Dose range finding approach for rodent preweaning juvenile animal studies

Authors: Posobiec, Lorraine M., Laffan, Susan B.

Source: Birth defects research. 113(5):409-426

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115842707.0x000001&indx=1&recIds=ETOCvdc_100115842707.0x000001

The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure

Authors: Cadilla, Rodolfo, Deaton, David N., Do, Young, Elkins, Patricia A., Ennulat, Daniela, Guss, Jeffrey H., Holt, Jason, Jeune, Michael R., King, Andrew G., Klapwijk, Jan C., Kramer, H. Fritz, Kramer, Nicholas J., Laffan, Susan B., Masuria, Paresh I., McDougal, Alan V., Mortenson, Paul N., Musetti, Caterina, Peckham, Gregory E., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Rendina, Alan R., Sati, Girish, Saxty, Gordon, Shearer, Barry G., Shewchuk, Lisa M., Sneddon, Helen F., Stewart, Eugene L., Stuart, J. Darren, Thomas, Dean N., Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tiahshun, Youngman, Mark A.

Source: In Bioorganic & Medicinal Chemistry 1 December 2020 28(23)

Absence of developmental and reproductive toxicity in animals exposed to dolutegravir

Authors: Stanislaus, Dinesh J., Posobiec, Lorraine M., Laffan, Susan B., Solomon, Howard M., Ziejewski, Mary K., Romach, Elizabeth H.

Source: Birth defects research. 112(3):245-261

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Weight of Evidence: Is an Animal Study Warranted? Assessments for Carcinogenicity, Drug Abuse Liability, and Pediatric Safety.

Authors: Ramani, Thulasi, Wange, Ronald L., Manetz, T. Scott, Kruzich, Paul J., Laffan, Susan B., Compton, David R.

Source: International Journal of Toxicology (Sage); Sep/Oct2024, Vol. 43 Issue 5, p435-455, 21p

Subject Terms: DRUG abuse, SAFETY regulations, CARCINOGENICITY, ARGUMENT, MANUSCRIPTS

Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects

Authors: Theunissen, Peter T., Beken, Sonia, Beyer, Bruce, Breslin, William J., Cappon, Gregg D., Chen, Connie L., Chmielewski, Gary, de Schaepdrijver, Luc, Enright, Brian, Foreman, Jennifer E., Harrouk, Wafa, Hew, Kok-Wah, Hoberman, Alan M., Y. Hui, Julia, Knudsen, Thomas B., Laffan, Susan B., Makris, Susan L., Martin, Matthew, McNerney, Mary Ellen, Siezen, Christine L., Stanislaus, Dinesh J., Stewart, Jane, Thompson, Kary E., Tornesi, Belen, Van der Laan, Jan Willem, Weinbauer, Gerhard F., Wood, Sandra, Piersma, Aldert H.

Source: Critical reviews in toxicology. 47(5):409-421

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103787320.0x000001&indx=1&recIds=ETOCvdc_100103787320.0x000001

Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects

Authors: Theunissen, Peter T., Beken, Sonja, Beyer, Bruce K., Breslin, William J., Cappon, Gregg D., Chen, Connie L., Chmielewski, Gary, De Schaepdrijver, Luc, Enright, Brian, Foreman, Jennifer E., Harrouk, Wafa, Hew, Kok-Wah, Hoberman, Alan M., Hui, Julia Y., Knudsen, Thomas B., Laffan, Susan B., Makris, Susan L., Martin, Matt, McNerney, Mary Ellen, Siezen, Christine L., Stanislaus, Dinesh J., Stewart, Jane, Thompson, Kary E., Tornesi, Belen, Van der Laan, Jan Willem, Weinbauer, Gerhard F., Wood, Sandra, Piersma, Aldert H.

Source: Critical reviews in toxicology. 46(10):900-910

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103787182.0x000001&indx=1&recIds=ETOCvdc_100103787182.0x000001

Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates.

Authors: Laffan, Susan B.¹ (AUTHOR), Thomson, Andrew S.² (AUTHOR), Mai, Shing² (AUTHOR), Fishman, Cindy¹ (AUTHOR), Kambara, Takahito³ (AUTHOR), Nistala, Kiran⁴ (AUTHOR), Raymond, James T.⁵ (AUTHOR), Chen, Shugui² (AUTHOR), Ramani, Thulasi⁶ (AUTHOR), Pageon, Laura⁶ (AUTHOR), Polsky, Rodd² (AUTHOR), Watkins, Mark¹ (AUTHOR), Ottolangui, Gemma⁷ (AUTHOR), White, John R.² (AUTHOR), Maier, Curtis¹ (AUTHOR), Herdman, Michael⁸ (AUTHOR), Bouma, Gerben^4,8 (AUTHOR) gerben.x.bouma@gsk.com

Source: PLoS ONE. 4/23/2020, Vol. 15 Issue 4, p1-18. 18p.

Subject Terms: *IMMUNE complexes, *IMMUNOLOGIC diseases, *CHRONIC diseases, *KRA, *MONKEYS, *CHEMOKINES, *MONOCLONAL antibodies

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Nonclinical Models for Neonatal Pediatric Drug Development

Authors: Davis-Bruno, Karen, De Schaepdrijver, Luc, Annaert, Pieter, Campion, Sarah, Carleer, Jacqueline, Chapin, Robert, Harrouk, Wafa, Laffan, Susan B., McCune, S., Moffat, Graeme, Tassinari, M.S., Urmaliya, V., Chen, C.L.

Source: In Reproductive Toxicology September 2016 64:49-49

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Artesunate‐induced depletion of embryonic erythroblasts precedes embryolethality and teratogenicity in vivo

Authors: White, Tacey E.K., Bushdid, Paul B., Ritter, Sandra, Laffan, Susan B., Clark, Robert L.

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology; October 2006, Vol. 77 Issue: 5 p413-429, 17p

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