Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.

Authors: Valenstein, Max L., Lalgudi, Pranav V., Kedir, Jibril F., Condon, Kendall J., Platzek, Anna, Freund, Daniel G., Taylor, Martin S., Xu, Yunhan, Chivukula, Raghu R., Sabatini, David M.

Source: Nature; Jan2025, Vol. 637 Issue 8045, pE11-E14, 4p

Discovery and engineering of the antibody response to a prominent skin commensal

Authors: Bousbaine, Djenet, Bauman, Katherine D., Chen, Y. Erin, Lalgudi, Pranav V., Nguyen, Tam T. D., Swenson, Joyce M., Yu, Victor K., Tsang, Eunice, Conlan, Sean, Li, David B., Jbara, Amina, Zhao, Aishan, Naziripour, Arash, Veinbachs, Alessandra, Lee, Yu E., Phung, Jennie L., Dimas, Alex, Jain, Sunit, Meng, Xiandong, Pham, Thi Phuong Thao, McLaughlin, Martin I., Barkal, Layla J., Gribonika, Inta, Van Rompay, Koen K. A., Kong, Heidi H., Segre, Julia A., Belkaid, Yasmine, Barnes, Christopher O., Fischbach, Michael A.

Source: Nature; February 2025, Vol. 638 Issue: 8052 p1054-1064, 11p

Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway.

Authors: Valenstein, Max L.^1,2,3,4, Lalgudi, Pranav V.^2,3, Xin Gu^3,4,5, Kedir, Jibril F.^2,3,4, Taylor, Martin S.^4,5,6,7,8, Chivukula, Raghu R.^1,4,9,10,11 mlvalenstein@mgb.org, Sabatini, David M.¹² david.sabatini@iocb.cz

Source: Proceedings of the National Academy of Sciences of the United States of America. 8/27/2024, Vol. 121 Issue 35, p1-12. 17p.

Subject Terms: *N-terminal residues, *CELL metabolism, *AMINO acids, *CELLULAR signal transduction, *CELL growth

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.

Authors: Gu, Xin, Jouandin, Patrick, Lalgudi, Pranav V., Binari, Rich, Valenstein, Max L., Reid, Michael A., Allen, Annamarie E., Kamitaki, Nolan, Locasale, Jason W., Perrimon, Norbert, Sabatini, David M.

Source: Nature; Aug2022, Vol. 608 Issue 7921, p209-216, 8p

Structure of the nutrient-sensing hub GATOR2.

Authors: Valenstein, Max L., Rogala, Kacper B., Lalgudi, Pranav V., Brignole, Edward J., Gu, Xin, Saxton, Robert A., Chantranupong, Lynne, Kolibius, Jonas, Quast, Jan-Philipp, Sabatini, David M.

Source: Nature; Jul2022, Vol. 607 Issue 7919, p610-616, 7p

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Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.

Authors: Gu, Xin, Jouandin, Patrick, Lalgudi, Pranav V., Binari, Rich, Valenstein, Max L., Reid, Michael A., Allen, Annamarie E., Kamitaki, Nolan, Locasale, Jason W., Perrimon, Norbert, Sabatini, David M.

Source: Nature; Sep2022, Vol. 609 Issue 7929, pE11-E11, 1p

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