Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections

Authors: Buckley, Peter T., Chan, Rita, Fernandez, Jeffrey, Luo, Jinquan, Lacey, Keenan A., DuMont, Ashley L., O’Malley, Aidan, Brezski, Randall J., Zheng, Songmao, Malia, Thomas, Whitaker, Brian, Zwolak, Adam, Payne, Angela, Clark, Desmond, Sigg, Martin, Lacy, Eilyn R., Kornilova, Anna, Kwok, Debra, McCarthy, Steve, Wu, Bingyuan, Morrow, Brian, Nemeth-Seay, Jennifer, Petley, Ted, Wu, Sam, Strohl, William R., Lynch, Anthony Simon, Torres, Victor J.

Source: In Cell Host & Microbe 10 May 2023 31(5):751-765

Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis

Authors: Edavettal, Suzanne, Cejudo-Martin, Pilar, Dasgupta, Bidisha, Yang, Danlin, Buschman, Matthew D., Domingo, Derrick, Van Kolen, Kristof, Jaiprasat, Pharavee, Gordon, Renata, Schutsky, Keith, Geist, Brian, Taylor, Natalie, Soubrane, Camille Helene, Van Der Helm, Elisabeth, LaCombe, Ann, Ainekulu, Zemeda, Lacy, Eilyn, Aligo, Jason, Ho, Jason, He, Yingbo, Lebowitz, Peter F., Patterson, James T., Scheer, Justin M., Singh, Sanjaya

Source: In Med 9 December 2022 3(12):860-882

769 GUSELKUMAB, AN IL-23P19 SUBUNIT-SPECIFIC MONOCLONAL ANTIBODY, BINDS CD64+ MYELOID CELLS AND POTENTLY NEUTRALIZES IL-23 PRODUCED FROM THE SAME CELLS

Authors: Abreu, Maria T., Atreya, Raja, Krueger, James G., Eyerich, Kilian, Sachen, Kacey, Greving, Carrie, Hammaker, Deepa, Bao, Phuc, Lacy, Eilyn, Sarabia, Indra, Deming, Janise, Elloso, M. Merle, Ritchlin, Christopher, McInnes, Iain B., Allez, Matthieu, Fourie, Anne

Source: Gastroenterology. 164(6):S-163-S-163

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194427487.0x000001&indx=1&recIds=ETOCvdc_100194427487.0x000001

Pharmacological Profile of JNJ-64179375: A Novel, Long-Acting Exosite-1 Thrombin Inhibitor

Authors: Huang Devine, Zheng ^*, Du, Fuyong, Li, Qiu, Bunce, Matthew, Lacy, Eilyn R., Chintala, Madhu

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2019 371(2):375-384

Human IgG subclass cross-species reactivity to mouse and cynomolgus monkey Fcγ receptors

Authors: Derebe, Mehabaw G., Nanjunda, Rupesh K., Gilliland, Gary L., Lacy, Eilyn R., Chiu, Mark L.

Source: In Immunology Letters May 2018 197:1-8

Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

Authors: Hinke, Simon A., Cieniewicz, Anne M., Kirchner, Thomas, D'Aquino, Katharine, Nanjunda, Rupesh, Aligo, Jason, Perkinson, Robert, Cooper, Philip, Boayke, Ken, Chiu, Mark L., Jarantow, Steve, Lacy, Eilyn R., Liang, Yin, Johnson, Dana L., Whaley, Jean M., Lingham, Russell B., Kihm, Anthony J.

Source: In Molecular Metabolism April 2018 10:87-99

Monoclonal antibodies targeting ST2L Domain 1 or Domain 3 differentially modulate IL-33-induced cytokine release by human mast cell and basophilic cell lines

Authors: Fursov, Natalie, Lu, Jin, Healy, Catherine, Wu, Sheng-Jiun, Lacy, Eilyn, Filer, Angela, Li, Yawei, Liu, Changbao, Lamb, Roberta, Jones, Brian, Reddy, Ramachandra, Petley, Ted, Duffy, Karen

Source: In Molecular Immunology July 2016 75:178-187

Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody

Authors: Jarantow, Stephen W., Bushey, Barbara S., Pardinas, Jose R., Boakye, Ken, Lacy, Eilyn R., Sanders, Renouard, Sepulveda, Manuel A., Moores, Sheri L., Chiu, Mark L.

Source: In Journal of Biological Chemistry 9 October 2015 290(41):24689-24704

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

Authors: Vafa, Omid, Gilliland, Gary L., Brezski, Randall J., Strake, Brandy, Wilkinson, Teresa, Lacy, Eilyn R., Scallon, Bernard, Teplyakov, Alexey, Malia, Thomas J., Strohl, William R.

