Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer.

Authors: Milgram, Benjamin C., Borrelli, Deanna R., Brooijmans, Natasja, Henderson, Jack A., Hilbert, Brendan J., Huff, Michael R., Ito, Takahiro, Jackson, Erica L., Jonsson, Philip, Ladd, Brendon, O'Hearn, Erin L., Pagliarini, Raymond A., Roberts, Simon A., Ronseaux, Sébastien, Stuart, Darrin D., Wang, Weixue, Guzman-Perez, Angel

Source: Journal of Medicinal Chemistry; 2/13/2025, Vol. 68 Issue 3, p2403-2421, 19p

A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination

Authors: Vieux, Ellen F., Agafonov, Roman V., Emerson, Lydia, Isasa, Marta, Deibler, Richard W., Simard, Jeffrey R., Cocozziello, David, Ladd, Brendon, Lee, Linda, Li, Heng, Archer, Stephen, Fitzgerald, Mark, Michael, Ryan, Nasveschuk, Christopher G., Park, Eunice S., Kern, Gunther, Proia, David A., Phillips, Andrew J., Fisher, Stewart L. ^*

Source: In SLAS Discovery April 2021 26(4):547-559

Development of an AchillesTAG degradation system and its application to control CAR-T activity

Authors: Veits, Gesine K., Henderson, Christina S., Vogelaar, Abigail, Eron, Scott J., Lee, Linda, Hart, Ashley, Deibler, Richard W., Baddour, Joelle, Elam, W. Austin, Agafonov, Roman V., Freda, Jessica, Chaturvedi, Prasoon, Ladd, Brendon, Carlson, Mark W., Vora, Harit U., Scott, Thomas G., Tieu, Trang, Jain, Arushi, Chen, Chi-Li, Kibbler, Emily S., Pop, Marius S., He, Minsheng, Kern, Gunther, Maple, Hannah J., Marsh, Graham P., Norley, Mark C., Oakes, Catherine S., Henderson, James A., Sowa, Mathew E., Phillips, Andrew J., Proia, David A., Park, Eunice S., Patel, Joe Sahil, Fisher, Stewart L., Nasveschuk, Christopher G., Zeid, Rhamy

Source: In Current Research in Chemical Biology 2021 1

Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity

Authors: Ladd, Brendon, Ackroyd, Jeffrey J., Hicks, J. Kevin, Canman, Christine E., Flanagan, Sheryl A., Shewach, Donna S.

Source: In DNA Repair December 2013 12(12):1114-1121

KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors

Authors: Black, Joshua C., Manning, Amity L., Van Rechem, Capucine, Kim, Jaegil, Ladd, Brendon, Cho, Juok, Pineda, Cristiana M., Murphy, Nancy, Daniels, Danette L., Montagna, Cristina, Lewis, Peter W., Glass, Kimberly, Allis, C. David, Dyson, Nicholas J., Getz, Gad, Whetstine, Johnathan R.

Source: In Cell 1 August 2013 154(3):541-555

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression

Authors: Black, Joshua C., Atabakhsh, Elnaz, Kim, Jaegil, Biette, Kelly M., Van Rechem, Capucine, Ladd, Brendon, Burrowes, Paul d., Donado, Carlos, Mattoo, Hamid, Kleinstiver, Benjamin P.

Source: Genes & development. 29(10):1018-1031

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN601364114&indx=1&recIds=ETOCRN601364114

Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity

Authors: O’Konek, Jessica J., Ladd, Brendon, Flanagan, Sheryl A., Im, Mike M., Boucher, Paul D., Thepsourinthone, Tico S., Secrist, John A., III, Shewach, Donna S.

Source: In Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2010 684(1):1-10

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Regulation of Tissue-Specific and Extracellular Matrix-Related Genes by a Class I Histone Deacetylase

Authors: Whetstine, Johnathan R., Ceron, Julian, Ladd, Brendon, Dufourcq, Pascale, Reinke, Valerie, Shi, Yang ^*

Source: In Molecular Cell 2005 18(4):483-490

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