHOR) Freddie.Hamdy@nds.ox.ac.uk, Lamb, Alastair D.^1,2 (AUTHOR), Tullis, Iain D. C.³ (AUTHOR), Verrill, Clare^1,2 (AUTHOR), Rombach, Ines^4,5 (AUTHOR), Rao, Srinivasa R.¹ (AUTHOR), Colling, Richard^1,2 (AUTHOR), Barber, Paul R.⁶ (AUTHOR), Volpi, Davide³ (AUTHOR), Barbera-Martin, Luis² (AUTHOR), Lopez, J Francisco^1,2 (AUTHOR), Omer, Altan² (AUTHOR), Hewitt, Aimi¹ (AUTHOR), Lovell, Shelagh^1,2 (AUTHOR), Niederer, Jane^1,2 (AUTHOR), Lambert, Adam¹ (AUTHOR), Snoeck, Joke¹ (AUTHOR), Thomson, Claire¹ (AUTHOR), Leslie, Tom^1,2 (AUTHOR), Bryant, Richard J.^1,2 (AUTHOR)

Source: European Journal of Nuclear Medicine & Molecular Imaging. Aug2024, Vol. 51 Issue 10, p3009-3025. 17p.

Subject Terms: *PROSTATE-specific membrane antigen, *RADICAL prostatectomy, *SURGICAL excision, *PROSTATE cancer, *OPTICAL images

Perspectives on technology – prostate cancer: is local anaesthetic transperineal prostate biopsy really better than transrectal biopsy?

Authors: Berridge, Christopher, Omer, Altan, Lopez, Francisco, Bryant, Richard J., Lamb, Alastair D.

Source: BJU International; Aug2024, Vol. 134 Issue 2, p166-174, 9p

Subject Terms: PROSTATE biopsy, PROSTATE cancer, BIOPSY, RANDOMIZED controlled trials, ANTIBIOTIC prophylaxis, ANESTHETICS

Company/Entity: AMERICAN Urological Association, NATIONAL Institute for Health & Care Excellence (Great Britain)

Molecular analysis of archival diagnostic prostate cancer biopsies identifies genomic similarities in cases with progression post‐radiotherapy, and those with de novo metastatic disease.

Authors: Charlton, Philip Vincent, O'Reilly, Dawn, Philippou, Yiannis, Rao, Srinivasa Rao, Lamb, Alastair David Gordon, Mills, Ian Geoffrey, Higgins, Geoff Stuart, Hamdy, Freddie Charles, Verrill, Clare, Buffa, Francesca Meteora, Bryant, Richard John

Source: Prostate; Jul2024, Vol. 84 Issue 10, p977-990, 14p