Adjuvants influence the maturation of VRC01-like antibodies during immunization

Authors: Knudsen, Maria L., Agrawal, Parul, MacCamy, Anna, Parks, K. Rachael, Gray, Matthew D., Takushi, Brittany N., Khechaduri, Arineh, Salladay, Kelsey R., Coler, Rhea N., LaBranche, Celia C., Montefiori, David, Stamatatos, Leonidas

Source: In iScience 18 November 2022 25(11)

Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Authors: Sahoo, Anusmita, Hodge, Edgar A., LaBranche, Celia C., Styles, Tiffany M., Shen, Xiaoying, Cheedarla, Narayanaiah, Shiferaw, Ayalnesh, Ozorowski, Gabriel, Lee, Wen-Hsin, Ward, Andrew B., Tomaras, Georgia D., Montefiori, David C., Irvine, Darrell J., Lee, Kelly K., Amara, Rama Rao

Source: In Cell Reports 1 March 2022 38(9)

The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat

Authors: Montefiori, David C., Interrante, Maria V. Filsinger, Bell, Benjamin N., Rubio, Adonis A., Joyce, Joseph G., Shiver, John W., LaBranche, Celia C., Kim, Peter S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jan . 118(3), 1-6.

Access URL: https://www.jstor.org/stable/27012233

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

Authors: Williams, Wilton B., Meyerhoff, R. Ryan, Edwards, R.J., Li, Hui, Manne, Kartik, Nicely, Nathan I., Henderson, Rory, Zhou, Ye, Janowska, Katarzyna, Mansouri, Katayoun, Gobeil, Sophie, Evangelous, Tyler, Hora, Bhavna, Berry, Madison, Abuahmad, A. Yousef, Sprenz, Jordan, Deyton, Margaret, Stalls, Victoria, Kopp, Megan, Hsu, Allen L., Borgnia, Mario J., Stewart-Jones, Guillaume B.E., Lee, Matthew S., Bronkema, Naomi, Moody, M. Anthony, Wiehe, Kevin, Bradley, Todd, Alam, S. Munir, Parks, Robert J., Foulger, Andrew, Oguin, Thomas, Sempowski, Gregory D., Bonsignori, Mattia, LaBranche, Celia C., Montefiori, David C., Seaman, Michael, Santra, Sampa, Perfect, John, Francica, Joseph R., Lynn, Geoffrey M., Aussedat, Baptiste, Walkowicz, William E., Laga, Richard, Kelsoe, Garnett, Saunders, Kevin O., Fera, Daniela, Kwong, Peter D., Seder, Robert A., Bartesaghi, Alberto, Shaw, George M., Acharya, Priyamvada, Haynes, Barton F.

Source: In Cell 27 May 2021 184(11):2955-2972

Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates

Authors: Silva de Castro, Isabela, Gorini, Giacomo, Mason, Rosemarie, Gorman, Jason, Bissa, Massimiliano, Rahman, Mohammad A., Arakelyan, Anush, Kalisz, Irene, Whitney, Stephen, Becerra-Flores, Manuel, Ni, Eric, Peachman, Kristina, Trinh, Hung V., Read, Michael, Liu, Mei-Hue, Van Ryk, Donald, Paquin-Proulx, Dominic, Shubin, Zhanna, Tuyishime, Marina, Peele, Jennifer, Ahmadi, Mohammed S., Verardi, Raffaello, Hill, Juliane, Beddall, Margaret, Nguyen, Richard, Stamos, James D., Fujikawa, Dai, Min, Susie, Schifanella, Luca, Vaccari, Monica, Galli, Veronica, Doster, Melvin N., Liyanage, Namal P.M., Sarkis, Sarkis, Caccuri, Francesca, LaBranche, Celia, Montefiori, David C., Tomaras, Georgia D., Shen, Xiaoying, Rosati, Margherita, Felber, Barbara K., Pavlakis, George N., Venzon, David J., Magnanelli, William, Breed, Matthew, Kramer, Josh, Keele, Brandon F., Eller, Michael A., Cicala, Claudia, Arthos, James, Ferrari, Guido, Margolis, Leonid, Robert-Guroff, Marjorie, Kwong, Peter D., Roederer, Mario, Rao, Mangala, Cardozo, Timothy J., Franchini, Genoveffa

Source: In iScience 19 February 2021 24(2)

Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2

Authors: Park, Kyung Soo, Bazzill, Joseph D., Son, Sejin, Nam, Jutaek, Shin, Seung Won, Ochyl, Lukasz J., Stuckey, Jeanne A., Meagher, Jennifer L., Chang, Louise, Song, Jun, Montefiori, David C., LaBranche, Celia C., Smith, Janet L., Xu, Jie, Moon, James J.

