Haplodeficiency of the 9p21 tumor suppressor locus causes myeloid disorders driven by the bone marrow microenvironment

Authors: Feng, Jue, Hsu, Pei-Feng, Esteva, Eduardo, Labella, Rossella, Wang, Yueyang, Khodadadi-Jamayran, Alireza, Pucella, Joseph, Liu, Cynthia Z., Arbini, Arnaldo A., Tsirigos, Aristotelis, Kousteni, Stavroula, Reizis, Boris

Source: In Blood 3 August 2023 142(5):460-476

Zoledronic Acid in a Mouse Model of Human Fibrous Dysplasia: Ineffectiveness on Tissue Pathology, Formation of 'Giant Osteoclasts' and Pathogenetic Implications

Authors: Corsi, Alessandro, Palmisano, Biagio, Spica, Emanuela, Di Filippo, Annamaria, Coletta, Ilenia, Dello Spedale Venti, Michele, Labella, Rossella, Fabretti, Francesca, Donsante, Samantha, Remoli, Cristina, Serafini, Marta, Riminucci, Mara

Source: Calcified tissue international. 107(6):603-610

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184376497.0x000001&indx=1&recIds=ETOCvdc_100184376497.0x000001

Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis.

Authors: Bisikirska, Brygida, Labella, Rossella, Cuesta-Dominguez, Alvaro, Luo, Na, De Angelis, Jessica, Mosialou, Ioanna, Lin, Chyuan-Sheng, Beck, David, Lata, Sneh, Shyu, Peter Timothy, McMahon, Donald J., Guo, Edward, Hagen, Jacob, Chung, Wendy K., Shane, Elizabeth, Cohen, Adi, Kousteni, Stavroula

Source: Science Translational Medicine; 10/16/2024, Vol. 16 Issue 769, p1-14, 14p

Subject Terms: GENETIC testing, FAMILY history (Genealogy), GENETIC variation, BONE remodeling, IDIOPATHIC diseases, BONE fractures

Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy Development.

Authors: Trivanović, Drenka, Vujačić, Marko, Labella, Rossella, Djordjević, Ivana Okić, Ćazić, Marija, Chernak, Brian, Jauković, Aleksandra

Source: Current Osteoporosis Reports; Aug2024, Vol. 22 Issue 4, p367-377, 11p

2002 – MATRICELLULAR PROTEIN DEFICIENCY TRANSFORMS MDS TO MYELOID LEUKEMIA THROUGH INDUCTION OF TGF-Β-MEDIATED EPITHELIAL-TO-MESENCHYMAL TRANSITION

Authors: Cuesta-Dominguez, Alvaro, Mosialou, Ioanna, Bisikirska, Brygida, Labella, Rossella, Galan-Diez, Marta, Ali, Abdullah, Kotini, Diana, Chen, Ziwei, Olszewska, Malgorzata, Jaud, Manon, Braunstein, Stephanie, Viny, Aaron, Zhao, Junfei, Rabadan, Raul, Papapetrou, Eirini, Raza, Azra, Kousteni, Stavroula

Source: In Experimental Hematology August 2024 137 Supplement

RANKL Inhibition in Fibrous Dysplasia of Bone: A Preclinical Study in a Mouse Model of the Human Disease

Authors: Palmisano, Biagio, Spica, Emanuela, Remoli, Cristina, Labella, Rossella, Di Filippo, Annamaria, Donsante, Samantha, Bini, Fabiano, Raimondo, Domenico, Marinozzi, Franco, Boyde, Alan, Robey, Pamela, Corsi, Alessandro, Riminucci, Mara

Source: Journal of bone and mineral research. 34(12):2171-2182

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099962751.0x000001&indx=1&recIds=ETOCvdc_100099962751.0x000001

Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system

Authors: Chen, Junyu, Lippo, Luciana, Labella, Rossella, Tan, Sin Lih, Marsden, Brian D, Dustin, Michael L, Ramasamy, Saravana K, Kusumbe, Anjali P

Source: EMBO journal. 40(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115875041.0x000001&indx=1&recIds=ETOCvdc_100115875041.0x000001

2013 – MESENCHYMAL STROMAL CELL MITOCHONDRIAL TRANSFER FUELS MDS TO AML TRANSFORMATION

Authors: Labella, Rossella, Ali, Abdullah, Mosialou, Ioanna, De Angelis, Jessica, Vgenopoulou, Paraskevi, Zhao, Junfei, Vanderberg, Andrew, Rabadan, Raul, Raza, Azra, Kousteni, Stavroula

Source: Experimental hematology. 124(S):S43-S43

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195477741.0x000001&indx=1&recIds=ETOCvdc_100195477741.0x000001

Activated Gs⍺ pathway and estrogens reveal different subsets of adiponectin-expressing osteoprogenitors within bone marrow stroma

Authors: Palmisano, Biagio, Labella, Rossella, Donsante, Samantha, Coletta, Ilenia, Farinacci, Giorgia, Venti, Michele Dello Spedale, Robey, Pamela Gehron, Corsi, Alessandro, Riminucci, Mara

Source: In Bone Reports May 2022 16 Supplement

Bone Marrow Adipose Tissue: Regulation of Osteoblastic Niche, Hematopoiesis and Hematological Malignancies.