Source: In Methods 1 January 2014 65(1):114-126

Thrombogenic Collagen-Mimetic Peptides: Self-Assembly of Triple Helix-Based Fibrils Driven by Hydrophobic Interactions

Authors: Cejas, Mabel A., Kinney, William A., Chen, Cailin, Vinter, Jeremy G., Almond,, Harold R., Balss, Karin M., Maryanoff, Cynthia A., Schmidt, Ute, Breslav, Michael, Mahan, Andrew, Lacy, Eilyn, Maryanoff, Bruce E.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2008 Jun . 105(25), 8513-8518.

Access URL: https://www.jstor.org/stable/25462817

Structural Basis for the Dual Recognition of IL-12 and IL-23 by Ustekinumab

Authors: Luo, Jinquan, Wu, Sheng-Jiun, Lacy, Eilyn R., Orlovsky, Yevgeniya, Baker, Audrey, Teplyakov, Alexey, Obmolova, Galina, Heavner, George A., Richter, Hans-Thomas, Benson, Jacqueline

Source: In Journal of Molecular Biology 8 October 2010 402(5):797-812

"Stapling" scFv for multispecific biotherapeutics of superior properties.

Authors: Boucher, Lauren E., Prinslow, Elisabeth Geyer, Feldkamp, Michael, Yi, Fang, Nanjunda, Rupesh, Wu, Sheng-Jiun, Liu, Tun, Lacy, Eilyn R., Jacobs, Steven, Kozlyuk, Natalia, Del Rosario, Brian, Wu, Bingyuan, Aquino, Patricia, Davidson, Robert C., Heyne, Samantha, Mazzanti, Nicholas, Testa, James, Diem, Michael D., Gorre, Elsa, Mahan, Andrew

Source: mAbs; Jan-Dec2023, Vol. 15 Issue 1, p1-15, 15p

43272 Differentiation of Therapeutic Monoclonal Antibodies Targeting IL-23 for the Treatment of Psoriatic Disease

Authors: Eyerich, Kilian, Krueger, James G., Sachen, Kacey, Greving, Carrie, Hammaker, Deepa, Bao, Phuc, Lacy, Eilyn, McInnes, Iain B., Fourie, Anne

Source: In Journal of the American Academy of Dermatology September 2023 89(3) Supplement:AB149-AB149

Molecular Basis for the Specificity of p27 Toward Cyclin-dependent Kinases that Regulate Cell Division

Authors: Lacy, Eilyn R. ^{†, ‡}, Wang, Yuefeng ^†, Post, Jeremy, Nourse, Amanda, Webb, William, Mapelli, Marina, Musacchio, Andrea, Siuzdak, Gary, Kriwacki, Richard W.

Source: In Journal of Molecular Biology 2005 349(4):764-773

Influence of a terminal formamido group on the sequence recognition of DNA by polyamides.

Authors: Lacy, Eilyn R., Le, N. Minh, Price, Carly A.

Source: Journal of the American Chemical Society; March 13 2002, Vol. 124 Issue 10, p2153-2163, 11p

Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody.

Authors: Van Kolen, Kristof, Malia, Thomas J., Theunis, Clara, Nanjunda, Rupesh, Teplyakov, Alexey, Ernst, Robin, Wu, Sheng-Jiun, Luo, Jinquan, Borgers, Marianne, Vandermeeren, Marc, Bottelbergs, Astrid, Wintmolders, Cindy, Lacy, Eilyn, Maurin, Hervé, Larsen, Peter, Willems, Roland, Van De Casteele, Tom, Triana-Baltzer, Gallen, Slemmon, Randy, Galpern, Wendy

Source: Journal of Alzheimer's Disease; 2020, Vol. 77 Issue 4, p1397-1416, 20p

Subject Terms: MONOCLONAL antibodies, SURFACE plasmon resonance, CELL analysis, ALZHEIMER'S disease, POSTMORTEM changes, IMMUNOSTAINING, PROTEINS, RESEARCH, NERVE tissue proteins, ANIMAL experimentation, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESEARCH funding, DRUG development, PHOSPHORYLATION, MICE

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding.

Authors: Lacy, Eilyn R.¹, Filippov, Igor^1,2, Lewis, William S.³, Otieno, Steve^1,4, Xiao, Limin¹, Weiss, Sonja⁵, Hengst, Ludger⁵, Kriwacki, Richard W.¹ richard.kriwac.ki@stjude.org

Source: Nature Structural & Molecular Biology. Apr2004, Vol. 11 Issue 4, p358-364. 7p.

Subject Terms: *CELL proliferation, *CYCLIN-dependent kinases, *CYTOPLASM, *CELL cycle, *BIOLOGICAL rhythms, *BIOLOGY

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