Source: In Journal of Controlled Release 10 February 2021 330:529-539

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Authors: Angyal, Adrienne, Brown, Rebecca L., Carrilero, Laura, Green, Luke R., Groves, Danielle C., Johnson, Katie J., Keeley, Alexander J., Lindsey, Benjamin B., Parsons, Paul J., Raza, Mohammad, Rowland-Jones, Sarah, Smith, Nikki, Tucker, Rachel M., Wang, Dennis, Wyles, Matthew D., Korber, Bette, Fischer, Will M., Gnanakaran, Sandrasegaram, Yoon, Hyejin, Theiler, James, Abfalterer, Werner, Hengartner, Nick, Giorgi, Elena E., Bhattacharya, Tanmoy, Foley, Brian, Hastie, Kathryn M., Parker, Matthew D., Partridge, David G., Evans, Cariad M., Freeman, Timothy M., de Silva, Thushan I., McDanal, Charlene, Perez, Lautaro G., Tang, Haili, Moon-Walker, Alex, Whelan, Sean P., LaBranche, Celia C., Saphire, Erica O., Montefiori, David C.

Source: In Cell 20 August 2020 182(4):812-827

Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge

Authors: Felber, Barbara K., Lu, Zhongyan, Hu, Xintao, Valentin, Antonio, Rosati, Margherita, Remmel, Christopher A.L., Weiner, Joshua A., Carpenter, Margaret C., Faircloth, Katelyn, Stanfield-Oakley, Sherry, Williams, Wilton B., Shen, Xiaoying, Tomaras, Georgia D., LaBranche, Celia C., Montefiori, David, Trinh, Hung V., Rao, Mangala, Alam, Munir S., Vandergrift, Nathan A., Saunders, Kevin O., Wang, Yunfei, Rountree, Wes, Das, Jishnu, Alter, Galit, Reed, Steven G., Aye, Pyone P., Schiro, Faith, Pahar, Bapi, Dufour, Jason P., Veazey, Ronald S., Marx, Preston A., Venzon, David J., Shaw, George M., Ferrari, Guido, Ackerman, Margaret E., Haynes, Barton F., Pavlakis, George N.

Source: In Cell Reports 12 May 2020 31(6)

Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs

Authors: Seaman, Michael S., Bilska, Miroslawa, Ghantous, Fadi, Eaton, Amanda, LaBranche, Celia C., Greene, Kelli, Gao, Hongmei, Weiner, Joshua A., Ackerman, Margaret E., Garber, David A., Rosenberg, Yvonne J., Sarzotti-Kelsoe, Marcella, Montefiori, David C.

Source: In Journal of Immunological Methods April 2020 479

Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization

Authors: Parks, K. Rachael, MacCamy, Anna J., Trichka, Josephine, Gray, Matthew, Weidle, Connor, Borst, Andrew J., Khechaduri, Arineh, Takushi, Brittany, Agrawal, Parul, Guenaga, Javier, Wyatt, Richard T., Coler, Rhea, Seaman, Michael, LaBranche, Celia, Montefiori, David C., Veesler, David, Pancera, Marie, McGuire, Andrew, Stamatatos, Leonidas

Source: In Cell Reports 3 December 2019 29(10):3060-3072

Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields

Authors: Gorman, Jason, Mason, Rosemarie D., Nettey, Leonard, Cavett, Nicole, Chuang, Gwo-Yu, Peng, Dongjun, Tsybovsky, Yaroslav, Verardi, Raffaello, Nguyen, Richard, Ambrozak, David, Biris, Kristin, LaBranche, Celia C., Ramesh, Akshaya, Schramm, Chaim A., Zhou, Jing, Bailer, Robert T., Kepler, Thomas B., Montefiori, David C., Shapiro, Lawrence, Douek, Daniel C., Mascola, John R., Roederer, Mario, Kwong, Peter D.