Authors: Labella, Rossella¹ (AUTHOR), Vujačić, Marko² (AUTHOR), Trivanović, Drenka³ (AUTHOR) drenka.trivanovic@imi.bg.ac.rs

Source: Stem Cell Reviews & Reports. Jul2023, Vol. 19 Issue 5, p1135-1151. 17p.

Subject Terms: *ADIPOGENESIS, *BONE marrow, *ADIPOSE tissues, *HEMATOPOIESIS, *STEM cell niches, *HEMATOLOGIC malignancies, *HOMEOSTASIS, *HEMATOPOIETIC stem cells

Gsα^R201C and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells.

Authors: Palmisano, Biagio, Labella, Rossella, Donsante, Samantha, Remoli, Cristina, Spica, Emanuela, Coletta, Ilenia, Farinacci, Giorgia, Dello Spedale Venti, Michele, Saggio, Isabella, Serafini, Marta, Robey, Pamela Gehron, Corsi, Alessandro, Riminucci, Mara

Source: Bone Research; 7/19/2022, Vol. 10 Issue 1, p1-15, 15p

Subject Terms: MESENCHYMAL stem cells, BONE marrow, OSTEOCLASTS, BONE marrow cells, BONE growth, ADIPONECTIN

3061 – HAPLODEFICIENCY OF THE 9P21 TUMOR SUPPRESSOR LOCUS CAUSES MYELOID DISORDERS DRIVEN BY THE BONE MARROW MICROENVIRONMENT

Authors: Feng, Jue, Hsu, Pei-Feng, Esteva, Eduardo, Labella, Rossella, Wang, Yueyang, Khodadadi-Jamayran, Alireza, Pucella, Joseph, Liu, Cynthia, Arbini, Arnaldo, Tsirigos, Aristotelis, Kousteni, Stavroula, Reizis, Boris

Source: In Experimental Hematology 2023 124 Supplement:S80-S80

Next Generation Bone Marrow Adiposity Researchers: Report From the 1^st BMAS Summer School 2021.

Authors: Labella, Rossella, Little-Letsinger, Sarah, Avilkina, Viktorjia, Sarkis, Rita, Tencerova, Michaela, Vlug, Annegreet, Palmisano, Biagio

Source: Frontiers in Endocrinology; 4/13/2022, Vol. 13, p1-8, 8p

Subject Terms: BONE marrow, SUMMER schools, OBESITY, CAREER development, MESENCHYMAL stem cells

Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society.

Authors: Tratwal, Josefine, Labella, Rossella, Bravenboer, Nathalie, Kerckhofs, Greet, Douni, Eleni, Scheller, Erica L., Badr, Sammy, Karampinos, Dimitrios C., Beck-Cormier, Sarah, Palmisano, Biagio, Poloni, Antonella, Moreno-Aliaga, Maria J., Fretz, Jackie, Rodeheffer, Matthew S., Boroumand, Parastoo, Rosen, Clifford J., Horowitz, Mark C., van der Eerden, Bram C. J., Veldhuis-Vlug, Annegreet G., Naveiras, Olaia

Source: Frontiers in Endocrinology; 2/28/2020, p1-36, 36p

Subject Terms: BONE marrow, MESENCHYMAL stem cells, OBESITY, CELL separation, OSTEOPOROSIS

GsαR201Cand estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells

Authors: Palmisano, Biagio, Labella, Rossella, Donsante, Samantha, Remoli, Cristina, Spica, Emanuela, Coletta, Ilenia, Farinacci, Giorgia, Dello Spedale Venti, Michele, Saggio, Isabella, Serafini, Marta, Robey, Pamela Gehron, Corsi, Alessandro, Riminucci, Mara

Source: Bone Research; December 2022, Vol. 10 Issue: 1

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging.

Authors: Junyu Chen^1,2, Sivan, Unnikrishnan¹, Sin Lih Tan¹, Lippo, Luciana¹, De Angelis, Jessica¹, Labella, Rossella¹, Singh, Amit^1,3, Chatzis, Alexandros¹, Cheuk, Stanley^4,5, Medhghalchi, Mino⁶, Gil, Jesus^7,8, Hollander, Georg⁴, Marsden, Brian D.^6,9, Williams, Richard⁶, Ramasamy, Saravana K.^7,8, Kusumbe, Anjali P.¹ anjali.kusumbe@kennedy.ox.ac.uk

Source: Science Advances. 2/3/2021, Vol. 7 Issue 6, p1-17. 17p.

Subject Terms: *PERICYTES, *AGING, *THREE-dimensional imaging, *CELLULAR aging, *VASCULAR endothelial growth factor receptors, *MEDICAL sciences