Source: In Immunity 15 October 2019 51(4):724-734

Parallel Induction of CH505 B Cell Ontogeny-Guided Neutralizing Antibodies and tHIVconsvX Conserved Mosaic-Specific T Cells against HIV-1

Authors: Wee, Edmund G., Moyo, Nathifa A., Saunders, Kevin O., LaBranche, Celia, Donati, Filippo, Capucci, Silvia, Parks, Robert, Borthwick, Nicola, Hannoun, Zara, Montefiori, David C., Haynes, Barton F., Hanke, Tomáš

Source: In Molecular Therapy - Methods & Clinical Development 13 September 2019 14:148-160

Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques

Authors: Pardi, Norbert, LaBranche, Celia C., Ferrari, Guido, Cain, Derek W., Tombácz, István, Parks, Robert J., Muramatsu, Hiromi, Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Polacino, Patricia, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Haynes, Barton F., Montefiori, David C., Hu, Shiu-Lok, Weissman, Drew

Source: In Molecular Therapy - Nucleic Acids 15 April 2019 15:36-47

Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial

Authors: Priddy, Frances H, Lewis, David J M, Gelderblom, Huub C, Hassanin, Hana, Streatfield, Claire, LaBranche, Celia, Hare, Jonathan, Cox, Josephine H, Dally, Len, Bendel, Daryl, Montefiori, David, Sayeed, Eddy, Ackland, Jim, Gilmour, Jill, Schnepp, Bruce C, Wright, J Fraser, Johnson, Philip

Source: In The Lancet HIV April 2019 6(4):e230-e239

The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans

Authors: Nguyen, Dung N., Redman, Richard L., Horiya, Satoru, Bailey, Jennifer K., Xu, Bokai, Stanfield, Robyn L., Temme, J. Sebastian, LaBranche, Celia C., Wang, Shiyu, Rodal, Avital A.

Source: ACS chemical biology. 15(3):789-798

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN623845483&indx=1&recIds=ETOCRN623845483

An Engineered Biomimetic MPER Peptide Vaccine Induces Weakly HIV Neutralizing Antibodies in Mice

Authors: Shao, Shuai, Huang, Wei-Chiao, Lin, Cuiyan, Hicar, Mark D., LaBranche, Celia C., Montefiori, David C., Lovell, Jonathan F.

Source: Annals of biomedical engineering. 48(7):1991-2001

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168242359.0x000001&indx=1&recIds=ETOCvdc_100168242359.0x000001

Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys

Authors: Himes, Jonathon E., Goswami, Ria, Mangan, Riley J., Kumar, Amit, Jeffries, Thomas L., Jr., Eudailey, Joshua A., Heimsath, Holly, Nguyen, Quang N., Pollara, Justin, LaBranche, Celia, Chen, Meng, Vandergrift, Nathan A., Peacock, James W., Schiro, Faith, Midkiff, Cecily, Ferrari, Guido, Montefiori, David C., Hernandez, Xavier Alvarez, Aye, Pyone Pyone, Permar, Sallie R.

Source: In Mucosal Immunology November 2018 11(6):1716-1726

Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers

Authors: de Taeye, Steven W., de la Peña, Alba Torrents, Vecchione, Andrea, Scutigliani, Enzo, Sliepen, Kwinten, Burger, Judith A., van der Woude, Patricia, Schorcht, Anna, Schermer, Edith E., van Gils, Marit J., LaBranche, Celia C., Montefiori, David C., Wilson, Ian A., Moore, John P., Ward, Andrew B., Sanders, Rogier W.

Source: In Journal of Biological Chemistry 2 February 2018 293(5):1688-1701

Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization

Authors: Hogan, Michael J., Conde-Motter, Angela, Jordan, Andrea P.O., Yang, Lifei, Cleveland, Brad, Guo, Wenjin, Romano, Josephine, Ni, Houping, Pardi, Norbert, LaBranche, Celia C., Montefiori, David C., Hu, Shiu-Lok, Hoxie, James A., Weissman, Drew

Source: In Virology 15 January 2018 514:106-117

HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

Authors: Jones, Andrew, Shen, Xiaoying, Walter, Korey, LaBranche, Celia, Wyatt, Linda, Tomaras, Georgia, Montefiori, David, Moss, Bernard, Barouch, Dan, Clements, John, Kozlowski, Pamela, Varadarajan, Raghavan, Amara, Rama

Source: Nature communications. 10(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114606586.0x000001&indx=1&recIds=ETOCvdc_100114606586.0x000001